{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T10:33:17Z","timestamp":1786444397968,"version":"build-2736575974"},"reference-count":177,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Ischemia-reperfusion injury (IRI) constitutes a common pathological basis for organ dysfunction across various critical clinical conditions, including ischemic stroke, myocardial infarction, and organ transplantation. This review focuses on the functions of unconventional T cells in IRI in the brain, liver, kidneys, heart, and mucosal barrier organs, highlighting their diverse regulatory mechanisms in various tissue injury patterns. It also examines the dual functions of these cells in IRI: instead of solely acting as consistent pro-inflammatory effectors, they demonstrate a context-dependent immunomodulatory profile influenced by the organ microenvironment and disease stage, capable of promoting inflammatory damage and facilitating anti-inflammatory repair. Their behavior is shaped by a common injury response program that integrates local antigen cues, the cytokine milieu, metabolic checkpoints, and signals from the repair stage. Expounding on the spatiotemporal heterogeneity, functional plasticity, and regulatory networks of unconventional T cells in IRI will enhance our understanding of the immunopathological mechanisms. It also offers a theoretical basis and potential targets for formulating precision immunomodulatory strategies tailored to specific time windows and cell subsets.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1931069","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T09:55:01Z","timestamp":1786442101000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multifaceted mechanisms of unconventional T cells in ischemia-reperfusion injury"],"prefix":"10.3389","volume":"17","author":[{"given":"Jiajun","family":"Li","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Zhejiang Chinese Medical University","place":["Hangzhou, China"]},{"name":"Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peizhe","family":"Lin","sequence":"additional","affiliation":[{"name":"Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghan","family":"Yuan","sequence":"additional","affiliation":[{"name":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Wang","sequence":"additional","affiliation":[{"name":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruo","family":"Jia","sequence":"additional","affiliation":[{"name":"Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghan","family":"Fan","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Zhejiang Chinese Medical University","place":["Hangzhou, China"]},{"name":"Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Zhejiang Chinese Medical University","place":["Hangzhou, China"]},{"name":"Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Han","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Zhejiang Chinese Medical University","place":["Hangzhou, China"]},{"name":"Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiujun","family":"Guo","sequence":"additional","affiliation":[{"name":"Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhou","family":"He","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion--from mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41392-023-01688-x","article-title":"Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e24600","article-title":"Cardiac endothelial ischemia\/reperfusion injury-derived protein damage-associated molecular patterns disrupt the integrity of the endothelial barrier","volume":"10","author":"Kumphune","year":"2024","journal-title":"Heliyon"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nature13909","article-title":"Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS","volume":"515","author":"Chouchani","year":"2014","journal-title":"Nature"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0311613","article-title":"Defining the molecular response to ischemia-reperfusion injury and remote ischemic preconditioning in human kidney transplantation","volume":"19","author":"Nordstr\u00f6m","year":"2024","journal-title":"PLoS One"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104419","article-title":"Danger signals released during cold ischemia storage activate NLRP3 inflammasome in myeloid cells and influence early allograft function in liver transplantation","volume":"87","author":"Lucas-Ruiz","year":"2023","journal-title":"EBioMedicine"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.122.027600","article-title":"Impact of reperfusion on temporal immune cell dynamics after myocardial infarction","volume":"12","author":"Zhang","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12111944","article-title":"Inflammation in myocardial ischemia\/reperfusion injury: underlying mechanisms and therapeutic potential","volume":"12","author":"Francisco","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"B9","doi-asserted-by":"publisher","first-page":"14524","DOI":"10.1038\/s41598-024-64710-4","article-title":"Neutrophil NLRP3 promotes cardiac injury following acute myocardial infarction through IL-1\u03b2 production, VWF release and NET deposition in the myocardium","volume":"14","author":"Heger","year":"2024","journal-title":"Sci Rep"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00486.2006","article-title":"Role of alpha\/beta and gamma\/delta T cells in renal ischemia-reperfusion injury","volume":"293","author":"Hochegger","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00549-8","article-title":"Liver ischaemia-reperfusion injury: a new understanding of the role of innate immunity","volume":"19","author":"Hirao","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2024.11.035","article-title":"Group 1 innate lymphoid cells protect liver transplants from ischemia-reperfusion injury via an interferon gamma-mediated pathway","volume":"25","author":"Kojima","year":"2025","journal-title":"Am J Transplant"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3298","article-title":"The burgeoning family of unconventional T cells","volume":"16","author":"Godfrey","year":"2015","journal-title":"Nat Immunol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0345-y","article-title":"Thymic development of unconventional T cells: how NKT cells, MAIT cells and \u03b3\u03b4 T cells emerge","volume":"20","author":"Pellicci","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/s41568-019-0153-5","article-title":"\u03b3\u03b4 T cells: pleiotropic immune effectors with therapeutic potential in cancer","volume":"19","author":"Silva-Santos","year":"2019","journal-title":"Nat Rev Cancer"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0444-8","article-title":"The biology and functional importance of MAIT cells","volume":"20","author":"Godfrey","year":"2019","journal-title":"Nat Immunol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0034-2","article-title":"Tissue-specific functions of invariant natural killer T cells","volume":"18","author":"Crosby","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/nri3328","article-title":"Recognition of CD1d-restricted antigens by natural killer T cells","volume":"12","author":"Rossjohn","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03578-0","article-title":"A multilayered immune system through the lens of unconventional T cells","volume":"595","author":"Mayassi","year":"2021","journal-title":"Nature"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1099529","article-title":"Early activation and recruitment of invariant natural killer T cells during liver ischemia-reperfusion: the major role of the alarmin interleukin-33","volume":"14","author":"Robin","year":"2023","journal-title":"Front Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.10.028","article-title":"Dephosphorylation of AMP-activated protein kinase exacerbates ischemia\/reperfusion-induced acute kidney injury via mitochondrial dysfunction","volume":"101","author":"Ma","year":"2022","journal-title":"Kidney Int"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14020213","article-title":"Molecular insights into ischemia-reperfusion injury in coronary artery disease: mechanisms and therapeutic implications: a comprehensive review","volume":"14","author":"Ghanta","year":"2025","journal-title":"Antioxidants (Basel)"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103258","article-title":"Cellular and molecular mechanisms of hepatic ischemia-reperfusion injury: the role of oxidative stress and therapeutic approaches","volume":"75","author":"George","year":"2024","journal-title":"Redox Biol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-025-00752-9","article-title":"Rapid mitochondrial repolarization upon reperfusion after cardiac ischemia","volume":"4","author":"Giles","year":"2025","journal-title":"Nat Cardiovasc Res"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.12.001","article-title":"Nrf2 for protection against oxidant generation and mitochondrial damage in cardiac injury","volume":"179","author":"Chen","year":"2022","journal-title":"Free Radic Biol Med"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.02.007","article-title":"Ischemia\/reperfusion induces the recruitment of leukocytes from whole blood under flow conditions","volume":"36","author":"Cassie","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1159\/000489241","article-title":"Current mechanistic concepts in ischemia and reperfusion injury","volume":"46","author":"Wu","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"B28","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.yjmcc.2014.11.005","article-title":"The mitochondrial permeability transition pore and its role in myocardial ischemia reperfusion injury","volume":"78","author":"Ong","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-024-01027-3","article-title":"DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways","volume":"24","author":"Huang","year":"2024","journal-title":"Nat Rev Immunol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.769331","article-title":"High-mobility group box-1 in ischemia-reperfusion injury of the heart","volume":"117","author":"Andrassy","year":"2008","journal-title":"Circulation"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m113.521161","article-title":"Lipopolysaccharide activates Toll-like receptor 4 (TLR4)-mediated NF-\u03baB signaling pathway and proinflammatory response in human pericytes","volume":"289","author":"Guijarro-Mu\u00f1oz","year":"2014","journal-title":"J Biol Chem"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102048","article-title":"IL-1\u03b1 and IL-1\u03b2 recruit different myeloid cells and promote different stages of sterile inflammation","volume":"187","author":"Rider","year":"2011","journal-title":"J Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"9101","DOI":"10.1038\/s41467-024-53307-0","article-title":"IL-1\u03b2-induced epithelial cell and fibroblast transdifferentiation promotes neutrophil recruitment in chronic rhinosinusitis with nasal polyps","volume":"15","author":"Xie","year":"2024","journal-title":"Nat Commun"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2011111072","article-title":"C3a and C5a promote renal ischemia-reperfusion injury","volume":"23","author":"Peng","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms262311693","article-title":"The pleiotropic effect of complement C5a-C5aR1 pathway in diseases: from immune regulation to targeted therapy","volume":"26","author":"Xu","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03478-3","article-title":"Gasdermin D pore structure reveals preferential release of mature interleukin-1","volume":"593","author":"Xia","year":"2021","journal-title":"Nature"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-025-02280-x","article-title":"Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response","volume":"26","author":"Sun","year":"2025","journal-title":"Nat Immunol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2022.06.008","article-title":"Mechanisms of the \"No-Reflow\" phenomenon after acute myocardial infarction: potential role of pericytes","volume":"8","author":"Kaul","year":"2023","journal-title":"JACC Basic Transl Sci"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02532-0","article-title":"Decoding organ fibrosis: mechanistic insights and emerging therapeutic strategies","volume":"11","author":"Chen","year":"2026","journal-title":"Signal Transduct Target Ther"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay5516","article-title":"Butyrophilin 2A1 is essential for phosphoantigen reactivity by \u03b3\u03b4 T cells","volume":"367","author":"Rigau","year":"2020","journal-title":"Science"},{"key":"B42","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.immuni.2020.02.014","article-title":"Butyrophilin-2A1 directly binds germline-encoded regions of the V\u03b39V\u03b42 TCR and is essential for phosphoantigen sensing","volume":"52","author":"Karunakaran","year":"2020","journal-title":"Immunity"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2024.05.008","article-title":"Innate-like T cells in liver disease","volume":"45","author":"Yang","year":"2024","journal-title":"Trends Immunol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100616-060725","article-title":"Unconventional or preset \u03b1\u03b2 T cells: evolutionarily conserved tissue-resident T cells recognizing nonpeptidic ligands","volume":"33","author":"Legoux","year":"2017","journal-title":"Annu Rev Cell Dev Biol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf0095","article-title":"Early-life imprinting of unconventional T cells and tissue homeostasis","volume":"374","author":"Constantinides","year":"2021","journal-title":"Science"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12911","article-title":"Interaction of microglia with infiltrating immune cells in the different phases of stroke","volume":"30","author":"Berchtold","year":"2020","journal-title":"Brain Pathol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-022-08709-y","article-title":"Interleukin-1 mediates ischemic brain injury via induction of IL-17A in \u03b3\u03b4 T cells and CXCL1 in astrocytes","volume":"24","author":"Sch\u00e4dlich","year":"2022","journal-title":"Neuromolecular Med"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-026-03794-3","article-title":"Single-cell omics and flow cytometry identify distinct immune states of dural and brain-infiltrating IL-17-producing \u03b3\u03b4 T cells after experimental stroke","volume":"23","author":"Zha","year":"2026","journal-title":"J Neuroinflamm"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107678","article-title":"V\u03b34 T cell-derived IL-17A is essential for amplification of inflammatory cascades in ischemic brain tissue after stroke","volume":"96","author":"Lu","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24359","article-title":"Microglial IL-1RA ameliorates brain injury after ischemic stroke by inhibiting astrocytic CXCL1-mediated neutrophil recruitment and microvessel occlusion","volume":"71","author":"Huang","year":"2023","journal-title":"Glia"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1038\/s42003-025-08636-1","article-title":"Microglia are prominent producers of inflammatory cytokines during the hyperacute phase of ischemic stroke","volume":"8","author":"Bourne","year":"2025","journal-title":"Commun Biol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26062505","article-title":"The role of IL-17A in mediating inflammatory responses and progression of neurodegenerative diseases","volume":"26","author":"Zheng","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-04203-7","article-title":"IL-17A aggravated blood-brain barrier disruption via activating Src signaling in epilepsy mice","volume":"61","author":"Wang","year":"2024","journal-title":"Mol Neurobiol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1002\/cns.70825","article-title":"IL-17A promotes NETs formation via the PKC\u03b6-ERK-ROS-PAD4 pathway in a mouse model of ischemic stroke","volume":"32","author":"Liu","year":"2026","journal-title":"CNS Neurosci Ther"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcad090","article-title":"A preclinical randomized controlled multi-centre trial of anti-interleukin-17A treatment for acute ischaemic stroke","volume":"5","author":"Gelderblom","year":"2023","journal-title":"Brain Commun"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4068","article-title":"Commensal microbiota affects ischemic stroke outcome by regulating intestinal \u03b3\u03b4 T cells","volume":"22","author":"Benakis","year":"2016","journal-title":"Nat Med"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-024-01318-w","article-title":"Neutrophil extracellular traps induce brain edema around intracerebral hematoma via ERK-mediated regulation of MMP9 and AQP4","volume":"16","author":"Tang","year":"2025","journal-title":"Transl Stroke Res"},{"key":"B58","doi-asserted-by":"publisher","first-page":"4286","DOI":"10.1038\/s41467-023-39857-9","article-title":"V\u03b31 and V\u03b34 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males","volume":"14","author":"Abou-El-Hassan","year":"2023","journal-title":"Nat Commun"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.664312","article-title":"Inhibition of perforin-mediated neurotoxicity attenuates neurological deficits after ischemic stroke","volume":"15","author":"Pan","year":"2021","journal-title":"Front Cell Neurosci"},{"key":"B60","doi-asserted-by":"publisher","first-page":"6779","DOI":"10.1038\/s41467-025-62181-3","article-title":"Small intestinal \u03b3\u03b4 T17 cells promote SAE through STING\/C1q-induced microglial synaptic pruning in male mice","volume":"16","author":"Wu","year":"2025","journal-title":"Nat Commun"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.01.005","article-title":"Microbial colonization drives expansion of IL-1 receptor 1-expressing and IL-17-producing gamma\/delta T cells","volume":"7","author":"Duan","year":"2010","journal-title":"Cell Host Microbe"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2321686121","article-title":"Lipidomic scanning of self-lipids identifies headless antigens for natural killer T cells","volume":"121","author":"Cheng","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1126\/science.1210301","article-title":"Functional innervation of hepatic iNKT cells is immunosuppressive following stroke","volume":"334","author":"Wong","year":"2011","journal-title":"Science"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3390\/cells13161401","article-title":"The alteration of circulating invariant natural killer T, \u03b3\u03b4T, and natural killer cells after ischemic stroke in relation to clinical outcomes: a prospective case-control study","volume":"13","author":"Frydrychowicz","year":"2024","journal-title":"Cells"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.09.010","article-title":"Infiltration of invariant natural killer T cells occur and accelerate brain infarction in permanent ischemic stroke in mice","volume":"633","author":"Wang","year":"2016","journal-title":"Neurosci Lett"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00006","article-title":"Prolonged activation of invariant natural killer T cells and T(H)2-skewed immunity in stroke patients","volume":"8","author":"Wong","year":"2017","journal-title":"Front Neurol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.682708","article-title":"Interleukin 10 (IL-10)-mediated immunosuppression: MARCH-I induction regulates antigen presentation by macrophages but not dendritic cells","volume":"290","author":"Mittal","year":"2015","journal-title":"J Biol Chem"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2025.1651656","article-title":"Elevated systemic immune-inflammation index is associated with stroke-associated pneumonia in acute ischemic stroke: a retrospective cohort study","volume":"16","author":"Duan","year":"2025","journal-title":"Front Neurol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adq5796","article-title":"Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation","volume":"16","author":"Tamura","year":"2024","journal-title":"Sci Transl Med"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0191-y","article-title":"Mucosal-associated invariant T cells and disease","volume":"19","author":"Toubal","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2414230122","article-title":"Human MAIT cell response profiles biased toward IL-17 or IL-10 are distinct effector states directed by the cytokine milieu","volume":"122","author":"Boulouis","year":"2025","journal-title":"Proc Natl Acad Sci USA"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1161\/str.56.suppl_1.wmp120","article-title":"Circulating mucosal-associated invariant T cells are associated with acute human ischemic stroke and predict poor outcome","volume":"14","author":"Ozawa","year":"2025","journal-title":"J Am Heart Assoc"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.120.018803","article-title":"Mucosal-associated invariant T cells are involved in acute ischemic stroke by regulating neuroinflammation","volume":"10","author":"Nakajima","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"B74","doi-asserted-by":"publisher","first-page":"3249","DOI":"10.1016\/j.celrep.2019.07.039","article-title":"Activation and in vivo evolution of the MAIT cell transcriptome in mice and humans reveals tissue repair functionality","volume":"28","author":"Hinks","year":"2019","journal-title":"Cell Rep"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-026-09572-4","article-title":"Functional remodeling of iNKT cells by sulfatide-reactive type II NKT cells reprograms alveolar macrophages to alleviate lung ischemia-reperfusion injury","volume":"9","author":"Li","year":"2026","journal-title":"Commun Biol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061097","article-title":"Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation","volume":"203","author":"Lappas","year":"2006","journal-title":"J Exp Med"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.02.032","article-title":"NKT-cell subsets: promoters and protectors in inflammatory liver disease","volume":"59","author":"Kumar","year":"2013","journal-title":"J Hepatol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.b2300159","article-title":"Key role of interferon regulatory factor 1 (IRF-1) in regulating liver disease: progress and outlook","volume":"25","author":"Chen","year":"2024","journal-title":"J Zhejiang Univ-Sci B"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2023.0099","article-title":"Updates on the immune cell basis of hepatic ischemia-reperfusion injury","volume":"46","author":"Heo","year":"2023","journal-title":"Mol Cells"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2025.114728","article-title":"Inhibition of crosstalk between iNKT cells and macrophages mitigates ischemia-reperfusion injury in steatotic livers","volume":"451","author":"Kuroda","year":"2025","journal-title":"Exp Cell Res"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-332033","article-title":"Novel IL-4\/HB-EGF-dependent crosstalk between eosinophils and macrophages controls liver regeneration after ischaemia and reperfusion injury","volume":"73","author":"Yang","year":"2024","journal-title":"Gut"},{"key":"B82","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.immuni.2017.09.016","article-title":"iNKT cells orchestrate a switch from inflammation to resolution of sterile liver injury","volume":"47","author":"Liew","year":"2017","journal-title":"Immunity"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.13939","article-title":"Activation of invariant natural killer T cells enhances ischemia-reperfusion injury in steatotic mouse livers","volume":"39","author":"Kuroda","year":"2025","journal-title":"In Vivo"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-324478","article-title":"Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells","volume":"71","author":"Lett","year":"2022","journal-title":"Gut"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3390\/cells15010069","article-title":"MAIT cells in liver disease","volume":"15","author":"Azad","year":"2025","journal-title":"Cells"},{"key":"B86","doi-asserted-by":"publisher","first-page":"4022","DOI":"10.1038\/s41467-025-59308-x","article-title":"Liver transplant-facilitated CD161(+)V\u03b17.2(+) MAIT cell recovery demonstrates clinical benefits in hepatic failure patients","volume":"16","author":"Wang","year":"2025","journal-title":"Nat Commun"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.14218\/jcth.2023.00355","article-title":"Immune regulatory networks and therapy of \u03b3\u03b4 T cells in liver cancer: recent trends and advancements","volume":"12","author":"Yin","year":"2024","journal-title":"J Clin Transl Hepatol"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12051751","article-title":"Inhibition of \u03b3\u03b4-TcR or IL17a reduces T-cell and neutrophil infiltration after ischemia\/reperfusion injury in mouse liver","volume":"12","author":"Al Mogrampi","year":"2023","journal-title":"J Clin Med"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22042036","article-title":"Steatotic livers are more susceptible to ischemia reperfusion damage after transplantation and show increased \u03b3\u03b4 T cell infiltration","volume":"22","author":"Eggenhofer","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B90","doi-asserted-by":"publisher","first-page":"6423","DOI":"10.1038\/s41598-024-57139-2","article-title":"Analysis and experimental validation of IL-17 pathway and key genes as central roles associated with inflammation in hepatic ischemia-reperfusion injury","volume":"14","author":"Tan","year":"2024","journal-title":"Sci Rep"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010479","article-title":"Infections, reactions of natural killer T cells and natural killer cells, and kidney injury","volume":"23","author":"Uchida","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1047367","article-title":"Identification of renal ischemia reperfusion injury subtypes and predictive strategies for delayed graft function and graft survival based on neutrophil extracellular trap-related genes","volume":"13","author":"Wu","year":"2022","journal-title":"Front Immunol"},{"key":"B93","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s10753-025-02364-8","article-title":"Interleukin-33 promotes neutrophil extracellular trap formation to aggravate renal ischemia-reperfusion injury through ST2\/PI3K\/Akt and ST2\/PAD4 pathways","volume":"49","author":"Zhang","year":"2026","journal-title":"Inflammation"},{"key":"B94","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1186\/s13054-024-05069-w","article-title":"Mitochondrial dysfunction in sepsis: mechanisms and therapeutic perspectives","volume":"28","author":"Hu","year":"2024","journal-title":"Crit Care"},{"key":"B95","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/s41419-025-07386-6","article-title":"Human proximal tubular epithelial cell interleukin-1 receptor signalling triggers G2\/M arrest and cellular senescence during hypoxic kidney injury","volume":"16","author":"Giuliani","year":"2025","journal-title":"Cell Death Dis"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00694-0","article-title":"Regulated cell death pathways in kidney disease","volume":"19","author":"Sanz","year":"2023","journal-title":"Nat Rev Nephrol"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1172\/jci63170","article-title":"Dendritic cells tolerized with adenosine A2AR agonist attenuate acute kidney injury","volume":"122","author":"Li","year":"2012","journal-title":"J Clin Invest"},{"key":"B98","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1681\/asn.2014121248","article-title":"Hypoxia-inducible factor-2\u03b1 limits natural killer T cell cytotoxicity in renal ischemia\/reperfusion injury","volume":"27","author":"Zhang","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2010080815","article-title":"Sulfatide-reactive natural killer T cells abrogate ischemia-reperfusion injury","volume":"22","author":"Yang","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1097\/tp.0000000000004038","article-title":"DAMPs released from injured renal tubular epithelial cells activate innate immune signals in healthy renal tubular epithelial cells","volume":"106","author":"DeWolf","year":"2022","journal-title":"Transplantation"},{"key":"B101","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1038\/s41581-021-00466-8","article-title":"Unconventional T cells and kidney disease","volume":"17","author":"Kaminski","year":"2021","journal-title":"Nat Rev Nephrol"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1097\/cm9.0000000000002679","article-title":"Single-cell RNA sequencing reveals the transcriptomic landscape of kidneys in patients with ischemic acute kidney injury","volume":"136","author":"Tang","year":"2023","journal-title":"Chin Med J (Engl)"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.2215\/cjn.11830720","article-title":"Inherited kidney complement diseases","volume":"16","author":"Lemaire","year":"2021","journal-title":"Clin J Am Soc Nephrol"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.3161","article-title":"Paralemmin-3 contributes to lipopolysaccharide-induced inflammatory response and is involved in lipopolysaccharide-Toll-like receptor-4 signaling in alveolar macrophages","volume":"40","author":"Chen","year":"2017","journal-title":"Int J Mol Med"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-014-0224-z","article-title":"Rapamycin protects kidney against ischemia reperfusion injury through recruitment of NKT cells","volume":"12","author":"Zhang","year":"2014","journal-title":"J Transl Med"},{"key":"B106","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1186\/s13054-018-2094-x","article-title":"Postoperative cellular stress in the kidney is associated with an early systemic \u03b3\u03b4 T-cell immune cell response","volume":"22","author":"G\u00f6cze","year":"2018","journal-title":"Crit Care"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107433","article-title":"HMGB1-TLR4-IL-23-IL-17A axis accelerates renal ischemia-reperfusion injury via the recruitment and migration of neutrophils","volume":"94","author":"Zhang","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1602025","article-title":"Pathogenic role for \u03b3\u03b4 T cells in autoimmune anti-myeloperoxidase glomerulonephritis","volume":"199","author":"Gan","year":"2017","journal-title":"J Immunol"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-2022-0","article-title":"\u03b3\u03b4 T cells in immune-mediated kidney disease","volume":"54","author":"Waterh\u00f6lter","year":"2024","journal-title":"Eur J Immunol"},{"key":"B110","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1186\/s12967-019-2022-0","article-title":"Kidney injury in response to crystallization of calcium oxalate leads to rearrangement of the intrarenal T cell receptor delta immune repertoire","volume":"17","author":"Zhu","year":"2019","journal-title":"J Transl Med"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2018101064","article-title":"Human tissue-resident mucosal-associated invariant T (MAIT) cells in renal fibrosis and CKD","volume":"30","author":"Law","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"B112","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/s1074-7613(01)00168-6","article-title":"MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function","volume":"15","author":"Das","year":"2001","journal-title":"Immunity"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1172\/JCI185218","article-title":"T cells in cardiac health and disease","volume":"135","author":"Mart\u00edn","year":"2025","journal-title":"J Clin Invest"},{"key":"B114","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/s41392-024-01840-1","article-title":"Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets","volume":"9","author":"Chen","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00016.2017","article-title":"PTX3, a humoral pattern recognition molecule, in innate immunity, tissue repair, and cancer","volume":"98","author":"Garlanda","year":"2018","journal-title":"Physiol Rev"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1575968","article-title":"Advances in understanding the role of pentraxin-3 in lung infections","volume":"16","author":"Ma","year":"2025","journal-title":"Front Immunol"},{"key":"B117","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1186\/s12974-025-03600-6","article-title":"Cardiac arrest triggers IL-17-mediated neuroinflammation and astrocyte polarization: insights into pathogenesis and intervention","volume":"22","author":"Li","year":"2025","journal-title":"J Neuroinflamm"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0785-3","article-title":"Interleukin-33 activates regulatory T cells to suppress innate \u03b3\u03b4 T cell responses in the lung","volume":"21","author":"Faustino","year":"2020","journal-title":"Nat Immunol"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1680878","article-title":"Macrophage-tregs crosstalk: the \"hub\" of the immune network in MASLD","volume":"16","author":"Zhao","year":"2025","journal-title":"Front Immunol"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-7365467\/v1","article-title":"Regulatory T cells sabotage anti-tumor \u03b3\u03b4 T cells by creating IL-2-deficient environments","volume":"223","author":"Blanco-Dom\u00ednguez","year":"2026","journal-title":"J Exp Med"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2013.02.126","article-title":"NKG2D blockade significantly attenuates ischemia-reperfusion injury in a cardiac transplantation model","volume":"45","author":"Shen","year":"2013","journal-title":"Transplant Proc"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiad087","article-title":"The mutual regulation between \u03b3\u03b4 T cells and macrophages during wound healing","volume":"115","author":"Hu","year":"2024","journal-title":"J Leukoc Biol"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.3390\/cells11091490","article-title":"Depletion of \u03b3\u03b4 T cells leads to reduced angiogenesis and increased infiltration of inflammatory M1-like macrophages in ischemic muscle tissue","volume":"11","author":"Arnholdt","year":"2022","journal-title":"Cells"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6040041","article-title":"Natural killer T cells in liver ischemia-reperfusion injury","volume":"6","author":"Zimmerman","year":"2017","journal-title":"J Clin Med"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0065-8","article-title":"Cardioimmunology: the immune system in cardiac homeostasis and disease","volume":"18","author":"Swirski","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1172\/jci72308","article-title":"IL-10-producing NKT10 cells are a distinct regulatory invariant NKT cell subset","volume":"124","author":"Sag","year":"2014","journal-title":"J Clin Invest"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1457690","article-title":"The iNKT cell ligand \u03b1-GalCer prevents murine septic shock by inducing IL10-producing iNKT and B cells","volume":"15","author":"Park","year":"2024","journal-title":"Front Immunol"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.112.270132","article-title":"Activation of natural killer T cells ameliorates postinfarct cardiac remodeling and failure in mice","volume":"111","author":"Sobirin","year":"2012","journal-title":"Circ Res"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxae019","article-title":"Recent advances regarding the potential roles of invariant natural killer T cells in cardiovascular diseases with immunological and inflammatory backgrounds","volume":"36","author":"Iwabuchi","year":"2024","journal-title":"Int Immunol"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13718","article-title":"Tregs protect against invariant NKT cell-mediated autoimmune colitis and hepatitis","volume":"171","author":"Venken","year":"2024","journal-title":"Immunology"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-019-02417-6","article-title":"Regulatory T cells induce CD4(-) NKT cell anergy and suppress NKT cell cytotoxic function","volume":"68","author":"Ihara","year":"2019","journal-title":"Cancer Immunol Immunother"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2024.1385457","article-title":"RNAseq of INOCA patients identifies innate, invariant, and acquired immune changes: potential autoimmune microvascular dysfunction","volume":"11","author":"Jaatinen","year":"2024","journal-title":"Front Cardiovasc Med"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-023-00934-1","article-title":"MR1 antigen presentation to MAIT cells and other MR1-restricted T cells","volume":"24","author":"McWilliam","year":"2024","journal-title":"Nat Rev Immunol"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1101\/745414","article-title":"Neutrophils suppress mucosal-associated invariant T cells in humans","volume":"50","author":"Schneider","year":"2020","journal-title":"Eur J Immunol"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-01088-9","article-title":"Unconventional immune cells in the gut mucosal barrier: regulation by symbiotic microbiota","volume":"55","author":"Yoo","year":"2023","journal-title":"Exp Mol Med"},{"key":"B136","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41392-023-01722-y","article-title":"Lung microbiome: new insights into the pathogenesis of respiratory diseases","volume":"9","author":"Li","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"B137","doi-asserted-by":"publisher","first-page":"18628","DOI":"10.1038\/s41598-021-96525-y","article-title":"Lack of gamma delta T cells ameliorates inflammatory response after acute intestinal ischemia reperfusion in mice","volume":"11","author":"Funken","year":"2021","journal-title":"Sci Rep"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700655","article-title":"IL-17A produced by innate lymphoid cells is essential for intestinal ischemia-reperfusion injury","volume":"199","author":"Geha","year":"2017","journal-title":"J Immunol"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5085(22)62604-0","article-title":"IL10 secretion endows intestinal human iNKT cells with regulatory functions towards pathogenic T lymphocytes","volume":"16","author":"Burrello","year":"2022","journal-title":"J Crohns Colitis"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114948","article-title":"IFN-\u03b3-dependent regulation of intestinal epithelial homeostasis by NKT cells","volume":"43","author":"Lebrusant-Fernandez","year":"2024","journal-title":"Cell Rep"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfaf366","article-title":"Mucosal-associated invariant T cells and the gut-kidney axis: a review","volume":"19","author":"Zhang","year":"2026","journal-title":"Clin Kidney J"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14111295","article-title":"Lung ischemia-reperfusion injury in lung transplant surgery: where do we stand","volume":"14","author":"Berzenji","year":"2025","journal-title":"Antioxidants (Basel)"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13215","article-title":"CD4 T cells but not Th17 cells are required for mouse lung transplant obliterative bronchiolitis","volume":"15","author":"Wu","year":"2015","journal-title":"Am J Transplant"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.1220","article-title":"Effects of therapeutic hypercapnia on the expression and function of \u03b3\u03b4T cells in transplanted lungs in rats","volume":"12","author":"Xie","year":"2024","journal-title":"Immun Inflammation Dis"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-022-01651-6","article-title":"Immune response associated with ischemia and reperfusion injury during organ transplantation","volume":"71","author":"Tang","year":"2022","journal-title":"Inflammation Res"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02171-2023","article-title":"CD94(+) natural killer cells potentiate pulmonary ischaemia-reperfusion injury","volume":"64","author":"Tsao","year":"2024","journal-title":"Eur Respir J"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.10.863","article-title":"Interleukin-17A contributes to myocardial ischemia\/reperfusion injury by regulating cardiomyocyte apoptosis and neutrophil infiltration","volume":"59","author":"Liao","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-020-08824-3","article-title":"New insights on the role of TRP channels in calcium signalling and immunomodulation: review of pathways and implications for clinical practice","volume":"60","author":"Froghi","year":"2021","journal-title":"Clin Rev Allergy Immunol"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052719","article-title":"TRP ion channels in immune cells and their implications for inflammation","volume":"25","author":"Yan","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073693","article-title":"The role of IL-22 in wound healing. Potential implications in clinical practice","volume":"23","author":"Zaharie","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.875076","article-title":"Skin \u03b3\u03b4 t cells and their function in wound healing","volume":"13","author":"Hu","year":"2022","journal-title":"Front Immunol"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20211504","article-title":"Il-17a-producing \u03b3\u03b4t cells promote muscle regeneration in a microbiota-dependent manner","volume":"219","author":"Mann","year":"2022","journal-title":"J Exp Med"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.70125","article-title":"Interleukin-17a-producing gamma delta t cells accelerate mineralization in human dental pulp stem cells","volume":"50","author":"Kumagai","year":"2026","journal-title":"Cell Biol Int"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.10.003","article-title":"Sulfatide-mediated activation of type ii natural killer t cells prevents hepatic ischemic reperfusion injury in mice","volume":"140","author":"Arrenberg","year":"2011","journal-title":"Gastroenterology"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.754106","article-title":"Activation of inkt cells facilitates liver repair after hepatic ischemia reperfusion injury through acceleration of macrophage polarization","volume":"12","author":"Goto","year":"2021","journal-title":"Front Immunol"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.09.010","article-title":"Il-33 exacerbates liver sterile inflammation by amplifying neutrophil extracellular trap formation","volume":"68","author":"Yazdani","year":"2017","journal-title":"J Hepatol"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2023.109249","article-title":"Immune checkpoint molecule tim-3 promotes nkt cell apoptosis and predicts poorer prognosis in sepsis","volume":"254","author":"Wu","year":"2023","journal-title":"Clin Immunol"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.819992","article-title":"Emerging roles of mucosal-associated invariant t cells in rheumatology","volume":"13","author":"Li","year":"2022","journal-title":"Front Immunol"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0616-6","article-title":"The molecular basis underpinning the potency and specificity of mait cell antigens","volume":"21","author":"Awad","year":"2020","journal-title":"Nat Immunol"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxab070","article-title":"Characteristics of mucosal-associated invariant t cells and their roles in immune diseases","volume":"33","author":"Chiba","year":"2021","journal-title":"Int Immunol"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102714","article-title":"Quantitative affinity measurement of small molecule ligand binding to major histocompatibility complex class-i-related protein 1 mr1","volume":"298","author":"Wang","year":"2022","journal-title":"J Biol Chem"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20241287","article-title":"Antibiotic use in early life impairs mait cell-mediated immunity in adulthood","volume":"223","author":"LeBlanc","year":"2026","journal-title":"J Exp Med"},{"key":"B163","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1038\/s41467-019-10198-w","article-title":"Diverse mr1-restricted t cells in mice and humans","volume":"10","author":"Koay","year":"2019","journal-title":"Nat Commun"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.7881","article-title":"Cold liver ischemia-reperfusion injury critically depends on liver t cells and is improved by donor pretreatment with interleukin 10 in mice","volume":"31","author":"Le Moine","year":"2000","journal-title":"Hepatology"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.02.009","article-title":"Interferon gamma induces reversible metabolic reprogramming of m1 macrophages to sustain cell viability and pro-inflammatory activity","volume":"30","author":"Wang","year":"2018","journal-title":"EBioMedicine"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.08.020","article-title":"Il-4\/il-13-mediated polarization of renal macrophages\/dendritic cells to an m2a phenotype is essential for recovery from acute kidney injury","volume":"91","author":"Zhang","year":"2017","journal-title":"Kidney Int"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2009060615","article-title":"Distinct macrophage phenotypes contribute to kidney injury and repair","volume":"22","author":"Lee","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.101.9.1019","article-title":"Crucial role of endogenous interleukin-10 production in myocardial ischemia\/reperfusion injury","volume":"101","author":"Yang","year":"2000","journal-title":"Circulation"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-018-0162-0","article-title":"Protective effect and mechanism of il-10 on renal ischemia-reperfusion injury","volume":"99","author":"Sakai","year":"2019","journal-title":"Lab Invest"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2011.11.010","article-title":"Ex vivo induced regulatory t cells regulate inflammatory response of kupffer cells by tgf-beta and attenuate liver ischemia reperfusion injury","volume":"12","author":"Feng","year":"2012","journal-title":"Int Immunopharmacol"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1159\/000512986","article-title":"Smad3-targeted therapy protects against cisplatin-induced aki by attenuating programmed cell death and inflammation via a nox4-dependent mechanism","volume":"7","author":"Yang","year":"2021","journal-title":"Kidney Dis (Basel)"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1509070112","article-title":"Il-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-egfr interactions","volume":"112","author":"Monticelli","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.021","article-title":"A distinct function of regulatory t cells in tissue protection","volume":"162","author":"Arpaia","year":"2015","journal-title":"Cell"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1126\/science.7973639","article-title":"The function of kgf in morphogenesis of epithelium and reepithelialization of wounds","volume":"266","author":"Werner","year":"1994","journal-title":"Science"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3181","article-title":"Fgf9 from dermal \u03b3\u03b4 t cells induces hair follicle neogenesis after wounding","volume":"19","author":"Gay","year":"2013","journal-title":"Nat Med"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2013060611","article-title":"Il-22 ameliorates renal ischemia-reperfusion injury by targeting proximal tubule epithelium","volume":"25","author":"Xu","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.119.014814","article-title":"Interleukin-22 directly activates myocardial stat3 (signal transducer and activator of transcription-3) signaling pathway and prevents myocardial ischemia reperfusion injury","volume":"9","author":"Takahashi","year":"2020","journal-title":"J Am Heart Assoc"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1931069\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T09:55:02Z","timestamp":1786442102000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1931069\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,11]]},"references-count":177,"alternative-id":["10.3389\/fimmu.2026.1931069"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1931069","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,11]]},"article-number":"1931069"}}