{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:12:50Z","timestamp":1788415970189,"version":"build-2803163510"},"reference-count":289,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2025QC910"],"award-info":[{"award-number":["ZR2025QC910"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Ischemic stroke evolves beyond arterial occlusion through an inflammation-centered network linking neurovascular dysfunction, immune remodeling, metabolic reprogramming, and regulated cell death. These interactions are organized across the hyperacute, acute, subacute, and chronic phases. Hyperacute energy failure, excitotoxicity, thromboinflammation, pericyte contraction, and capillary stalling can sustain microcirculatory no-reflow despite recanalization. Acute injury is characterized by blood\u2013brain barrier disruption, innate immune amplification, mitochondrial stress, as well as ferroptotic, necroptotic, pyroptotic, and proposed cuproptotic pathways. Subacute recovery involves debris clearance, immune resolution, angiogenesis, metabolic adaptation, and oligodendrocyte-lineage repair, whereas chronic outcomes reflect persistent inflammation, white-matter remodeling, and neural plasticity. Cell-specific metabolism and brain-border and systemic immune\u2013metabolic communication further shape injury and recovery. Experimental evidence is distinguished from findings in human blood, thrombectomy-derived samples, imaging, and brain tissue. Therapeutic translation requires stage-matched interventions compatible with reperfusion and rehabilitation, clinically realistic post-onset dosing, mechanistic biomarkers, and appropriate safety evaluation. This framework links early microvascular rescue with immune resolution, metabolic recovery, and network repair.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1918327","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:16:25Z","timestamp":1788412585000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Inflammation-centered neurovascular\u2013immune\u2013metabolic remodeling in ischemic stroke: stage-dependent mechanisms, regulated cell death, and therapeutic translation"],"prefix":"10.3389","volume":"17","author":[{"given":"Linjing","family":"Song","sequence":"first","affiliation":[{"name":"First School of Clinical Medicine, Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijin","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhui","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Health and Rehabilitation Sciences","place":["Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojiao","family":"Shang","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanyu","family":"Du","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Health, University of Health and Rehabilitation Sciences","place":["Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fafeng","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiu","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Health, University of Health and Rehabilitation Sciences","place":["Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102758","article-title":"Global, regional, and national burden of ischemic stroke, 1990\u20132021: an analysis of data from the global burden of disease study 2021","volume":"75","author":"Li","year":"2024","journal-title":"eClinicalMedicine"},{"key":"B2","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/S1474-4422(24)00369-7","article-title":"Global, regional, and national burden of stroke and its risk factors, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021","volume":"23","year":"2024","journal-title":"Lancet Neurol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(26)00009-8","article-title":"Stroke in China: advances in prevention and management on the path to a healthy China","volume":"25","author":"Wu","year":"2026","journal-title":"Lancet Neurol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41392-023-01688-x","article-title":"Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"B5","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s12974-026-03749-8","article-title":"Spatiotemporal dynamics of brain pericytes in ischemic stroke","volume":"23","author":"Zhong","year":"2026","journal-title":"J Neuroinflamm"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2026.108999","article-title":"NETosis in ischemic stroke: Mechanisms, implications, and therapeutic prospects","volume":"281","author":"Krishnamoorthy","year":"2026","journal-title":"Pharmacol Ther"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/medsci14010111","article-title":"Immunotherapies for ischemic stroke patients: current status and future directions","volume":"14","author":"McCabe","year":"2026","journal-title":"Med Sci (Basel)"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2026.1762764","article-title":"The spatiotemporal dynamic evolution of post-stroke neuroinflammation: energy metabolism mechanisms of acute response and chronic progression","volume":"17","author":"Du","year":"2026","journal-title":"Front Pharmacol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.neuroscience.2026.03.054","article-title":"Neuroinflammation in stroke-A review of implications for precision immunomodulation","volume":"604","author":"Zharikova","year":"2026","journal-title":"Neuroscience"},{"key":"B10","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s12035-025-05640-8","article-title":"Microglia mitochondrial metabolism in neurological diseases","volume":"63","author":"Wang","year":"2026","journal-title":"Mol Neurobiol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.115990","article-title":"Interplay between lipid metabolism and macrophage dynamics in ischemic stroke: From mechanistic insights to therapeutic strategies","volume":"169","author":"Huang","year":"2026","journal-title":"Int Immunopharmacol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2025.5490","article-title":"The role of astrocyte metabolic reprogramming in ischemic stroke (Review)","volume":"55","author":"Chen","year":"2025","journal-title":"Int J Mol Med"},{"key":"B13","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/s41401-024-01405-6","article-title":"VEGFD\/VEGFR3 signaling contributes to the dysfunction of the astrocyte IL-3\/microglia IL-3R\u03b1 cross-talk and drives neuroinflammation in mouse ischemic stroke","volume":"46","author":"Wang","year":"2025","journal-title":"Acta Pharmacol Sin"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2026.04.002","article-title":"Mitochondrial dysfunction in cerebrovascular diseases","author":"Marcheggiani","year":"2026","journal-title":"Trends Mol Med"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR-D-24-01384","article-title":"Advances in metabolomics of biomarkers for ischemic stroke: From bench to clinic","volume":"21","author":"Sun","year":"2026","journal-title":"Neural Regener Res"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-025-04357-8","article-title":"Exploring NMDAR pathways in ischemic stroke: implications for neurotoxic and neuroprotective mechanisms and therapeutic strategies","volume":"398","author":"Khan","year":"2025","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27052279","article-title":"Molecular mechanisms and targeted intervention strategies of calcium overload in ischemic stroke","volume":"27","author":"Jiang","year":"2026","journal-title":"Int J Mol Sci"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/ana.78197","article-title":"Astrocytic mitochondria transplantation rescues neuron loss and dendritic injuries in acute cerebral ischemic stroke mouse model by flexibly regulating mitochondria dynamics","volume":"99","author":"Bian","year":"2026","journal-title":"Ann Neurol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27052448","article-title":"Cerebral ischemia-reperfusion injury: unraveling the mitophagy-oxidative stress axis for neuroprotective strategies","volume":"27","author":"Zhou","year":"2026","journal-title":"Int J Mol Sci"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.148589","article-title":"Neuronal Nitric Oxide Synthase (nNOS) uncoupling in ischemic stroke: Mechanisms of oxidative\/nitrosative stress and opportunities for neuroprotection: A review","volume":"332","author":"Anwar","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2024.06.005","article-title":"Targeting TRPM channels for cerebral ischemia-reperfusion injury","volume":"45","author":"Liu","year":"2024","journal-title":"Trends Pharmacol Sci"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2026.03.054","article-title":"Inhibition of endothelial ALOX12 mitigates cerebral ischemia-reperfusion injury by suppressing 12-HETE","volume":"250","author":"Wang","year":"2026","journal-title":"Free Radic Biol Med"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2026.168188","article-title":"NADPH oxidase 5 promotes adhesion and infiltration of immune cells in the brain. Implications in ischemic stroke","volume":"1872","author":"Marqu\u00e9s","year":"2026","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1716041","article-title":"Immune-mediated blood-brain barrier disruption after ischemic stroke: mechanisms and therapeutic targets","volume":"16","author":"Wang","year":"2025","journal-title":"Front Immunol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2025.2601437","article-title":"Elevated serum NLRP3 inflammasome level potentially predicts haemorrhagic transformation and unfavourable outcome in acute ischemic stroke patients","volume":"57","author":"Lin","year":"2025","journal-title":"Ann Med"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27052281","article-title":"Serum amyloid A-dependent inflammasome activation and acute injury in a mouse model of experimental stroke","volume":"27","author":"Yu","year":"2026","journal-title":"Int J Mol Sci"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/cns.70886","article-title":"Perivascular SPP1 drives microglial synaptic engulfment after ischemic stroke","volume":"32","author":"Xu","year":"2026","journal-title":"CNS Neurosci Ther"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100471RR","article-title":"Neutrophil extracellular traps contribute to tissue plasminogen activator resistance in acute ischemic stroke","volume":"35","author":"Zhang","year":"2021","journal-title":"FASEB J"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1172\/JCI154225","article-title":"Neutrophil extracellular traps regulate ischemic stroke brain injury","volume":"132","author":"Denorme","year":"2022","journal-title":"J Clin Invest"},{"key":"B30","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1038\/s41467-020-16191-y","article-title":"Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke","volume":"11","author":"Kang","year":"2020","journal-title":"Nat Commun"},{"key":"B31","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1186\/s12974-025-03582-5","article-title":"Targeting hypercoagulability in ischemic stroke modulates fibrin-driven microglial polarization via JAK-STAT pathway","volume":"22","author":"Guan","year":"2025","journal-title":"J Neuroinflamm"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27083657","article-title":"Multimodal single-cell transcriptomic and chromatin accessibility profiling reveals monocyte-derived macrophage dynamics following ischemic stroke","volume":"27","author":"Hamblin","year":"2026","journal-title":"Int J Mol Sci"},{"key":"B33","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1186\/s12974-022-02552-5","article-title":"Phagocytosis converts infiltrated monocytes to microglia-like phenotype in experimental brain ischemia","volume":"19","author":"Ju","year":"2022","journal-title":"J Neuroinflamm"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1114663","article-title":"Single-cell analyses reveal the dynamic functions of Itgb2+ microglia subclusters at different stages of cerebral ischemia-reperfusion injury in transient middle cerebral occlusion mice model","volume":"14","author":"Zeng","year":"2023","journal-title":"Front Immunol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.7150\/thno.68895","article-title":"M2 microglia-derived extracellular vesicles promote white matter repair and functional recovery via miR-23a-5p after cerebral ischemia in mice","volume":"12","author":"Li","year":"2022","journal-title":"Theranostics"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1016\/j.immuni.2021.04.022","article-title":"Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke","volume":"54","author":"Shi","year":"2021","journal-title":"Immunity"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202500765","article-title":"Immunomodulation with local, sustained delivery of pituitary adenylate cyclase activating polypeptide results in improved functional recovery in stroke-injured mice","volume":"14","author":"Ho","year":"2025","journal-title":"Adv Healthc Mater"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2024.105674","article-title":"M2a macrophages regulate fibrosis and affect the outcome after stroke via PU.1\/mTOR pathway in fibroblasts","volume":"173","author":"Huang","year":"2024","journal-title":"Neurochem Int"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.368299","article-title":"M2 macrophages mediate fibrotic scar formation in the early stages after cerebral ischemia in rats","volume":"18","author":"Huang","year":"2023","journal-title":"Neural Regener Res"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2022.105295","article-title":"Effects of enriched environment on microglia and functional white matter recovery in rats with post stroke cognitive impairment","volume":"154","author":"Guo","year":"2022","journal-title":"Neurochem Int"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/cns.70687","article-title":"Cellular communication networks mediated by microglia in ischemic stroke","volume":"31","author":"Ma","year":"2025","journal-title":"CNS Neurosci Ther"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70597","article-title":"Dual-functionalized extracellular vesicles promote brain repair and remodeling following ischemic stroke in mice","volume":"31","author":"Shi","year":"2025","journal-title":"CNS Neurosci Ther"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2025.102687","article-title":"Characterizing hypoxia-orchestrated post-stroke changes in oligodendrocyte precursor cells for optimized cell therapy","volume":"20","author":"Kuwata","year":"2025","journal-title":"Stem Cell Rep"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70456","article-title":"Endothelial changes at different stages after ischemic stroke contribute to the regulation of immune cell infiltration","volume":"31","author":"Dai","year":"2025","journal-title":"CNS Neurosci Ther"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR-D-25-00554","article-title":"Therapeutic potential of astrocyte transdifferentiated neurons","volume":"21","author":"Liang","year":"2026","journal-title":"Neural Regener Res"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70448","article-title":"Transcription factor-based gene therapy enables functional repair of rat following chronic ischemic stroke","volume":"31","author":"Wang","year":"2025","journal-title":"CNS Neurosci Ther"},{"key":"B47","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10456-025-09987-3","article-title":"Genetic deletion of microRNA-15a\/16-1 in pericytes stimulates cerebral angiogenesis and promotes functional recovery after ischemic stroke","volume":"28","author":"Sun","year":"2025","journal-title":"Angiogenesis"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR-D-24-01417","article-title":"Different roles of astrocytes in the blood-brain barrier during the acute and recovery phases of stroke","volume":"21","author":"Cheng","year":"2026","journal-title":"Neural Regener Res"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17700913","article-title":"Imaging the physiological evolution of the ischemic penumbra in acute ischemic stroke","volume":"38","author":"Leigh","year":"2018","journal-title":"J Cereb Blood Flow Metab"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-023-03404-w","article-title":"TAT-PEP alleviated cognitive impairment by alleviating neuronal mitochondria damage and apoptosis after cerebral ischemic reperfusion injury","volume":"60","author":"Zhao","year":"2023","journal-title":"Mol Neurobiol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18785567","article-title":"Brain ischemic insult induces cofilin rod formation leading to synaptic dysfunction in neurons","volume":"39","author":"Shu","year":"2019","journal-title":"J Cereb Blood Flow Metab"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2023.100543","article-title":"N-terminomic changes in neurons during excitotoxicity reveal proteolytic events associated with synaptic dysfunctions and potential targets for neuroprotection","volume":"22","author":"Ameen","year":"2023","journal-title":"Mol Cell Proteomics"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c01578","article-title":"Preferential synaptic type of GABA-A receptor ligands enhancing neuronal survival and facilitating functional recovery after ischemic stroke","volume":"67","author":"Mordyl","year":"2024","journal-title":"J Med Chem"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2017-0090","article-title":"Metabolic regulation of synaptic activity","volume":"29","author":"Fedorovich","year":"2018","journal-title":"Rev Neurosci"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3390\/life12060910","article-title":"Crosstalk of astrocytes and other cells during ischemic stroke","volume":"12","author":"He","year":"2022","journal-title":"Life (Basel)"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071639","article-title":"Glial cells as therapeutic approaches in brain ischemia-reperfusion injury","volume":"10","author":"Hern\u00e1ndez","year":"2021","journal-title":"Cells"},{"key":"B57","article-title":"Glutamate provides cytoprotective effect for astrocytes against ischemic insult and promotes astrogliosis","volume":"15","author":"Yang","year":"2024","journal-title":"Aging Dis"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X22666240131121032","article-title":"Metabolic reprogramming in gliocyte post-cerebral ischemia\/ reperfusion: From pathophysiology to therapeutic potential","volume":"22","author":"Gong","year":"2024","journal-title":"Curr Neuropharmacol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s11064-025-04370-6","article-title":"Reactive astrocytes release GDNF to promote brain recovery and neuronal survival following ischemic stroke","volume":"50","author":"Zhang","year":"2025","journal-title":"Neurochem Res"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23848","article-title":"GLAST-CreERT2 mediated deletion of GDNF increases brain damage and exacerbates long-term stroke outcomes after focal ischemic stroke in mouse model","volume":"68","author":"Zhang","year":"2020","journal-title":"Glia"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20030571","article-title":"Dual roles of astrocyte-derived factors in regulation of blood-brain barrier function after brain damage","volume":"20","author":"MiChinaga","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.012133","article-title":"Astrocyte-derived pentraxin 3 supports blood-brain barrier integrity under acute phase of stroke","volume":"47","author":"Shindo","year":"2016","journal-title":"Stroke"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2025.177553","article-title":"Regulation of blood-brain barrier integrity by brain microvascular endothelial cells in ischemic stroke: A therapeutic opportunity","volume":"996","author":"Tang","year":"2025","journal-title":"Eur J Pharmacol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s12974-020-01780-x","article-title":"KLF4 alleviates cerebral vascular injury by ameliorating vascular endothelial inflammation and regulating tight junction protein expression following ischemic stroke","volume":"17","author":"Zhang","year":"2020","journal-title":"J Neuroinflamm"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2022.0225","article-title":"P-glycoprotein aggravates blood brain barrier dysfunction in experimental ischemic stroke by inhibiting endothelial autophagy","volume":"13","author":"Huang","year":"2022","journal-title":"Aging Dis"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S444009","article-title":"Extracellular vesicles maintain blood-brain barrier integrity by the suppression of caveolin-1\/CD147\/VEGFR2\/MMP pathway after ischemic stroke","volume":"19","author":"Li","year":"2024","journal-title":"Int J Nanomedicine"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103415","article-title":"A mechanistic systems biology model of brain microvascular endothelial cell signaling reveals dynamic pathway-based therapeutic targets for brain ischemia","volume":"78","author":"Li","year":"2024","journal-title":"Redox Biol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.125.052018","article-title":"Translational insights into pericyte-mediated regulation of cerebral blood flow: Implications for ischemic stroke","volume":"56","author":"Fangma","year":"2025","journal-title":"Stroke"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2023.1267785","article-title":"Brain pericyte biology: from physiopathological mechanisms to potential therapeutic applications in ischemic stroke","volume":"17","author":"Fu","year":"2023","journal-title":"Front Cell Neurosci"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/nature09513","article-title":"Pericytes are required for blood-brain barrier integrity during embryogenesis","volume":"468","author":"Daneman","year":"2010","journal-title":"Nature"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2025.0197","article-title":"Microcirculation dysfunction in subacute stroke: The role of delayed capillary pericyte loss","volume":"17","author":"Xu","year":"2025","journal-title":"Aging Dis"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad401","article-title":"Continued dysfunction of capillary pericytes promotes no-reflow after experimental stroke in vivo","volume":"147","author":"Shrouder","year":"2024","journal-title":"Brain"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108260","article-title":"Neutrophils obstructing brain capillaries are a major cause of no-reflow in ischemic stroke","volume":"33","author":"El Amki","year":"2020","journal-title":"Cell Rep"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2024.114728","article-title":"PI3K\u03b4 inhibition alleviates the brain injury during cerebral ischemia reperfusion via suppressing pericyte contraction in a TNF-\u03b1 dependent manner","volume":"375","author":"Qiu","year":"2024","journal-title":"Exp Neurol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202415374","article-title":"Integrin \u03b18-mediated pericyte morphogenesis controls blood-brain barrier integrity","volume":"12","author":"Gong","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-024-01298-x","article-title":"Rapamycin treatment reduces brain pericyte constriction in ischemic stroke","volume":"16","author":"Beard","year":"2025","journal-title":"Transl Stroke Res"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-021-00784-4","article-title":"Iptakalim improves cerebral microcirculation in mice after ischemic stroke by inhibiting pericyte contraction","volume":"43","author":"Guo","year":"2022","journal-title":"Acta Pharmacol Sin"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03824-x","article-title":"Exploring the multi-repair effects of advanced biomimetic rapamycin nanoparticles on cerebral ischemia-reperfusion injury","volume":"24","author":"Wang","year":"2025","journal-title":"J Nanobiotechnology"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1548122","article-title":"Protective effect of brain microvascular endothelial cell-derived exosomes on blood-brain barrier induced by ischemia-reperfusion injury in vivo and in vitro","volume":"16","author":"Sun","year":"2025","journal-title":"Front Pharmacol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121983","article-title":"Human iPS-derived blood-brain barrier model exhibiting enhanced barrier properties empowered by engineered basement membrane","volume":"293","author":"Choi","year":"2023","journal-title":"Biomaterials"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2026.117896","article-title":"ABI3BP protects against cerebral ischemia-reperfusion injury by preserving blood-brain barrier integrity and activating PI3K\/Akt signaling","volume":"249","author":"Wang","year":"2026","journal-title":"Biochem Pharmacol"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00032","article-title":"Matrix metalloproteinases and blood-brain barrier disruption in acute ischemic stroke","volume":"4","author":"Lakhan","year":"2013","journal-title":"Front Neurol"},{"key":"B83","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3892\/mmr.2025.13590","article-title":"Matrix metalloproteinase-9 in hemorrhagic transformation after acute ischemic stroke (Review)","volume":"32","author":"Guo","year":"2025","journal-title":"Mol Med Rep"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1134956","article-title":"Crosstalk between oxidative stress and neutrophil response in early ischemic stroke: a comprehensive transcriptome analysis","volume":"14","author":"Mu","year":"2023","journal-title":"Front Immunol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2025.111647","article-title":"Multifunctionality of tissue inhibitor of metalloproteinase-1 in central nervous system diseases","volume":"233","author":"Zhong","year":"2025","journal-title":"Brain Res Bull"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2025.06.002","article-title":"The role of efferocytosis in ischemic stroke and insights from retinopathy","volume":"48","author":"Morris","year":"2025","journal-title":"Trends Neurosci"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S539404","article-title":"Single-cell RNA sequencing reveals microglial heterogeneity and functional states after cerebral ischemia-reperfusion injury","volume":"18","author":"Tang","year":"2025","journal-title":"J Inflammation Res"},{"key":"B88","doi-asserted-by":"publisher","first-page":"8294","DOI":"10.1038\/s41467-025-63949-3","article-title":"Multicolor fate mapping of microglia reveals polyclonal proliferation, heterogeneity, and cell-cell interactions after ischemic stroke in mice","volume":"16","author":"Kikhia","year":"2025","journal-title":"Nat Commun"},{"key":"B89","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1007\/s12035-025-05622-w","article-title":"The role of TREM2 after stroke: From mechanisms to therapeutic potential","volume":"63","author":"Zhou","year":"2025","journal-title":"Mol Neurobiol"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305614","article-title":"TREM2-IGF1 mediated glucometabolic enhancement underlies microglial neuroprotective properties during ischemic stroke","volume":"11","author":"Yang","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"B91","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/s10753-025-02397-z","article-title":"TREML2 modulates microglial phagocytosis of myelin debris via TLR9 in chronic cerebral ischemia","volume":"49","author":"Xu","year":"2025","journal-title":"Inflammation"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2025.113396","article-title":"Chemerin 15 enhances microglial phagocytosis to attenuate cerebral ischemia-reperfusion injury through the ChemR23\/p38 MAPK pathway","volume":"28","author":"Yang","year":"2025","journal-title":"iScience"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.037148","article-title":"Revealing the novel role of purinergic receptor P2X4 in phagocytic uptake after ischemic stroke","volume":"13","author":"Gamiotea-Turro","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2025.2597624","article-title":"HDAC1 dysregulation promotes pro-inflammatory microglial activation and aggravates post-stroke neuroinflammation","volume":"57","author":"Chen","year":"2025","journal-title":"Ann Med"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.7150\/thno.103449","article-title":"Orchestrating the frontline: HDAC3-miKO recruits macrophage reinforcements for accelerated myelin debris clearance after stroke","volume":"15","author":"Li","year":"2025","journal-title":"Theranostics"},{"key":"B96","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1186\/s12974-025-03585-2","article-title":"Microglial NLRC5 drives lysosomal dysfunction to disrupt autophagic flux and promote post-stroke neuroinflammation","volume":"22","author":"Xu","year":"2025","journal-title":"J Neuroinflamm"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR-D-25-00738","article-title":"Intercellular communication between peripheral monocytes and central nervous system cells in stroke","volume":"21","author":"Kanazawa","year":"2026","journal-title":"Neural Regener Res"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-025-03638-6","article-title":"NAD+ depletion drives age-related monocyte hyperinflammation after stroke and is reversed by nicotinamide riboside","volume":"23","author":"Cabrera","year":"2025","journal-title":"J Neuroinflamm"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24359","article-title":"Microglial IL-1RA ameliorates brain injury after ischemic stroke by inhibiting astrocytic CXCL1-mediated neutrophil recruitment and microvessel occlusion","volume":"71","author":"Huang","year":"2023","journal-title":"Glia"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.04.070","article-title":"Oligodendrocyte degeneration and recovery after focal cerebral ischemia","volume":"169","author":"McIver","year":"2010","journal-title":"Neuroscience"},{"key":"B102","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1159\/000496200","article-title":"Oligodendrocyte progenitor cell proliferation and fate after white matter stroke in juvenile and adult mice","volume":"40","author":"Dingman","year":"2019","journal-title":"Dev Neurosci"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-2206-9","article-title":"Oligodendrocyte precursor cells transplantation protects blood-brain barrier in a mouse model of brain ischemia via Wnt\/\u03b2-catenin signaling","volume":"11","author":"Wang","year":"2020","journal-title":"Cell Death Dis"},{"key":"B104","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41419-023-05689-0","article-title":"CD11c+ microglia promote white matter repair after ischemic stroke","volume":"14","author":"Jia","year":"2023","journal-title":"Cell Death Dis"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.593046","article-title":"Role of T lymphocytes and interferon-gamma in ischemic stroke","volume":"113","author":"Yilmaz","year":"2006","journal-title":"Circulation"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18792372","article-title":"Experimental ischemic stroke induces long-term T cell activation in the brain","volume":"39","author":"Xie","year":"2019","journal-title":"J Cereb Blood Flow Metab"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2021.05.001","article-title":"Delayed diapedesis of CD8 T cells contributes to long-term pathology after ischemic stroke in male mice","volume":"95","author":"Selvaraj","year":"2021","journal-title":"Brain Behav Immun"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0824-5","article-title":"Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery","volume":"565","author":"Ito","year":"2019","journal-title":"Nature"},{"key":"B109","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/s12974-024-03206-4","article-title":"Microglia LILRB4 upregulation reduces brain damage after acute ischemic stroke by limiting CD8+ T cell recruitment","volume":"21","author":"Ma","year":"2024","journal-title":"J Neuroinflamm"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-013-9413-3","article-title":"IL-10-producing B-cells limit CNS inflammation and infarct volume in experimental stroke","volume":"28","author":"Bodhankar","year":"2013","journal-title":"Metab Brain Dis"},{"key":"B111","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s12974-017-0890-x","article-title":"B cells do not have a major pathophysiologic role in acute ischemic stroke in mice","volume":"14","author":"Schuhmann","year":"2017","journal-title":"J Neuroinflamm"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4098-14.2015","article-title":"B-lymphocyte-mediated delayed cognitive impairment following stroke","volume":"35","author":"Doyle","year":"2015","journal-title":"J Neurosci"},{"key":"B113","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s12975-021-00923-3","article-title":"Natural killer cells are present in Rag1-\/- mice and promote tissue damage during the acute phase of ischemic stroke","volume":"13","author":"Rolfes","year":"2022","journal-title":"Transl Stroke Res"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02689-x","article-title":"Brain endothelial CXCL12 attracts protective natural killer cells during ischemic stroke","volume":"20","author":"Wang","year":"2023","journal-title":"J Neuroinflamm"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2018.08.002","article-title":"Interleukin 8 (CXCL8)-CXC chemokine receptor 2 (CXCR2) axis contributes to MiR-4437-associated recruitment of granulocytes and natural killer cells in ischemic stroke","volume":"101","author":"He","year":"2018","journal-title":"Mol Immunol"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1177\/1756286418774254","article-title":"Danger signals in stroke and their role on microglia activation after ischemia","volume":"11","author":"G\u00fclke","year":"2018","journal-title":"Ther Adv Neurol Disord"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1038\/s41598-025-31205-9","article-title":"Remimazolam alleviates cerebral ischemia-reperfusion injury of rats by inhibiting NF-\u03baB\/NLRP3 inflammasome pyroptosis","volume":"16","author":"Liu","year":"2025","journal-title":"Sci Rep"},{"key":"B118","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1186\/s12974-025-03590-5","article-title":"Enterococcus-derived cytolysin exacerbates ischemic stroke by disrupting the blood-brain barrier via NLRP3 activation","volume":"22","author":"Huang","year":"2025","journal-title":"J Neuroinflamm"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.7150\/thno.47651","article-title":"HDAC3 inhibition ameliorates ischemia\/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway","volume":"10","author":"Liao","year":"2020","journal-title":"Theranostics"},{"key":"B120","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1038\/s41419-024-07208-1","article-title":"STING orchestrates microglia polarization via interaction with LC3 in autophagy after ischemia","volume":"15","author":"Kong","year":"2024","journal-title":"Cell Death Dis"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1080\/02699052.2017.1312018","article-title":"Circulating extracellular DNA levels are acutely elevated in ischaemic stroke and associated with innate immune system activation","volume":"31","author":"O\u2019Connell","year":"2017","journal-title":"Brain Inj"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-024-03004-y","article-title":"Assessment of associations between neutrophil extracellular trap biomarkers in blood and thrombi in acute ischemic stroke patients","volume":"57","author":"Baumann","year":"2024","journal-title":"J Thromb Thrombolysis"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2014.05.042","article-title":"Downregulation of serum brain specific microRNA is associated with inflammation and infarct volume in acute ischemic stroke","volume":"22","author":"Liu","year":"2015","journal-title":"J Clin Neurosci"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.7150\/thno.48761","article-title":"M2 microglial small extracellular vesicles reduce glial scar formation via the miR-124\/STAT3 pathway after ischemic stroke in mice","volume":"11","author":"Li","year":"2021","journal-title":"Theranostics"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1454116","article-title":"Astrocyte-derived exosomal miR-378a-5p mitigates cerebral ischemic neuroinflammation by modulating NLRP3-mediated pyroptosis","volume":"15","author":"Sun","year":"2024","journal-title":"Front Immunol"},{"key":"B126","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s12035-025-05387-2","article-title":"IL17A mediates glycolysis-dependent primary angiogenesis and exacerbates ischemic stroke injury","volume":"63","author":"Xu","year":"2025","journal-title":"Mol Neurobiol"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27031424","article-title":"The role of TNF-\u03b1 in ischemic stroke","volume":"27","author":"Ko\u0142odziejska","year":"2026","journal-title":"Int J Mol Sci"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2026.111873","article-title":"Targeted inhibition of microglial C5aR1 by PMX205 mitigates post-ischemic stroke neuroinflammation and promotes functional recovery","volume":"239","author":"Cao","year":"2026","journal-title":"Brain Res Bull"},{"key":"B129","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s10565-026-10177-0","article-title":"Multi-omics analysis and experimental validation reveal the IRF7-CXCL10 axis as a master regulator of microglial PCD in ischemic stroke","volume":"42","author":"Lai","year":"2026","journal-title":"Cell Biol Toxicol"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021098","article-title":"Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation","volume":"198","author":"Prass","year":"2003","journal-title":"J Exp Med"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1765","article-title":"Central nervous system injury-induced immune deficiency syndrome","volume":"6","author":"Meisel","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.038867","article-title":"Immunodepression, infections, and functional outcome in ischemic stroke","volume":"53","author":"Westendorp","year":"2022","journal-title":"Stroke"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4194","article-title":"Translocation and dissemination of commensal bacteria in post-stroke infection","volume":"22","author":"Stanley","year":"2016","journal-title":"Nat Med"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4068","article-title":"Commensal microbiota affects ischemic stroke outcome by regulating intestinal \u03b3\u03b4 T cells","volume":"22","author":"Benakis","year":"2016","journal-title":"Nat Med"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1114-16.2016","article-title":"Microbiota dysbiosis controls the neuroinflammatory response after stroke","volume":"36","author":"Singh","year":"2016","journal-title":"J Neurosci"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.029262","article-title":"Distinct commensal bacterial signature in the gut is associated with acute and long-term protection from ischemic stroke","volume":"51","author":"Benakis","year":"2020","journal-title":"Stroke"},{"key":"B137","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.bbi.2021.05.008","article-title":"Stroke affects intestinal immune cell trafficking to the central nervous system","volume":"96","author":"Brea","year":"2021","journal-title":"Brain Behav Immun"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-021-00887-4","article-title":"Immune cell infiltration into the brain after ischemic stroke in humans compared to mice and rats: a systematic review and meta-analysis","volume":"12","author":"Beuker","year":"2021","journal-title":"Transl Stroke Res"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-014118","article-title":"The Blood And Clot Thrombectomy Registry And Collaboration (BACTRAC) protocol: novel method for evaluating human stroke","volume":"11","author":"Fraser","year":"2019","journal-title":"J neurointerv Surg"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X211028496","article-title":"Isolation and identification of leukocyte populations in intracranial blood collected during mechanical thrombectomy","volume":"42","author":"Shaw","year":"2022","journal-title":"J Cereb Blood Flow Metab"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-021-00938-w","article-title":"Platelet activation and chemokine release are related to local neutrophil-dominant inflammation during hyperacute human stroke","volume":"13","author":"Kollikowski","year":"2022","journal-title":"Transl Stroke Res"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X221078617","article-title":"Defining cerebral leukocyte populations in local ischemic blood samples from patients with hyperacute stroke","volume":"42","author":"Zimmermann","year":"2022","journal-title":"J Cereb Blood Flow Metab"},{"key":"B143","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s12974-021-02157-4","article-title":"Intracranial VCAM1 at time of mechanical thrombectomy predicts ischemic stroke severity","volume":"18","author":"Maglinger","year":"2021","journal-title":"J Neuroinflamm"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2025.115550","article-title":"Single-nuclei RNA sequencing unveils astrocyte and oligodendrocyte lineage cells in post-stroke human brain","volume":"396","author":"Zhao","year":"2026","journal-title":"Exp Neurol"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202501658RR","article-title":"Spatial myeloid landscape of large artery atherosclerotic and cardioembolic thrombi retrieved by mechanical thrombectomy","volume":"39","author":"Jo","year":"2025","journal-title":"FASEB J"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.124.047092","article-title":"Association between thrombus composition and etiology in patients with acute ischemic stroke treated by thrombectomy","volume":"56","author":"Staessens","year":"2025","journal-title":"Stroke"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X251327944","article-title":"Elucidating stroke etiology through lipidomics of thrombi and plasma in acute ischemic stroke patients undergoing endovascular thrombectomy","volume":"46","author":"Cheng","year":"2026","journal-title":"J Cereb Blood Flow Metab"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2026.107422","article-title":"A NETs-centric multi-omics framework prioritizes PGLYRP1 and MMP9 as subtype-associated thromboinflammatory biomarker candidates and putative therapeutic hypotheses in ischemic stroke","volume":"225","author":"Tan","year":"2026","journal-title":"Neurobiol Dis"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf7844","article-title":"Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma","volume":"373","author":"Cugurra","year":"2021","journal-title":"Science"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01029-1","article-title":"Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels","volume":"25","author":"Mazzitelli","year":"2022","journal-title":"Nat Neurosci"},{"key":"B151","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1186\/s12974-023-02980-x","article-title":"Lateralized response of skull bone marrow via osteopontin signaling in mice after ischemia reperfusion","volume":"20","author":"Xu","year":"2023","journal-title":"J Neuroinflamm"},{"key":"B152","doi-asserted-by":"publisher","first-page":"5499","DOI":"10.1016\/j.cell.2025.06.045","article-title":"A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis","volume":"188","author":"Kothari","year":"2025","journal-title":"Cell"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.7150\/thno.119474","article-title":"Nociceptive neurons promote myeloid-derived suppressor cell mobilization to alleviate post-stroke neuroinflammation","volume":"15","author":"Cai","year":"2025","journal-title":"Theranostics"},{"key":"B154","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/s12974-026-03794-3","article-title":"Single-cell omics and flow cytometry identify distinct immune states of dural and brain-infiltrating IL-17-producing \u03b3\u03b4 T cells after experimental stroke","volume":"23","author":"Zha","year":"2026","journal-title":"J Neuroinflamm"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20221983","article-title":"VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model","volume":"221","author":"Boisserand","year":"2024","journal-title":"J Exp Med"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0342643","article-title":"Meningeal lymphatic-associated brain swelling in acute stroke","volume":"21","author":"Patil","year":"2026","journal-title":"PloS One"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-024-01279-0","article-title":"CCN1 is a therapeutic target for reperfused ischemic brain injury","volume":"16","author":"Lee","year":"2025","journal-title":"Transl Stroke Res"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.3390\/cimb48030259","article-title":"Meningeal lymphatics drives macrophage clearance via CCL2-CCR2 axis after cerebral ischemia","volume":"48","author":"Wang","year":"2026","journal-title":"Curr Issues Mol Biol"},{"key":"B159","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1038\/s41467-025-56847-1","article-title":"Single-cell analysis identifies Ifi27l2a as a gene regulator of microglial inflammation in the context of aging and stroke in mice","volume":"16","author":"Kim","year":"2025","journal-title":"Nat Commun"},{"key":"B160","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s13073-024-01368-7","article-title":"Microglial heterogeneity in the ischemic stroke mouse brain of both sexes","volume":"16","author":"Del \u00c1guila","year":"2024","journal-title":"Genome Med"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurot.2025.e00745","article-title":"TNFR2 signaling shapes the sex-specific remyelinating properties of microglia after experimental stroke","volume":"22","author":"Raffaele","year":"2025","journal-title":"Neurotherapeutics"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.629337","article-title":"The X-chromosome has a different pattern of gene expression in women compared with men with ischemic stroke","volume":"43","author":"Stamova","year":"2012","journal-title":"Stroke"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1155\/jimr\/1172895","article-title":"Spatiotemporal double-edged sword of macrophages: Temporal regulation of neuroinflammation and neurorepair in ischemic stroke","volume":"2026","author":"Zhang","year":"2026","journal-title":"J Immunol Res"},{"key":"B164","doi-asserted-by":"publisher","first-page":"3089","DOI":"10.1038\/s41467-025-58254-y","article-title":"Repair-associated macrophages increase after early-phase microglia attenuation to promote ischemic stroke recovery","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat Commun"},{"key":"B165","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s12987-026-00794-6","article-title":"Endothelial cells temporally orchestrate lymphocyte dynamics and functional outcomes after ischemic stroke","volume":"23","author":"Zhou","year":"2026","journal-title":"Fluids Barriers CNS"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1784112","article-title":"Lactylation at the crossroads of metabolism and epigenetics in neuroinflammation","volume":"17","author":"Wang","year":"2026","journal-title":"Front Immunol"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1038\/nature11314","article-title":"Oligodendroglia metabolically support axons and contribute to neurodegeneration","volume":"487","author":"Lee","year":"2012","journal-title":"Nature"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1080\/17590914.2025.2488935","article-title":"Assessment of phase-dependent alterations in cortical glycolytic and mitochondrial metabolism following ischemic stroke","volume":"17","author":"Rahimpour","year":"2025","journal-title":"ASN Neuro"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.115502","article-title":"The role of lactate and lactylation in ischemic stroke","volume":"165","author":"Wei","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113801","article-title":"Lactate modulates microglial inflammatory responses through HIF-1\u03b1-mediated CCL7 signaling after cerebral ischemia in mice","volume":"146","author":"Zhang","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2025.107061","article-title":"Histone H3 lysine 18 lactylation attenuates neuroinflammation and neurological damage by regulating microglial plxnb2 after ischemic stroke","volume":"215","author":"Li","year":"2025","journal-title":"Neurobiol Dis"},{"key":"B172","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1038\/s42003-024-07425-6","article-title":"Therapeutic potential of microglial SMEK1 in regulating H3K9 lactylation in cerebral ischemia-reperfusion","volume":"7","author":"Si","year":"2024","journal-title":"Commun Biol"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR-D-24-01344","article-title":"Lactate and lactylation modifications in neurological disorders","volume":"21","author":"Gu","year":"2026","journal-title":"Neural Regener Res"},{"key":"B174","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.brainresbull.2018.06.018","article-title":"Mitophagy is activated in brain damage induced by cerebral ischemia and reperfusion via the PINK1\/Parkin\/p62 signalling pathway","volume":"142","author":"Lan","year":"2018","journal-title":"Brain Res Bull"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkad018","article-title":"Targeting neuronal mitophagy in ischemic stroke: an update","volume":"11","author":"Li","year":"2023","journal-title":"Burns Trauma"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.123","article-title":"Sirtuin 3 mediates neuroprotection of ketones against ischemic stroke","volume":"35","author":"Yin","year":"2015","journal-title":"J Cereb Blood Flow Metab"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00046","article-title":"Rational application of \u03b2-hydroxybutyrate attenuates ischemic stroke by suppressing oxidative stress and mitochondrial-dependent apoptosis via activation of the Erk\/CREB\/eNOS pathway","volume":"12","author":"Li","year":"2021","journal-title":"ACS Chem Neurosci"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.31083\/FBL27634","article-title":"The role of phospholipids in mitochondrial dynamics and associated diseases","volume":"30","author":"Plouzennec","year":"2025","journal-title":"Front Biosci (Landmark Ed)"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR-D-24-01523","article-title":"Lipid metabolism, microglia, and stroke","volume":"21","author":"Chen","year":"2026","journal-title":"Neural Regener Res"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2025.1603292","article-title":"Exploring novel roles of lipid droplets and lipid metabolism in regulating inflammation and blood-brain barrier function in neurological diseases","volume":"19","author":"Fu","year":"2025","journal-title":"Front Neurosci"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.16118","article-title":"Chronic consequences of ischemic stroke: Profiling brain injury and inflammation in a mouse model with reperfusion","volume":"12","author":"Murphy","year":"2024","journal-title":"Physiol Rep"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106130","article-title":"Targeting foam cell formation to improve recovery from ischemic stroke","volume":"181","author":"Zbesko","year":"2023","journal-title":"Neurobiol Dis"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202517825","article-title":"AXL promotes ischemic myelin repair through alleviating myelin debris deposition and lipid droplets accumulation","volume":"13","author":"Jia","year":"2026","journal-title":"Adv Sci (Weinh)"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-025-01505-x","article-title":"MMP-9 inhibitor SB-3CT improves neurological outcomes in ischemic stroke mice by modulation of astrocytic lipid metabolism","volume":"46","author":"Du","year":"2025","journal-title":"Acta Pharmacol Sin"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00541","article-title":"Lipid paradox in statin-na\u00efve acute ischemic stroke but not hemorrhagic stroke","volume":"9","author":"Cheng","year":"2018","journal-title":"Front Neurol"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000252799.64165.d5","article-title":"Cholesterol level and symptomatic hemorrhagic transformation after ischemic stroke thrombolysis","volume":"68","author":"Bang","year":"2007","journal-title":"Neurology"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1159\/000329315","article-title":"Cholesterol levels and risk of hemorrhagic transformation after acute ischemic stroke","volume":"32","author":"D\u2019Amelio","year":"2011","journal-title":"Cerebrovasc Dis"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061894","article-title":"High-dose atorvastatin after stroke or transient ischemic attack","volume":"355","author":"Amarenco","year":"2006","journal-title":"N Engl J Med"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-04184-7","article-title":"Excitotoxic storms of ischemic stroke: a non-neuronal perspective","volume":"61","author":"Yang","year":"2024","journal-title":"Mol Neurobiol"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1576884","article-title":"Optimization of neuron-specific interfering peptides targeting GABAB receptor downregulation for proteolytic stability for conferring neuroprotection in a mouse model of cerebral ischemia","volume":"16","author":"Hleihil","year":"2025","journal-title":"Front Pharmacol"},{"key":"B191","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/s41598-025-30283-z","article-title":"The ADMA-NO-NOX2 axis and its association with leptomeningeal collateral impairment in acute ischemic stroke","volume":"16","author":"De Michele","year":"2025","journal-title":"Sci Rep"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2025.111529","article-title":"New insights into tryptophan metabolism in ischemic stroke: a promising therapeutic target","volume":"230","author":"Chen","year":"2025","journal-title":"Brain Res Bull"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30173628","article-title":"Microbiota-derived tryptophan metabolite indole-3-propionic acid-emerging role in neuroprotection","volume":"30","author":"Owe-Larsson","year":"2025","journal-title":"Molecules"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat Cell Biol"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat Chem Biol"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.171","article-title":"Tau-mediated iron export prevents ferroptotic damage after ischemic stroke","volume":"22","author":"Tuo","year":"2017","journal-title":"Mol Psychiatry"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio711","article-title":"Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury","volume":"1","author":"Degterev","year":"2005","journal-title":"Nat Chem Biol"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.11.031","article-title":"Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase","volume":"148","author":"Sun","year":"2012","journal-title":"Cell"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2018.0728","article-title":"Necrostatin-1 prevents necroptosis in brains after ischemic stroke via inhibition of RIPK1-mediated RIPK3\/MLKL signaling","volume":"10","author":"Deng","year":"2019","journal-title":"Aging Dis"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1157054","article-title":"The brain protection of MLKL inhibitor necrosulfonamide against focal ischemia\/reperfusion injury associating with blocking the nucleus and nuclear envelope translocation of MLKL and RIP3K","volume":"14","author":"Zhou","year":"2023","journal-title":"Front Pharmacol"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13384","article-title":"Caspase-1 inhibition prevents neuronal death by targeting the canonical inflammasome pathway of pyroptosis in a murine model of cerebral ischemia","volume":"26","author":"Li","year":"2020","journal-title":"CNS Neurosci Ther"},{"key":"B205","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41420-023-01349-6","article-title":"Gasdermin D inhibition ameliorates neutrophil mediated brain damage in acute ischemic stroke","volume":"9","author":"Hu","year":"2023","journal-title":"Cell Death Discov"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e36559","article-title":"Exploring cuproptosis-related molecular clusters and immunological characterization in ischemic stroke through machine learning","volume":"10","author":"Qin","year":"2024","journal-title":"Heliyon"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1410431","article-title":"Identification of potential biomarkers of cuproptosis in cerebral ischemia","volume":"11","author":"Qin","year":"2024","journal-title":"Front Nutr"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2024.100837","article-title":"Molecular mechanisms and therapeutic strategies for ferroptosis and cuproptosis in ischemic stroke","volume":"40","author":"Wang","year":"2024","journal-title":"Brain Behav Immun Health"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2024.101262","article-title":"Iron promotes both ferroptosis and necroptosis in the early stage of reperfusion in ischemic stroke","volume":"11","author":"Du","year":"2024","journal-title":"Genes Dis"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2025.105950","article-title":"Vagus nerve stimulation inhibits PANoptosis and promotes neurofunctional recovery of cerebral ischemic stroke in a Sirt1-dependent manner","volume":"184","author":"Tang","year":"2025","journal-title":"Neurochem Int"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70329","article-title":"Activity and heterogeneity of astrocytes in neurological diseases: Molecular mechanisms and therapeutic targets","volume":"6","author":"Mao","year":"2025","journal-title":"MedComm (2020)"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126568","article-title":"Neuroprotective function of high glycolytic activity in astrocytes: Common roles in stroke and neurodegenerative diseases","volume":"22","author":"Takahashi","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2026.112206","article-title":"Cell-specific energy crisis in the ageing brain: Mitochondrial dynamics drives neuron-glia metabolic uncoupling and neurodegeneration","volume":"232","author":"Wang","year":"2026","journal-title":"Mech Ageing Dev"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.576895","article-title":"Effect of stress hyperglycemia on neurological deficit and mortality in the acute ischemic stroke people with and without diabetes","volume":"11","author":"Li","year":"2020","journal-title":"Front Neurol"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2025.101343","article-title":"Apolipoproteins in circulation: At the interface of thrombosis and stroke initiation","volume":"100","author":"Etuze","year":"2025","journal-title":"Prog Lipid Res"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105667","article-title":"Impact of diabetes and ischemic stroke on the cerebrovasculature: A female perspective","volume":"167","author":"Wolf","year":"2022","journal-title":"Neurobiol Dis"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000210063","article-title":"Endothelial cell senescence effect on the blood-brain barrier in stroke and cognitive impairment","volume":"103","author":"Real","year":"2024","journal-title":"Neurology"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2025.1363","article-title":"Vascular aging and multi-omic regulation in ischemic stroke: Toward precision neurorepair","author":"Pirscoveanu","year":"2025","journal-title":"Aging Dis"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102600","article-title":"Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke","volume":"59","author":"Mottahedin","year":"2023","journal-title":"Redox Biol"},{"key":"B222","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.freeradbiomed.2024.03.011","article-title":"TIGAR reduces neuronal ferroptosis by inhibiting succinate dehydrogenase activity in cerebral ischemia","volume":"216","author":"Wang","year":"2024","journal-title":"Free Radic Biol Med"},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202411873","article-title":"Succinate dehydrogenase subunit A (SDHA) mediated microglia extracellular traps formation participating in cerebral ischemic reperfusion injury","volume":"12","author":"Zhao","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.06.004","article-title":"Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation","volume":"24","author":"Lampropoulou","year":"2016","journal-title":"Cell Metab"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1038\/nature25986","article-title":"Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1","volume":"556","author":"Mills","year":"2018","journal-title":"Nature"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.22.10625","article-title":"Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization","volume":"91","author":"Pellerin","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.781063","article-title":"Monocarboxylate transporter 1 may benefit cerebral ischemia via facilitating lactate transport from glial cells to neurons","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Neurol"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2025.105954","article-title":"Astrocyte-neuron metabolic crosstalk in ischaemic stroke","volume":"185","author":"Ren","year":"2025","journal-title":"Neurochem Int"},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1159\/000343657","article-title":"New evidence of neuroprotection by lactate after transient focal cerebral ischaemia: Extended benefit after intracerebroventricular injection and efficacy of intravenous administration","volume":"34","author":"Berthet","year":"2012","journal-title":"Cerebrovasc Dis"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.115","article-title":"A probable dual mode of action for both L- and D-lactate neuroprotection in cerebral ischemia","volume":"35","author":"Castillo","year":"2015","journal-title":"J Cereb Blood Flow Metab"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2012.12.017","article-title":"Neuroprotective effects of lactate in brain ischemia: Dependence on anesthetic drugs","volume":"62","author":"Horn","year":"2013","journal-title":"Neurochem Int"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.7150\/thno.96375","article-title":"Astrocyte-derived lactate aggravates brain injury of ischemic stroke in mice by promoting the formation of protein lactylation","volume":"14","author":"Xiong","year":"2024","journal-title":"Theranostics"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-026-01622-5","article-title":"Unveiling the \u201cGlycolysis-Lactate-Lactylation\u201d axis: A novel target in ischemic cerebrovascular disease","author":"Xie","year":"2026","journal-title":"Neurosci Bull"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70712","article-title":"Blood-brain barrier: Structure, function, diseases, and drug delivery systems","volume":"7","author":"He","year":"2026","journal-title":"MedComm (2020)"},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2026.02.037","article-title":"The role of pericytes in homeostasis and cardiovascular disease: A comprehensive review","author":"Zang","year":"2026","journal-title":"J Adv Res"},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.7150\/thno.127083","article-title":"Microvascular endothelial metabolic dysfunction drives cerebral edema through bioenergetic failure after ischemia-reperfusion","volume":"16","author":"Zhou","year":"2026","journal-title":"Theranostics"},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1700564","article-title":"The role of astrocytes in ischemic stroke - mechanisms, functions and treatment","volume":"13","author":"Wang","year":"2025","journal-title":"Front Cell Dev Biol"},{"key":"B238","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.852416","article-title":"Crosstalk between the oxidative stress and glia cells after stroke: From mechanism to therapies","volume":"13","author":"Zhu","year":"2022","journal-title":"Front Immunol"},{"key":"B239","doi-asserted-by":"publisher","DOI":"10.3390\/cells9122650","article-title":"High mobility group box-1 and blood-brain barrier disruption","volume":"9","author":"Nishibori","year":"2020","journal-title":"Cells"},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00560.2020","article-title":"ATP induces contraction of cultured brain capillary pericytes via activation of P2Y-type purinergic receptors","volume":"320","author":"H\u00f8rlyck","year":"2021","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B241","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-03939-6","article-title":"Crosstalk among glial cells in the blood-brain barrier injury after ischemic stroke","volume":"61","author":"Lu","year":"2024","journal-title":"Mol Neurobiol"},{"key":"B242","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/s12974-023-02888-6","article-title":"Transcriptomics and translatomics identify a robust inflammatory gene signature in brain endothelial cells after ischemic stroke","volume":"20","author":"Arbaizar-Rovirosa","year":"2023","journal-title":"J Neuroinflamm"},{"key":"B243","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10523","article-title":"Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and long-term ischaemic reperfusion brain injury","volume":"7","author":"Shi","year":"2016","journal-title":"Nat Commun"},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.94.5.939","article-title":"Endothelial ICAM-1 expression associated with inflammatory cell response in human ischemic stroke","volume":"94","author":"Lindsberg","year":"1996","journal-title":"Circulation"},{"key":"B245","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-023-01701-y","article-title":"MANF protein expression is upregulated in immune cells in the ischemic human brain and systemic recombinant MANF delivery in rat ischemic stroke model demonstrates anti-inflammatory effects","volume":"12","author":"Anttila","year":"2024","journal-title":"Acta Neuropathol Commun"},{"key":"B246","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3233-16.2017","article-title":"ST2\/IL-33-dependent microglial response limits acute ischemic brain injury","volume":"37","author":"Yang","year":"2017","journal-title":"J Neurosci"},{"key":"B247","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s12974-023-02705-0","article-title":"Microglia\/macrophages require vitamin D signaling to restrain neuroinflammation and brain injury in a murine ischemic stroke model","volume":"20","author":"Cui","year":"2023","journal-title":"J Neuroinflamm"},{"key":"B248","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s40478-018-0581-6","article-title":"CNS-border associated macrophages respond to acute ischemic stroke attracting granulocytes and promoting vascular leakage","volume":"6","author":"Pedragosa","year":"2018","journal-title":"Acta Neuropathol Commun"},{"key":"B249","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2024.114680","article-title":"Perivascular macrophages in cerebrovascular diseases","volume":"374","author":"Uchikawa","year":"2024","journal-title":"Exp Neurol"},{"key":"B250","doi-asserted-by":"publisher","DOI":"10.1117\/1.NPh.9.3.031914","article-title":"Immune-vascular mural cell interactions: Consequences for immune cell trafficking, cerebral blood flow, and the blood-brain barrier","volume":"9","author":"Barkaway","year":"2022","journal-title":"Neurophotonics"},{"key":"B251","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2024.2350821","article-title":"Hyperglycaemia perturbs blood-brain barrier integrity through its effects on endothelial cell characteristics and function","volume":"13","author":"Hashmat","year":"2025","journal-title":"Tissue Barriers"},{"key":"B252","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02884","article-title":"Von Willebrand factor and platelet glycoprotein Ib: A thromboinflammatory axis in stroke","volume":"10","author":"Denorme","year":"2019","journal-title":"Front Immunol"},{"key":"B253","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0221-1","article-title":"Thrombo-inflammation in acute ischaemic stroke - implications for treatment","volume":"15","author":"Stoll","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"B254","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-05-643338","article-title":"Low ADAMTS13 activity is associated with an increased risk of ischemic stroke","volume":"126","author":"Sonneveld","year":"2015","journal-title":"Blood"},{"key":"B255","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2024.111466","article-title":"Glycolytic reprogramming in microglia: A potential therapeutic target for ischemic stroke","volume":"124","author":"Zhang","year":"2024","journal-title":"Cell Signal"},{"key":"B256","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112617","article-title":"Resolvin D1 reprograms energy metabolism to promote microglia to phagocytize neutrophils after ischemic stroke","volume":"42","author":"Li","year":"2023","journal-title":"Cell Rep"},{"key":"B257","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2026.108127","article-title":"Histone H4 lysine 5 lactylation: A key regulator of immune metabolism in microglia during ischemic stroke","volume":"225","author":"Li","year":"2026","journal-title":"Pharmacol Res"},{"key":"B258","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02779-w","article-title":"A breakdown of metabolic reprogramming in microglia induced by CKLF1 exacerbates immune tolerance in ischemic stroke","volume":"20","author":"Ma","year":"2023","journal-title":"J Neuroinflamm"},{"key":"B259","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1111\/jnc.14267","article-title":"Hexokinase 2-dependent hyperglycolysis driving microglial activation contributes to ischemic brain injury","volume":"144","author":"Li","year":"2018","journal-title":"J Neurochem"},{"key":"B260","doi-asserted-by":"publisher","first-page":"6152","DOI":"10.1038\/s41467-026-72779-w","article-title":"Triose phosphate isomerase 1 remodels mitochondrial cristae ultrastructure to rewire microglial immunometabolism against ischemic stroke","volume":"17","author":"Zhang","year":"2026","journal-title":"Nat Commun"},{"key":"B261","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s10565-025-10085-9","article-title":"Characterization of SPTLC2 as a key driver promoting microglial activation and energy metabolism reprogramming after ischemic stroke through bulk and single-cell analyses combined with experimental validation","volume":"41","author":"Lai","year":"2025","journal-title":"Cell Biol Toxicol"},{"key":"B262","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112880","article-title":"Suppressing nuclear translocation of microglial PKM2 confers neuroprotection via downregulation of neuroinflammation after mouse cerebral ischemia-reperfusion injury","volume":"141","author":"Gao","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B263","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1007\/s00415-026-13783-4","article-title":"No-reflow phenomenon after vessel recanalization in acute ischemic stroke: mechanisms, diagnosis, and treatment directions","volume":"273","author":"Zhang","year":"2026","journal-title":"J Neurol"},{"key":"B264","doi-asserted-by":"publisher","DOI":"10.1093\/stmcls\/sxaf055","article-title":"Brain pericytes derived from human pluripotent stem cells retain vascular and phagocytic functions under hypoxia","volume":"43","author":"Zhang","year":"2025","journal-title":"Stem Cells"},{"key":"B265","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2024.12.042","article-title":"Intravenous tenecteplase bridging reperfusion ameliorates cerebral ischemia\/reperfusion injury by improving microvascular circulation in rats","volume":"23","author":"Ning","year":"2025","journal-title":"J Thromb Haemost"},{"key":"B266","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02674-w","article-title":"Delayed NLRP3 inflammasome inhibition ameliorates subacute stroke progression in mice","volume":"20","author":"Bellut","year":"2023","journal-title":"J Neuroinflamm"},{"key":"B267","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X20666220706115957","article-title":"Neutrophil heterogeneity and its roles in the inflammatory network after ischemic stroke","volume":"21","author":"Xie","year":"2023","journal-title":"Curr Neuropharmacol"},{"key":"B268","doi-asserted-by":"publisher","DOI":"10.3390\/cells13201737","article-title":"L-PGDS-PGD2-DP1 axis regulates phagocytosis by CD36+ MGs\/M\u03a6s that are exclusively present within ischemic areas after stroke","volume":"13","author":"Nakagomi","year":"2024","journal-title":"Cells"},{"key":"B269","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c09817","article-title":"Targeted mRNA nanoparticles ameliorate blood-brain barrier disruption postischemic stroke by modulating microglia polarization","volume":"18","author":"Gao","year":"2024","journal-title":"ACS Nano"},{"key":"B270","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1186\/s12951-024-02560-y","article-title":"Anti-ferroptosis exosomes engineered for targeting M2 microglia to improve neurological function in ischemic stroke","volume":"22","author":"Wang","year":"2024","journal-title":"J Nanobiotechnology"},{"key":"B271","doi-asserted-by":"publisher","DOI":"10.1172\/JCI162253","article-title":"Complement C3a treatment accelerates recovery after stroke via modulation of astrocyte reactivity and cortical connectivity","volume":"133","author":"Stokowska","year":"2023","journal-title":"J Clin Invest"},{"key":"B272","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-04210-8","article-title":"Transcriptome analysis reveals dynamic microglial-induced A1 astrocyte reactivity via C3\/C3aR\/NF-\u03baB signaling after ischemic stroke","volume":"61","author":"Wang","year":"2024","journal-title":"Mol Neurobiol"},{"key":"B273","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR-D-24-01424","article-title":"Regulatory T cells in stroke inflammation: Therapeutic perspectives","volume":"21","author":"Sun","year":"2026","journal-title":"Neural Regener Res"},{"key":"B274","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2023.1260389","article-title":"Postconditioning promotes recovery in the neurovascular unit after stroke","volume":"17","author":"Esposito","year":"2023","journal-title":"Front Cell Neurosci"},{"key":"B275","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2026.01.005","article-title":"Dynamics and heterogeneity of the neurovascular unit in ischemic stroke","volume":"47","author":"Teng","year":"2026","journal-title":"Trends Pharmacol Sci"},{"key":"B276","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s11658-026-00906-y","article-title":"NFAT1+ microglia promote antiinflammatory polarization and angiogenesis via the HAS3-HA-LYVE1 axis to improve ischemic stroke outcomes","volume":"31","author":"Zhang","year":"2026","journal-title":"Cell Mol Biol Lett"},{"key":"B277","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2025.11.068","article-title":"Butylphthalide enhances neurorestoration following ischemic stroke by restructuring microvasculature through vimentin modulation","author":"Xiao","year":"2025","journal-title":"J Adv Res"},{"key":"B278","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.034947","article-title":"Top priorities for cerebroprotective studies-a paradigm shift: Report from STAIR XI","volume":"52","author":"Lyden","year":"2021","journal-title":"Stroke"},{"key":"B279","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.038047","article-title":"The Stroke Preclinical Assessment Network: Rationale, design, feasibility, and stage 1 results","volume":"53","author":"Lyden","year":"2022","journal-title":"Stroke"},{"key":"B280","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.57.8.1428","article-title":"Use of anti-ICAM-1 therapy in ischemic stroke: results of the Enlimomab Acute Stroke Trial","volume":"57","year":"2001","journal-title":"Neurology"},{"key":"B281","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000092527.33910.89","article-title":"Acute Stroke Therapy by Inhibition of Neutrophils (ASTIN): an adaptive dose-response study of UK-279,276 in acute ischemic stroke","volume":"34","author":"Krams","year":"2003","journal-title":"Stroke"},{"key":"B282","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.29.1.12","article-title":"Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group","volume":"29","author":"Yamaguchi","year":"1998","journal-title":"Stroke"},{"key":"B283","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1161\/STROKEAHA.106.476648","article-title":"Emergency administration of abciximab for treatment of patients with acute ischemic stroke: results of an international phase III trial: Abciximab in Emergency Treatment of Stroke Trial (AbESTT-II)","volume":"39","author":"Adams","year":"2008","journal-title":"Stroke"},{"key":"B284","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70223-0","article-title":"High-dose albumin treatment for acute ischaemic stroke (ALIAS) Part 2: a randomised, double-blind, phase 3, placebo-controlled trial","volume":"12","author":"Ginsberg","year":"2013","journal-title":"Lancet Neurol"},{"key":"B285","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.020750","article-title":"SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke): A randomized controlled phase 2 trial","volume":"49","author":"Smith","year":"2018","journal-title":"Stroke"},{"key":"B286","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000029828.51413.82","article-title":"Prognostic relevance of early serial C-reactive protein measurements after first ischemic stroke","volume":"33","author":"Winbeck","year":"2002","journal-title":"Stroke"},{"key":"B287","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.126.056147","article-title":"Inflammation in acute ischemic stroke: Translational barriers and implications for treatment","volume":"57","author":"Dias","year":"2026","journal-title":"Stroke"},{"key":"B288","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2026.106167","article-title":"Effect of IL-6 receptor inhibition on infarct volume after endovascular treatment for ischaemic stroke: a phase 2, randomised, placebo-controlled trial","volume":"125","author":"Chu","year":"2026","journal-title":"EBioMedicine"},{"key":"B289","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)01862-8","article-title":"Efficacy and safety of minocycline in patients with acute ischaemic stroke (EMPHASIS): a multicentre, double-blind, randomised controlled trial","volume":"407","author":"Lu","year":"2026","journal-title":"Lancet"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1918327\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:16:30Z","timestamp":1788412590000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1918327\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":289,"alternative-id":["10.3389\/fimmu.2026.1918327"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1918327","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]},"article-number":"1918327"}}