{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:10:37Z","timestamp":1788844237246,"version":"build-2803163510"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Systemic autoimmune rheumatic diseases (SARDs) are associated with a higher risk of cardiovascular diseases. During pregnancy, maternal immune disbalance might impact the vasculature of the newborn. We, therefore, aimed to investigate a possible association between maternal inflammatory rheumatic disease and inflammatory signaling in the umbilical cord of the newborn.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-center study included neonates of women with connective tissue disorders (CTDs) and inflammatory joint diseases (IJDs) and healthy controls (HC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The tissue of umbilical cords (UCs) of neonates born to IJD patients showed elevated ICAM-1 expression, indicating increased inflammatory response. Monocyte subsets in venous umbilical cord blood (VUCB) showed an equal distribution of non-classical monocytes in all groups. Leukocytes in VUCB showed no significant differences between the three groups although a trend of Treg reduction and an increase in cytotoxic T lymphocytes (CTLs) in the IJD offspring group were detectable. Cytokine levels of VUCB serum were overall low, except IL-8 with significantly elevated concentrations in the IJD neonate group. In the maternal serum of IJD patients, IL-8 levels were low comparable to IL-8 in healthy umbilical cord vein (UCV) serum, indicating a\n                      <jats:italic>de novo<\/jats:italic>\n                      synthesis of IL-8 in the UCV of neonates. Platelet-derived growth factor AA (PDGF-AA) was significantly reduced in the sera of IJD and CTD offspring. Furthermore, a significant reduction of human UCV smooth muscle cell (HUVSMC) proliferation incubated with plasma of the VUCB-IJD sera of neonates, possibly an effect of reduced PDGF-AA levels, is detectable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Well-controlled SARD during pregnancy does not seem to influence most of the inflammatory signaling in the UC. However, the elevated levels of IL-8 in the serum of neonates of women with IJD might have an impact on long-term vascular health and cardiovascular events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1931512","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T04:26:35Z","timestamp":1788841595000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Increased interleukin-8 levels in cord blood serum of newborn\u2014possible effect of cytokine dysregulation in pregnancies complicated by rheumatic disease on newborn vasculature"],"prefix":"10.3389","volume":"17","author":[{"given":"Klara","family":"Rosta","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division Gynecological Endocrinology and Reproductive Medicine, Medical University of Vienna","place":["Vienna, 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