{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:05:24Z","timestamp":1784264724290,"version":"3.55.0"},"reference-count":153,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Parasite-derived molecules have emerged as a promising source of natural bioactive compounds with immunomodulatory and antitumor properties, attracting increasing attention in cancer research. Derived from both protozoan and helminth parasites, these molecules exhibit diverse biological activities that extend beyond parasite survival and represent a novel resource for cancer therapy. Accumulating evidence demonstrates that parasite-derived molecules suppress tumor progression through complementary immune-mediated and non-immune mechanisms, including activation of innate and adaptive antitumor immunity, remodeling of the tumor microenvironment, induction of apoptosis and autophagy, inhibition of angiogenesis and metastasis, and regulation of tumor metabolism. Recent preclinical studies have demonstrated encouraging therapeutic efficacy across multiple tumor models, including melanoma, lung cancer, colorectal cancer, breast cancer, hepatocellular carcinoma, and other malignancies. In addition to summarizing the major classes of parasite-derived molecules and their mechanisms of action, this review highlights recent advances in translational research, including combination therapeutic strategies, immunogenicity and safety, delivery system optimization, and manufacturing and regulatory considerations. Despite encouraging preclinical findings, substantial challenges remain before clinical translation can be achieved. By integrating current mechanistic evidence with emerging translational perspectives, this review provides a comprehensive overview of parasite-derived molecules as potential anticancer agents and offers insights to facilitate their future development and clinical application in cancer therapy.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1901126","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:23:47Z","timestamp":1784262227000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Parasite in cancer therapy: molecular mechanisms and translational potential"],"prefix":"10.3389","volume":"17","author":[{"given":"Juanyan","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Hou","sequence":"additional","affiliation":[{"name":"West China School of Medicine, West China Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolin","family":"Tang","sequence":"additional","affiliation":[{"name":"West China School of Medicine, West China Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/s41392-025-02280-1","article-title":"Immune evasion in cancer: mechanisms and cutting-edge therapeutic approaches","volume":"10","author":"Tufail","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"B2","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s13027-025-00679-7","article-title":"Bridging the gap for diverse applications of parasites as advanced cancer therapeutics: current progress and future directions","volume":"20","author":"Eissa","year":"2025","journal-title":"Infect Agent Cancer"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.32604\/or.2025.071891","article-title":"Parasitic infections and carcinogenesis: molecular mechanisms, immune modulation, and emerging therapeutic strategies","volume":"34","author":"Paw\u0142owska","year":"2026","journal-title":"Oncol Res"},{"key":"B4","doi-asserted-by":"publisher","first-page":"395","DOI":"10.3390\/bioengineering9080395","article-title":"Anti-tumor effect of parasitic protozoans","volume":"9","author":"Ding","year":"2022","journal-title":"Bioengineering (Basel)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4103\/tp.tp_5_25","article-title":"Immunomodulation by helminthic parasites and worm therapy","volume":"15","author":"Sharma","year":"2025","journal-title":"Trop Parasitol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-093019-122827","article-title":"Immune system investigation using parasitic helminths","volume":"39","author":"Douglas","year":"2021","journal-title":"Annu Rev Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/sji.13001","article-title":"A review on the interactions between dendritic cells, filarial parasite and parasite-derived molecules in regulating the host immune responses","volume":"93","author":"Joardar","year":"2021","journal-title":"Scand J Immunol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.619776","article-title":"Schistosome infection and schistosome-derived products as modulators for the prevention and alleviation of immunological disorders","volume":"12","author":"Mu","year":"2021","journal-title":"Front Immunol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.652395","article-title":"A Schistosoma japonicum microRNA exerts antitumor effects through inhibition of both cell migration and angiogenesis by targeting PGAM1","volume":"11","author":"Hu","year":"2021","journal-title":"Front Oncol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"107983","DOI":"10.1016\/j.exppara.2020.107983","article-title":"Trichinella spiralis muscle larvae excretory\/secretory products trigger apoptosis and S-phase arrest of the non-small-cell lung cancer line A549","volume":"218","author":"Wu","year":"2020","journal-title":"Exp Parasitol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"106172","DOI":"10.1016\/j.actatropica.2021.106172","article-title":"Excretory-secretory product of Trichinella spiralis inhibits tumor cell growth by regulating the immune response and inducing apoptosis","volume":"225","author":"Ding","year":"2022","journal-title":"Acta Trop"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.786543","article-title":"Identification of a Schistosoma japonicum microRNA that suppresses hepatoma cell growth and migration by targeting host FZD4 gene","volume":"12","author":"Jiang","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1051\/parasite\/2026006","article-title":"Toxoplasma gondii as a drug for anti-tumor immunotherapy: mechanisms, challenges, and perspectives","volume":"33","author":"Li","year":"2026","journal-title":"Parasite"},{"key":"B14","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1186\/s12964-024-01822-4","article-title":"Parasite-enhanced immunotherapy: transforming the \u201ccold\u201d tumors to \u201chot\u201d battlefields","volume":"22","author":"Xie","year":"2024","journal-title":"Cell Commun Signal"},{"key":"B15","doi-asserted-by":"publisher","first-page":"108125","DOI":"10.1016\/j.actatropica.2026.108125","article-title":"Antitumor effects of leishmania donovani by inducing a pro-inflammatory tumor microenvironment in hepatocellular carcinoma","volume":"279","author":"Lu","year":"2026","journal-title":"Acta Trop"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00696-25","article-title":"A hidden \u201cpromoter\u201d: Schistosoma japonicum soluble egg antigen activates MAPK\/PI3K-AKT pathways and inhibits autophagy to facilitate colorectal cancer","volume":"94","author":"Zhang","year":"2026","journal-title":"Infect Immun"},{"key":"B17","doi-asserted-by":"publisher","first-page":"62","DOI":"10.18632\/oncotarget.27417","article-title":"Toxoplasma gondii GRA8-derived peptide immunotherapy improves tumor targeting of colorectal cancer","volume":"11","author":"Kim","year":"2020","journal-title":"Oncotarget"},{"key":"B18","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s12964-020-00570-5","article-title":"Plasmodium infection inhibits tumor angiogenesis through effects on tumor-associated macrophages in a murine implanted hepatoma model","volume":"18","author":"Wang","year":"2020","journal-title":"Cell Commun Signal"},{"key":"B19","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s11686-025-00996-2","article-title":"Neospora caninum inhibits Lewis cancer and B16f10 melanoma lung metastasis development by activating the immune response in murine models","volume":"70","author":"Qian","year":"2025","journal-title":"Acta Parasitol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1173379","article-title":"Toxoplasma gondii gra5 deletion mutant protects hosts against Toxoplasma gondii infection and breast tumors","volume":"14","author":"Chen","year":"2023","journal-title":"Front Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.76623","article-title":"Ivermectin induces cell cycle arrest and caspase-dependent apoptosis in human urothelial carcinoma cells","volume":"19","author":"Tung","year":"2022","journal-title":"Int J Med Sci"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00508-21","article-title":"Novel murine pancreatic tumor model demonstrates immunotherapeutic control of tumor progression by a Toxoplasma gondii protein","volume":"89","author":"Payne","year":"2021","journal-title":"Infect Immun"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13255","article-title":"Novel tumour suppressor roles for GZMA and RASGRP1 in Theileria annulata-transformed macrophages and human B lymphoma cells","volume":"22","author":"Rchiad","year":"2020","journal-title":"Cell Microbiol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1209755","article-title":"Protective efficacy of Toxoplasma gondii GRA12 or GRA7 recombinant proteins encapsulated in PLGA nanoparticles against acute Toxoplasma gondii infection in mice","volume":"13","author":"Sun","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1186\/s13071-020-04251-7","article-title":"TgROP18 targets IL20RB for host-defense-related-STAT3 activation during Toxoplasma gondii infection","volume":"13","author":"Kong","year":"2020","journal-title":"Parasit Vectors"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2024.02.062","article-title":"Protective efficacy of recombinant Toxoplasma gondii dense granule protein 15 against toxoplasmosis in C57BL\/6 mice","volume":"42","author":"Hasan","year":"2024","journal-title":"Vaccine"},{"key":"B27","doi-asserted-by":"publisher","first-page":"351","DOI":"10.3390\/pathogens15040351","article-title":"Toxoplasma gondii and a cancer biology dichotomy: a systematic review of experimental studies of its antitumor and pro-tumor effects","volume":"15","author":"Jhandi","year":"2026","journal-title":"Pathogens"},{"key":"B28","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s13027-023-00500-3","article-title":"Prophylactic antineoplastic activity of Toxoplasma gondii RH derived antigen against ehrlich solid carcinoma with evidence of shared antigens by comparative immunoblotting","volume":"18","author":"Eissa","year":"2023","journal-title":"Infect Agent Cancer"},{"key":"B29","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1186\/s13071-021-05032-6","article-title":"A uracil auxotroph Toxoplasma gondii exerting immunomodulation to inhibit breast cancer growth and metastasis","volume":"14","author":"Xu","year":"2021","journal-title":"Parasit Vectors"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12816","article-title":"The immunology of Plasmodium vivax malaria","volume":"293","author":"Antonelli","year":"2020","journal-title":"Immunol Rev"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0901-5_12","article-title":"Immune recognition of Plasmodium-infected erythrocytes","volume":"653","author":"Cordery","year":"2009","journal-title":"Adv Exp Med Biol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"604","DOI":"10.3892\/ol.2024.14737","article-title":"Plasmodium infection downregulates hypoxia\u2013inducible factor 1\u03b1 expression to suppress the vascularization and tumorigenesis of liver cancer","volume":"28","author":"Wu","year":"2024","journal-title":"Oncol Lett"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ctm.2025.06.009","article-title":"Leishmania plasma membrane - general composition, structure and biological functions","volume":"95","author":"Rios-Barros","year":"2025","journal-title":"Curr Top Membr"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00009-21","article-title":"Leishmania donovani metacyclic promastigotes impair phagosome properties in inflammatory monocytes","volume":"89","author":"Matte","year":"2021","journal-title":"Infect Immun"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.805720","article-title":"Lipophosphoglycan from dermotropic New World Leishmania upregulates interleukin-32 and proinflammatory cytokines through TLR4 and NOD2 receptors","volume":"12","author":"Silveira","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.biochi.2022.11.015","article-title":"The glycoprotein gp63- a potential pan drug target for developing new antileishmanial agents","volume":"207","author":"Devsani","year":"2023","journal-title":"Biochimie"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009224","article-title":"Variation in Leishmania chemokine suppression driven by diversification of the GP63 virulence factor","volume":"15","author":"Antonia","year":"2021","journal-title":"PloS NeglTrop Dis"},{"key":"B38","doi-asserted-by":"publisher","first-page":"8894549","DOI":"10.1155\/2020\/8894549","article-title":"Leishmania mexicana: novel insights of immune modulation through amastigote exosomes","author":"Soto-Serna","year":"2020","journal-title":"J Immunol Res"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.934611","article-title":"Leishmania infection-derived extracellular vesicles drive transcription of genes involved in M2 polarization","volume":"12","author":"Emerson","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"qiae196","DOI":"10.1093\/jleuko\/qiae196","article-title":"Leishmania amazonensis-derived extracellular vesicles (EVs) induce neutrophil extracellular traps (NETs)","volume":"117","author":"Pereira-Silva","year":"2024","journal-title":"J Leukoc Biol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.semcancer.2023.02.002","article-title":"Extracellular vesicles as next generation immunotherapeutics","volume":"90","author":"Greening","year":"2023","journal-title":"Semin Cancer Biol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-020-01112-0","article-title":"Targeting of antitumor immune responses with live-attenuated Leishmania strains in breast cancer model","volume":"27","author":"Caner","year":"2020","journal-title":"Breast Cancer"},{"key":"B43","doi-asserted-by":"publisher","first-page":"106676","DOI":"10.1016\/j.actatropica.2022.106676","article-title":"Schistosome secretomes","volume":"236","author":"Skelly","year":"2022","journal-title":"Acta Trop"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13190","article-title":"Regulatory T-cells in helminth infection: induction, function and therapeutic potential","volume":"160","author":"White","year":"2020","journal-title":"Immunology"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2024.11.009","article-title":"Schistosoma mansoni soluble egg antigen suppresses colorectal cancer growth in vitro and in vivo","volume":"58","author":"Pekkle Lam","year":"2025","journal-title":"J Microbiol Immunol Infect"},{"key":"B46","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3892\/etm.2020.9535","article-title":"IFN-\u03b3 and IL-18 in conditioned media of parasite-infected host and IL-21-silenced colorectal cancer cells","volume":"21","author":"Ge","year":"2021","journal-title":"Exp Ther Med"},{"key":"B47","doi-asserted-by":"publisher","first-page":"116628","DOI":"10.1016\/j.biopha.2024.116628","article-title":"Helminth-derived molecules improve 5-fluorouracil treatment on experimental colon tumorigenesis","volume":"175","author":"Mendoza-Rodr\u00edguez","year":"2024","journal-title":"BioMed Pharmacother"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2024.2347377","article-title":"The effects of anti-lung cancer in nude mice by a fully human single-chain antibody against associated antigen Ts7TMR between A549 cells and Trichinella spiralis","volume":"52","author":"Yue","year":"2024","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1186\/s13104-026-07872-w","article-title":"Assessing the impact of Fasciola hepatica excretory-secretory antigens on A549 cells: viability, apoptosis, ROS, and stem cell markers","volume":"19","author":"Ajam","year":"2026","journal-title":"BMC Res Notes"},{"key":"B50","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/0166-6851(93)90172-t","article-title":"Cathepsin L proteinase secreted by Fasciola hepatica in vitro prevents antibody-mediated eosinophil attachment to newly excysted juveniles","volume":"62","author":"Carmona","year":"1993","journal-title":"Mol Biochem Parasitol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/s0020-7519(03)00171-1","article-title":"Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines","volume":"33","author":"Dalton","year":"2003","journal-title":"Int J Parasitol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.47665\/tb.41.2.005","article-title":"Preliminary studies on the effect of excretory secretory (ES) Ascaris lumbricoides antigens on colorectal cell line viability","volume":"41","author":"Ab Talib","year":"2024","journal-title":"Trop BioMed"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.3390\/biology12101340","article-title":"Comparison of antibody responses against two molecules from Ascaris lumbricoides: The allergen Asc l 5 and the immunomodulatory protein Al-CPI","volume":"12","author":"Ahumada","year":"2023","journal-title":"Biol (Basel)"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13231","article-title":"Schistosome and intestinal helminth modulation of macrophage immunometabolism","volume":"162","author":"Cortes-Selva","year":"2021","journal-title":"Immunology"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00060","article-title":"Echinococcus granulosus: Cure for cancer revisited","volume":"5","author":"Ranasinghe","year":"2018","journal-title":"Front Med (Lausanne)"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01137","article-title":"Employing parasite against cancer: A lesson from the canine tapeworm Echinococcus granulocus","volume":"10","author":"Guan","year":"2019","journal-title":"Front Pharmacol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"11465","DOI":"10.1038\/s41598-023-38159-w","article-title":"Design of ion channel blocking, toxin-like Kunitz inhibitor peptides from the tapeworm, Echinococcus granulosus, with potential anti-cancer activity","volume":"13","author":"Rashno","year":"2023","journal-title":"Sci Rep"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2024.108829","article-title":"MicroRNA-145 enhances lung cancer cell progression after exposure to lyophilized fertile hydatid cyst fluid of Echinococcus granulosus sensu stricto","volume":"265","author":"Mosajakhah","year":"2024","journal-title":"Exp Parasitol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13702","article-title":"Leishmania surface molecule lipophosphoglycan-TLR2 interaction moderates TPL2-mediated TLR2 signalling for parasite survival","volume":"171","author":"Ghosh","year":"2024","journal-title":"Immunology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.bbrc.2021.08.052","article-title":"Live attenuated rubella vectors expressing Plasmodium falciparum circumsporozoite protein (Pf-CSP) provide a novel malaria vaccine platform in the rhesus macaque","volume":"577","author":"Virnik","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.33594\/000000815","article-title":"Mast cell response to parasites: From recognition and activation to host defense modulation","volume":"59","author":"\u017belechowska","year":"2025","journal-title":"Cell Physiol Biochem"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-021-02122-x","article-title":"The parasite-derived peptide FhHDM-1 activates the PI3K\/Akt pathway to prevent cytokine-induced apoptosis of \u03b2-cells","volume":"99","author":"Camaya","year":"2021","journal-title":"J Mol Med (Berl)"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.999412","article-title":"Helminth infection and helminth-derived products: A novel therapeutic option for non-alcoholic fatty liver disease","volume":"13","author":"Liu","year":"2022","journal-title":"Front Immunol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.807821","article-title":"Helminth glycans at the host-parasite interface and their potential for developing novel therapeutics","volume":"8","author":"Bunte","year":"2021","journal-title":"Front Mol Biosci"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.710513","article-title":"Parasite-derived excretory-secretory products alleviate gut microbiota dysbiosis and improve cognitive impairment induced by a high-fat diet","volume":"12","author":"Wu","year":"2021","journal-title":"Front Immunol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-025-01821-y","article-title":"Intact glycoconjugates from Taenia crassiceps excreted\/secreted products ameliorate chemically induced colitis by modulating inflammation and strengthening adherens junctions","volume":"33","author":"Ledesma-Soto","year":"2025","journal-title":"Inflammopharmacology"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2024.102987","article-title":"Immunomodulation by Leishmania parasites: Potential for controlling other diseases","volume":"104","author":"Goto","year":"2025","journal-title":"Parasitol Int"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082462","article-title":"The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)","volume":"206","author":"Steinfelder","year":"2009","journal-title":"J Exp Med"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111381","article-title":"Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor","volume":"209","author":"Everts","year":"2012","journal-title":"J Exp Med"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1007\/s11686-022-00639-w","article-title":"Leishmania mexicana lipophosphoglycan activates dermal \u03b3\u03b4 T cells with participation of TLR2","volume":"68","author":"Soto-Olgu\u00edn","year":"2023","journal-title":"Acta Parasitol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"534","DOI":"10.3390\/pathogens12040534","article-title":"Toll-like receptor-9 (TLR-9) signaling is crucial for inducing protective immunity following immunization with genetically modified live attenuated Leishmania parasites","volume":"12","author":"Bhattacharya","year":"2023","journal-title":"Pathogens"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2024.106885","article-title":"Differential structure and immunomodulatory functions of lipophosphoglycan between Leishmania spp","volume":"268","author":"Teufel","year":"2024","journal-title":"Immunol Lett"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11880","article-title":"Leishmania amazonensis from distinct clinical forms\/hosts has polymorphisms in lipophosphoglycans, displays variations in immunomodulatory properties and, susceptibility to antileishmanial drugs","volume":"46","author":"R\u00eago","year":"2022","journal-title":"Cell Biol Int"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111406","article-title":"Plasmodium infection inhibits triple negative 4T1 breast cancer potentially through induction of CD8+ T cell-mediated antitumor responses in mice","volume":"138","author":"Pan","year":"2021","journal-title":"BioMed Pharmacother"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.62.3.9","article-title":"Murine model of primary acquired ocular toxoplasmosis: Fluorescein angiography and multiplex immune mediator profiles in the aqueous humor","volume":"62","author":"Li","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2021.104361","article-title":"The diverse roles of myeloid derived suppressor cells in mucosal immunity","volume":"365","author":"Ashkenazi-Preiser","year":"2021","journal-title":"Cell Immunol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2023.1208538","article-title":"Transcriptome profiling of A549 non-small cell lung cancer cells in response to Trichinella spiralis muscle larvae excretory\/secretory products","volume":"10","author":"Wang","year":"2023","journal-title":"Front Vet Sci"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.882608","article-title":"Peptide of Trichinella spiralis infective larval extract that harnesses growth of human hepatoma cells","volume":"12","author":"Ruenchit","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1035765","article-title":"Pathology and molecular mechanisms of Schistosoma japonicum-associated liver fibrosis","volume":"12","author":"Liu","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1012268","article-title":"Winners vs. losers: Schistosoma mansoni intestinal and liver eggs exhibit striking differences in gene expression and immunogenicity","volume":"20","author":"Peterkov\u00e1","year":"2024","journal-title":"PloS Pathog"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X24000506","article-title":"Is Schistosoma mansoni playing a part in liver carcinogenesis","volume":"98","author":"Jain","year":"2024","journal-title":"J Helminthol"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2025.2532803","article-title":"PI3K\/AKT signaling in parasites and parasite diseases: Role and therapeutic potential","volume":"16","author":"Yan","year":"2025","journal-title":"Virulence"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01455-24","article-title":"T lymphocyte-dependent IL-10 down-regulates a cytokine storm driven by Toxoplasma gondii GRA24","volume":"15","author":"Doherty","year":"2024","journal-title":"mBio"},{"key":"B84","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.3390\/biomedicines12102227","article-title":"Treatment of refractory mucosal leishmaniasis is associated with parasite overexpression of HSP70 and ATPase and reduced host hydrogen peroxide production (Brief Report)","volume":"12","author":"Urdapilleta","year":"2024","journal-title":"Biomedicines"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.3390\/genes15091165","article-title":"Schistosoma japonicumsja-let-7 inhibits the growth of hepatocellular carcinoma cells via cross-species regulation of Col1\u03b12","volume":"15","author":"Zhong","year":"2024","journal-title":"Genes (Basel)"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.984134","article-title":"DNA methylation alterations caused by Leishmania infection may generate a microenvironment prone to tumour development","volume":"12","author":"Vega-Benedetti","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.0c01584","article-title":"Homology modeling of leishmanolysin (gp63) from Leishmania panamensis and molecular docking of flavonoids","volume":"5","author":"Mercado-Camargo","year":"2020","journal-title":"ACS Omega"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2021.10.006","article-title":"Structural parasitology of the malaria parasite Plasmodium falciparum","volume":"47","author":"Anton","year":"2022","journal-title":"Trends Biochem Sci"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000641","article-title":"Erythroid cells and malaria parasites: It\u2019s a match","volume":"28","author":"Neveu","year":"2021","journal-title":"Curr Opin Hematol"},{"key":"B90","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ijpddr.2020.07.002","article-title":"Repurposing bioenergetic modulators against protozoan parasites responsible for tropical diseases","volume":"14","author":"Mart\u00ednez-Fl\u00f3rez","year":"","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02031-20","article-title":"Toxoplasma gondii extends the life span of infected human neutrophils by inducing cytosolic PCNA and blocking activation of apoptotic caspases","volume":"12","author":"Lima","year":"2021","journal-title":"mBio"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-021-07070-6","article-title":"The host mTOR pathway and parasitic diseases pathogenesis","volume":"120","author":"Rashidi","year":"2021","journal-title":"Parasitol Res"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.645807","article-title":"Schistosoma japonicum infection leads to the reprogramming of glucose and lipid metabolism in the colon of mice","volume":"8","author":"Yang","year":"2021","journal-title":"Front Vet Sci"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.825458","article-title":"Released parasite-derived kinases as novel targets for antiparasitic therapies","volume":"12","author":"Silvestre","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-020-04862-1","article-title":"Effect of cathepsine L1 on transformation of Malignant melanoma B16 cells into melanocytes","volume":"169","author":"Zaichikova","year":"2020","journal-title":"Bull Exp Biol Med"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-021-07283-9","article-title":"Antitumor effects of a Toxoplasma mutant lacking lactate dehydrogenases","volume":"120","author":"Li","year":"2021","journal-title":"Parasitol Res"},{"key":"B97","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1007\/s00262-025-04069-1","article-title":"Molecular mimicry between parasites and cancer: A novel approach for developing cancer vaccines and therapeutic antibodies","volume":"74","author":"Eissa","year":"2025","journal-title":"Cancer Immunol Immunother"},{"key":"B98","doi-asserted-by":"publisher","first-page":"7845","DOI":"10.3390\/ijms21217845","article-title":"Gastrointestinal nematode-derived antigens alter colorectal cancer cell proliferation and migration through regulation of cell cycle and epithelial-mesenchymal transition proteins","volume":"21","author":"Jacobs","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B99","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1186\/s13046-021-02043-0","article-title":"Regorafenib enhances anti-PD1 immunotherapy efficacy in murine colorectal cancers and their combination prevents tumor regrowth","volume":"40","author":"Doleschel","year":"2021","journal-title":"J Exp Clin Cancer Res"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.14611","article-title":"Baicalein enhances radiosensitivity in colorectal cancer via JAK2\/STAT3 pathway inhibition","volume":"104","author":"Yu","year":"2024","journal-title":"Chem Biol Drug Des"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-020-09518-4","article-title":"Sodium butyrate modulates gut microbiota and immune response in colorectal cancer liver metastatic mice","volume":"36","author":"Ma","year":"2020","journal-title":"Cell Biol Toxicol"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2021.111408","article-title":"Bioactive half-sandwich Rh and Ir bipyridyl complexes containing artemisinin","volume":"219","author":"Chellan","year":"2021","journal-title":"J Inorg Biochem"},{"key":"B103","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.arcmed.2019.12.003","article-title":"In vitro employment of recombinant Taenia solium calreticulin as a novel strategy against breast and ovarian cancer stem-like cells","volume":"51","author":"Schcolnik-Cabrera","year":"2020","journal-title":"Arch Med Res"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.2174\/0118715206325844240909144543","article-title":"Doramectin induces apoptosis in B16 melanoma cells","volume":"25","author":"Crotts","year":"2025","journal-title":"Anti-Cancer Agents Med Chem"},{"key":"B105","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/s41419-021-03611-0","article-title":"Development of a bispecific immune engager using a recombinant malaria protein","volume":"12","author":"Nordmaj","year":"2021","journal-title":"Cell Death Dis"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202501624","article-title":"Cathepsin L-activatable fluorescent probe for real-time monitoring of drug-resistant breast cancer cells","volume":"31","author":"Yu","year":"2025","journal-title":"Chemistry"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1039\/d3sc00556a","article-title":"An AND-gate bioluminescent probe for precise tumor imaging","volume":"14","author":"Wang","year":"2023","journal-title":"Chem Sci"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEA.2020.0190","article-title":"Bioprinting on live tissue for investigating cancer cell dynamics","volume":"27","author":"Suarez-Martinez","year":"2021","journal-title":"Tissue Eng Part A"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009192","article-title":"Albendazole reduces hepatic inflammation and endoplasmic reticulum-stress in a mouse model of chronic Echinococcus multilocularis infection","volume":"16","author":"Weingartner","year":"2022","journal-title":"PloS NeglTrop Dis"},{"key":"B110","doi-asserted-by":"publisher","first-page":"665","DOI":"10.3390\/biomedicines13030665","article-title":"Small biological fighters against cancer: Viruses, bacteria, archaea, fungi, protozoa, and microalgae","volume":"13","author":"Bruno","year":"2025","journal-title":"Biomedicines"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2020.03.006","article-title":"Effects of the dietary fibre inulin and Trichuris suis products on inflammatory responses in lipopolysaccharide-stimulated macrophages","volume":"121","author":"Myhill","year":"2020","journal-title":"Mol Immunol"},{"key":"B112","doi-asserted-by":"publisher","first-page":"972","DOI":"10.3390\/jcm9040972","article-title":"Deriving immune modulating drugs from viruses-a new class of biologics","volume":"9","author":"Yaron","year":"2020","journal-title":"J Clin Med"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113705","article-title":"Use of C. elegans as a 3R-compliant in vivo model for the chemoprevention of cisplatin-induced neurotoxicity","volume":"341","author":"Wellenberg","year":"2021","journal-title":"Exp Neurol"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12834","article-title":"Innate and adaptive immune responses following PD-L1 blockade in treating chronic murine alveolar echinococcosis","volume":"43","author":"Jebbawi","year":"2021","journal-title":"Parasite Immunol"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00487","article-title":"The role of PD-1 in acute and chronic infection","volume":"11","author":"Jubel","year":"2020","journal-title":"Front Immunol"},{"key":"B116","doi-asserted-by":"publisher","first-page":"20275","DOI":"10.1038\/s41598-019-56336-8","article-title":"Immunotherapy using anti-PD-1 and anti-PD-L1 in Leishmania amazonensis-infected BALB\/c mice reduce parasite load","volume":"9","author":"da Fonseca-Martins","year":"2019","journal-title":"Sci Rep"},{"key":"B117","doi-asserted-by":"publisher","first-page":"eabf3861","DOI":"10.1126\/sciimmunol.abf3861","article-title":"PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques","volume":"6","author":"Kauffman","year":"2021","journal-title":"Sci Immunol"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae183","article-title":"Exacerbation of CMV and nontuberculous mycobacterial infections following PD-1 blockade for HIV-associated Kaposi sarcoma","volume":"11","author":"Anidi","year":"2024","journal-title":"Open Forum Infect Dis"},{"key":"B119","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.3390\/vaccines11121826","article-title":"Agonistic bivalent human scFvs-Fc\u03b3 fusion antibodies to OX40 ectodomain enhance T cell activities against cancer","volume":"11","author":"Mahasongkram","year":"2023","journal-title":"Vaccines (Basel)"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2020.104049","article-title":"Suppressed dendritic cell functions by cystatin C lead to compromised immunity in vivo","volume":"349","author":"Chen","year":"2020","journal-title":"Cell Immunol"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.685984","article-title":"Exosome-depleted excretory-secretory products of the fourth-stage larval Angiostrongylus cantonensis promotes alternative activation of macrophages through metabolic reprogramming by the PI3K-Akt pathway","volume":"12","author":"Wan","year":"2021","journal-title":"Front Immunol"},{"key":"B122","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1186\/s12951-025-03201-8","article-title":"The immunogenic potential of an optimized mRNA lipid nanoparticle formulation carrying sequences from virus and protozoan antigens","volume":"23","author":"Fernandes","year":"2025","journal-title":"J Nanobiotechnol"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1272084","article-title":"IgG4 autoantibodies and autoantigens in the context of IgG4-autoimmune disease and IgG4-related disease","volume":"15","author":"Motta","year":"2024","journal-title":"Front Immunol"},{"key":"B124","doi-asserted-by":"publisher","first-page":"e241712","DOI":"10.1136\/bcr-2021-241712","article-title":"Bilious mask: parasite masquerading as Malignant gall bladder polyp","volume":"14","author":"Philip","year":"2021","journal-title":"BMJ Case Rep"},{"key":"B125","doi-asserted-by":"publisher","first-page":"8839740","DOI":"10.1155\/2020\/8839740","article-title":"Intestinal parasites infection in children with cancer in Ahvaz, Southwest Iran","volume":"2020","author":"Salehi Kahyesh","year":"2020","journal-title":"Interdiscip Perspect Infect Dis"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.101847","article-title":"Atypical multisystemic manifestations of Ascaris infection in a patient with Burkitt lymphoma: a fatal diagnostic challenge","volume":"18","author":"Aguirre Fernandez","year":"2026","journal-title":"Cureus"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2020.155266","article-title":"Cytokines in the generation and function of regulatory T cell subsets in leishmaniasis","volume":"147","author":"Ghosh","year":"2021","journal-title":"Cytokine"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/j.cimid.2025.102337","article-title":"DNA damage induced by parasitic infections in humans and animals","volume":"119","author":"Rajkovi\u0107","year":"2025","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2025.103224","article-title":"Tick saliva molecules as potential immunomodulatory therapeutics","volume":"112","author":"Hatta","year":"2025","journal-title":"Parasitol Int"},{"key":"B130","doi-asserted-by":"publisher","first-page":"748","DOI":"10.3390\/cancers15030748","article-title":"Unraveling the complex interconnection between specific inflammatory signaling pathways and mechanisms involved in HIV-associated colorectal oncogenesis","volume":"15","author":"Damane","year":"2023","journal-title":"Cancers (Basel)"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1111\/pim.70085","article-title":"Infection-driven autoimmune amplification versus molecule-specific immune modulation: the dual role of Toxocara canis in autoimmunity","volume":"48","author":"Abou-El-Naga","year":"2026","journal-title":"Parasite Immunol"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2300166","article-title":"Single-cell analysis of CX3CR1+ cells reveals a pathogenic role for BIRC5+ myeloid proliferating cells driven by Staphylococcus aureus leukotoxins","volume":"211","author":"Loredan","year":"2023","journal-title":"J Immunol"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00275-21","article-title":"Pharmacogene sequencing of a Gabonese population with severe Plasmodium falciparum malaria reveals multiple novel variants with putative relevance for antimalarial treatment","volume":"65","author":"Pernaute-Lau","year":"2021","journal-title":"Antimicrob Agents Chemother"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1562729","article-title":"Prostate and urinary microbiomes in prostate cancer development: focus on Cutibacterium acnes","volume":"15","author":"Fu","year":"2025","journal-title":"Front Cell Infect Microbiol"},{"key":"B135","doi-asserted-by":"publisher","first-page":"6334","DOI":"10.3390\/molecules28176334","article-title":"Exploring the potential of lapatinib, fulvestrant, and paclitaxel conjugated with glycidylated PAMAM G4 dendrimers for cancer and parasite treatment","volume":"28","author":"Uram","year":"2023","journal-title":"Molecules"},{"key":"B136","doi-asserted-by":"publisher","first-page":"7295","DOI":"10.3390\/molecules28217295","article-title":"The use of cyclodextrin inclusion complexes to increase the solubility and pharmacokinetic profile of albendazole","volume":"28","author":"Ding","year":"2023","journal-title":"Molecules"},{"key":"B137","doi-asserted-by":"publisher","first-page":"6436","DOI":"10.3390\/molecules26216436","article-title":"Engineered fully human single-chain monoclonal antibodies to PIM2 kinase","volume":"26","author":"Kaewchim","year":"2021","journal-title":"Molecules"},{"key":"B138","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.3390\/jcm11102847","article-title":"Protozoan intestinal parasitic infection in patients with hematological Malignancies","volume":"11","author":"\u0141anocha","year":"2022","journal-title":"J Clin Med"},{"key":"B139","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s00436-025-08500-5","article-title":"Identifying zoonotic risks: molecular insights into Cryptosporidium and Enterocytozoon bieneusi in pediatric cancer patients in Ahvaz, 2024","volume":"124","author":"Makipour","year":"2025","journal-title":"Parasitol Res"},{"key":"B140","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.3390\/biomedicines13071686","article-title":"Repurposing rafoxanide: From parasite killer to cancer fighter","volume":"13","author":"Pacifico","year":"2025","journal-title":"Biomedicines"},{"key":"B141","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3390\/pharmaceutics13010065","article-title":"New protein-coated silver nanoparticles: Characterization, antitumor and amoebicidal activity, antiproliferative selectivity, genotoxicity, and biocompatibility evaluation","volume":"13","author":"Valenzuela-Salas","year":"2021","journal-title":"Pharmaceutics"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.13658","article-title":"Contributions of the international plant science community to the fight against infectious diseases in humans-part 2: Affordable drugs in edible plants for endemic and re-emerging diseases","volume":"19","author":"He","year":"2021","journal-title":"Plant Biotechnol J"},{"key":"B143","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1186\/s12879-025-11207-8","article-title":"Global prevalence of intestinal parasites in cancer patients: a systematic review and meta-analysis","volume":"25","author":"Wondmagegn","year":"2025","journal-title":"BMC Infect Dis"},{"key":"B144","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1186\/s12879-024-10431-y","article-title":"Evaluation of strongyloidiasis prevalence in immunocompromised patients referred to hospitals: a case study of Iran\u2019s capital","volume":"25","author":"Arab-Mazar","year":"2025","journal-title":"BMC Infect Dis"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1038\/s44318-025-00691-y","article-title":"Cancer in disguise: a parasite within","volume":"45","author":"Wagner","year":"2026","journal-title":"EMBO J"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.2174\/0929867329666220507011719","article-title":"Antitumor and antiparasitic activity of antimicrobial peptides derived from snake venom: a systematic review approach","volume":"29","author":"de Moura","year":"2022","journal-title":"Curr Med Chem"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2023.0035","article-title":"The dichotomy of interleukin-9 function in the tumor microenvironment","volume":"43","author":"Cannon","year":"2023","journal-title":"J Interferon Cytokine Res"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-021-07384-5","article-title":"Long non-coding RNAs as possible therapeutic targets in protozoa, and in Schistosoma and other helminths","volume":"121","author":"Silveira","year":"2022","journal-title":"Parasitol Res"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.03412-23","article-title":"TurboID mapping reveals the exportome of secreted intrinsically disordered proteins in the transforming parasite Theileria annulata","volume":"15","author":"Br\u00fchlmann","year":"2024","journal-title":"mBio"},{"key":"B150","doi-asserted-by":"publisher","first-page":"5477","DOI":"10.3390\/ijms26125477","article-title":"Multifaceted roles of guanylate-binding proteins in cancer","volume":"26","author":"Ahmetoglu","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.892401","article-title":"Analysis of gut microbiota signature and microbe-disease progression associations in locally advanced non-small cell lung cancer patients treated with concurrent chemoradiotherapy","volume":"12","author":"Xi","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"B152","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1007\/s11655-024-3803-8","article-title":"Scorpiones, scolopendra and gekko inhibit lung cancer growth and metastasis by ameliorating hypoxic tumor microenvironment via PI3K\/AKT\/mTOR\/HIF-1\u03b1 signaling pathway","volume":"30","author":"Mao","year":"2024","journal-title":"Chin J Integr Med"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-020-01393-6","article-title":"Study of toxoplasmosis and toxocariasis in patients suffering from ophthalmic disorders using serological and molecular methods","volume":"40","author":"Saki","year":"2020","journal-title":"Int Ophthalmol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1901126\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:23:49Z","timestamp":1784262229000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1901126\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,17]]},"references-count":153,"alternative-id":["10.3389\/fimmu.2026.1901126"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1901126","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,17]]},"article-number":"1901126"}}