{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:03:36Z","timestamp":1789643016221,"version":"4.0.0"},"reference-count":208,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020230","name":"Health Commission of Jilin Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Pediatric asthma is a chronic inflammatory airway disease with high heterogeneity. Its onset and progression are closely related to environmental exposures in early life and impaired immune regulation. Gut microbiota dysbiosis not only alters the production of metabolites such as short-chain fatty acids, 12,13-diHOME, and succinate, but also drives airway inflammation through multiple immunoregulatory mechanisms. Gut microbial dysbiosis can affect the production of metabolites, such as short-chain fatty acids, and promote airway inflammation through complex immune regulatory mechanisms. In addition, multi-axis interactions, including the gut-brain-lung and gut-bone-lung axis, may influence inflammatory phenotypes and disease heterogeneity in pediatric asthma. This review summarizes the characteristics of gut microbiota dysbiosis in pediatric asthma and focuses on the core mechanisms by which the gut\u2013lung axis contributes to asthma pathogenesis, including metabolite-mediated regulation, disruption of immune homeostasis, mucosal barrier dysfunction, and multi-axis crosstalk. It also summarizes potential intervention approaches targeting the gut microbiota. Elucidating the gut microbiota\u2013immune\u2013multi-organ regulatory network may provide a theoretical basis for the early identification and precision intervention of pediatric asthma.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1901737","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:31:12Z","timestamp":1789641072000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["From gut microbiota dysbiosis to immune dysregulation: pathogenic mechanisms and emerging therapeutic perspectives in pediatric asthma"],"prefix":"10.3389","volume":"17","author":[{"given":"Zhimei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Affiliated Hospital of Changchun University of Chinese Medicine","place":["Jilin, Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keying","family":"Yu","sequence":"additional","affiliation":[{"name":"Cardiology Department, Affiliated Hospital of Changchun University of Chinese Medicine","place":["Jilin, Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Preventive Treatment, Affiliated Hospital of Changchun University of Chinese Medicine","place":["Jilin, Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Department, JiLin Women and Children Health Hospital","place":["Jilin, Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenglu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, BaiCheng Traditional Chinese Medicine 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