{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:18:33Z","timestamp":1787894313315,"version":"build-2784847793"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between admission C-reactive protein (CRP) levels and complicated or high-risk presentations in acute Stanford type B aortic dissection (TBAD) and to evaluate the potential value of CRP as a simple, inexpensive, and widely available inflammatory marker for early risk stratification in acute TBAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational study included patients with acute TBAD admitted to two centers between January 2010 and January 2025. Patients were classified as complicated\/high-risk or uncomplicated according to the SVS\/STS reporting standards and STS\/AATS guidelines. Admission CRP levels within 24\u00a0h were compared between groups, and logistic regression and ROC curve analyses were used to evaluate the association and discriminatory performance of CRP for complicated\/high-risk TBAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 95 patients with acute TBAD, 62 were classified as complicated\/high-risk and 33 as uncomplicated. Admission CRP levels were significantly higher in the complicated\/high-risk group than in the uncomplicated group [74.1 (27.2, 137.4) vs. 2.9 (0.6, 9.6) mg\/L,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001]. CRP was significantly associated with complicated\/high-risk TBAD in the unadjusted model (OR, 1.046; 95% CI, 1.023\u20131.070;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001) and after adjustment for age and sex (adjusted OR, 1.048; 95% CI, 1.023\u20131.074;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001). The AUC of CRP was 0.897 (95% CI, 0.830\u20130.964), with an optimal cutoff of 19.4 mg\/L.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated admission CRP was significantly associated with complicated\/high-risk acute TBAD and showed good discriminatory performance. As a rapid, low-cost, and widely available inflammatory marker, CRP may provide an adjunctive tool for early risk stratification in acute TBAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1936267","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:34:44Z","timestamp":1787891684000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Elevated admission C-reactive protein identifies complicated or high-risk acute Stanford type B aortic dissection"],"prefix":"10.3389","volume":"17","author":[{"given":"Zhaoyang","family":"Li","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Hebei University\/School of Clinical Medicine","place":["Hebei, China"]},{"name":"Vascular Surgery Department, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yankui","family":"Li","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department, The Second Hospital of Tianjin Medical University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02126","article-title":"How C-reactive protein structural isoforms with distinctive bioactivities affect disease progression","volume":"11","author":"Rajab","year":"2020","journal-title":"Front Immunol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00754","article-title":"Role of C-reactive 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