{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:36:44Z","timestamp":1787841404203,"version":"build-2784847793"},"reference-count":221,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Inflammatory disease is sustained not only by immune activation but also by the failure of activated cells to terminate effector programs and return tissues to homeostasis. This review evaluates N\n                    <jats:sup>6<\/jats:sup>\n                    -methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) as a post-transcriptional regulator of that persistence. Rather than cataloguing diseases or classifying individual m\n                    <jats:sup>6<\/jats:sup>\n                    A regulators as pro- or anti-inflammatory, we organize the evidence around a causal chain linking a regulator and target RNA to a site- or reader-dependent change in RNA fate, an immune-cell phenotype, and a disease outcome. Mechanistically developed evidence is concentrated in macrophages and T cells, including STAT1 stability and decay, SOCS turnover, SLC37A2 translation, and lineage-specific T-cell programs. Mechanisms in other innate and adaptive immune populations are emerging, but cell-subset resolution and disease-stage validation remain uneven. Across inflammatory signaling, immunometabolic, and cell-death pathways, the same m\n                    <jats:sup>6<\/jats:sup>\n                    A regulator can produce opposing outcomes through different target transcripts or readers. We therefore distinguish mechanistically resolved, functional\/intermediate, and associative evidence while highlighting the limitations of global m\n                    <jats:sup>6<\/jats:sup>\n                    A assays, bulk-tissue profiling, and pathway-level inference. The translational value of m\n                    <jats:sup>6<\/jats:sup>\n                    A is likely to depend on target-RNA selection, cell-specific delivery, disease-stage timing, and preservation of protective immunity and tissue repair. An evidence-aware, transcript-centered framework may help move m\n                    <jats:sup>6<\/jats:sup>\n                    A research from descriptive association toward causal immune-state biology and clinically testable interventions.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1918662","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:53:10Z","timestamp":1787838790000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["m6A modification in immune-cell inflammatory fate: from RNA fate regulation to therapeutic translation in inflammatory diseases"],"prefix":"10.3389","volume":"17","author":[{"given":"Yizhang","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiye","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Surgery, Affiliated Nantong Clinical College of Nantong University, Nantong First People\u2019s Hospital","place":["Nantong, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyang","family":"Ding","sequence":"additional","affiliation":[{"name":"The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2022.116089","article-title":"Resolution of inflammation: Intervention strategies and future applications","volume":"449","author":"Panezai","year":"2022","journal-title":"Toxicol Appl Pharmacol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319822","article-title":"Inflammation resolution: Implications for atherosclerosis","volume":"130","author":"Doran","year":"2022","journal-title":"Circ Res"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ai.2023.09.001","article-title":"Post-transcriptional regulation of myeloid cell-mediated inflammatory responses","volume":"160","author":"Liu","year":"2023","journal-title":"Adv Immunol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.796012","article-title":"Shaping the innate immune response through post-transcriptional regulation of gene expression mediated by RNA-binding proteins","volume":"12","author":"Guillemin","year":"2021","journal-title":"Front Immunol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-021-04073-5","article-title":"RNA metabolism and links to inflammatory regulation and disease","volume":"79","author":"Lai","year":"2021","journal-title":"Cell Mol Life Sci"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00450-x","article-title":"The role of m6A modification in the biological functions and diseases","volume":"6","author":"Jiang","year":"2021","journal-title":"Signal Transduction Targeted Ther"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-101921-045401","article-title":"RNA modification in the immune system","volume":"41","author":"Han","year":"2023","journal-title":"Annu Rev Immunol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.18645","article-title":"N6-methyladenosine (m6A) modification in inflammation: A bibliometric analysis and literature review","volume":"12","author":"Li","year":"2024","journal-title":"PeerJ"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-023-01002-x","article-title":"N6-methyladenosine in myeloid cells: A novel regulatory factor for inflammation-related diseases","volume":"80","author":"Pang","year":"2024","journal-title":"J Physiol Biochem"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-02918-y","article-title":"Potential roles of N6-methyladenosine (m6A) in immune cells","volume":"19","author":"Liu","year":"2021","journal-title":"J Transl Med"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.4089","article-title":"M6A modification and T cells in adipose tissue inflammation","volume":"42","author":"Yang","year":"2024","journal-title":"Cell Biochem Funct"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1764","article-title":"Immune dysregulation and RNA N6-methyladenosine modification in sepsis","volume":"14","author":"Chen","year":"2023","journal-title":"Wiley Interdiscip Reviews: RNA"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-023-03149-w","article-title":"M6A methylation modification in autoimmune diseases, a promising treatment strategy based on epigenetics","volume":"25","author":"Huang","year":"2023","journal-title":"Arthritis Res Ther"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1221609","article-title":"Emerging role of METTL3 in inflammatory diseases: Mechanisms and therapeutic applications","volume":"14","author":"Song","year":"2023","journal-title":"Front Immunol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-00845-6","article-title":"Trained immunity, tolerance, priming and differentiation: Distinct immunological processes","volume":"22","author":"Divangahi","year":"2021","journal-title":"Nat Immunol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-102119-073855","article-title":"Trained immunity: Reprogramming innate immunity in health and disease","volume":"39","author":"Bekkering","year":"2021","journal-title":"Annu Rev Immunol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.10.011","article-title":"The intersection of epigenetics and metabolism in trained immunity","volume":"54","author":"Fanucchi","year":"2021","journal-title":"Immunity"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.07.001","article-title":"Establishment, maintenance, and recall of inflammatory memory","volume":"28","author":"Larsen","year":"2021","journal-title":"Cell Stem Cell"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.11.026","article-title":"Macrophages acquire a TNF-dependent inflammatory memory in allergic asthma","volume":"149","author":"Lechner","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100973","article-title":"The detection and functions of RNA modification m6A based on m6A writers and erasers","volume":"297","author":"Zhang","year":"2021","journal-title":"J Biol Chem"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2022.0017","article-title":"m6A in the signal transduction network","volume":"45","author":"Jang","year":"2022","journal-title":"Molecules Cells"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2023.2246256","article-title":"RNA modification-mediated translational control in immune cells","volume":"20","author":"Zhang","year":"2023","journal-title":"RNA Biol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1159\/000534162","article-title":"N6-methyladenosine (m6A) modification in natural immune cell-mediated inflammatory diseases","volume":"15","author":"Teng","year":"2023","journal-title":"J Innate Immun"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.755691","article-title":"The emerging role of m6A modification in regulating the immune system and autoimmune diseases","volume":"9","author":"Wang","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac945","article-title":"RM2Target: A comprehensive database for targets of writers, erasers and readers of RNA modifications","volume":"51","author":"Bao","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-024-09921-1","article-title":"hucMSC-Ex alleviates inflammatory bowel disease in mice by enhancing M2-type macrophage polarization via the METTL3-Slc37a2-YTHDF1 axis","volume":"40","author":"Xu","year":"2024","journal-title":"Cell Biol Toxicol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-021-00756-x","article-title":"The METTL3\/MALAT1\/PTBP1\/USP8\/TAK1 axis promotes pyroptosis and M1 polarization of macrophages and contributes to liver fibrosis","volume":"7","author":"Shu","year":"2021","journal-title":"Cell Death Discov"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24019","article-title":"Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling","volume":"36","author":"Li","year":"2022","journal-title":"J Clin Lab Anal"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23845","article-title":"METTL3-mediated TIM1 promotes macrophage M1 polarization and inflammation through IGF2BP2-dependent manner","volume":"38","author":"Du","year":"2024","journal-title":"J Biochem Mol Toxicol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2504697122","article-title":"ALKBH5 demethylates the m6A modification of SOCS3 in microglia\/macrophages and alleviates neuroinflammation after brain injury","volume":"122","author":"Cai","year":"2025","journal-title":"PNAS"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.940918","article-title":"Predictive value of drug efficacy by M6A modification patterns in rheumatoid arthritis patients","volume":"13","author":"Song","year":"2022","journal-title":"Front Immunol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-023-10610-7","article-title":"Comprehensive analysis of N6-methyladenosine RNA methylation regulators in the diagnosis and subtype classification of rheumatoid arthritis","volume":"62","author":"Zhang","year":"2024","journal-title":"Biochem Genet"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-024-02194-8","article-title":"The role of m6A methylation genes in predicting poor prognosis in sepsis: Identifying key biomarkers and therapeutic targets","volume":"29","author":"Wang","year":"2024","journal-title":"Eur J Med Res"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-023-00295-x","article-title":"Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis increasing the risk of cerebrovascular complications","volume":"2","author":"Dib","year":"2023","journal-title":"Nat Cardiovasc Res"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.10.039","article-title":"Adipose tissue macrophage dysfunction is associated with a breach of vascular integrity in NASH","volume":"80","author":"Boesch","year":"2024","journal-title":"J Hepatol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.679797","article-title":"Macrophage plasticity and atherosclerosis therapy","volume":"8","author":"Lin","year":"2021","journal-title":"Front Mol Biosci"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001601","article-title":"Tissue-resident macrophages in the control of infection and resolution of inflammation","volume":"55","author":"Mu","year":"2021","journal-title":"Shock"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202100209","article-title":"The m6A reader IGF2BP2 regulates macrophage phenotypic activation and inflammatory diseases by stabilizing TSC1 and PPAR\u03b3","volume":"8","author":"Wang","year":"2021","journal-title":"Adv Sci"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.10.032","article-title":"RNA-m6A modification of HDGF mediated by Mettl3 aggravates the progression of atherosclerosis by regulating macrophages polarization via energy metabolism reprogramming","volume":"635","author":"Zheng","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04331-0","article-title":"Mettl14 mediates the inflammatory response of macrophages in atherosclerosis through the NF-\u03baB\/IL-6 signaling pathway","volume":"79","author":"Zheng","year":"2022","journal-title":"Cell Mol Life Sci"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01797-1","article-title":"METTL14 downregulation drives S100A4+ monocyte-derived macrophages via MyD88\/NF-\u03baB pathway to promote MAFLD progression","volume":"9","author":"Wang","year":"2024","journal-title":"Signal Transduction Targeted Ther"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/s44319-023-00047-9","article-title":"DDX5 inhibits inflammation by modulating m6A levels of TLR2\/4 transcripts during bacterial infection","volume":"25","author":"Xu","year":"2024","journal-title":"EMBO Rep"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-025-02156-8","article-title":"Inhibiting METTL3 in macrophages alleviates colitis by enhancing M2 polarization via upregulating IRAKM","volume":"75","author":"Zhang","year":"2026","journal-title":"Inflammation Res"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00832-3","article-title":"Neutrophils in chronic inflammatory diseases","volume":"19","author":"Herrero-Cervera","year":"2022","journal-title":"Cell Mol Immunol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70063","article-title":"Neutrophil heterogeneity and plasticity: Unveiling the multifaceted roles in health and disease","volume":"6","author":"He","year":"2025","journal-title":"MedComm"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-025-00337-9","article-title":"Neutrophil extracellular traps (NETs) in health and disease","volume":"6","author":"Shahzad","year":"2025","journal-title":"Mol BioMed"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.953195","article-title":"The role of neutrophil extracellular traps in acute lung injury","volume":"13","author":"Scozzi","year":"2022","journal-title":"Front Immunol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.321750","article-title":"NETs-induced thrombosis impacts on cardiovascular and chronic kidney disease","volume":"132","author":"Thakur","year":"2023","journal-title":"Circ Res"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-022-00916-w","article-title":"Mechanisms of immunothrombosis and vasculopathy in antiphospholipid syndrome","volume":"44","author":"Knight","year":"2022","journal-title":"Semin Immunopathology"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0241-2021","article-title":"Neutrophil extracellular traps in chronic lung disease: Implications for pathogenesis and therapy","volume":"31","author":"Keir","year":"2022","journal-title":"Eur Respir Rev"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110436","article-title":"The role of neutrophil extracellular traps in sepsis and sepsis-related acute lung injury","volume":"124","author":"Zou","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110834","article-title":"Rethinking neutrophil extracellular traps","volume":"124","author":"Liu","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.157342","article-title":"Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2 infection","volume":"7","author":"Adrover","year":"2022","journal-title":"JCI Insight"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01020-z","article-title":"m6A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration","volume":"7","author":"Liu","year":"2022","journal-title":"Signal Transduction Targeted Ther"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-023-01115-9","article-title":"The RNA m6A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression","volume":"21","author":"Liu","year":"2024","journal-title":"Cell Mol Immunol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2026.01.044","article-title":"METTL3 promotes neutrophil extracellular trap formation via SYK\/ERK\/MEK signaling during acute lung injury","author":"Luo","year":"2026","journal-title":"J Adv Res"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-024-3081-9","article-title":"Upregulation of m6A writer WTAP by histone lactylation promotes inflammatory response via TLR2 in neutrophils","volume":"69","author":"Du","year":"2026","journal-title":"Sci China Life Sci"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1707663","article-title":"Unveiling novel therapeutic mechanisms of Xinfeng capsule: modulating the ALKBH5-m6A-LINC00968 axis to alleviate oxidative stress-driven NETosis in rheumatoid arthritis","volume":"16","author":"Sun","year":"2025","journal-title":"Front Immunol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-024-07257-z","article-title":"Downregulated YTHDF2 expression in systemic lupus erythematosus is associated with inflammatory and neutrophil cytokine production","volume":"44","author":"Zhao","year":"2025","journal-title":"Clin Rheumatol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13394","article-title":"Unboxing dendritic cells: Tales of multi-faceted biology and function","volume":"164","author":"Giza","year":"2021","journal-title":"Immunology"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-090122-041105","article-title":"Ontogeny and function of plasmacytoid dendritic cells","volume":"42","author":"Adams","year":"2024","journal-title":"Annu Rev Immunol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084190","article-title":"Type I interferon production of plasmacytoid dendritic cells under control","volume":"22","author":"Bencze","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13331","article-title":"Modulation of plasmacytoid dendritic cells response in inflammation and autoimmunity","volume":"323","author":"Ah Kioon","year":"2024","journal-title":"Immunol Rev"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202300893R","article-title":"Mettl3 induced miR-338-3p expression in dendritic cells promotes antigen-specific Th17 cell response via regulation of Dusp16","volume":"37","author":"Wei","year":"2023","journal-title":"FASEB J"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25803-0","article-title":"METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells","volume":"12","author":"Song","year":"2021","journal-title":"Nat Commun"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210279","article-title":"The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity","volume":"218","author":"Ma","year":"2021","journal-title":"J Exp Med"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-23-0339","article-title":"mTOR signaling promotes rapid m6A mRNA methylation to regulate NK-cell activation and effector functions","volume":"12","author":"Meng","year":"2024","journal-title":"Cancer Immunol Res"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01548-4","article-title":"m6A RNA modification regulates innate lymphoid cell responses in a lineage-specific manner","volume":"24","author":"Zhang","year":"2023","journal-title":"Nat Immunol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00680-1","article-title":"Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m6A demethylation of Nr4a1 mRNA","volume":"18","author":"Liu","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.670471","article-title":"Maintenance of barrier tissue integrity by unconventional lymphocytes","volume":"12","author":"Cox","year":"2021","journal-title":"Front Immunol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-022-00685-8","article-title":"Metabolic control of innate lymphoid cells in health and disease","volume":"4","author":"Zhou","year":"2022","journal-title":"Nat Metab"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.867351","article-title":"Heterogeneity of ILC2s in the intestine; homeostasis and pathology","volume":"13","author":"Sunaga","year":"2022","journal-title":"Front Immunol"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.586471","article-title":"The role of group 3 innate lymphoid cells in lung infection and immunity","volume":"11","author":"Yang","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.828191","article-title":"Metabolism characteristics of Th17 and regulatory T cells in autoimmune diseases","volume":"13","author":"Qin","year":"2022","journal-title":"Front Immunol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1687755","article-title":"Metabolic reprogramming as a therapeutic target for modulating the Th17\/Treg balance in autoimmune diseases: a comprehensive review","volume":"16","author":"Hu","year":"2025","journal-title":"Front Immunol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1425847","article-title":"Imbalance of Th17 cells, Treg cells and associated cytokines in patients with systemic lupus erythematosus: a meta-analysis","volume":"15","author":"Huang","year":"2024","journal-title":"Front Immunol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2023.04.008","article-title":"Mettl14 sustains FOXP3 expression to promote the differentiation and functions of induced-regulatory T cells via the mTOR signaling pathway","volume":"258","author":"Liu","year":"2023","journal-title":"Immunol Lett"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01268-1","article-title":"The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells","volume":"23","author":"Ito-Kureha","year":"2022","journal-title":"Nat Immunol"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiae087","article-title":"N6-methyladenosine promotes TNF mRNA degradation in CD4+ T lymphocytes","volume":"116","author":"van Vroonhoven","year":"2024","journal-title":"J Leukocyte Biol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2025.05.004","article-title":"The m6A demethylase FTO controls Th1 differentiation and immunity against infections","volume":"183","author":"Yao","year":"2025","journal-title":"Mol Immunol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-07606-z","article-title":"FTO controls CD8+ T cell survival and effector response by modulating m6A methylation of Fas","volume":"16","author":"Sun","year":"2025","journal-title":"Cell Death Dis"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-53997-6","article-title":"YTHDF2 upregulation and subcellular localization dictate CD8 T cell polyfunctionality in anti-tumor immunity","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat Commun"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-021-00568-0","article-title":"Transcriptional regulatory network for the establishment of CD8+ T cell exhaustion","volume":"53","author":"Seo","year":"2021","journal-title":"Exp Mol Med"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxac038","article-title":"CD8 T-cell heterogeneity during T-cell exhaustion and PD-1-targeted immunotherapy","volume":"34","author":"Ando","year":"2022","journal-title":"Int Immunol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxac013","article-title":"A variety of \u2018exhausted\u2019 T cells in the tumor microenvironment","volume":"34","author":"Nagasaki","year":"2022","journal-title":"Int Immunol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.70089","article-title":"Targeting METTL3 as a checkpoint to enhance T cells for tumour immunotherapy","volume":"14","author":"Wu","year":"2024","journal-title":"Clin Transl Med"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1155\/mi\/6217272","article-title":"WTAP accelerates exhaustion of CD8+ T cells and progression of hepatocellular carcinoma by promoting m6A modification and translation of PD1 mRNA","volume":"2025","author":"Li","year":"2025","journal-title":"Mediators Inflammation"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-083122-044829","article-title":"B cell-directed therapy in autoimmunity","volume":"42","author":"Abeles","year":"2024","journal-title":"Annu Rev Immunol"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202149675","article-title":"Targeting B cells and plasma cells in autoimmune diseases: From established treatments to novel therapeutic approaches","volume":"53","author":"Merino-Vico","year":"2023","journal-title":"Eur J Immunol"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2022.102861","article-title":"Autoantibodies in systemic lupus erythematosus: From immunopathology to therapeutic target","volume":"132","author":"Lou","year":"2022","journal-title":"J Autoimmun"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-00544-4","article-title":"Toll-like receptor signalling in B cells during systemic lupus erythematosus","volume":"17","author":"Fillatreau","year":"2021","journal-title":"Nat Rev Rheumatol"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04433-9","article-title":"Age-associated B cells in autoimmune diseases","volume":"79","author":"Mouat","year":"2022","journal-title":"Cell Mol Life Sci"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1731285","article-title":"Aberrant B cell responses as drivers of autoantibody generation and epitope diversification in SLE pathogenesis","volume":"16","author":"Tariq","year":"2025","journal-title":"Front Immunol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12010040","article-title":"Altered germinal-center metabolism in B cells in autoimmunity","volume":"12","author":"Shiraz","year":"2022","journal-title":"Metabolites"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.908034","article-title":"Alternative B cell differentiation during infection and inflammation","volume":"13","author":"Courey-Ghaouzi","year":"2022","journal-title":"Front Immunol"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.821729","article-title":"Single-cell technologies for the study of antibody-secreting cells","volume":"12","author":"Broketa","year":"2021","journal-title":"Front Immunol"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2101071","article-title":"Mettl14-mediated m6A modification is essential for germinal center B cell response","volume":"208","author":"Huang","year":"2022","journal-title":"J Immunol"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2025.123884","article-title":"M6A modification of RRM2 drives B cell hyperactivity in primary Sj\u00f6gren's syndrome","volume":"379","author":"Yang","year":"2025","journal-title":"Life Sci"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-025-01587-x","article-title":"RNA N6-methyladenosine reader protein YTHDF1 promotes plasma cell differentiation via IRF4 regulation in systemic lupus erythematosus","volume":"57","author":"Lu","year":"2025","journal-title":"Exp Mol Med"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2025.101144","article-title":"m6A eraser ALKBH5\/treRNA1\/DDX46 axis regulates BCR expression","volume":"62","author":"Kapadia","year":"2025","journal-title":"Neoplasia"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20210139","article-title":"Inhibitory feedback control of NF-\u03baB signalling in health and disease","volume":"478","author":"Prescott","year":"2021","journal-title":"Biochem J"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2022.110283","article-title":"METTL3 regulates LPS-induced inflammatory response via the NOD1 signaling pathway","volume":"93","author":"Cai","year":"2022","journal-title":"Cell Signalling"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11101954","article-title":"M6A RNA methylation mediates NOD1\/NF-kB signaling activation in the liver of piglets challenged with lipopolysaccharide","volume":"11","author":"Xu","year":"2022","journal-title":"Antioxidants"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00212.2019","article-title":"The N6-methyladenosine-forming enzyme METTL3 facilitates M1 macrophage polarization through the methylation of STAT1 mRNA","volume":"317","author":"Liu","year":"2019","journal-title":"Am J Physiol Cell Physiol"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106432","article-title":"RBM4 regulates M1 macrophages polarization through targeting STAT1-mediated glycolysis","volume":"83","author":"Huangfu","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-025-01594-y","article-title":"METTL3\/RBM15 augments the stability of Kdm6b mRNA and promotes STAT1-mediated macrophage activation and atherosclerosis","volume":"57","author":"Huangfu","year":"2025","journal-title":"Exp Mol Med"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-022-02960-1","article-title":"Augmented PFKFB3-mediated glycolysis by interferon-\u03b3 promotes inflammatory M1 polarization through the JAK2\/STAT1 pathway in local vascular inflammation in Takayasu arteritis","volume":"24","author":"Chen","year":"2022","journal-title":"Arthritis Res Ther"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1038\/nature23450","article-title":"m6A mRNA methylation controls T cell homeostasis by targeting the IL-7\/STAT5\/SOCS pathways","volume":"548","author":"Li","year":"2017","journal-title":"Nature"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-023-00822-2","article-title":"Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets","volume":"23","author":"Vande Walle","year":"2024","journal-title":"Nat Rev Drug Discov"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.04.025","article-title":"A 360\u00b0 view of the inflammasome: Mechanisms of activation, cell death, and diseases","volume":"186","author":"Barnett","year":"2023","journal-title":"Cell"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113821","article-title":"Unraveling the priming phase of NLRP3 inflammasome activation: Molecular insights and clinical relevance","volume":"146","author":"Liao","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1232629","article-title":"Reframing the link between metabolism and NLRP3 inflammasome: therapeutic opportunities","volume":"14","author":"Ortega","year":"2023","journal-title":"Front Immunol"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-032521-102529","article-title":"Role of the inflammasome in liver disease","volume":"17","author":"de Carvalho Ribeiro","year":"2022","journal-title":"Annu Rev Pathol"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.15698\/cst2022.10.272","article-title":"Pyroptosis in NLRP3 inflammasome-related atherosclerosis","volume":"6","author":"Zeng","year":"2022","journal-title":"Cell Stress"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106253","article-title":"METTL14 regulates microglia\/macrophage polarization and NLRP3 inflammasome activation after ischemic stroke by the KAT3B-STING axis","volume":"185","author":"Li","year":"2023","journal-title":"Neurobiol Dis"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06407-6","article-title":"METTL14 contributes to acute lung injury by stabilizing NLRP3 expression in an IGF2BP2-dependent manner","volume":"15","author":"Cao","year":"2024","journal-title":"Cell Death Dis"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.05.076","article-title":"RNA m6A reader YTHDF1 facilitates inflammation via enhancing NLRP3 translation","volume":"616","author":"Hao","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-00872-2","article-title":"YTHDF1 alleviates sepsis by upregulating WWP1 to induce NLRP3 ubiquitination and inhibit caspase-1-dependent pyroptosis","volume":"8","author":"Zhang","year":"2022","journal-title":"Cell Death Discov"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1186\/s13062-025-00648-5","article-title":"The role of IGF2BP2 in macrophage-mediated NLRP3 inflammasome activation in the pathogenesis of dry AMD","volume":"20","author":"Zhao","year":"2025","journal-title":"Biol Direct"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111537","article-title":"Apolipoprotein C3 facilitates NLRP3 mediated pyroptosis of macrophages through mitochondrial damage by accelerating the interaction between SCIMP and SYK pathway in acute lung injury","volume":"128","author":"Pu","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-022-00909-1","article-title":"Pyroptosis in inflammation-related respiratory disease","volume":"78","author":"Feng","year":"2022","journal-title":"J Physiol Biochem"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101993","article-title":"Immunometabolism and immune response regulate macrophage function in atherosclerosis","volume":"90","author":"Xue","year":"2023","journal-title":"Ageing Res Rev"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2023.102369","article-title":"Tissue-specific macrophage immunometabolism","volume":"84","author":"Ben-Arosh","year":"2023","journal-title":"Curr Opin Immunol"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1117548","article-title":"The role of immunometabolism in macrophage polarization and its impact on acute lung injury\/acute respiratory distress syndrome","volume":"14","author":"Wang","year":"2023","journal-title":"Front Immunol"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1080\/08830185.2022.2095374","article-title":"Dysregulated metabolism: A friend-to-foe skewer of macrophages","volume":"42","author":"Mortezaee","year":"2023","journal-title":"Int Rev Immunol"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.826811","article-title":"The role of peroxisome proliferator-activated receptor gamma and atherosclerosis: Post-translational modification and selective modulators","volume":"13","author":"Yin","year":"2022","journal-title":"Front Physiol"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-021-00870-5","article-title":"A novel therapeutic strategy for atherosclerosis: autophagy-dependent cholesterol efflux","volume":"78","author":"Guo","year":"2022","journal-title":"J Physiol Biochem"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167354","article-title":"The m6A eraser FTO suppresses ferroptosis via mediating ACSL4 in LPS-induced macrophage inflammation","volume":"1870","author":"Zhao","year":"2024","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2021.01.005","article-title":"Critical roles of FTO-mediated mRNA m6A demethylation in regulating adipogenesis and lipid metabolism: Implications in lipid metabolic disorders","volume":"9","author":"Yang","year":"2022","journal-title":"Genes Dis"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1016\/j.arteri.2026.500943","article-title":"MUC2 promotes cholesterol efflux in foam cells through ALKBH5-mediated m6A modification of ABCA1 mRNA","author":"He","year":"2026","journal-title":"Cl\u00ednica e Investigaci\u00f3n en Arterioscler"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2026.104568","article-title":"Macrophage METTL3 synergizes with YTHDF2 to promote atherosclerosis by inhibiting the LXR-\u03b1\/ABCA1 pathway","volume":"36","author":"Tu","year":"2026","journal-title":"Nutrition Metab Cardiovasc Dis"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16059","article-title":"Signaling pathways and defense mechanisms of ferroptosis","volume":"289","author":"Liu","year":"2022","journal-title":"FEBS J"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.03.019","article-title":"Ironing out the role of ferroptosis in immunity","volume":"57","author":"Bell","year":"2024","journal-title":"Immunity"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04775-z","article-title":"Interaction between macrophages and ferroptosis","volume":"13","author":"Yang","year":"2022","journal-title":"Cell Death Dis"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1474285","article-title":"Inflammation in a ferroptotic environment","volume":"15","author":"Wickert","year":"2024","journal-title":"Front Pharmacol"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2021.04.009","article-title":"The role of mitophagy in pulmonary sepsis","volume":"59","author":"Mohsin","year":"2021","journal-title":"Mitochondrion"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.31448","article-title":"N6-methyladenosine demethyltransferase FTO alleviates sepsis by upregulating BNIP3 to induce mitophagy","volume":"239","author":"Qi","year":"2024","journal-title":"J Cell Physiol"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1016\/j.advms.2024.05.002","article-title":"Dexmedetomidine improves mitophagy and pyroptosis through the ALKBH5\/FUNDC1 axis during epidural-related maternal fever","volume":"69","author":"Xiao","year":"2024","journal-title":"Adv Med Sci"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103918","article-title":"Redox-sensitive m6A regulation in atherosclerosis: METTL3 at the crossroads of mitochondrial quality control and pyroptosis","volume":"88","author":"Wu","year":"2025","journal-title":"Redox Biol"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.3390\/cells14110794","article-title":"Mitochondrial dysfunction: The silent catalyst of kidney disease progression","volume":"14","author":"Pavlovic","year":"2025","journal-title":"Cells"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2025.102821","article-title":"Mechanisms underlying the interplay between autophagy and the inflammasome in age-related diseases: Implications for exercise immunology","volume":"110","author":"Ramos","year":"2025","journal-title":"Ageing Res Rev"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.3390\/ph14030218","article-title":"m6A RNA methylation in systemic autoimmune diseases-a new target for epigenetic-based therapy","volume":"14","author":"Wardowska","year":"2021","journal-title":"Pharmaceuticals"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1080\/08830185.2023.2280544","article-title":"RNA methylation: A potential therapeutic target in autoimmune disease","volume":"43","author":"Li","year":"2024","journal-title":"Int Rev Immunol"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2023.02.013","article-title":"The role of m6A RNA methylation in autoimmune diseases: Novel therapeutic opportunities","volume":"11","author":"Shan","year":"2024","journal-title":"Genes Dis"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.116066","article-title":"Emerging roles and mechanism of m6A methylation in rheumatoid arthritis","volume":"170","author":"Xu","year":"2024","journal-title":"Biomedicine Pharmacotherapy"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.731842","article-title":"N6-methyladenosine and rheumatoid arthritis: A comprehensive review","volume":"12","author":"Wu","year":"2021","journal-title":"Front Immunol"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1717671","article-title":"Neutrophil extracellular traps in rheumatoid arthritis: pathogenic mechanisms and therapeutic potential","volume":"16","author":"Mao","year":"2025","journal-title":"Front Immunol"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1394108","article-title":"Macrophage polarization in rheumatoid arthritis: signaling pathways, metabolic reprogramming, and crosstalk with synovial fibroblasts","volume":"15","author":"Zheng","year":"2024","journal-title":"Front Immunol"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2021.03.002","article-title":"Neutrophil extracellular traps in inflammatory bowel disease: Pathogenic mechanisms and clinical translation","volume":"12","author":"Drury","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2024.109929","article-title":"Hypoxia-induced ALKBH5 aggravates synovial aggression and inflammation in rheumatoid arthritis by regulating the m6A modification of CH25H","volume":"261","author":"Fan","year":"2024","journal-title":"Clin Immunol"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1002\/art.42676","article-title":"ALKBH5-mediated RNA m6A methylation regulates the migration, invasion, and proliferation of rheumatoid fibroblast-like synoviocytes","volume":"76","author":"Kuang","year":"2024","journal-title":"Arthritis Rheumatol"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-024-03735-y","article-title":"METTL3 facilitates kidney injury through promoting IRF4-mediated plasma cell infiltration via an m6A-dependent manner in systemic lupus erythematosus","volume":"22","author":"Liu","year":"2024","journal-title":"BMC Med"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2021.09.005","article-title":"ROR\u03b3t protein modifications and IL-17-mediated inflammation","volume":"42","author":"Kumar","year":"2021","journal-title":"Trends Immunol"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.637829","article-title":"Role of the IL-23\/IL-17 pathway in rheumatic diseases: An overview","volume":"12","author":"Schinocca","year":"2021","journal-title":"Front Immunol"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.2174\/1381612829666230904150808","article-title":"Role of Th17 and IL-17 cytokines on inflammatory and auto-immune diseases","volume":"29","author":"Akhter","year":"2023","journal-title":"Curr Pharm Des"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-025-01535-9","article-title":"Th17 cell pathogenicity in autoimmune disease","volume":"57","author":"Park","year":"2025","journal-title":"Exp Mol Med"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108402","article-title":"The role of IL-17 and anti-IL-17 agents in the immunopathogenesis and management of autoimmune and inflammatory diseases","volume":"102","author":"Berry","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.3390\/cells11071101","article-title":"Emerging roles and mechanism of m6A methylation in cardiometabolic diseases","volume":"11","author":"Xu","year":"2022","journal-title":"Cells"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112222","article-title":"m6A epitranscriptomic modification of inflammation in cardiovascular disease","volume":"134","author":"Zhang","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202202_28096","article-title":"The potential roles of RNA N6-methyladenosine in atherosclerosis","volume":"26","author":"Chen","year":"2022","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-025-07839-w","article-title":"Peli1, regulated by m6A modification, suppresses NLRP3 inflammasome activation in atherosclerosis by inhibiting YB-1","volume":"8","author":"Liu","year":"2025","journal-title":"Commun Biol"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155939","article-title":"Leonurine improves atherosclerosis by activating foam cell autophagy and metabolic remodeling via METTL3-mediated AKT1S1 mRNA stability modulation","volume":"134","author":"Yu","year":"2024","journal-title":"Phytomedicine"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-024-02536-0","article-title":"METTL14 derived from exosomes of M1 macrophages promotes high glucose-induced apoptosis, inflammation and oxidative stress in glomerular endothelial cells by mediating PAQR3 m6A modification","volume":"28","author":"Li","year":"2024","journal-title":"Clin Exp Nephrol"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.06.012","article-title":"Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease - novel insights into cellular communication circuits","volume":"77","author":"Peiseler","year":"2022","journal-title":"J Hepatol"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2021.1887730","article-title":"Hepatocyte and immune cell crosstalk in non-alcoholic fatty liver disease","volume":"15","author":"Carranza-Trejo","year":"2021","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2023.0284","article-title":"Inflammation resolution in the cardiovascular system: Arterial hypertension, atherosclerosis, and ischemic heart disease","volume":"40","author":"Gonzalez","year":"2024","journal-title":"Antioxidants Redox Signaling"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13278","article-title":"Specialized pro-resolving mediators enhance the clearance of dead cells","volume":"319","author":"Fredman","year":"2023","journal-title":"Immunol Rev"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.10.012","article-title":"The immunology of sepsis","volume":"54","author":"van der Poll","year":"2021","journal-title":"Immunity"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104363","article-title":"Immunopathophysiology of human sepsis","volume":"86","author":"Wiersinga","year":"2022","journal-title":"EBioMedicine"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxab380","article-title":"The pathophysiology of sepsis-2021 update: Part 1, immunology and coagulopathy leading to endothelial injury","volume":"79","author":"Jacobi","year":"2022","journal-title":"Am J Health Syst Pharm"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00679-0","article-title":"The signal pathways and treatment of cytokine storm in COVID-19","volume":"6","author":"Yang","year":"2021","journal-title":"Signal Transduction Targeted Ther"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1681764","article-title":"The endothelial-immunothrombotic storm in viral sepsis: Lessons from COVID-19","volume":"16","author":"Zhou","year":"2025","journal-title":"Front Immunol"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.2147\/ITT.S569962","article-title":"Neutrophil extracellular traps in sepsis and sepsis-related organ dysfunction","volume":"14","author":"Yan","year":"2025","journal-title":"ImmunoTargets Ther"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115719","article-title":"N6-methyladenosine modification: Regulatory mechanisms and therapeutic potential in sepsis","volume":"168","author":"Wang","year":"2023","journal-title":"Biomedicine Pharmacotherapy"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2020.11.008","article-title":"N6-methyladenosine regulates host responses to viral infection","volume":"46","author":"McFadden","year":"2021","journal-title":"Trends Biochem Sci"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13020","article-title":"How RNA modifications regulate the antiviral response","volume":"304","author":"Thompson","year":"2021","journal-title":"Immunol Rev"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110373","article-title":"TBK1-METTL3 axis facilitates antiviral immunity","volume":"38","author":"Chen","year":"2022","journal-title":"Cell Rep"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108798","article-title":"Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine","volume":"34","author":"McFadden","year":"2021","journal-title":"Cell Rep"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2409132121","article-title":"Lactylation of RNA m6A demethylase ALKBH5 promotes innate immune response to DNA herpesviruses and mpox virus","volume":"121","author":"Li","year":"2024","journal-title":"Proc Natl Acad Sci"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.3390\/v16040601","article-title":"m6A methylation in regulation of antiviral innate immunity","volume":"16","author":"Karandashov","year":"2024","journal-title":"Viruses"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010142","article-title":"Viral RNA N6-methyladenosine modification modulates both innate and adaptive immune responses of human respiratory syncytial virus","volume":"17","author":"Xue","year":"2021","journal-title":"PloS Pathog"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.03943-22","article-title":"Epitranscriptomic N6-methyladenosine profile of SARS-CoV-2-infected human lung epithelial cells","volume":"11","author":"Phillips","year":"2023","journal-title":"Microbiol Spectr"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.73628","article-title":"m6A modifications regulate intestinal immunity and rotavirus infection","volume":"11","author":"Wang","year":"2022","journal-title":"eLife"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(24)00390-X","article-title":"The intestinal barrier: A pivotal role in health, inflammation, and cancer","volume":"10","author":"Neurath","year":"2025","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.718356","article-title":"Inflammatory and microbiota-related regulation of the intestinal epithelial barrier","volume":"8","author":"Barbara","year":"2021","journal-title":"Front Nutr"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147618","article-title":"Innate lymphoid cells in intestinal homeostasis and inflammatory bowel disease","volume":"22","author":"Saez","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2024.2449079","article-title":"Interactions between epithelial mesenchymal plasticity, barrier dysfunction and innate immune pathways shape the genesis of allergic airway disease","volume":"19","author":"Brasier","year":"2025","journal-title":"Expert Rev Respir Med"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2021.787128","article-title":"Airway basal cells, protectors of epithelial walls in health and respiratory diseases","volume":"2","author":"Ruysseveldt","year":"2021","journal-title":"Front Allergy"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1668173","article-title":"The AhR\/IL-22 axis in chronic gut inflammation: Unraveling mechanisms and therapeutic prospects","volume":"16","author":"Kang","year":"2025","journal-title":"Front Immunol"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-024-05514-7","article-title":"Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease","volume":"81","author":"Zhu","year":"2024","journal-title":"Cell Mol Life Sci"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-024-2799-6","article-title":"Downregulation of METTL3 enhances TRADD-mediated apoptosis in inflammatory bowel disease","volume":"68","author":"Gong","year":"2025","journal-title":"Sci China Life Sci"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111968","article-title":"Palmatine inhibits expression fat mass and obesity associated protein (FTO) and exhibits a curative effect in dextran sulfate sodium (DSS)-induced experimental colitis","volume":"132","author":"Ji","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113947","article-title":"YTHDF1-CLOCK axis contributes to pathogenesis of allergic airway inflammation through LLPS","volume":"43","author":"Wang","year":"2024","journal-title":"Cell Rep"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202400545R","article-title":"Targeted inhibition of m6A demethylase FTO by FB23 attenuates allergic inflammation in the airway epithelium","volume":"38","author":"Lian","year":"2024","journal-title":"FASEB J"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljaf087","article-title":"The landscape of N6-methyladenosine RNA methylation in skin diseases","volume":"192","author":"Zhang","year":"2025","journal-title":"Br J Dermatol"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-02222-w","article-title":"Unraveling the landscape of m6A RNA methylation in wound healing and scars","volume":"10","author":"Zhang","year":"2024","journal-title":"Cell Death Discov"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2025.5671","article-title":"Dysregulated programmed cell death of intestinal epithelial cells in ulcerative colitis: Molecular mechanisms and novel therapeutic interventions","volume":"56","author":"Wu","year":"2025","journal-title":"Int J Mol Med"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-332043","article-title":"Patient-derived organoid biobank identifies epigenetic dysregulation of intestinal epithelial MHC-I as a novel mechanism in severe Crohn's disease","volume":"73","author":"Dennison","year":"2024","journal-title":"Gut"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03536-w","article-title":"Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia","volume":"593","author":"Yankova","year":"2021","journal-title":"Nature"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-023-00139-x","article-title":"RNA modification: mechanisms and therapeutic targets","volume":"4","author":"Qiu","year":"2023","journal-title":"Mol BioMed"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105815","article-title":"Recent advances of m6A demethylases inhibitors and their biological functions in human diseases","volume":"23","author":"You","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-024-01286-6","article-title":"Insights into the m6A demethylases FTO and ALKBH5: structural, biological function, and inhibitor development","volume":"14","author":"Gao","year":"2024","journal-title":"Cell Bioscience"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.787","article-title":"RNA modification in normal hematopoiesis and hematologic Malignancies","volume":"5","author":"Chen","year":"2024","journal-title":"MedComm"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1007\/s10142-024-01467-z","article-title":"Regulation of m6A (N6-methyladenosine) methylation modifiers in solid cancers","volume":"24","author":"Singh","year":"2024","journal-title":"Funct Integr Genomics"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.114988","article-title":"Epigenetic orchestration of RNA m6A methylation in wound healing and post-wound events","volume":"21","author":"Zhang","year":"2025","journal-title":"Int J Biol Sci"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202451008","article-title":"Lipid nanoparticle-mediated RNA delivery for immune cell modulation","volume":"54","author":"Kim","year":"2024","journal-title":"Eur J Immunol"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.145854","article-title":"Antibody targeted delivery of lipid nanoparticles for RNA therapeutics to immune cells","volume":"320","author":"Kiaie","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines14050957","article-title":"Functionalized lipid nanoparticles for targeted RNA delivery in immune and inflammatory diseases","volume":"14","author":"Jang","year":"2026","journal-title":"Biomedicines"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03921-x","article-title":"Macrophage membrane-coated nanoparticles in inflammatory diseases: from bioinspired design to translational potential","volume":"24","author":"Hou","year":"2025","journal-title":"J Nanobiotechnol"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2022.100772","article-title":"Therapeutic potential of exosome-based personalized delivery platform in chronic inflammatory diseases","volume":"18","author":"Wang","year":"2023","journal-title":"Asian J Pharm Sci"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2024.115316","article-title":"Nanoparticle-neutrophils interactions for autoimmune regulation","volume":"209","author":"Kupor","year":"2024","journal-title":"Adv Drug Delivery Rev"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.05.018","article-title":"Therapeutic applications of nanoparticles targeting neutrophil and extracellular traps","volume":"358","author":"Rezaei","year":"2023","journal-title":"J Controlled Release"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1746254","article-title":"Immunomodulatory therapy for sepsis: from pathophysiological mechanisms to precision treatment","volume":"15","author":"Xiao","year":"2025","journal-title":"Front Cell Infect Microbiol"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2020.1851199","article-title":"Monitoring immunomodulation in patients with sepsis","volume":"21","author":"Kyriazopoulou","year":"2021","journal-title":"Expert Rev Mol Diagn"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2023.152781","article-title":"Significance of m6A in subtype identification, immunological evolution, and therapeutic sensitivity of RA","volume":"229","author":"Ma","year":"2024","journal-title":"Immunobiology"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2023.152329","article-title":"Predicting best treatment in rheumatoid arthritis","author":"Lewis","year":"2024","journal-title":"Semin Arthritis Rheumatism"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-023-01129-2","article-title":"Synovial tissue insights into heterogeneity of rheumatoid arthritis","volume":"26","author":"Jonsson","year":"2024","journal-title":"Curr Rheumatol Rep"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaf130","article-title":"Spatiotemporal analysis of Crohn's disease reveals PECAM2 signaling at the basis of the inflammation-to-fibrosis transition","volume":"19","author":"Massimino","year":"2025","journal-title":"J Crohn\u2019s Colitis"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1038\/s41435-023-00242-7","article-title":"Uncovering intestinal macrophages through the integration of single-cell and spatial transcriptomics","volume":"25","author":"Garrido-Trigo","year":"2024","journal-title":"Genes Immun"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-023-05379-w","article-title":"Exploration of m6A methylation regulators as epigenetic targets for immunotherapy in advanced sepsis","volume":"24","author":"Qian","year":"2023","journal-title":"BMC Bioinf"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1918662\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:53:13Z","timestamp":1787838793000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1918662\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":221,"alternative-id":["10.3389\/fimmu.2026.1918662"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1918662","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]},"article-number":"1918662"}}