{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:50:22Z","timestamp":1791366622194,"version":"4.3.1"},"reference-count":156,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Gastric precancerous states are important intermediate stages in gastric carcinogenesis, yet strategies that directly modify their persistent biological drivers remain limited. Current management mainly includes\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    eradication, endoscopic surveillance, and mucosal protective strategies. Biotics, including probiotics, synbiotics, postbiotics, and next-generation microbial products, have been investigated as potential strategies to modulate persistent microbial, metabolic, inflammatory, and barrier alterations. However, existing evidence derives from studies of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    -associated gastritis and gastric precancerous lesions, as well as related gastric cancer and gastrointestinal models, making it important to distinguish direct evidence from findings in related disease contexts. This review examines evidence for biotic modulation of microbial homeostasis, metabolic and postbiotic signaling, immune and barrier function, and host\u2013microbiota interactions across anatomical compartments during gastric precancerous progression. Current evidence is concentrated largely in\n                    <jats:italic>H. pylori<\/jats:italic>\n                    -associated gastritis, where biotics have been reported to influence microbial composition, inflammatory signaling, metabolic profiles, and barrier function, whereas direct evidence in established atrophy, intestinal metaplasia, and dysplasia remains limited. These findings support further investigation of biotics as strategies for risk modification and homeostatic support rather than as substitutes for established clinical management. Future studies will require better standardization of strains, formulations, dosage, and treatment duration, together with clearly defined histological outcomes and long-term clinical endpoints.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1927527","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:58:32Z","timestamp":1791363512000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Biotics-based modulation of gastric precancerous states: microbial, metabolic, and epithelial mechanisms"],"prefix":"10.3389","volume":"17","author":[{"given":"Xi","family":"Li","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoyan","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinling","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Hao","sequence":"additional","affiliation":[{"name":"Affiliated Zigong Hospital of Chengdu University of Traditional Chinese Medicine","place":["Zigong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"B1","article-title":"Human gastric carcinogenesis: a multistep and multifactorial process\u2014first American Cancer Society Award Lecture on Cancer Epidemiology and Prevention","volume":"52","author":"Correa","year":"1992","journal-title":"Cancer 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