{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:07:56Z","timestamp":1789470476676,"version":"build-2803163510"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Childhood asthma has traditionally been characterized as a localized chronic airway inflammatory disease, with structural remodeling viewed merely as a downstream consequence of persistent inflammation. However, clinical evidence revealing significant structural changes in the airways of children as young as 2.5 years old challenges this paradigm, suggesting that the developmental origins of asthma are established much earlier through systemic mechanisms. While local adaptive immune cascades undoubtedly amplify mucosal pathology, emerging paradigms emphasize that systemic immune reprogramming plays a foundational role in dictating early structural divergence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To address these anomalies, this review proposes the \u201cSystemic Priming and Homeostasis in Pediatric Asthma\u201d (SPHPA) model to elucidate how early-life environmental exposures translate into lifelong pathological imprints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We highlight the pivotal role of the lung-bone marrow axis, where early-life triggers\u2014such as respiratory syncytial virus or human rhinovirus infections and early-life allergens\u2014induce trained immunity in hematopoietic stem cells (HSCs). This systemic programming pre-activates the monocyte-macrophage lineage prior to their recruitment to the lungs. Central to this process is the LYN-SHIP-1-Trib1 signaling circuit, where LYN acts as a molecular gatekeeper. We discuss the non-canonical \u201cfunctional flip\u201d of SHIP-1 from an anti-inflammatory inhibitor to a pro-inflammatory scaffold under stressful pulmonary microenvironments, fueled by metabolic reprogramming events such as proline biosynthesis and histone lactylation (H3K18la). Upon homing to the lungs, these primed monocytes undergo pathogenic alternative activation (M2-like macrophage polarization) via the SHIP-1-STAT5-Trib1 circuit, directly driving airway smooth muscle (ASM) hypertrophy, goblet cell hyperplasia, and reticular basement membrane (RBM) thickening even before the establishment of chronic mucosal inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Understanding systemic monocyte pre-activation provides a novel window for early intervention. Future strategies should shift from localized anti-inflammatory treatments toward resetting systemic innate immune memory using conformation-specific ligands and epigenetic modulators, potentially reversing the trajectory of severe pediatric asthma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1895388","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:51:18Z","timestamp":1789469478000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic immune programming in the life course of childhood asthma: a new perspective on monocyte pre-activation and trained immunity"],"prefix":"10.3389","volume":"17","author":[{"given":"Ran","family":"Ma","sequence":"first","affiliation":[{"name":"Graduate School, Hebei Medical University","place":["Shijiazhuang, Hebei, China"]},{"name":"Department of Respiratory Medicine, Hebei Children\u2019s 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