{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:51:18Z","timestamp":1789487478339,"version":"build-2803163510"},"reference-count":127,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Immune-mediated inflammatory diseases have traditionally been investigated within organ-specific frameworks. Although increasing evidence has revealed extensive communication along individual gut-organ axes, these interactions are often described through separate mechanisms, including microbial dysbiosis, barrier disruption, soluble mediators, and immune-cell redistribution. A central challenge remains to determine how intestinal immune states are established and how they are translated into organ-specific inflammatory responses. In this review, we propose that the intestine functions as a dynamic immune programming niche for mobile immunity, where microbial, epithelial, and stromal signals collectively shape immune-cell states before their systemic dissemination. Through this niche-dependent education, immune cells acquire distinct phenotypic and migratory programs, while retaining sufficient plasticity to be further reconfigured within peripheral tissues. By integrating evidence across the gut-liver, gut-joint, gut-skin, gut-brain, and other organ axes, we establish a framework in which intestinal immune niches are followed by systemic trafficking, tissue-specific recruitment, and local functional reprogramming. This perspective shifts the focus of gut-organ communication from isolated organ interactions toward a directional process involving immune-cell generation, trafficking, and tissue-specific adaptation. This perspective reframes gut-organ communication as gut-driven immune redistribution rather than isolated organ-axis interactions, highlights intestinal immune programming and immune-cell trafficking as potential targets for systemic immune intervention.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1888071","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T14:28:35Z","timestamp":1789482515000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["From intestinal immune niches to systemic inflammation: programming cellular plasticity and immune redistribution across organs"],"prefix":"10.3389","volume":"17","author":[{"given":"Bohang","family":"Zeng","sequence":"first","affiliation":[{"name":"College of Food Engineering, Harbin University of Commerce","place":["Harbin, 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