{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:14:47Z","timestamp":1788243287134,"version":"build-2803163510"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006087","name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Mexico has been one of the countries most affected by the COVID-19 pandemic. Several factors can influence the susceptibility to SARS-CoV-2 infection, particularly highly polymorphic genes in the HLA system. Therefore, this pilot study analyzed the association between HLA-DRB1 genetic polymorphisms and the susceptibility and\/or resistance to symptomatic SARS-CoV-2 infection in a population from the Metropolitan Area of the Valley of Mexico. Individuals with a confirmed SARS-CoV-2 infection were recruited (n = 90), as well as a seronegative control group without reported symptomatic infection (n = 60). The HLA-DRB1 locus was typed using NGS. We found a significant increase in the frequency of the\n                    <jats:italic>HLA-DRB1*14<\/jats:italic>\n                    allele in the control group (OR\u00a0=\u00a00.37; 95% CI: 0.18\u20130.72; p = 0.003; pc = 0.03). These data suggest that HLA-DRB1*14, a prevalent allele in the Mexican population, is associated with a reduced risk of symptomatic SARS-CoV-2 infection in this cohort.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1907153","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:33:00Z","timestamp":1788240780000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["HLA-DRB1*14 is associated with lower odds of symptomatic SARS-CoV-2 infection in Mexican individuals"],"prefix":"10.3389","volume":"17","author":[{"given":"Eric G.","family":"Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda, Unidad de Medicina Experimental \u201cDoctor Ruy P\u00e9rez-Tamayo\u201d, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)","place":["Ciudad de M\u00e9xico, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego A.","family":"Daza-Mendoza","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda, Unidad de Medicina Experimental \u201cDoctor Ruy P\u00e9rez-Tamayo\u201d, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)","place":["Ciudad de M\u00e9xico, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Gonz\u00e1lez-Rivas","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda, Unidad de Medicina Experimental \u201cDoctor Ruy P\u00e9rez-Tamayo\u201d, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)","place":["Ciudad de M\u00e9xico, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica","family":"Serrano-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda, Unidad de Medicina Experimental 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