{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:59:58Z","timestamp":1790315998299,"version":"4.1.0"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hepatocellular carcinoma (HCC) often coexists with depression, elevating patient mortality by 39%. The tryptophan metabolic axis bridges tumor and neuropsychiatric immune dysfunction, yet the immunometabolic crosstalk underlying HCC-depression comorbidity remains poorly defined, and reliable combinatorial immunotherapies are absent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We integrated public multi-omics datasets including TCGA, GEO, eQTLGen and FinnGen, and performed two-sample MR as well as genetic colocalization analyses to screen hub genes associated with HCC-depression comorbidity. GSEA\/GSVA, single-cell and spatial transcriptomics were adopted to dissect gene expression and perturbed tryptophan immune pathways. In silico docking predicted fluoxetine binding to BTN3A3, GLCE and RBCK1. A Hepa1-6\/CUMS comorbid mouse model combined with targeted tryptophan LC-MS metabolomics, flow cytometry and ELISA was used to verify combined therapeutic effects and tissue molecular alterations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seven overlapping risk genes for HCC and depression were identified.\n                      <jats:italic>BTN3A3<\/jats:italic>\n                      ,\n                      <jats:italic>GLCE<\/jats:italic>\n                      and\n                      <jats:italic>RBCK1<\/jats:italic>\n                      reached strict colocalization thresholds (SNP.PP.H4 &amp;gt; 0.90) and were predominantly expressed in T cells and M2 macrophages linked to tryptophan metabolism. Fluoxetine displayed stable binding affinity with all three hub proteins via molecular simulation.\n                      <jats:italic>In vivo<\/jats:italic>\n                      assays proved fluoxetine plus anti-PD-1 restrained tumor progression, alleviated depression-like phenotypes, normalized tissue GLCE\/RBCK1 levels and restored disordered tryptophan metabolism and immunosuppressive microenvironment in comorbid mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This work characterizes tryptophan-mediated immune disturbance in HCC-depression comorbidity.\n                      <jats:italic>GLCE<\/jats:italic>\n                      and\n                      <jats:italic>RBCK1<\/jats:italic>\n                      correlate with comorbid immunometabolic disorders. Fluoxetine combined with anti-PD-1 exerts synergistic immunoregulatory effects by reshaping tryptophan-related immune homeostasis, offering a preclinical metabolic immunotherapy strategy for concurrent HCC and depression.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1909503","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:32:53Z","timestamp":1790314373000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Shared immune perturbations in hepatocellular carcinoma-depression comorbidity and synergistic immunotherapeutic effects of fluoxetine combined with anti-PD-1"],"prefix":"10.3389","volume":"17","author":[{"given":"Shanshan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Shanxi University of Chinese Medicine","place":["Jinzhong, Shanxi, China"]},{"name":"State Key Laboratory of Traditional Chinese Medicine Syndrome","place":["Zhuhai, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunwei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Shanxi University of Chinese Medicine","place":["Jinzhong, Shanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianbin","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Translational Cancer Research of Chinese Medicines, International Institute for Translational Chinese Medicine, School of Pharmaceutical Science, Guangzhou University of Chinese Medicine","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Song","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Shanxi University of Chinese Medicine","place":["Taiyuan, Shanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Ping","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, The First Hospital of Shanxi Medical University","place":["Taiyuan, Shanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghong","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Second Hospital of Shanxi Medical University","place":["Taiyuan, Shanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Shanxi University of Chinese Medicine","place":["Jinzhong, Shanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Shanxi University of Chinese Medicine","place":["Jinzhong, Shanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Traditional Chinese Medicine Syndrome","place":["Zhuhai, Guangdong, China"]},{"name":"Guangdong Provincial Key Laboratory of Translational Cancer Research of Chinese Medicines, International Institute for Translational Chinese Medicine, School of Pharmaceutical Science, Guangzhou University of Chinese Medicine","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0136","article-title":"Global prevalence of depression and anxiety in patients with hepatocellular carcinoma: Systematic review and meta-analysis","volume":"28","author":"Tan","year":"2022","journal-title":"Clin Mol Hepatol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-024-00999-9","article-title":"Identification and validation of microbial biomarkers from cross-cohort datasets using Xmarkerfinder","volume":"19","author":"Gao","year":"2024","journal-title":"Nat Protoc"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adj9672","article-title":"Anti-Pd-1 cancer immunotherapy induces central nervous system immune-related adverse events by microglia activation","volume":"16","author":"Vinnakota","year":"2024","journal-title":"Sci Transl Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.03.039","article-title":"Uncoupling immune trajectories of response and adverse events from anti-Pd-1 immunotherapy in hepatocellular carcinoma","volume":"77","author":"Chuah","year":"2022","journal-title":"J Hepatol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2025.119554","article-title":"Effect of antidepressants use on cancer morbidity and mortality: A propensity score-matched longitudinal cohort study","volume":"387","author":"Ma","year":"2025","journal-title":"J Affect Disord"},{"key":"B6","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.cmet.2025.11.011","article-title":"Serotonin-licensed macrophages potentiate chemoresistance via inositol metabolic crosstalk in ovarian cancer","volume":"38","author":"Li","year":"2026","journal-title":"Cell Metab"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00383-9","article-title":"The immunological and metabolic landscape in primary and metastatic liver cancer","volume":"21","author":"Li","year":"2021","journal-title":"Nat Rev Cancer"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108293","article-title":"Is depression the missing link between inflammatory mediators and cancer","volume":"240","author":"Polity\u0144ska","year":"2022","journal-title":"Pharmacol Ther"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1016\/j.immuni.2025.04.012","article-title":"Phosphoantigen-induced inside-out stabilization of butyrophilin receptor complexes drives dimerization-dependent \u03b3\u03b4 Tcr activation","volume":"58","author":"Zhu","year":"2025","journal-title":"Immunity"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-024-01135-z","article-title":"Unsynchronized butyrophilin molecules dictate cancer cell evasion of V\u03b39v\u03b42 T-cell killing","volume":"21","author":"Wu","year":"2024","journal-title":"Cell Mol Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.matbio.2015.06.004","article-title":"Altered heparan sulfate structure in Glce(-\/-) mice leads to increased hedgehog signaling in endochondral bones","volume":"49","author":"Dierker","year":"2016","journal-title":"Matrix Biol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202416216","article-title":"D-glucuronyl C5-epimerase binds to Egfr to suppress kidney fibrosis","volume":"12","author":"Jing","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2022.100655","article-title":"Rnf31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells","volume":"3","author":"Zhang","year":"2022","journal-title":"Cell Rep Med"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13650","article-title":"Differential DNA methylation in the brain as potential mediator of the association between traffic-related Pm(2.5) and neuropathology markers of Alzheimer's disease","volume":"20","author":"Li","year":"2024","journal-title":"Alzheimers Dement"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-019-0021-y","article-title":"Mtss1 suppresses mammary tumor-initiating cells by enhancing Rbck1-mediated P65 ubiquitination","volume":"1","author":"Cong","year":"2020","journal-title":"Nat Cancer"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1016\/j.jid.2023.01.023","article-title":"Identification of the Btn3a3 gene as a molecule implicated in generalized pustular psoriasis in a Chinese population","volume":"143","author":"Zhang","year":"2023","journal-title":"J Invest Dermatol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1529847","article-title":"Cancer stem cells and tumor-associated macrophages as mates in tumor progression: Mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interaction","volume":"16","author":"Verona","year":"2025","journal-title":"Front Immunol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.573920","article-title":"High abundance of intratumoral \u03b3\u03b4 T cells favors a better prognosis in head and neck squamous cell carcinoma: A bioinformatic analysis","volume":"11","author":"Lu","year":"2020","journal-title":"Front Immunol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113926","article-title":"Facilitating microglia M2 polarization alleviates p-synephrine-induced depressive-like behaviours in Csds mice via the 5-Ht6r-Fyn-Erk1\/2 pathway","volume":"147","author":"Wang","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.09.005","article-title":"Expression and functions of transient receptor potential channels in liver diseases","volume":"13","author":"Wang","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2023.12.011","article-title":"Development of Lag-3\/Fgl1 blocking peptide and combination with radiotherapy for cancer immunotherapy","volume":"14","author":"Qian","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2024.06.012","article-title":"An integrative multi-context Mendelian randomization method for identifying risk genes across human tissues","volume":"111","author":"Lu","year":"2024","journal-title":"Am J Hum Genet"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2024.07.017","article-title":"Liver Eqtl meta-analysis illuminates potential molecular mechanisms of cardiometabolic traits","volume":"111","author":"Broadaway","year":"2024","journal-title":"Am J Hum Genet"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003158","article-title":"Psychological distress is prevalent and interdependent among patients with decompensated cirrhosis and their caregivers","volume":"120","author":"Ufere","year":"2025","journal-title":"Am J Gastroenterol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202506032","article-title":"Genetic evidence supporting a role for brain region volume and functional network alterations in major depression","volume":"12","author":"Xu","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"B26","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1186\/s12916-022-02506-x","article-title":"C-reactive protein and cancer risk: A pan-cancer study of prospective cohort and Mendelian randomization analysis","volume":"20","author":"Zhu","year":"2022","journal-title":"BMC Med"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1017\/s0033291723000867","article-title":"Depression and risk of gastrointestinal disorders: A comprehensive two-sample Mendelian randomization study of European ancestry","volume":"53","author":"Chen","year":"2023","journal-title":"Psychol Med"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1004325","article-title":"The forecasted prevalence of comorbidities and multimorbidity in people with Hiv in the United States through the year 2030: A modeling study","volume":"21","author":"Althoff","year":"2024","journal-title":"PloS Med"},{"key":"B29","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s12072-023-10615-9","article-title":"Integrating single-cell and bulk Rna sequencing reveals Ck19\u2009+\u2009cancer stem cells and their specific Spp1\u2009+\u2009tumor-associated macrophage niche in Hbv-related hepatocellular carcinoma","volume":"18","author":"Yang","year":"2024","journal-title":"Hepatol Int"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107142","article-title":"The Adam17 inhibitor Zldi-8 sensitized hepatocellular carcinoma cells to sorafenib through Notch1-integrin \u03b2-talk","volume":"203","author":"Xu","year":"2024","journal-title":"Pharmacol Res"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-024-02073-6","article-title":"Cross-ancestry genome-wide association study and systems-level integrative analyses implicate new risk genes and therapeutic targets for depression","volume":"9","author":"Li","year":"2025","journal-title":"Nat Hum Behav"},{"key":"B32","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1186\/s13046-023-02892-x","article-title":"Rit1 regulates mitosis and promotes proliferation by interacting with Smc3 and Pds5 in hepatocellular carcinoma","volume":"42","author":"Su","year":"2023","journal-title":"J Exp Clin Cancer Res"},{"key":"B33","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12935-024-03616-7","article-title":"The expression landscape and clinical significance of methyltransferase-like 17 in human cancer and hepatocellular carcinoma: A pan-cancer analysis using multiple databases","volume":"25","author":"Ding","year":"2025","journal-title":"Cancer Cell Int"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2021.100141","article-title":"Clusterprofiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"key":"B35","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12935-024-03242-3","article-title":"Signature construction and molecular subtype identification based on liver-specific genes for prediction of prognosis, immune activity, and anti-cancer drug sensitivity in hepatocellular carcinoma","volume":"24","author":"Zhang","year":"2024","journal-title":"Cancer Cell Int"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1542327","article-title":"Gene signatures associated with exosomes as diagnostic markers of postpartum depression and their role in immune infiltration","volume":"16","author":"He","year":"2025","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-7","article-title":"Gsva: Gene set variation analysis for microarray and Rna-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinf"},{"key":"B38","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ejca.2019.03.017","article-title":"5-hydroxytryptamine1a receptors on tumour cells induce immune evasion in lung adenocarcinoma patients with depression via autophagy\/Pstat3","volume":"114","author":"Liu","year":"2019","journal-title":"Eur J Cancer"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305653","article-title":"Loss of Esrp2 activates Tak1-Mapk signaling through the fetal Rna-splicing program to promote hepatocellular carcinoma progression","volume":"11","author":"Yan","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216594","article-title":"Deciphering the immune modulation through deep transcriptomic profiling and therapeutic implications of DNA damage repair pattern in hepatocellular carcinoma","volume":"582","author":"Hong","year":"2024","journal-title":"Cancer Lett"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-023-01316-4","article-title":"Single-cell spatial multi-omics and deep learning dissect enhancer-driven gene regulatory networks in liver zonation","volume":"26","author":"Bravo Gonz\u00e1lez-Blas","year":"2024","journal-title":"Nat Cell Biol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2024.09.032","article-title":"Identification of mitophagy-related genes and analysis of immune infiltration in the astrocytes based on machine learning in the pathogenesis of major depressive disorder","volume":"368","author":"Lei","year":"2025","journal-title":"J Affect Disord"},{"key":"B43","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12935-025-03728-8","article-title":"Exploring the potential mechanisms of sorafenib resistance in hepatocellular carcinoma cell lines based on Rna sequencing","volume":"25","author":"Sun","year":"2025","journal-title":"Cancer Cell Int"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2025.105569","article-title":"Using multiomic integration to improve blood biomarkers of major depressive disorder: A case-control study","volume":"113","author":"Mokhtari","year":"2025","journal-title":"EBioMedicine"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-025-01586-8","article-title":"Hepatitis B virus core protein promotes liver cancer progression by stabilizing Canx and suppressing Irf7 transcription","volume":"46","author":"You","year":"2025","journal-title":"Acta Pharmacol Sin"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1111\/apt.70161","article-title":"Clinical trial: Effect of a 28-day low Fodmap diet on gastrointestinal symptoms associated with endometriosis (Endofod)-a randomised, controlled crossover feeding study","volume":"61","author":"Varney","year":"2025","journal-title":"Aliment Pharmacol Ther"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-022-00961-z","article-title":"Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing Reps2 expression","volume":"44","author":"He","year":"2023","journal-title":"Acta Pharmacol Sin"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2023.107694","article-title":"Multi-cohort validation study of a four-gene signature for risk stratification and treatment response prediction in hepatocellular carcinoma","volume":"167","author":"Liu","year":"2023","journal-title":"Comput Biol Med"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbac245","article-title":"A comprehensive comparison on cell-type composition inference for spatial transcriptomics data","author":"Chen","year":"2022","journal-title":"Brief Bioinform"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-022-01480-9","article-title":"Benchmarking spatial and single-cell transcriptomics integration methods for transcript distribution prediction and cell type deconvolution","volume":"19","author":"Li","year":"2022","journal-title":"Nat Methods"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.7150\/thno.108925","article-title":"Single-nucleus rna sequencing and spatial transcriptomics reveal an immunosuppressive tumor microenvironment related to metastatic dissemination during pancreatic cancer liver metastasis","volume":"15","author":"Liu","year":"2025","journal-title":"Theranostics"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.34133\/research.0387","article-title":"Integrating single-cell and spatial transcriptomics to uncover and elucidate gp73-mediated pro-angiogenic regulatory networks in hepatocellular carcinoma","volume":"7","author":"Ye","year":"2024","journal-title":"Res (Wash D C)"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1002\/exp.20220133","article-title":"Spatial transcriptomic analysis of the mouse brain following chronic social defeat stress","volume":"3","author":"Wang","year":"2023","journal-title":"Explor (Beijing)"},{"key":"B54","doi-asserted-by":"publisher","first-page":"498","DOI":"10.3322\/caac.70018","article-title":"Advances in the treatment of hepatocellular carcinoma: An overview of the current and evolving therapeutic landscape for clinicians","volume":"75","author":"Moris","year":"2025","journal-title":"CA Cancer J Clin"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-025-01446-z","article-title":"Hepatic tryptophan metabolism links chronic stress to liver cancer: Stress & cancer","volume":"8","author":"Clarke","year":"2026","journal-title":"Nat Metab"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-025-01657-8","article-title":"Indoleamine 2,3-dioxygenase: A potential biomarker for neural damage severity of leprosy neuropathy","volume":"46","author":"Rahman","year":"2026","journal-title":"Cell Mol Neurobiol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2019.06.005","article-title":"Reprogramming lymphocytes for the treatment of melanoma: From biology to therapy","volume":"141","author":"B Nma","year":"2019","journal-title":"Adv Drug Delivery Rev"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.omton.2025.201121","article-title":"Recombinant calr polarizes and activates macrophages in tumors","volume":"34","author":"Manole","year":"2026","journal-title":"Mol Therapy: Oncol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1177\/10738584241245307","article-title":"Neuron-astrocyte interactions and circadian timekeeping in mammals","volume":"31","author":"Smyllie","year":"2025","journal-title":"Neuroscientist"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1182\/blood-2024-211687","article-title":"Dexamethasone targets e2f4 to induce erythroid progenitor renewal","volume":"144","author":"Papoin","year":"2024","journal-title":"Blood"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0431-8","article-title":"The toxoplasma effector teegr promotes parasite persistence by modulating nf-\u03bab signalling via ezh2","volume":"4","author":"Braun","year":"2019","journal-title":"Nat Microbiol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1685044","article-title":"Gut-lung immunometabolic crosstalk in sepsis: From microbiota to respiratory failure","volume":"12","author":"Li","year":"2025","journal-title":"Front Med"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-025-10945-w","article-title":"Reframing tace\u2013immunotherapy integration in unresectable hcc: From hypoxia to immunometabolic crosstalk","volume":"20","author":"Veerasatian","year":"2026","journal-title":"Hepatol Int"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2026.1803583","article-title":"Case report: Fluoxetine-induced leucocytoclastic vasculitis","author":"Qin","year":"2026","journal-title":"Front Psychiatry"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.5c00199","article-title":"Selective serotonin reuptake inhibitor fluoxetine alters gene expression patterns of sarcoma and significantly reduces tumor load through modulation of the tumor microenvironment and restoration of the host antitumor immune system","volume":"8","author":"Mahanti","year":"2025","journal-title":"ACS Pharmacol Trans Sci"},{"key":"B66","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3390\/pharmaceutics16070870","article-title":"Ido1 inhibitor ry103 suppresses trp-gcn2-mediated angiogenesis and counters immunosuppression in glioblastoma","volume":"16","author":"Xing","year":"2024","journal-title":"Pharmaceutics"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16020308","article-title":"Glioma\u2013immune cell crosstalk in tumor progression","volume":"16","author":"Elguindy","year":"2024","journal-title":"Cancers"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1097\/lvt.0000000000000841","article-title":"Retraction: Initial clinical results of orthotopic liver transplantation for hepatic alveolar echinococcosis","volume":"32","author":"Li","year":"2026","journal-title":"Liver Transplant"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-77","article-title":"Proc: An open-source package for r and s+ to analyze and compare roc curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinf"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1628142","article-title":"Immunometabolic crosstalk between tumor- associated macrophages and ferroptotic cancer cells: Mechanisms, regulation, and therapeutic applications","volume":"16","author":"Qian","year":"2026","journal-title":"Front Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1909503\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:32:54Z","timestamp":1790314374000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1909503\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":70,"alternative-id":["10.3389\/fimmu.2026.1909503"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1909503","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]},"article-number":"1909503"}}