{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:50:39Z","timestamp":1791287439794,"version":"4.1.0"},"reference-count":227,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\u03b3\u03b4 T cells are a unique lymphocyte lineage that bridges innate and adaptive immunity through MHC-unrestricted recognition of phosphoantigens, lipids, and stress-induced proteins. Their tissue-resident subsets, shaped by V\u03b3\/V\u03b4 chain usage, play essential roles in barrier surveillance, tissue homeostasis, and host defense.This review synthesizes recent advances that fundamentally reshape our understanding of \u03b3\u03b4 T cell biology. We highlight two conceptual frameworks: (1) dual recognition modalities of \u03b3\u03b4 TCRs, distinguishing structurally resolved ligand interactions from functionally supported recognition; and (2) a developmental wave model in which TCR signal strength and transcriptional networks program effector fates. Mouse and human studies are presented in dedicated species-specific sections and tables, with explicit attention to species-specific nomenclature and evidence levels.We cover \u03b3\u03b4 T cell development, tissue-resident programs, antigen recognition mechanisms (including butyrophilin-mediated phosphoantigen sensing, antibody-like foreign antigen recognition, and intracellular self-protein recognition), and the dual roles of \u03b3\u03b4 T cells in infection, cancer, and chronic inflammation. Therapeutic applications\u2014adoptive transfer, CAR-engineered cells, and extracellular-vesicle vaccines\u2014are critically appraised against current clinical evidence.Finally, we identify major unanswered questions: the complete \u03b3\u03b4 TCR ligand repertoire, the mechanisms maintaining tissue residency, and the translational gaps between mouse models and human disease. This review provides a structured framework for understanding \u03b3\u03b4 T cells as pivotal connectors of innate and adaptive immunity.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1920627","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:51:20Z","timestamp":1791283880000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["\u03b3\u03b4 T cells: bridging innate and adaptive immunity in development, tissue residency, and disease"],"prefix":"10.3389","volume":"17","author":[{"given":"Jiacheng","family":"Lou","sequence":"first","affiliation":[{"name":"Department of Pediatrics, the Second Hospital of Dalian Medical University","place":["Dalian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, the Second Hospital of Dalian Medical University","place":["Dalian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2713","article-title":"CD1d-lipid antigen recognition by the gammadelta TCR","volume":"14","author":"Uldrich","year":"2013","journal-title":"Nat Immunol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.11.001","article-title":"Crystal structure of Vdelta1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human gammadelta T cells","volume":"39","author":"Luoma","year":"2013","journal-title":"Immunity"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0253-5","article-title":"The gammadeltaTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness","volume":"19","author":"Melandri","year":"2018","journal-title":"Nat Immunol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nature12467","article-title":"Evolutionary implications of a third lymphocyte lineage in lampreys","volume":"501","author":"Hirano","year":"2013","journal-title":"Nature"},{"key":"B5","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.cell.2016.08.030","article-title":"Epithelia use butyrophilin-like molecules to shape organ-specific gammadelta T cell compartments","volume":"167","author":"Di","year":"2016","journal-title":"Cell"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2240","article-title":"Body-barrier surveillance by epidermal gammadelta TCRs","volume":"13","author":"Chodaczek","year":"2012","journal-title":"Nat Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01710-y","article-title":"Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of gammadelta T cells across organs in mice","volume":"25","author":"du","year":"2024","journal-title":"Nat Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.immuni.2012.06.003","article-title":"Development of interleukin-17-producing gammadelta T cells is restricted to a functional embryonic wave","volume":"37","author":"Haas","year":"2012","journal-title":"Immunity"},{"key":"B9","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.immuni.2018.09.010","article-title":"Interleukin-17-producing gammadelta T cells originate from SOX13(+) progenitors that are independent of gammadeltaTCR signaling","volume":"49","author":"Spidale","year":"2018","journal-title":"Immunity"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abf0125","article-title":"A fetal wave of human type 3 effector gammadelta cells with restricted TCR diversity persists into adulthood","volume":"6","author":"Tan","year":"2021","journal-title":"Sci Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"5842","DOI":"10.1038\/s41467-022-33488-2","article-title":"Identification of distinct functional thymic programming of fetal and pediatric human gammadelta thymocytes via single-cell analysis","volume":"13","author":"Sanchez","year":"2022","journal-title":"Nat Commun"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.02.053","article-title":"gammadelta intraepithelial lymphocyte migration limits transepithelial pathogen invasion and systemic disease in mice","volume":"148","author":"Edelblum","year":"2015","journal-title":"Gastroenterology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.immuni.2018.07.011","article-title":"Lung gammadelta T cells mediate protective responses during neonatal influenza infection that are associated with type 2 immunity","volume":"49","author":"Guo","year":"2018","journal-title":"Immunity"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-00847-4","article-title":"gammadelta T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis","volume":"22","author":"Junqueira","year":"2021","journal-title":"Nat Immunol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-376111","article-title":"Control of Plasmodium falciparum erythrocytic cycle: gammadelta T cells target the red blood cell-invasive merozoites","volume":"118","author":"Costa","year":"2011","journal-title":"Blood"},{"key":"B16","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/ni.3686","article-title":"Human gammadelta T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection","volume":"18","author":"Ravens","year":"2017","journal-title":"Nat Immunol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-255166","article-title":"The role of Vdelta2-negative gammadelta T cells during cytomegalovirus reactivation in recipients of allogeneic stem cell transplantation","volume":"116","author":"Knight","year":"2010","journal-title":"Blood"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.06.015","article-title":"gammadelta T cells exhibit multifunctional and protective memory in intestinal tissues","volume":"39","author":"Sheridan","year":"2013","journal-title":"Immunity"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05593-1","article-title":"gammadelta T cells are effectors of immunotherapy in cancers with HLA class I defects","volume":"613","author":"de","year":"2023","journal-title":"Nature"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06482-x","article-title":"CRISPR screens decode cancer cell pathways that trigger gammadelta T cell detection","volume":"621","author":"Mamedov","year":"2023","journal-title":"Nature"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj8695","article-title":"TCR-Vgammadelta usage distinguishes protumor from antitumor intestinal gammadelta T cell subsets","volume":"377","author":"Reis","year":"2022","journal-title":"Science"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1016\/j.cell.2016.07.046","article-title":"gammadelta T cells support pancreatic oncogenesis by restraining alphabeta T cell activation","volume":"166","author":"Daley","year":"2016","journal-title":"Cell"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/nature14282","article-title":"IL-17-producing gammadelta T cells and neutrophils conspire to promote breast cancer metastasis","volume":"522","author":"Coffelt","year":"2015","journal-title":"Nature"},{"key":"B24","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/s41467-021-27936-8","article-title":"Cancer cell-expressed BTNL2 facilitates tumour immune escape via engagement with IL-17A-producing gammadelta T cells","volume":"13","author":"Du","year":"2022","journal-title":"Nat Commun"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.05.026","article-title":"The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal gammadelta T cell function","volume":"37","author":"Witherden","year":"2012","journal-title":"Immunity"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3181","article-title":"Fgf9 from dermal gammadelta T cells induces hair follicle neogenesis after wounding","volume":"19","author":"Gay","year":"2013","journal-title":"Nat Med"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10928","article-title":"IL-17-producing gammadelta T cells enhance bone regeneration","volume":"7","author":"Ono","year":"2016","journal-title":"Nat Commun"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0094-2","article-title":"gammadelta T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis","volume":"19","author":"Kohlgruber","year":"2018","journal-title":"Nat Immunol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.immuni.2011.08.001","article-title":"Pivotal role of dermal IL-17-producing gammadelta T cells in skin inflammation","volume":"35","author":"Cai","year":"2011","journal-title":"Immunity"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.08.013","article-title":"gammadelta T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism","volume":"33","author":"Petermann","year":"2010","journal-title":"Immunity"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1126\/science.adh0301","article-title":"Conserved gammadelta T cell selection by BTNL proteins limits progression of human inflammatory bowel disease","volume":"381","author":"Dart","year":"2023","journal-title":"Science"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adx8474","article-title":"Single-cell profiling reveals diverse gammadelta T cell subsets in ulcerative colitis","volume":"11","author":"Mayer","year":"2026","journal-title":"Sci Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"7464","DOI":"10.1038\/ncomms8464","article-title":"IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)Vgamma6(+)gammadelta T cells","volume":"6","author":"Akitsu","year":"2015","journal-title":"Nat Commun"},{"key":"B34","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1053\/j.gastro.2015.09.008","article-title":"Interleukin 17, produced by gammadelta T cells, contributes to hepatic inflammation in a mouse model of biliary atresia and is increased in livers of patients","volume":"150","author":"Klemann","year":"2016","journal-title":"Gastroenterology"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adg9814","article-title":"Payload-delivering engineered gammadelta T cells display enhanced cytotoxicity, persistence, and efficacy in preclinical models of osteosarcoma","volume":"16","author":"Fowler","year":"2024","journal-title":"Sci Transl Med"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abj0835","article-title":"Development of ICT01, a first-in-class, anti-BTN3A antibody for activating Vgamma9Vdelta2 T cell-mediated antitumor immune response","volume":"13","author":"De","year":"2021","journal-title":"Sci Transl Med"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0515-7","article-title":"Allogeneic Vgamma9Vdelta2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer","volume":"18","author":"Xu","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay5516","article-title":"Butyrophilin 2A1 is essential for phosphoantigen reactivity by gammadelta T cells","volume":"367","author":"Rigau","year":"2020","journal-title":"Science"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/j.immuni.2019.02.016","article-title":"A structural change in butyrophilin upon phosphoantigen binding underlies phosphoantigen-mediated Vgamma9Vdelta2 T cell activation","volume":"50","author":"Yang","year":"2019","journal-title":"Immunity"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1016\/j.immuni.2025.04.012","article-title":"Phosphoantigen-induced inside-out stabilization of butyrophilin receptor complexes drives dimerization-dependent gammadelta TCR activation","volume":"58","author":"Zhu","year":"2025","journal-title":"Immunity"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1016\/j.immuni.2025.05.011","article-title":"Structures of butyrophilin multimers reveal a plier-like mechanism for Vgamma9Vdelta2 T cell receptor activation","volume":"58","author":"Zhang","year":"2025","journal-title":"Immunity"},{"key":"B42","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/ni.2782","article-title":"Two waves of distinct hematopoietic progenitor cells colonize the fetal thymus","volume":"15","author":"Ramond","year":"2014","journal-title":"Nat Immunol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"6477","DOI":"10.1038\/ncomms7477","article-title":"A clonotypic Vgamma4Jgamma1\/Vdelta5Ddelta2Jdelta1 innate gammadelta T-cell population restricted to the CCR6(+)CD27(-) subset","volume":"6","author":"Kashani","year":"2015","journal-title":"Nat Commun"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1126\/science.1216557","article-title":"Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis","volume":"335","author":"Yuan","year":"2012","journal-title":"Science"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-23-1452","article-title":"Biologic and clinical analysis of childhood gamma delta T-ALL identifies LMO2\/STAG2 rearrangements as extremely high risk","volume":"14","author":"Kimura","year":"2024","journal-title":"Cancer Discov"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-01855-4","article-title":"Perinatal thymic-derived CD8alphabeta-expressing gammadelta T cells are innate IFN-gamma producers that expand in IL-7R-STAT5B-driven neoplasms","volume":"25","author":"Sumaria","year":"2024","journal-title":"Nat Immunol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"4248","DOI":"10.1038\/s41467-024-48652-z","article-title":"Invariant gammadeltaTCR natural killer-like effector T cells in the naked mole-rat","volume":"15","author":"Sanchez","year":"2024","journal-title":"Nat Commun"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13850","article-title":"Innate and adaptive immune traits are differentially affected by genetic and environmental factors","volume":"8","author":"Mangino","year":"2017","journal-title":"Nat Commun"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adn3954","article-title":"Human gammadelta T cells in diverse tissues exhibit site-specific maturation dynamics across the life span","volume":"9","author":"Gray","year":"2024","journal-title":"Sci Immunol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2247","article-title":"Intrathymic programming of effector fates in three molecularly distinct gammadelta T cell subtypes","volume":"13","author":"Narayan","year":"2012","journal-title":"Nat Immunol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.01.016","article-title":"Rank signaling links the development of invariant gammadelta T cell progenitors and Aire(+) medullary epithelium","volume":"36","author":"Roberts","year":"2012","journal-title":"Immunity"},{"key":"B52","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.immuni.2016.10.023","article-title":"Aire inhibits the generation of a perinatal population of interleukin-17A-producing gammadelta T cells to promote immunologic tolerance","volume":"45","author":"Fujikado","year":"2016","journal-title":"Immunity"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.10.021","article-title":"Noncanonical mode of ERK action controls alternative alphabeta and gammadelta T cell lineage fates","volume":"41","author":"Lee","year":"2014","journal-title":"Immunity"},{"key":"B54","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1038\/s41467-017-02225-5","article-title":"HEB is required for the specification of fetal IL-17-producing gammadelta T cells","volume":"8","author":"In","year":"2017","journal-title":"Nat Commun"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2490","article-title":"Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells","volume":"14","author":"Cohen","year":"2013","journal-title":"Nat Immunol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.01.010","article-title":"A network of high-mobility group box transcription factors programs innate interleukin-17 production","volume":"38","author":"Malhotra","year":"2013","journal-title":"Immunity"},{"key":"B57","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1038\/s41467-017-00882-0","article-title":"A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development","volume":"8","author":"Mao","year":"2017","journal-title":"Nat Commun"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aas9818","article-title":"Metabolic signaling directs the reciprocal lineage decisions of alphabeta and gammadelta T cells","volume":"3","author":"Yang","year":"2018","journal-title":"Sci Immunol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3424","article-title":"TCR signal strength controls thymic differentiation of discrete proinflammatory gammadelta T cell subsets","volume":"17","author":"Munoz-Ruiz","year":"2016","journal-title":"Nat Immunol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"7404","DOI":"10.1038\/s41467-022-35014-w","article-title":"Dietary glucosamine overcomes the defects in alphabeta-T cell ontogeny caused by the loss of de novo hexosamine biosynthesis","volume":"13","author":"Werlen","year":"2022","journal-title":"Nat Commun"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adr7167","article-title":"TCRgamma constant usage tunes human gammadelta T cell antigen sensitivity, thymic programming, and peripheral function","volume":"11","author":"Viswanathan","year":"2026","journal-title":"Sci Immunol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.immuni.2011.04.018","article-title":"Skint-1 identifies a common molecular mechanism for the development of interferon-gamma-secreting versus interleukin-17-secreting gammadelta T cells","volume":"35","author":"Turchinovich","year":"2011","journal-title":"Immunity"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-022-00912-y","article-title":"TOX deficiency facilitates the differentiation of IL-17A-producing gammadelta T cells to drive autoimmune hepatitis","volume":"19","author":"He","year":"2022","journal-title":"Cell Mol Immunol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-03-274506","article-title":"Mutation of inhibitory helix-loop-helix protein Id3 causes gammadelta T-cell lymphoma in mice","volume":"116","author":"Li","year":"2010","journal-title":"Blood"},{"key":"B65","doi-asserted-by":"publisher","first-page":"5078","DOI":"10.1038\/s41467-024-49496-3","article-title":"E proteins control the development of NKgammadeltaT cells through their invariant T cell receptor","volume":"15","author":"Mihai","year":"2024","journal-title":"Nat Commun"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1038\/s41467-017-01963-w","article-title":"Three distinct developmental pathways for adaptive and two IFN-gamma-producing gammadelta T subsets in adult thymus","volume":"8","author":"Buus","year":"2017","journal-title":"Nat Commun"},{"key":"B67","doi-asserted-by":"publisher","first-page":"4367","DOI":"10.1038\/s41467-020-18155-8","article-title":"Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells","volume":"11","author":"Lee","year":"2020","journal-title":"Nat Commun"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2585","article-title":"Deficiency in IL-17-committed Vgamma4(+) gammadelta T cells in a spontaneous Sox13-mutant CD45.1(+) congenic mouse substrain provides protection from dermatitis","volume":"14","author":"Gray","year":"2013","journal-title":"Nat Immunol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/s41590-018-0274-0","article-title":"The transcription factor c-Maf is essential for the commitment of IL-17-producing gammadelta T cells","volume":"20","author":"Zuberbuehler","year":"2019","journal-title":"Nat Immunol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-334995","article-title":"Notch-Hes1 pathway is required for the development of IL-17-producing gammadelta T cells","volume":"118","author":"Shibata","year":"2011","journal-title":"Blood"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.02.019","article-title":"RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in gammadelta T cells","volume":"34","author":"Powolny-Budnicka","year":"2011","journal-title":"Immunity"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.10.017","article-title":"The inhibitory receptor BTLA controls gammadelta T cell homeostasis and inflammatory responses","volume":"39","author":"Bekiaris","year":"2013","journal-title":"Immunity"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2702","article-title":"Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory gammadelta T cell subsets","volume":"14","author":"Schmolka","year":"2013","journal-title":"Nat Immunol"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aao1392","article-title":"MicroRNA-146a controls functional plasticity in gammadelta T cells by targeting NOD1","volume":"3","author":"Schmolka","year":"2018","journal-title":"Sci Immunol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-00848-3","article-title":"Distinct metabolic programs established in the thymus control effector functions of gammadelta T cell subsets in tumor microenvironments","volume":"22","author":"Lopes","year":"2021","journal-title":"Nat Immunol"},{"key":"B76","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.immuni.2023.01.025","article-title":"Skin gammadelta T cell inflammatory responses are hardwired in the thymus by oxysterol sensing via GPR183 and calibrated by dietary cholesterol","volume":"56","author":"Frascoli","year":"2023","journal-title":"Immunity"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3504","article-title":"CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis","volume":"17","author":"Cibrian","year":"2016","journal-title":"Nat Immunol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"3151","DOI":"10.1038\/s41467-018-05487-9","article-title":"gammadelta T cells control humoral immune response by inducing T follicular helper cell differentiation","volume":"9","author":"Rezende","year":"2018","journal-title":"Nat Commun"},{"key":"B79","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/s41590-024-02073-8","article-title":"Signature cytokine-associated transcriptome analysis of effector gammadelta T cells identifies subset-specific regulators of peripheral activation","volume":"26","author":"Inacio","year":"2025","journal-title":"Nat Immunol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abo4365","article-title":"A three-stage developmental pathway for human Vgamma9Vdelta2 T cells within the postnatal thymus","volume":"8","author":"Perriman","year":"2023","journal-title":"Sci Immunol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"9841","DOI":"10.1038\/s41467-024-51673-3","article-title":"Early-life thymectomy leads to an increase of granzyme-producing gammadelta T cells in children with congenital heart disease","volume":"15","author":"Cramer","year":"2024","journal-title":"Nat Commun"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2665","article-title":"Butyrophilin 3A1 binds phosphorylated antigens and stimulates human gammadelta T cells","volume":"14","author":"Vavassori","year":"2013","journal-title":"Nat Immunol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-430470","article-title":"Key implication of CD277\/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human gammadelta T-cell subset","volume":"120","author":"Harly","year":"2012","journal-title":"Blood"},{"key":"B84","doi-asserted-by":"publisher","first-page":"7617","DOI":"10.1038\/s41467-023-41938-8","article-title":"A distinct topology of BTN3A IgV and B30.2 domains controlled by juxtamembrane regions favors optimal human gammadelta T cell phosphoantigen sensing","volume":"14","author":"Karunakaran","year":"2023","journal-title":"Nat Commun"},{"key":"B85","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.immuni.2019.09.006","article-title":"Butyrophilin-like 3 directly binds a human Vgamma4(+) T cell receptor using a modality distinct from clonally-restricted antigen","volume":"51","author":"Willcox","year":"2019","journal-title":"Immunity"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.10.013","article-title":"Docking complete: A step further toward the Holy Grail of gammadelta T cell biology","volume":"51","author":"Cai","year":"2019","journal-title":"Immunity"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07920-0","article-title":"Structure of a fully assembled gammadelta T cell antigen receptor","volume":"634","author":"Gully","year":"2024","journal-title":"Nature"},{"key":"B88","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/s41467-024-55467-5","article-title":"Structural characterization of two gammadelta TCR\/CD3 complexes","volume":"16","author":"Hoque","year":"2025","journal-title":"Nat Commun"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07439-4","article-title":"Structures of human gammadelta T cell receptor-CD3 complex","volume":"630","author":"Xin","year":"2024","journal-title":"Nature"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay2767","article-title":"BTN3A1 governs antitumor responses by coordinating alphabeta and gammadelta T cells","volume":"369","author":"Payne","year":"2020","journal-title":"Science"},{"key":"B91","doi-asserted-by":"publisher","first-page":"3769","DOI":"10.1038\/s41467-020-17557-y","article-title":"Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial gammadelta T cell compartments","volume":"11","author":"Jandke","year":"2020","journal-title":"Nat Commun"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-01124-8","article-title":"Normality sensing licenses local T cells for innate-like tissue surveillance","volume":"23","author":"McKenzie","year":"2022","journal-title":"Nat Immunol"},{"key":"B93","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1038\/s41467-025-67653-0","article-title":"gammadelta T cell receptor recognition of CD1d in a lipid-independent manner","volume":"17","author":"Rice","year":"2025","journal-title":"Nat Commun"},{"key":"B94","doi-asserted-by":"publisher","first-page":"3872","DOI":"10.1038\/s41467-022-31443-9","article-title":"Atypical sideways recognition of CD1a by autoreactive gammadelta T cell receptors","volume":"13","author":"Wegrecki","year":"2022","journal-title":"Nat Commun"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav3900","article-title":"A class of gammadelta T cell receptors recognize the underside of the antigen-presenting molecule MR1","volume":"366","author":"Le","year":"2019","journal-title":"Science"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2394","article-title":"Cytomegalovirus and tumor stress surveillance by binding of a human gammadelta T cell antigen receptor to endothelial protein C receptor","volume":"13","author":"Willcox","year":"2012","journal-title":"Nat Immunol"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1126\/science.1106885","article-title":"Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22","volume":"308","author":"Adams","year":"2005","journal-title":"Science"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-025-01258-x","article-title":"gammadelta T-cell autoresponses to ectopic membrane proteins: A new type of pattern recognition","volume":"22","author":"You","year":"2025","journal-title":"Cell Mol Immunol"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aba9010","article-title":"Human gammadelta T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA2","volume":"6","author":"Harly","year":"2021","journal-title":"Sci Immunol"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-00860-7","article-title":"Tumor hypoxia represses gammadelta T cell-mediated antitumor immunity against brain tumors","volume":"22","author":"Park","year":"2021","journal-title":"Nat Immunol"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.add1599","article-title":"NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis","volume":"8","author":"Marinovic","year":"2023","journal-title":"Sci Immunol"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-11-464685","article-title":"The co-receptor BTLA negatively regulates human Vgamma9Vdelta2 T-cell proliferation: a potential way of immune escape for lymphoma cells","volume":"122","author":"Gertner-Dardenne","year":"2013","journal-title":"Blood"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-506584","article-title":"Inhibiting inhibitory pathways in human gammadelta T cells","volume":"122","author":"Lopez","year":"2013","journal-title":"Blood"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-363655","article-title":"Antibody-dependent anti-cytomegalovirus activity of human gammadelta T cells expressing CD16 (FcgammaRIIIa)","volume":"119","author":"Couzi","year":"2012","journal-title":"Blood"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-390153","article-title":"Engagement of NKp30 on Vdelta1 T cells induces the production of CCL3, CCL4, and CCL5 and suppresses HIV-1 replication","volume":"119","author":"Hudspeth","year":"2012","journal-title":"Blood"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.ade5343","article-title":"Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells","volume":"8","author":"Palmer","year":"2023","journal-title":"Sci Immunol"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.06.011","article-title":"gammadelta T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response","volume":"37","author":"Zeng","year":"2012","journal-title":"Immunity"},{"key":"B108","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1016\/j.str.2025.07.006","article-title":"Antibody-like recognition of a gammadelta T cell receptor toward a foreign antigen","volume":"33","author":"Rashleigh","year":"2025","journal-title":"Structure"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00720-w","article-title":"Self-activation of Vgamma9Vdelta2 T cells by exogenous phosphoantigens involves TCR and butyrophilins","volume":"18","author":"Laplagne","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"B110","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/s41467-019-08604-4","article-title":"Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions","volume":"10","author":"Gutierrez-Arcelus","year":"2019","journal-title":"Nat Commun"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2315592121","article-title":"gammadelta T cell antigen receptor polyspecificity enables T cell responses to a broad range of immune challenges","volume":"121","author":"Guo","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"B112","doi-asserted-by":"publisher","first-page":"6737","DOI":"10.1038\/s41467-024-51209-9","article-title":"Gut-derived memory gammadelta T17 cells exacerbate sepsis-induced acute lung injury in mice","volume":"15","author":"Xie","year":"2024","journal-title":"Nat Commun"},{"key":"B113","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1038\/s41467-018-03773-0","article-title":"Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20\/CCR-6-mediated lymphocyte recruitment","volume":"9","author":"Wunderlich","year":"2018","journal-title":"Nat Commun"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15632","article-title":"IL-17-producing gammadelta T cells switch migratory patterns between resting and activated states","volume":"8","author":"McKenzie","year":"2017","journal-title":"Nat Commun"},{"key":"B115","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.immuni.2017.06.014","article-title":"An ocular commensal protects against corneal infection by driving an interleukin-17 response from mucosal gammadelta T cells","volume":"47","author":"St","year":"2017","journal-title":"Immunity"},{"key":"B116","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/s41467-025-67120-w","article-title":"Comprehensive profiling of smoke-induced T cells in mice implicates clonal gammadeltaT17 cells as a hallmark of COPD","volume":"17","author":"Mei","year":"2025","journal-title":"Nat Commun"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax9364","article-title":"An innate-like Vdelta1(+) gammadelta T cell compartment in the human breast is associated with remission in triple-negative breast cancer","volume":"11","author":"Wu","year":"2019","journal-title":"Sci Transl Med"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024025345","article-title":"Iron overload in HFE-related hemochromatosis severely impairs Vdelta2+ gammadelta T-cell homeostasis","volume":"146","author":"Erdogdu","year":"2025","journal-title":"Blood"},{"key":"B119","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1038\/s41467-020-15572-7","article-title":"Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas","volume":"11","author":"Daniels","year":"2020","journal-title":"Nat Commun"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.08.016","article-title":"Nociceptive sensory fibers drive interleukin-23 production from CD301b+ dermal dendritic cells and drive protective cutaneous immunity","volume":"43","author":"Kashem","year":"2015","journal-title":"Immunity"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-025-01276-z","article-title":"Metabolic reprogramming of interleukin-17-producing gammadelta T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions","volume":"7","author":"Kao","year":"2025","journal-title":"Nat Metab"},{"key":"B122","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.chom.2017.10.006","article-title":"Staphylococcus aureus epicutaneous exposure drives skin inflammation via IL-36-mediated T cell responses","volume":"22","author":"Liu","year":"2017","journal-title":"Cell Host Microbe"},{"key":"B123","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.chom.2017.10.008","article-title":"Staphylococcus aureus virulent PSMalpha peptides induce keratinocyte alarmin release to orchestrate IL-17-dependent skin inflammation","volume":"22","author":"Nakagawa","year":"2017","journal-title":"Cell Host Microbe"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-23-0798","article-title":"Preexisting skin-resident CD8 and gammadelta T-cell circuits mediate immune response in Merkel cell carcinoma and predict immunotherapy efficacy","volume":"14","author":"Reinstein","year":"2024","journal-title":"Cancer Discov"},{"key":"B125","doi-asserted-by":"publisher","first-page":"7265","DOI":"10.1038\/s41467-024-50970-1","article-title":"High-sensitive sensory neurons exacerbate rosacea-like dermatitis in mice by activating gammadelta T cells directly","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat Commun"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aba5683","article-title":"Activation of TRPA1 nociceptor promotes systemic adult mammalian skin regeneration","volume":"5","author":"Wei","year":"2020","journal-title":"Sci Immunol"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07869-0","article-title":"A gammadelta T cell-IL-3 axis controls allergic responses through sensory neurons","volume":"634","author":"Flayer","year":"2024","journal-title":"Nature"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0161-8","article-title":"Epithelial damage and tissue gammadelta T cells promote a unique tumor-protective IgE response","volume":"19","author":"Crawford","year":"2018","journal-title":"Nat Immunol"},{"key":"B129","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s43587-023-00431-z","article-title":"Targeting lymphoid-derived IL-17 signaling to delay skin aging","volume":"3","author":"Sola","year":"2023","journal-title":"Nat Aging"},{"key":"B130","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.immuni.2026.01.006","article-title":"Effector differentiation by stem-like intraepithelial gammadelta T cells is required for host defense against infection","volume":"59","author":"Xie","year":"2026","journal-title":"Immunity"},{"key":"B131","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.cell.2017.08.046","article-title":"Intestinal epithelial and intraepithelial T cell crosstalk mediates a dynamic response to infection","volume":"171","author":"Hoytema van","year":"2017","journal-title":"Cell"},{"key":"B132","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1053\/j.gastro.2021.11.028","article-title":"gammadelta intraepithelial lymphocytes facilitate pathological epithelial cell shedding via CD103-mediated granzyme release","volume":"162","author":"Hu","year":"2022","journal-title":"Gastroenterology"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.09.003","article-title":"Interleukin-23-independent IL-17 production regulates intestinal epithelial permeability","volume":"43","author":"Lee","year":"2015","journal-title":"Immunity"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adk7429","article-title":"Dysregulation of gammadelta intraepithelial lymphocytes precedes Crohn\u2019s disease-like ileitis","volume":"10","author":"Xu","year":"2025","journal-title":"Sci Immunol"},{"key":"B135","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.cell.2018.12.039","article-title":"Chronic inflammation permanently reshapes tissue-resident immunity in celiac disease","volume":"176","author":"Mayassi","year":"2019","journal-title":"Cell"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adf4312","article-title":"Gluten induces rapid reprogramming of natural memory alphabeta and gammadelta intraepithelial T cells to induce cytotoxicity in celiac disease","volume":"8","author":"Kornberg","year":"2023","journal-title":"Sci Immunol"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba8310","article-title":"gammadelta T cells regulate the intestinal response to nutrient sensing","volume":"371","author":"Sullivan","year":"2021","journal-title":"Science"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01447-8","article-title":"Dectin-1 signaling on colonic gammadelta T cells promotes psychosocial stress responses","volume":"24","author":"Zhu","year":"2023","journal-title":"Nat Immunol"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.02.019","article-title":"Alterations in intestinal microbiota lead to production of interleukin 17 by intrahepatic gammadelta T-cell receptor-positive cells and pathogenesis of cholestatic liver disease","volume":"154","author":"Tedesco","year":"2018","journal-title":"Gastroenterology"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4068","article-title":"Commensal microbiota affects ischemic stroke outcome by regulating intestinal gammadelta T cells","volume":"22","author":"Benakis","year":"2016","journal-title":"Nat Med"},{"key":"B141","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1038\/s41467-021-22242-9","article-title":"Host-derived lipids orchestrate pulmonary gammadelta T cell response to provide early protection against influenza virus infection","volume":"12","author":"Wang","year":"2021","journal-title":"Nat Commun"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aav2026","article-title":"Ketogenic diet activates protective gammadelta T cell responses against influenza virus infection","volume":"4","author":"Goldberg","year":"2019","journal-title":"Sci Immunol"},{"key":"B143","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.cell.2018.12.040","article-title":"Commensal microbiota promote lung cancer development via gammadelta T cells","volume":"176","author":"Jin","year":"2019","journal-title":"Cell"},{"key":"B144","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/s41423-025-01301-x","article-title":"gammadelta(+) T-cell-derived IL-17A stimulates airway epithelial\/stromal cells to secrete G-CSF, promoting lung-specific pathogenic Siglec-F(+) neutrophil development in PPE-induced emphysema","volume":"22","author":"Hong","year":"2025","journal-title":"Cell Mol Immunol"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.02.003","article-title":"Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and gammadelta T cells","volume":"40","author":"Van","year":"2014","journal-title":"Immunity"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0785-3","article-title":"Interleukin-33 activates regulatory T cells to suppress innate gammadelta T cell responses in the lung","volume":"21","author":"Faustino","year":"2020","journal-title":"Nat Immunol"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2028-z","article-title":"gammadelta T cells and adipocyte IL-17RC control fat innervation and thermogenesis","volume":"578","author":"Hu","year":"2020","journal-title":"Nature"},{"key":"B148","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s42255-019-0160-6","article-title":"Ketogenesis activates metabolically protective gammadelta T cells in visceral adipose tissue","volume":"2","author":"Goldberg","year":"2020","journal-title":"Nat Metab"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08131-3","article-title":"Rhythmic IL-17 production by gammadelta T cells maintains adipose de novo lipogenesis","volume":"636","author":"Douglas","year":"2024","journal-title":"Nature"},{"key":"B150","doi-asserted-by":"publisher","first-page":"5334","DOI":"10.1038\/s41467-026-71540-7","article-title":"gammadelta T cell-stromal networks modulate matrix composition and vascularity in foreign body response","volume":"17","author":"Ruta","year":"2026","journal-title":"Nat Commun"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.007","article-title":"Human liver infiltrating gammadelta T cells are composed of clonally expanded circulating and tissue-resident populations","volume":"69","author":"Hunter","year":"2018","journal-title":"J Hepatol"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00656-1","article-title":"Single-cell analysis reveals the origins and intrahepatic development of liver-resident IFN-gamma-producing gammadelta T cells","volume":"18","author":"Hu","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0776-4","article-title":"Meningeal gammadelta T cells regulate anxiety-like behavior via IL-17a signaling in neurons","volume":"21","author":"Alves de","year":"2020","journal-title":"Nat Immunol"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aay5199","article-title":"Meningeal gammadelta T cell-derived IL-17 controls synaptic plasticity and short-term memory","volume":"4","author":"Ribeiro","year":"2019","journal-title":"Sci Immunol"},{"key":"B155","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1016\/j.chom.2021.08.004","article-title":"Aberrant gut-microbiota-immune-brain axis development in premature neonates with brain damage","volume":"29","author":"Seki","year":"2021","journal-title":"Cell Host Microbe"},{"key":"B156","doi-asserted-by":"publisher","first-page":"251ra117","DOI":"10.1126\/scitranslmed.3009793","article-title":"Loss and dysfunction of Vdelta2(+) gammadelta T cells are associated with clinical tolerance to malaria","volume":"6","author":"Jagannathan","year":"2014","journal-title":"Sci Transl Med"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3023","article-title":"Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage","volume":"15","author":"Sutherland","year":"2014","journal-title":"Nat Immunol"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.07.021","article-title":"A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread","volume":"150","author":"Kastenmuller","year":"2012","journal-title":"Cell"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aau6759","article-title":"Human IFN-gamma immunity to mycobacteria is governed by both IL-12 and IL-23","volume":"3","author":"Martinez-Barricarte","year":"2018","journal-title":"Sci Immunol"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2012.70","article-title":"Human Vgamma9Vdelta2-T cells efficiently kill influenza virus-infected lung alveolar epithelial cells","volume":"10","author":"Li","year":"2013","journal-title":"Cell Mol Immunol"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa4282","article-title":"Immunodeficiencies. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations","volume":"349","author":"Okada","year":"2015","journal-title":"Science"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.ade3525","article-title":"NK-like CD8(+) gammadelta T cells are expanded in persistent Mycobacterium tuberculosis infection","volume":"8","author":"Roy","year":"2023","journal-title":"Sci Immunol"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-02-625269","article-title":"Haplo graft engineering: sculpting to a T","volume":"125","author":"Fuchs","year":"2015","journal-title":"Blood"},{"key":"B164","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1038\/s41467-026-69538-2","article-title":"Adoptive gammadelta T cell therapy controls cytomegalovirus infection in preclinical transplantation models","volume":"17","author":"Marseres","year":"2026","journal-title":"Nat Commun"},{"key":"B165","doi-asserted-by":"publisher","first-page":"4286","DOI":"10.1038\/s41467-024-48527-3","article-title":"Cytomegalovirus drives Vdelta1(+) gammadelta T cell expansion and clonality in common variable immunodeficiency","volume":"15","author":"Chan","year":"2024","journal-title":"Nat Commun"},{"key":"B166","doi-asserted-by":"publisher","first-page":"5114","DOI":"10.1016\/j.cell.2023.09.024","article-title":"Human MCTS1-dependent translation of JAK2 is essential for IFN-gamma immunity to mycobacteria","volume":"186","author":"Bohlen","year":"2023","journal-title":"Cell"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2013.26","article-title":"The interaction of influenza H5N1 viral hemagglutinin with sialic acid receptors leads to the activation of human gammadelta T cells","volume":"10","author":"Lu","year":"2013","journal-title":"Cell Mol Immunol"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0174-2","article-title":"CD137 costimulation enhances the antiviral activity of Vgamma9Vdelta2-T cells against influenza virus","volume":"5","author":"Pei","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-356535","article-title":"HIV envelope-mediated, CCR5\/alpha4beta7-dependent killing of CD4-negative gammadelta T cells which are lost during progression to AIDS","volume":"118","author":"Li","year":"2011","journal-title":"Blood"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2014.77","article-title":"Distortion of memory Vdelta2 gammadelta T cells contributes to immune dysfunction in chronic HIV infection","volume":"12","author":"Li","year":"2015","journal-title":"Cell Mol Immunol"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-017-0006-5","article-title":"Gut-homing Delta42PD1(+)Vdelta2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection","volume":"2","author":"Cheung","year":"2017","journal-title":"Nat Microbiol"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-283549","article-title":"Mechanisms underlying gammadelta T-cell subset perturbations in SIV-infected Asian rhesus macaques","volume":"116","author":"Harris","year":"2010","journal-title":"Blood"},{"key":"B173","doi-asserted-by":"publisher","first-page":"5243","DOI":"10.1038\/s41467-020-19080-6","article-title":"Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19","volume":"11","author":"Carissimo","year":"2020","journal-title":"Nat Commun"},{"key":"B174","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.immuni.2018.01.009","article-title":"A macrophage colony-stimulating-factor-producing gammadelta T cell subset prevents malarial parasitemic recurrence","volume":"48","author":"Mamedov","year":"2018","journal-title":"Immunity"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.02.003","article-title":"A new link between gammadelta T cells and myeloid cells in malaria","volume":"48","author":"Lewis","year":"2018","journal-title":"Immunity"},{"key":"B176","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/s41590-025-02397-z","article-title":"Gammadelta T cell-derived IL-4 initiates CD8(+) T cell immunity","volume":"27","author":"Le","year":"2026","journal-title":"Nat Immunol"},{"key":"B177","doi-asserted-by":"publisher","first-page":"6035","DOI":"10.1038\/s41467-023-41634-7","article-title":"Modulation of lytic molecules restrain serial killing in gammadelta T lymphocytes","volume":"14","author":"Sandoz","year":"2023","journal-title":"Nat Commun"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-412726","article-title":"Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke","volume":"120","author":"Gelderblom","year":"2012","journal-title":"Blood"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-331298","article-title":"Differentiation, phenotype, and function of interleukin-17-producing human Vgamma9Vdelta2 T cells","volume":"118","author":"Caccamo","year":"2011","journal-title":"Blood"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14760","article-title":"Clonal selection in the human Vdelta1 T cell repertoire indicates gammadelta TCR-dependent adaptive immune surveillance","volume":"8","author":"Davey","year":"2017","journal-title":"Nat Commun"},{"key":"B181","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41392-025-02295-8","article-title":"Oleic acid restores the impaired antitumor immunity of gammadelta-T cells induced by palmitic acid","volume":"10","author":"Zhang","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202404432","article-title":"Gammadelta T cell-mediated tumor immunity is tightly regulated by STING and TGF-beta signaling pathways","volume":"12","author":"Luo","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"B183","doi-asserted-by":"publisher","first-page":"6949","DOI":"10.1038\/s41467-024-51025-1","article-title":"Dysfunctional tumor-infiltrating Vdelta1 + T lymphocytes in microsatellite-stable colorectal cancer","volume":"15","author":"Stary","year":"2024","journal-title":"Nat Commun"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01448-7","article-title":"Exhausted intratumoral Vdelta2(-) gammadelta T cells in human kidney cancer retain effector function","volume":"24","author":"Rancan","year":"2023","journal-title":"Nat Immunol"},{"key":"B185","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.1038\/s41467-026-69603-w","article-title":"Treg-gammadelta T cell axis determines sexual dimorphism in hepatocarcinogenesis","volume":"17","author":"Liang","year":"2026","journal-title":"Nat Commun"},{"key":"B186","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/s43018-022-00376-z","article-title":"A local human Vdelta1 T cell population is associated with survival in nonsmall-cell lung cancer","volume":"3","author":"Wu","year":"2022","journal-title":"Nat Cancer"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023022992","article-title":"CD155\/PVR determines acute myeloid leukemia targeting by Delta One T cells","volume":"143","author":"Mensurado","year":"2024","journal-title":"Blood"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abb0192","article-title":"Characterization of ascites- and tumor-infiltrating gammadelta T cells reveals distinct repertoires and a beneficial role in ovarian cancer","volume":"13","author":"Foord","year":"2021","journal-title":"Sci Transl Med"},{"key":"B189","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.ccell.2015.07.014","article-title":"IL-36gamma transforms the tumor microenvironment and promotes type 1 lymphocyte-mediated antitumor immune responses","volume":"28","author":"Wang","year":"2015","journal-title":"Cancer Cell"},{"key":"B190","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/s41392-023-01646-7","article-title":"Anti-PD-1 antibody armored gammadelta T cells enhance anti-tumor efficacy in ovarian cancer","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"B191","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1038\/s41467-017-00910-z","article-title":"The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells","volume":"8","author":"Baek","year":"2017","journal-title":"Nat Commun"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.058","article-title":"Probing the diversity of T cell dysfunction in cancer","volume":"166","author":"Sowell","year":"2016","journal-title":"Cell"},{"key":"B193","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/ncomms1585","article-title":"Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response","volume":"2","author":"Antsiferova","year":"2011","journal-title":"Nat Commun"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-417519","article-title":"Dysfunctional Vgamma9Vdelta2 T cells are negative prognosticators and markers of dysregulated mevalonate pathway activity in chronic lymphocytic leukemia cells","volume":"120","author":"Coscia","year":"2012","journal-title":"Blood"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2017.157","article-title":"Profiling the pattern of the human T-cell receptor gammadelta complementary determinant region 3 repertoire in patients with lung carcinoma via high-throughput sequencing analysis","volume":"16","author":"Chen","year":"2019","journal-title":"Cell Mol Immunol"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-023-00690-0","article-title":"PD-1 defines a distinct, functional, tissue-adapted state in Vdelta1(+) T cells with implications for cancer immunotherapy","volume":"5","author":"Davies","year":"2024","journal-title":"Nat Cancer"},{"key":"B197","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/s13045-016-0353-3","article-title":"Oligoclonal expansion of TCR Vdelta T cells may be a potential immune biomarker for clinical outcome of acute myeloid leukemia","volume":"9","author":"Jin","year":"2016","journal-title":"J Hematol Oncol"},{"key":"B198","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1158\/2159-8290.CD-RW2023-012","article-title":"Gammadelta T cells mediate immunotherapy response in HLA class I-deficient cancers","volume":"13","year":"2023","journal-title":"Cancer Discov"},{"key":"B199","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12943-025-02548-8","article-title":"A pan-cancer single cell landscape reveals heterogeneity and functional diversity of double-negative T cells","volume":"25","author":"Hao","year":"2026","journal-title":"Mol Cancer"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2011.50","article-title":"Antigen-presenting effects of effector memory Vgamma9Vdelta2 T cells in rheumatoid arthritis","volume":"9","author":"Hu","year":"2012","journal-title":"Cell Mol Immunol"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07911-6","article-title":"RORgammat inhibition selectively targets IL-17 producing iNKT and gammadelta-T cells enriched in Spondyloarthritis patients","volume":"10","author":"Venken","year":"2019","journal-title":"Nat Commun"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamaneurol.409","article-title":"Enriched CD161high CCR6+ gammadelta T cells in the cerebrospinal fluid of patients with multiple sclerosis","volume":"70","author":"Schirmer","year":"2013","journal-title":"JAMA Neurol"},{"key":"B203","doi-asserted-by":"publisher","first-page":"4286","DOI":"10.1038\/s41467-023-39857-9","article-title":"Vgamma1 and Vgamma4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males","volume":"14","author":"Abou-El-Hassan","year":"2023","journal-title":"Nat Commun"},{"key":"B204","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.immuni.2010.10.014","article-title":"T regulatory cells maintain intestinal homeostasis by suppressing gammadelta T cells","volume":"33","author":"Park","year":"2010","journal-title":"Immunity"},{"key":"B205","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1038\/ni.3488","article-title":"Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR-gammat ubiquitination","volume":"17","author":"Kathania","year":"2016","journal-title":"Nat Immunol"},{"key":"B206","doi-asserted-by":"publisher","first-page":"8726","DOI":"10.1038\/ncomms9726","article-title":"Identification and characterization of latency-associated peptide-expressing gammadelta T cells","volume":"6","author":"Rezende","year":"2015","journal-title":"Nat Commun"},{"key":"B207","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s13045-016-0329-3","article-title":"Interleukin-15 enhances the proliferation, stimulatory phenotype, and antitumor effector functions of human gamma delta T cells","volume":"9","author":"Van","year":"2016","journal-title":"J Hematol Oncol"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-019-0247-8","article-title":"Vitamin C promotes the proliferation and effector functions of human gammadelta T cells","volume":"17","author":"Kouakanou","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"B209","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/cmi.2011.16","article-title":"Anti-gammadelta TCR antibody-expanded gammadelta T cells: a better choice for the adoptive immunotherapy of lymphoid malignancies","volume":"9","author":"Zhou","year":"2012","journal-title":"Cell Mol Immunol"},{"key":"B210","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1182\/blood-2011-02-339135","article-title":"Differentiation of human peripheral blood Vdelta1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells","volume":"118","author":"Correia","year":"2011","journal-title":"Blood"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaf876","article-title":"TCRdb 2.0: an updated T-cell receptor sequence database","volume":"54","author":"Yue","year":"2026","journal-title":"Nucleic Acids Res"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202306364","article-title":"Dynamics of the gammadeltatcr repertoires during the dedifferentiation process and pilot implications for immunotherapy of thyroid cancer","volume":"11","author":"Hao","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-12-73","article-title":"The evolution of malignant and reactive gammadelta + T cell clones in a relapse T-ALL case after allogeneic stem cell transplantation","volume":"12","author":"Chen","year":"2013","journal-title":"Mol Cancer"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2678","article-title":"Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy","volume":"31","author":"Themeli","year":"2013","journal-title":"Nat Biotechnol"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-025-01527-0","article-title":"CCR5-targeted allogeneic gamma-delta CD19 chimeric antigen receptor T cells for HIV-associated B cell-malignancy immunotherapy","volume":"10","author":"Ramirez-Fernandez","year":"2026","journal-title":"Nat BioMed Eng"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202501772","article-title":"Rational design and organoid-based evaluation of a cocktail CAR-gammadelta T cell therapy for heterogeneous glioblastoma","volume":"12","author":"Zhu","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwaf256","article-title":"Chemical engineering of gammadelta T cells with cancer cell-targeting antibodies for enhanced tumor immunotherapy","volume":"12","author":"Chen","year":"2025","journal-title":"Natl Sci Rev"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12360","article-title":"Tumor vaccine based on extracellular vesicles derived from gammadelta-T cells exerts dual antitumor activities","volume":"12","author":"Wang","year":"2023","journal-title":"J Extracell Vesicles"},{"key":"B219","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1038\/s41467-024-45449-y","article-title":"Tumor reactive gammadelta T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient","volume":"15","author":"Lien","year":"2024","journal-title":"Nat Commun"},{"key":"B220","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1038\/s41467-021-22433-4","article-title":"Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates gammadelta T cell-mediated cytotoxicity in lung cancer","volume":"12","author":"Weng","year":"2021","journal-title":"Nat Commun"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-022-00894-x","article-title":"Glucose metabolism controls human gammadelta T-cell-mediated tumor immunosurveillance in diabetes","volume":"19","author":"Mu","year":"2022","journal-title":"Cell Mol Immunol"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-024-01163-9","article-title":"Lkb1 orchestrates gammadelta T-cell metabolic and functional fitness to control IL-17-mediated autoimmune hepatitis","volume":"21","author":"Xiao","year":"2024","journal-title":"Cell Mol Immunol"},{"key":"B223","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/s41392-020-00260-1","article-title":"Irreversible electroporation plus allogenic Vgamma9Vdelta2 T cells enhances antitumor effect for locally advanced pancreatic cancer patients","volume":"5","author":"Lin","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"B224","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1158\/2159-8290.CD-RW2022-134","article-title":"Pro- versus Antitumor gammadelta T-cell Activity Is Distinguished by TCR-Vgammadelta Use","volume":"12","year":"2022","journal-title":"Cancer Discov"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c11024","article-title":"Photosensitive hybrid gammadelta-T exosomes for targeted cancer photoimmunotherapy","volume":"19","author":"Gao","year":"2025","journal-title":"ACS Nano"},{"key":"B226","doi-asserted-by":"publisher","first-page":"6025","DOI":"10.1038\/ncomms7025","article-title":"Activating mutations of STAT5B and STAT3 in lymphomas derived from gammadelta-T or NK cells","volume":"6","author":"Kucuk","year":"2015","journal-title":"Nat Commun"},{"key":"B227","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1038\/s41423-020-00537-z","article-title":"Correction to: Cancer immunotherapy with gammadelta T cells: many paths ahead of us","volume":"17","author":"Kabelitz","year":"2020","journal-title":"Cell Mol Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1920627\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:51:22Z","timestamp":1791283882000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1920627\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":227,"alternative-id":["10.3389\/fimmu.2026.1920627"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1920627","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]},"article-number":"1920627"}}