{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:49:46Z","timestamp":1786121386652,"version":"build-2736575974"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008385","name":"Fondazione per la Ricerca sulla Fibrosi Cistica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008385","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    The onset of a new infection by a pathogen requires a rapid and prompt response from the body. Here, we present a simple and effective strategy to stimulate antibody production by grafting immunogenic peptides onto a beta-strand peptide scaffold. Analysis of the method using a known immunogenic region, the disulfide loop of the PilA protein of the\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    pilus, shows that the molecule folds properly in solution and, upon vaccination of mice, provides significant protection against intravenous challenge with the\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    PAK strain.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1908831","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T04:22:24Z","timestamp":1786076544000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Structured peptides as vaccine antigens against infections"],"prefix":"10.3389","volume":"17","author":[{"given":"Claudia","family":"Trappetti","sequence":"first","affiliation":[{"name":"Department of Pharmacy and Biotechnology FABIT, 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