{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:01:54Z","timestamp":1789970514397,"version":"4.0.1"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Several human IGHV genes recur in infection, autoreactivity, B-cell malignancy, and antibody-discovery studies, but their downstream V(D)J usage, observed heavy-light pairing, and CDRH3 properties have rarely been examined together in paired human repertoires.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We assembled 3,003,127 paired heavy- and light-chain records from public Observed Antibody Space (OAS) source files. After quality control, gene-level standardization, and exact-clonotype collapsing, the primary six-gene analysis included 712,143 exact clonotypes assigned to IGHV1-2, IGHV1-69, IGHV3-21, IGHV3-23, IGHV3-30, or IGHV4-34.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Marginal V-D effects were generally modest, whereas recurrent V-conditioned D-J modules and IGHV-associated VH-VL enrichment or depletion were repeatedly observed across OAS study groups in productive expressed repertoires. Several VH-VL directions persisted across studies and metadata-defined immune contexts, although two pairs were context-sensitive. External comparison with PairedAbNGS supported 8 of 10 evaluable key VH-VL directions and the broad IGHV-associated CDRH3 profiles. IGHV4-34 showed a study-robust, cross-resource positive shift in CDRH3 side-chain charge score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Together, these analyses provide a study-aware reference for V-conditioned D-J usage, VH-VL associations, and CDRH3 properties across six selected IGHV backgrounds, while defining the limits imposed by immune-context heterogeneity and productive-repertoire sampling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1888170","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:34:37Z","timestamp":1789968877000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Recurrent antibody repertoire features associated with six selected human IGHV genes: V(D)J usage, heavy-light pairing, and CDRH3 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Antibody Drug Engineering, The First Affiliated Hospital of Henan University, Henan University","place":["Kaifeng, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beifen","family":"Shen","sequence":"additional","affiliation":[{"name":"Academy of Military Medical Sciences","place":["Beijing, China"]},{"name":"State Key Laboratory of National Security Specially Needed Medicines","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wen","sequence":"additional","affiliation":[{"name":"College of Biotechnology, Jiangsu University of Science and Technology","place":["Zhenjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Academy of Military Medical Sciences","place":["Beijing, China"]},{"name":"State Key Laboratory of National Security Specially Needed Medicines","place":["Beijing, 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