{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:27:39Z","timestamp":1787120859347,"version":"build-2736575974"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the immunogenicity of a tetanus vaccine, adsorbed (TTVA) in people aged 18 years and above.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A randomized, double-blinded, and positive controlled clinical trial was conducted in Bijie, Guizhou Province, China. Participants aged 18 years and above were recruited and randomly assigned 1:1 to receive the experimental (TTVA) or control tetanus vaccine, adsorbed (TT) vaccine. Serum samples were collected from all participants before vaccination, 30 days after vaccination, and 6 months after vaccination in the first 240 participants to detect tetanus toxoid IgG antibody levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 30 days after vaccination, the geometric mean concentration (GMC) of antibodies in the experimental group and the control group were 3.205 and 2.387 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0012), the seroconversion rates were 89.07% and 87.47% (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.6149), the seropositivity were 98.38% and 98.79% (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.4850), and the geometric mean increase (GMI) were 35.529 and 27.604 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0026), respectively. Six months after vaccination, the GMCs of antibodies in the experimental group and the control group were 1.025 and 0.803, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.2119), the seropositivity were 98.25% and 95.73%, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.4008), and the GMIs were 9.466 and 7.661, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.2106).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TTVA vaccine has good immunogenicity in people aged 18 years and above.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/clinicaltrials.gov<\/jats:ext-link>\n                      , identifier NCT06120751.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1901212","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:45:38Z","timestamp":1787118338000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A phase III clinical trial on the immunogenicity of a tetanus vaccine, adsorbed in individuals aged 18 years and above in China"],"prefix":"10.3389","volume":"17","author":[{"given":"Qiuyue","family":"Mu","sequence":"first","affiliation":[{"name":"Guizhou Province Centers for Disease Control and Prevention","place":["Guiyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Li","sequence":"additional","affiliation":[{"name":"National Institutes for Food and Drug Control, State Key Laboratory of Drug 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