{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:20:33Z","timestamp":1788790833062,"version":"build-2803163510"},"reference-count":266,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"\n Memory CD8\n +<\/jats:sup>\n T cells provide accelerated protection against intracellular pathogens and tumors. Circulating memory T cells recirculate through blood and lymphoid tissues and can enter peripheral tissues during infection, whereas tissue-resident memory T cells (T\n RM<\/jats:sub>\n ), persist long-term in peripheral tissues, often at sites of previous pathogen infection where they can rapidly respond to antigen re-exposure. Although CD8\n +<\/jats:sup>\n T\n RM<\/jats:sub>\n cells lodge long-term within tissues, they are not stationary; many survey their local environment. CD8\n +<\/jats:sup>\n T\n RM<\/jats:sub>\n cells respond rapidly to antigen encounter by producing cytokines. These cytokines stimulate epithelial and innate immune cells to produce antimicrobial peptides and chemokines promoting recruitment of circulating leukocytes. Their localization within tissues provides protection against local reinfection, but persistent or dysregulated CD8\n +<\/jats:sup>\n T\n RM<\/jats:sub>\n cells may also sustain tissue inflammation and promote local disease recurrence in autoimmune and immune-mediated inflammatory diseases. Here, we review the mechanisms that establish and maintain CD8\n +<\/jats:sup>\n T\n RM<\/jats:sub>\n cells; evaluate evidence for their pathogenic roles in inflammatory disease; and discuss current and emerging therapeutic strategies for targeting pathogenic CD8\n +<\/jats:sup>\n T\n RM<\/jats:sub>\n cells.\n <\/jats:p>","DOI":"10.3389\/fimmu.2026.1903750","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:21:31Z","timestamp":1788787291000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evolving role of CD8+ tissue-resident memory T cells in autoimmune and immune mediated inflammatory diseases: linking pathogenesis to therapeutic approaches"],"prefix":"10.3389","volume":"17","author":[{"given":"Fatemeh Sadat","family":"Tabatabaei","sequence":"first","affiliation":[{"name":"Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School","place":["Boston, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon K.","family":"Bromley","sequence":"additional","affiliation":[{"name":"Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School","place":["Boston, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190414","article-title":"Resident memory CD8 T cells persist for years in human small intestine","volume":"216","author":"Bartolom\u00e9-Casado","year":"2019","journal-title":"J Exp Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aav5581","article-title":"Generation and persistence of human tissue-resident memory T cells in lung transplantation","volume":"4","author":"Snyder","year":"2019","journal-title":"Sci Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"5984","DOI":"10.1038\/s41598-019-42401-9","article-title":"Characterization of donor and recipient CD8+ tissue-resident memory T cells in transplant nephrectomies","volume":"9","author":"de Leur","year":"2019","journal-title":"Sci Rep"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1254803","article-title":"Skin-resident memory CD8+ T cells trigger a state of tissue-wide pathogen alert","volume":"346","author":"Ariotti","year":"2014","journal-title":"Science"},{"key":"B5","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1126\/science.1254536","article-title":"Resident memory CD8 T cells trigger protective innate and adaptive immune responses","volume":"346","author":"Schenkel","year":"2014","journal-title":"Science"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2568","article-title":"Sensing and alarm function of resident memory CD8+ T cells","volume":"14","author":"Schenkel","year":"2013","journal-title":"Nat Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-017-0029-3","article-title":"Intravital mucosal imaging of CD8(+) resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory","volume":"19","author":"Beura","year":"2018","journal-title":"Nat Immunol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.142.6.1854","article-title":"Leu 23 induction as an early marker of functional CD3\/T cell antigen receptor triggering. 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