{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T11:31:04Z","timestamp":1786534264092,"version":"build-2736575974"},"reference-count":162,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    N6-methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) modification is the most common epigenetic alteration in eukaryotic mRNA, significantly impacting metabolic reprogramming and the tumor microenvironment (TME) of colorectal cancer (CRC) by dynamically regulating RNA metabolic processes. Recent studies indicate that m\n                    <jats:sup>6<\/jats:sup>\n                    A modification interacts with CRC metabolic reprogramming, fostering an immunosuppressive TME. Specifically, m\n                    <jats:sup>6<\/jats:sup>\n                    A modification promotes CRC progression by regulating glucose, lipid, and amino acid metabolism while inhibiting the activity of antitumor immune cells (such as T cells, natural killer cells, and macrophages) and activating tumor immunosuppressive cells (including tumor-associated macrophages, myeloid-derived suppressor cells, regulatory T cells, tumor-associated neutrophils, and cancer-associated fibroblasts). This article systematically reviews the molecular mechanisms through which m\n                    <jats:sup>6<\/jats:sup>\n                    A modification drives the malignant progression of CRC via metabolic regulation, elucidates the metabolic network involving m\n                    <jats:sup>6<\/jats:sup>\n                    A modification and its role in shaping TME, and discusses the clinical potential of targeting m\n                    <jats:sup>6<\/jats:sup>\n                    A modification and\/or metabolic pathways, offering novel research avenues for CRC treatment.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1911067","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T10:42:05Z","timestamp":1786531325000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Crosstalk between m6A modification and metabolic reprogramming in colorectal cancer: from the immune microenvironment to clinical applications"],"prefix":"10.3389","volume":"17","author":[{"given":"Liang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Colorectal Anal surgery, Shenyang Coloproctology Hospital","place":["Shenyang, Liaoning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhitao","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Colorectal Anal surgery, Shenyang Coloproctology Hospital","place":["Shenyang, Liaoning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchun","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Colorectal Anal surgery, Shenyang Coloproctology Hospital","place":["Shenyang, Liaoning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Colorectal Anal surgery, Shenyang Coloproctology Hospital","place":["Shenyang, Liaoning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjian","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology Surgery, Shenyang Coloproctology Hospital","place":["Shenyang, Liaoning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hexue","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Colorectal Anal surgery, Shenyang Coloproctology Hospital","place":["Shenyang, Liaoning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J 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