{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:04:42Z","timestamp":1789535082936,"version":"build-2803163510"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Nuclear mRNA transport is essential for maintaining mRNA homeostasis and normal cellular functions; however, the mechanisms regulating the nuclear transport of E2F transcription factor 1 (\n                    <jats:italic>E2F1<\/jats:italic>\n                    ) mRNA remain poorly understood. In this study, we show that the nuclear RNA transport factor 1 (NXF1) is upregulated in Hemin-treated HT22 cells and intracerebral hemorrhage (ICH) mice, suggesting its involvement in ICH pathogenesis.\n                    <jats:italic>NXF1<\/jats:italic>\n                    knockdown exerted a protective effect against Hemin-induced inflammatory responses in HT22 cells. Consistently,\n                    <jats:italic>NXF1<\/jats:italic>\n                    downregulation ameliorated neurological deficits, reduced cell death, and decreased cytokine levels\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Mechanistically, NXF1-mediated neuroprotection was associated with mitophagy induction. Collectively, our findings provide novel insights into ICH progression and identify the RBM15\/NXF1\/E2F1 axis as a potential target for ICH intervention.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1892295","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:33:35Z","timestamp":1789533215000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["RBM15 affects mitophagy in intracerebral hemorrhage by promoting E2F1 nuclear translocation via NXF1"],"prefix":"10.3389","volume":"17","author":[{"given":"Jiwei","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Bengbu Medical University","place":["Bengbu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of 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