{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:09:15Z","timestamp":1788948555412,"version":"build-2803163510"},"reference-count":92,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Attenuated engineered strains of\n                    <jats:italic>Salmonella<\/jats:italic>\n                    have emerged as promising tools in cancer immunotherapy due to their intrinsic tumor-targeting properties and their ability to reshape the tumor immune microenvironment. Beyond their direct cytotoxic effects on tumor cells\n                    <jats:italic>, Salmonella<\/jats:italic>\n                    profoundly modulates both innate and adaptive immune responses, impacting multiple steps of the cancer\u2013immunity cycle. In this review, we discuss how attenuated\n                    <jats:italic>Salmonella<\/jats:italic>\n                    induces immunogenic tumor cell death, promotes antigen release and cross-presentation, enhances lymphocyte activation, and facilitates immune cell infiltration into the tumor microenvironment. We also address its role in controlling metastatic disease and the induction of long-term adaptive immune memory. Furthermore, we highlight unresolved questions regarding the contribution of immune activation, tolerance, and trained immunity, which may underlie the transient nature of antitumor effects observed in some models. Finally, we examine the translational hurdles that have limited clinical efficacy\u2014such as the balance between attenuation and potency, endotoxin tolerance, and preexisting immunity\u2014and outline emerging engineering strategies to overcome them. Understanding these mechanisms is essential for optimizing\n                    <jats:italic>Salmonella<\/jats:italic>\n                    -based strategies and their integration with current immunotherapies.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1916229","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T09:40:12Z","timestamp":1788946812000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Attenuated Salmonella as a modulator of the cancer\u2013immunity cycle: from innate activation to adaptive antitumor memory"],"prefix":"10.3389","volume":"17","author":[{"given":"Sof\u00eda","family":"Chilibroste","sequence":"first","affiliation":[{"name":"Unidad Acad\u00e9mica de Desarrollo Biotecnol\u00f3gico, Instituto de Higiene, Facultad de Medicina, Universidad de la Rep\u00fablica","place":["Montevideo, Uruguay"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Alejandro","family":"Chabalgoity","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Desarrollo Biotecnol\u00f3gico, Instituto de Higiene, Facultad de Medicina, Universidad de la Rep\u00fablica","place":["Montevideo, Uruguay"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Moreno","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Desarrollo Biotecnol\u00f3gico, Instituto de Higiene, Facultad de Medicina, Universidad de la Rep\u00fablica","place":["Montevideo, Uruguay"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"M\u00f3naco","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Desarrollo Biotecnol\u00f3gico, Instituto de Higiene, Facultad de Medicina, Universidad de la Rep\u00fablica","place":["Montevideo, 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