{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:28:00Z","timestamp":1791588480168,"version":"4.3.4"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    TRM cells are indispensable for continuous surveillance of tissues and direct elimination of invading pathogens through a diverse range of effector mechanisms. They balance adhesion, metabolic adaptation, and commensal tolerance against the capacity for swift, targeted attack, using local tissue signals and immunological memory as a finely calibrated control mechanism that prevents both chronic inflammation and persistent infection. Given their strategic co-localization with the peripheral nervous system (PNS) across multiple tissues, this raises a compelling question: do CD8\n                    <jats:sup>+<\/jats:sup>\n                    TRM cells actively regulate peripheral nerve function? In light of recent evidence on how chronic HIV infection influences mucosal CD8\n                    <jats:sup>+<\/jats:sup>\n                    TRM cells and tissue inflammation, this article critically evaluates the existing literature to assess the evidence and potential mechanisms underlying the involvement of CD8\n                    <jats:sup>+<\/jats:sup>\n                    TRM cells in peripheral nerve inflammation across diverse tissue and disease contexts.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1933495","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:37:46Z","timestamp":1789411066000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["CD8+ tissue-resident memory cells- do they modulate peripheral nervous system and 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