{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:53:57Z","timestamp":1791179637763,"version":"4.1.0"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    This study aims to systematically identify key hub genes in psoriasis pathogenesis through the integration of bioinformatics, machine learning and experimental validation methods. Four psoriasis microarray datasets were retrieved from the GEO database, with differentially expressed genes identified through comparative analysis. A dual machine learning approach screened core hub genes, whose expression levels and diagnostic efficacy were validated in an independent cohort. CIBERSORT was employed for immune cell infiltration analysis, whilst a multi-database approach constructed an mRNA-miRNA-lncRNA regulatory network. Molecular docking technology assessed interactions between the environmental pollutant bisphenol A, predicted drugs, and hub genes. Finally, an\n                    <jats:italic>in vitro<\/jats:italic>\n                    psoriasis model was established by stimulating HaCaT cells with the M5 cytokine mixture, with hub gene expression validated via RT-qPCR. Results show that 77 co-differentially expressed genes were identified in psoriasis. Machine learning screened five key hub genes: CARHSP1, HPSE, PCLAF, SERPINB4, and SPRR2C. These were significantly upregulated in the validation cohort and demonstrated strong discriminative value for distinguishing psoriatic lesional skin from paired non-lesional skin, rather than serving as standalone diagnostic biomarkers for psoriasis. Immune cell infiltration analysis revealed extensive associations with immune subpopulations including T cells and macrophages. Molecular docking computationally predicted a potential binding interaction between the environmental pollutant BPA and the hub gene HPSE, which awaits future experimental validation. Concurrently, Genistein and HPSE were suggested a potential interaction that awaits functional validation.\n                    <jats:italic>In vitro<\/jats:italic>\n                    experiments confirmed significant upregulation of HPSE, PCLAF, and SPRR2C mRNA levels in M5-induced psoriasis cell models. HPSE emerged as a multifunctional core gene associated with immune dysregulation. Molecular docking additionally predicted a potential interaction between the environmental pollutant BPA and HPSE; however, this interaction remains a computational hypothesis requiring experimental validation.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1937515","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:31:37Z","timestamp":1791178297000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of psoriasis-associated hub genes by integrated transcriptomics and machine learning"],"prefix":"10.3389","volume":"17","author":[{"given":"Yaqi","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Beijing, China"]},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology","place":["Beijing, China"]},{"name":"State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital","place":["Beijing, China"]},{"name":"Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Beijing, China"]},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology","place":["Beijing, China"]},{"name":"State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital","place":["Beijing, China"]},{"name":"Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Beijing, China"]},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology","place":["Beijing, China"]},{"name":"State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital","place":["Beijing, China"]},{"name":"Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Beijing, China"]},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology","place":["Beijing, China"]},{"name":"State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital","place":["Beijing, China"]},{"name":"Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Beijing, China"]},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology","place":["Beijing, China"]},{"name":"State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital","place":["Beijing, China"]},{"name":"Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Beijing, China"]},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology","place":["Beijing, China"]},{"name":"State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital","place":["Beijing, China"]},{"name":"Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengtao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Beijing, China"]},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology","place":["Beijing, China"]},{"name":"State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital","place":["Beijing, China"]},{"name":"Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Beijing, China"]},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology","place":["Beijing, China"]},{"name":"State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital","place":["Beijing, China"]},{"name":"Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Beijing, China"]},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology","place":["Beijing, China"]},{"name":"State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital","place":["Beijing, China"]},{"name":"Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61909-7","article-title":"Psoriasis","volume":"386","author":"Boehncke","year":"2015","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122991","article-title":"Advances in psoriasis research: From pathogenesis to therapeutics","volume":"355","author":"Sugumaran","year":"2024","journal-title":"Life Sci"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41572-025-00630-5","article-title":"Psoriasis","volume":"11","author":"Armstrong","year":"2025","journal-title":"Nat Rev Dis Primers"},{"key":"B5","article-title":"The skin in psoriasis: assessment and challenges","volume":"33","author":"Oji","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(99)70112-x","article-title":"Psoriasis causes as much disability as other major medical diseases","volume":"41","author":"Rapp","year":"1999","journal-title":"J Am Acad Dermatol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.jaad.2017.05.019","article-title":"Psoriasis and suicidality: A systematic review and meta-analysis","volume":"77","author":"Singh","year":"2017","journal-title":"J Am Acad Dermatol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061475","article-title":"Psoriasis pathogenesis and treatment","volume":"20","author":"Rendon","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B9","article-title":"Psoriasis: Recognition and management strategies","volume":"108","author":"Garner","year":"2023","journal-title":"Am Fam Physician"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18245","article-title":"Management of psoriasis as a systemic disease: What is the evidence","volume":"182","author":"Korman","year":"2020","journal-title":"Br J Dermatol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312793","article-title":"The cytokine mediated molecular pathophysiology of psoriasis and its clinical implications","volume":"22","author":"Singh","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2024.09.012","article-title":"Curing psoriasis","volume":"144","author":"Lwin","year":"2024","journal-title":"J Invest Dermatol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.47102\/annals-acadmedsg.2023367","article-title":"2023 guidelines on the management of psoriasis by the Dermatological Society of Singapore","volume":"53","author":"Oon","year":"2024","journal-title":"Ann Acad Med Singap"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13457","article-title":"Bioinformatics analysis to reveal the potential comorbidity mechanism in psoriasis and nonalcoholic steatohepatitis","volume":"29","author":"Xian","year":"2023","journal-title":"Skin Res Technol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s00335-026-10194-8","article-title":"Exploration of shared gene signatures and molecular mechanisms between psoriasis and COVID-19: Evidence from transcriptome data","volume":"37","author":"Dong","year":"2026","journal-title":"Mamm Genome"},{"key":"B17","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s12985-021-01606-z","article-title":"Is there a relationship between psoriasis and hepatitis C? A meta-analysis and bioinformatics investigation","volume":"18","author":"Liu","year":"2021","journal-title":"Virol J"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.971071","article-title":"L36G is associated with cutaneous antiviral competence in psoriasis","volume":"13","author":"Lu","year":"2022","journal-title":"Front Immunol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S354985","article-title":"Discovering novel biomarkers associated with the pathogenesis of psoriasis: Evidence from bioinformatic analysis","volume":"15","author":"Yang","year":"2022","journal-title":"Int J Gen Med"},{"key":"B20","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-3-030-34521-1_1","article-title":"Forty years of basic and translational heparanase research","volume":"1221","author":"Vlodavsky","year":"2020","journal-title":"Adv Exp Med Biol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-34521-1_12","article-title":"Heparanase: A dynamic promoter of myeloma progression","volume":"1221","author":"Purushothaman","year":"2020","journal-title":"Adv Exp Med Biol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03559-y","article-title":"Heparanase, cell signaling, and viral infections","volume":"77","author":"Koganti","year":"2020","journal-title":"Cell Mol Life Sci"},{"key":"B23","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1186\/s12967-020-02624-1","article-title":"Heparanase and the hallmarks of cancer","volume":"18","author":"Jayatilleke","year":"2020","journal-title":"J Transl Med"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.06.004","article-title":"Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis","volume":"38","author":"Ilan","year":"2006","journal-title":"Int J Biochem Cell Biol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.tibs.2017.10.007","article-title":"Opposing functions of heparanase-1 and heparanase-2 in cancer progression","volume":"43","author":"Vlodavsky","year":"2018","journal-title":"Trends Biochem Sci"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11339","article-title":"Distribution of heparan sulfate correlated with the expression of heparanase-1 and matrix metalloproteinase-9 in an ovariectomized rats skin","volume":"44","author":"Veridiano","year":"2020","journal-title":"Cell Biol Int"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-02-0091","article-title":"Heparin, heparan sulfate and heparanase in inflammatory reactions","volume":"102","author":"Li","year":"2009","journal-title":"Thromb Haemost"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-08-3301","article-title":"Role of endothelial heparanase in delayed-type hypersensitivity","volume":"107","author":"Edovitsky","year":"2006","journal-title":"Blood"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.180695","article-title":"Heparanase alters arterial structure, mechanics, and repair following endovascular stenting in mice","volume":"104","author":"Baker","year":"2009","journal-title":"Circ Res"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43792","article-title":"Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice","volume":"121","author":"Lerner","year":"2011","journal-title":"J Clin Invest"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2843","article-title":"The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis","volume":"18","author":"Schmidt","year":"2012","journal-title":"Nat Med"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1002\/art.23489","article-title":"Dramatic regulation of heparanase activity and angiogenesis gene expression in synovium from patients with rheumatoid arthritis","volume":"58","author":"Li","year":"2008","journal-title":"Arthritis Rheum"},{"key":"B33","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.atherosclerosis.2012.09.030","article-title":"Increased expression of heparanase in symptomatic carotid atherosclerosis","volume":"226","author":"Osterholm","year":"2013","journal-title":"Atherosclerosis"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2110-z","article-title":"Reactive oxygen species mediate high glucose-induced heparanase-1 production and heparan sulphate proteoglycan degradation in human and rat endothelial cells: a potential role in the pathogenesis of atherosclerosis","volume":"54","author":"Rao","year":"2011","journal-title":"Diabetologia"},{"key":"B35","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/modpathol.3800710","article-title":"Heparanase upregulation by colonic epithelium in inflammatory bowel disease","volume":"20","author":"Waterman","year":"2007","journal-title":"Mod Pathol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e318280298f","article-title":"Syndecan-1 and heparanase: potential markers for activity evaluation and differential diagnosis of Crohn's disease","volume":"19","author":"Zhang","year":"2013","journal-title":"Inflammation Bowel Dis"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1496-9","article-title":"Heparanase is preferentially expressed in human psoriatic lesions and induces development of psoriasiform skin inflammation in mice","volume":"71","author":"Lerner","year":"2014","journal-title":"Cell Mol Life Sci"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3390\/genes8050144","article-title":"DNA methylation targets influenced by bisphenol A and\/or genistein are associated with survival outcomes in breast cancer patients","volume":"8","author":"Jadhav","year":"2017","journal-title":"Genes (Basel)"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jenvman.2025.125708","article-title":"Exploring the toxicological impact of bisphenol a exposure on psoriasis through network toxicology, machine learning, and multi-dimensional bioinformatics analysis","volume":"385","author":"Feng","year":"2025","journal-title":"J Environ Manage"},{"key":"B40","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.mce.2015.08.003","article-title":"Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells","volume":"415","author":"Panchanathan","year":"2015","journal-title":"Mol Cell Endocrinol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"59","DOI":"10.4103\/ijd.ijd_641_22","article-title":"Heparanase contributes to psoriatic lesions through crosstalk with IL-17 pathway","volume":"68","author":"Zhu","year":"2023","journal-title":"Indian J Dermatol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.11788","article-title":"Bisphenol A at low nanomolar doses confers chemoresistance in estrogen receptor-alpha-positive and -negative breast cancer cells","volume":"117","author":"Lapensee","year":"2009","journal-title":"Environ Health Perspect"},{"key":"B43","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.critrevonc.2017.09.004","article-title":"Genistein: Its role in metabolic diseases and cancer","volume":"119","author":"Mukund","year":"2017","journal-title":"Crit Rev Oncol Hematol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2025.107040","article-title":"Multiple sclerosis lesions exhibit sex-specific steroid changes","volume":"214","author":"Luchetti","year":"2025","journal-title":"Neurobiol Dis"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2019.4099","article-title":"Genistein suppresses psoriasis-related inflammation through a STAT3-NF-\u03baB-dependent mechanism in keratinocytes","volume":"43","author":"Wang","year":"2019","journal-title":"Int J Mol Med"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192297","article-title":"Molecular action of isoflavone genistein in the human epithelial cell line HaCaT","volume":"13","author":"Smoli\u0144ska","year":"2018","journal-title":"PloS One"},{"key":"B47","doi-asserted-by":"publisher","first-page":"18585","DOI":"10.1038\/s41598-021-97992-8","article-title":"Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations","volume":"11","author":"Boche\u0144ska","year":"2021","journal-title":"Sci Rep"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1177\/030089169608200318","article-title":"Psoriasis and tamoxifen therapy: a case report","volume":"82","author":"Ferrari","year":"1996","journal-title":"Tumori"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.2174\/187437220181201054","article-title":"0.1MG\/ML tamoxifen gel improves plaque psoriasis. An open study","volume":"12","author":"Abdelmaksoud","year":"2018","journal-title":"Open Dermatol J"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.818173","article-title":"Estrogen acts through estrogen receptor-\u03b2 to promote mannan-induced psoriasis-like skin inflammation","volume":"13","author":"Wu","year":"2022","journal-title":"Front Immunol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1106136108","article-title":"Proliferating cell nuclear antigen (PCNA)-associated KIAA0101\/PAF15 protein is a cell cycle-regulated anaphase-promoting complex\/cyclosome substrate","volume":"108","author":"Emanuele","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"B52","doi-asserted-by":"publisher","first-page":"9169","DOI":"10.1038\/s41467-024-53330-1","article-title":"PCLAF-DREAM drives alveolar cell plasticity for lung regeneration","volume":"15","author":"Kim","year":"2024","journal-title":"Nat Commun"},{"key":"B53","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/s41419-024-06545-5","article-title":"Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammation","volume":"15","author":"Long","year":"2024","journal-title":"Cell Death Dis"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2022.4247","article-title":"Role of the long non-coding RNA, SPRR2C, based on an in vitro psoriatic keratinocyte cell model","volume":"32","author":"Yin","year":"2022","journal-title":"Eur J Dermatol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/s41419-020-03305-z","article-title":"Weighted gene coexpression network and experimental analyses identify lncRNA SPRR2C as a regulator of the IL-22-stimulated HaCaT cell phenotype through the miR-330\/STAT1\/S100A7 axis","volume":"12","author":"Luo","year":"2021","journal-title":"Cell Death Dis"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203385","article-title":"The life in a gradient: calcium, the lncRNA SPRR2C and mir542\/mir196a meet in the epidermis to regulate the aging process","volume":"13","author":"Breunig","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2014.12.014","article-title":"Genetic and epigenetic basis of psoriasis pathogenesis","volume":"64","author":"Chandra","year":"2015","journal-title":"Mol Immunol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002537","article-title":"A psoriasis-specific DNA methylation landscape reveals epigenetic coordination of epidermal differentiation","volume":"8","author":"Roberson","year":"2012","journal-title":"PloS Genet"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.835740","article-title":"Skin-Expressing lncRNAs in inflammatory responses","volume":"13","author":"Shefler","year":"2022","journal-title":"Front Genet"},{"key":"B60","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s13578-025-01371-4","article-title":"The RNA binding protein CARHSP1 facilitates tumor growth, metastasis and immune escape by enhancing IL-17RA mRNA stabilization in prostate cancer","volume":"15","author":"Jiang","year":"2025","journal-title":"Cell Biosci"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8049-7","article-title":"Recent progress in understanding the diversity of the human ov-serpin\/clade B serpin family","volume":"65","author":"Izuhara","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197710)40:4<1621::aid-cncr2820400435>3.0.co;2-i","article-title":"Radioimmunoassay for tumor antigen of human cervical squamous cell carcinoma","volume":"40","author":"Kato","year":"1977","journal-title":"Cancer"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00693-10","article-title":"CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes","volume":"31","author":"Pfeiffer","year":"2011","journal-title":"Mol Cell Biol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.36","article-title":"Assessment of the psoriatic transcriptome in a large sample: additional regulated genes and comparisons with in vitro models","volume":"130","author":"Gudjonsson","year":"2010","journal-title":"J Invest Dermatol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.340","article-title":"Integrative responses to IL-17 and TNF-\u03b1 in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis","volume":"131","author":"Chiricozzi","year":"2011","journal-title":"J Invest Dermatol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01610.x","article-title":"Overexpression of serpin squamous cell carcinoma antigens in psoriatic skin","volume":"118","author":"Takeda","year":"2002","journal-title":"J Invest Dermatol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14426","article-title":"Elevation of serum squamous cell carcinoma antigen 2 in patients with psoriasis: associations with disease severity and response to the treatment","volume":"174","author":"Watanabe","year":"2016","journal-title":"Br J Dermatol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.csbj.2023.11.049","article-title":"PANoptosis signaling enables broad immune response in psoriasis: From pathogenesis to new therapeutic strategies","volume":"23","author":"Hu","year":"2024","journal-title":"Comput Struct Biotechnol J"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1937515\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:31:38Z","timestamp":1791178298000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1937515\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,5]]},"references-count":68,"alternative-id":["10.3389\/fimmu.2026.1937515"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1937515","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,5]]},"article-number":"1937515"}}