{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:24:39Z","timestamp":1787225079782,"version":"build-2736575974"},"reference-count":110,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Despite the remarkable therapeutic efficacy of chimeric antigen receptor T (CAR-T) cell therapy in hematologic malignancies, its clinical translation in solid tumors remains impeded by challenges including insufficient intratumoral infiltration, tumor heterogeneity, and the immunosuppressive tumor microenvironment. Molecular imaging, which enables the visualization and quantitative analysis of the\n                    <jats:italic>in vivo<\/jats:italic>\n                    behavior of CAR-T cell\n                    <jats:italic>s<\/jats:italic>\n                    , serves as a critical prerequisite for advancing the clinical application of CAR-T cell therapy in solid tumors. This review summarizes recent advances in molecular imaging techniques for monitoring the\n                    <jats:italic>in vivo<\/jats:italic>\n                    fate of CAR-T cells, covering their dynamic distribution, tumor recognition, and real-time functional activity. Additionally, the potential clinical value and current limitations of these approaches are discussed. It is proposed that this interdisciplinary integration may improve the precision of therapeutic response assessment and facilitate the optimization of personalized treatment strategies in the context of CAR-T cell therapy.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1922326","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T10:38:11Z","timestamp":1787222291000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Imaging the fate of CAR-T cells in vivo"],"prefix":"10.3389","volume":"17","author":[{"given":"Hongyi","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University","place":["Suzhou, 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