{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:03:07Z","timestamp":1789729387572,"version":"4.0.1"},"reference-count":220,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by a remarkably broad and heterogeneous autoantigen repertoire. While epitope spreading, aberrant B-cell activation, and molecular mimicry act in concert with defective apoptotic clearance and sustained type I interferon signaling to drive systemic autoreactivity, many clinical manifestations of the disease are highly localized. The involvement of neuropsychiatric, renal, cutaneous, pulmonary, vascular, and hepatic systems appears to be shaped by tissue-specific autoantigen exposure and local microenvironments, where shared immunopathogenic pathways give rise to organ-associated autoantigenic landscapes. This review develops the concept of organ-associated autoantigenic landscapes, defined here as context-dependent configurations in which autoantibody\u2013autoantigen interactions intersect with regional microenvironments and may contribute to inflammatory cascades, complement activation, and cellular damage. Importantly, organ association does not imply strict organ specificity, as the same circulating autoantibody may acquire distinct clinical relevance across tissues depending on antigen accessibility and local effector conditions. By illustrating how specific autoantibody\u2013autoantigen axes may translate systemic autoimmunity into restricted clinical patterns, this framework provides a unifying model for disease heterogeneity and supports the development of precision, antigen-targeted therapeutic strategies.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1935460","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:09:58Z","timestamp":1789726198000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mapping organ-associated autoantigenic landscapes in systemic lupus erythematosus"],"prefix":"10.3389","volume":"17","author":[{"given":"Ekaterina O.","family":"Sosedskaia","sequence":"first","affiliation":[{"name":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences (RAS)","place":["Moscow, Russia"]},{"name":"Moscow Center for Advanced Studies","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina A.","family":"Ishina","sequence":"additional","affiliation":[{"name":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences (RAS)","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana M.","family":"Reshetnyak","sequence":"additional","affiliation":[{"name":"V.A. Nasonova Research Institute of Rheumatology","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeniy L.","family":"Nasonov","sequence":"additional","affiliation":[{"name":"V.A. Nasonova Research Institute of Rheumatology","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G.","family":"Gabibov","sequence":"additional","affiliation":[{"name":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences (RAS)","place":["Moscow, Russia"]},{"name":"Department of Chemistry, Lomonosov Moscow State University","place":["Moscow, Russia"]},{"name":"Faculty of Biology and Biotechnology, National Research University Higher School of Economics","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Y.","family":"Zakharova","sequence":"additional","affiliation":[{"name":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences (RAS)","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1100359","article-title":"Systemic lupus erythematosus","volume":"365","author":"Tsokos","year":"2011","journal-title":"N Engl J Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60128-8","article-title":"Systemic lupus erythematosus","volume":"384","author":"Lisnevskaia","year":"2014","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"16039","DOI":"10.1038\/nrdp.2016.39","article-title":"Systemic lupus erythematosus","volume":"2","author":"Kaul","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27094026","article-title":"Redefining difficult-to-treat systemic lupus erythematosus: Biomarkers of molecular refractoriness beyond clinical failure","volume":"27","author":"Matusiewicz","year":"2026","journal-title":"Int J Mol Sci"},{"key":"B5","doi-asserted-by":"publisher","first-page":"397","DOI":"10.47360\/1995-4484-2022-397-412","article-title":"Systemic lupus erythematosus: history and modernity","volume":"60","author":"Nasonov","year":"2022","journal-title":"Nauchno-Prakt Revmatol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00035","article-title":"Clearance deficiency and cell death pathways: A model for the pathogenesis of SLE","volume":"7","author":"Mahajan","year":"2016","journal-title":"Front Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0677-6","article-title":"Autoimmunity and organ damage in systemic lupus erythematosus","volume":"21","author":"Tsokos","year":"2020","journal-title":"Nat Immunol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000922","article-title":"An update on autoantibodies in systemic lupus erythematosus","volume":"35","author":"G\u00f3mez-Ba\u00f1uelos","year":"2023","journal-title":"Curr Opin Rheumatol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.151","article-title":"Anti-DNA antibodies \u2014 quintessential biomarkers of SLE","volume":"12","author":"Pisetsky","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1126\/science.1585181","article-title":"DNA hydrolyzing autoantibodies","volume":"256","author":"Shuster","year":"1992","journal-title":"Science"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.1.254","article-title":"Cleavage of supercoiled plasmid DNA by autoantibody Fab fragment: Application of the flow linear dichroism technique","volume":"92","author":"Gololobov","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"B12","doi-asserted-by":"publisher","first-page":"12679","DOI":"10.1038\/s41598-018-30938-0","article-title":"Diagnostics of autoimmune neurodegeneration using fluorescent probing","volume":"8","author":"Lomakin","year":"2018","journal-title":"Sci Rep"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.26442\/00403660.2023.05.202246","article-title":"Systemic lupus erythematosus and antiphospholipid syndrome: Past, present, future","volume":"95","author":"Nasonov","year":"2023","journal-title":"Ter Arkh"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2024.103535","article-title":"A critical view on autoantibodies in lupus nephritis: Concrete knowledge based on evidence","volume":"23","author":"Bruschi","year":"2024","journal-title":"Autoimmun Rev"},{"key":"B15","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1080\/1744666X.2026.2625964","article-title":"Old and new autoantibodies in systemic lupus erythematosus","volume":"22","author":"Parodis","year":"2026","journal-title":"Expert Rev Clin Immunol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1410032","article-title":"Anti-C1q antibodies: A biomarker for diagnosis and management of lupus nephritis. 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