{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:01:49Z","timestamp":1791198109319,"version":"4.1.0"},"reference-count":360,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Chronic inflammatory conditions are associated with sustained platelet activation and subsequent release of platelet-derived immunomodulatory factors. Among these, platelets are the largest circulating reservoir of transforming growth factor \u03b2 (TGF\u03b2), and as such can be implicated in all physiological processes where TGF\u03b2 plays a crucial role. TGF\u03b2 is associated with immune regulation via dampening of Th\n                    <jats:sub>1<\/jats:sub>\n                    responses, amplification of regulatory T lymphocyte polarization, and reduced inflammation, which can be beneficial in mitigating autoimmune diseases. However, in the case of solid tumors or persistent viral infections, this function can result in aberrant immune suppression and increased disease severity and pathology. TGF\u03b2 is also implicated in tissue remodeling and wound healing, however, in conditions associated with chronic platelet activation, such as diabetes, hypertension, and HIV infection, increased levels of platelet-derived TGF\u03b2 can exacerbate fibrosis, resulting in tissue and organ damage. Thus, whether TGF\u03b2 plays a pathogenic or pro-homeostatic role is dependent on the disease context. In order to harness the therapeutic potential of platelet-derived TGF\u03b2, it is crucial to first understand how its mechanism of action varies across physiologic and pathologic conditions. In this review, we aim to emphasize the highly pleiotropic nature of TGF\u03b2, highlight what is currently known about platelet-derived TGF\u03b2 across disease states, and to reinforce the importance of considering platelet-derived mediators as regulators of immunity and tissue responses, especially in the presence of chronic inflammation.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1938898","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:22:33Z","timestamp":1791195753000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Inflammation identity crisis: pathogenic nature of platelet-derived transforming growth factor \u03b2 in chronic inflammatory conditions"],"prefix":"10.3389","volume":"17","author":[{"given":"Karli R.","family":"Sutton","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbiology, University of Rochester School of Medicine and Dentistry","place":["Rochester, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel C.","family":"Eisenhart","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Rochester School of Medicine and Dentistry","place":["Rochester, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meera V.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Rochester School of Medicine and Dentistry","place":["Rochester, NY, United States"]},{"name":"Department of Neurology, University of Rochester School of Medicine and Dentistry","place":["Rochester, NY, United States"]},{"name":"Department of Neuroscience, University of Rochester School of Medicine and Dentistry","place":["Rochester, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.07.036","article-title":"TGF-\u03b2 signaling in health and disease","volume":"186","author":"Massagu\u00e9","year":"2023","journal-title":"Cell"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s41413-017-0005-4","article-title":"Transforming growth factor-\u03b2 in stem cells and tissue homeostasis","volume":"6","author":"Xu","year":"2018","journal-title":"Bone Res"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605556103","article-title":"VEGF, a prosurvival factor, acts in concert with TGF-\u03b21 to induce endothelial cell apoptosis","volume":"103","author":"Ferrari","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/srep16859","article-title":"Peritoneal VEGF-A expression is regulated by TGF-\u03b21 through an ID1 pathway in women with endometriosis","volume":"5","author":"Young","year":"2015","journal-title":"Sci Rep"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00052.2017","article-title":"TGF-\u03b21-VEGF-A pathway induces neoangiogenesis with peritoneal fibrosis in patients undergoing peritoneal dialysis","volume":"314","author":"Kariya","year":"2018","journal-title":"Am J Physiol Renal Physiol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/cells12162102","article-title":"Circulated TGF-\u03b21 and VEGF-A as biomarkers for Fabry disease-associated cardiomyopathy","volume":"12","author":"Ivanova","year":"2023","journal-title":"Cells"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2010.04.002","article-title":"TGF-\u03b2 and immune cells: an important regulatory axis in the tumor microenvironment and progression","volume":"31","author":"Yang","year":"2010","journal-title":"Trends Immunol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114697","article-title":"Targeting immunosuppression by TGF-\u03b21 for cancer immunotherapy","volume":"192","author":"de Streel","year":"2021","journal-title":"Biochem Pharmacol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/s41392-024-01764-w","article-title":"TGF-\u03b2 signaling in health, disease and therapeutics","volume":"9","author":"Deng","year":"2024","journal-title":"Sig Transduct Target Ther"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.919674","article-title":"TGF-\u03b2 enhances immunosuppression of myeloid-derived suppressor cells to induce transplant immune tolerance through affecting Arg-1 expression","volume":"13","author":"Cao","year":"2022","journal-title":"Front Immunol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2026.105141","article-title":"TGF-\u03b2-mediated suppression of NK cell function and targeting strategies in tumor immunotherapy","volume":"219","author":"Wang","year":"2026","journal-title":"Crit Rev Oncol\/Hematol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/mc.23196","article-title":"The role of transforming growth factor-beta in immune suppression and chronic inflammation of squamous cell carcinomas","volume":"59","author":"Strait","year":"2020","journal-title":"Mol Carcinog"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181efd018","article-title":"Pleiotropic effects of transforming growth factor-\u03b2 in hematopoietic stem-cell transplantation","volume":"90","author":"Coomes","year":"2010","journal-title":"Transplantation"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030869","article-title":"Characterization of multiple cytokine combinations and TGF-\u03b2 on differentiation and functions of myeloid-derived suppressor cells","volume":"19","author":"Lee","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-021-00846-3","article-title":"Role of myeloid-derived suppressor cell (MDSC) in autoimmunity and its potential as a therapeutic target","volume":"29","author":"Nourbakhsh","year":"2021","journal-title":"Inflammopharmacol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"17","DOI":"10.4049\/jimmunol.1300654","article-title":"Reciprocal relationship between myeloid-derived suppressor cells and T cells","volume":"191","author":"Nagaraj","year":"2013","journal-title":"J Immunol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.07.001","article-title":"TGF\u03b2 in cancer","volume":"134","author":"Massagu\u00e9","year":"2008","journal-title":"Cell"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.791272","article-title":"Transforming growth factor-beta (TGF-\u03b2) signaling in cancer-a betrayal within","volume":"13","author":"Baba","year":"2022","journal-title":"Front Pharmacol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-02036-z","article-title":"System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans","volume":"26","author":"Cortese","year":"2025","journal-title":"Nat Immunol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/316701a0","article-title":"Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells","volume":"316","author":"Derynck","year":"1985","journal-title":"Nature"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901944106","article-title":"GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells","volume":"106","author":"Tran","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8753","article-title":"GARP: a surface molecule of regulatory T cells that is involved in the regulatory function and TGF-\u03b2 releasing","volume":"7","author":"Sun","year":"2016","journal-title":"Oncotarget"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2012.01.020","article-title":"Epithelial cells utilize cortical actin\/myosin to activate latent TGF-\u03b2 through integrin \u03b1v\u03b26-dependent physical force","volume":"318","author":"Giacomini","year":"2012","journal-title":"Exp Cell Res"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171491","article-title":"Human monocytes and macrophages regulate immune tolerance via integrin \u03b1v\u03b28\u2013mediated TGF\u03b2 activation","volume":"215","author":"Kelly","year":"2018","journal-title":"J Exp Med"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-18-0310","article-title":"Autocrine TGF\u03b2 is a survival factor for monocytes and drives immunosuppressive lineage commitment","volume":"7","author":"Gonzalez-Junca","year":"2019","journal-title":"Cancer Immunol Res"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(99)00257-9","article-title":"Bidirectional regulation of macrophage function by TGF-\u03b2","volume":"1","author":"Ashcroft","year":"1999","journal-title":"Microbes Infection"},{"key":"B27","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s43556-022-00109-9","article-title":"TGF-beta signal transduction: biology, function and therapy for diseases","volume":"3","author":"Tie","year":"2022","journal-title":"Mol BioMed"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00229","article-title":"Making sense of latent TGFbeta activation","volume":"116","author":"Annes","year":"2003","journal-title":"J Cell Sci"},{"key":"B29","doi-asserted-by":"publisher","first-page":"7619","DOI":"10.1038\/s41467-026-75834-8","article-title":"Structural basis for the contribution of latent TGF\u03b2 binding protein to TGF\u03b2 latency and activation","volume":"17","author":"Biggin","year":"2026","journal-title":"Nat Commun"},{"key":"B30","doi-asserted-by":"publisher","first-page":"10469","DOI":"10.1038\/s41467-025-65465-w","article-title":"Latent-TGF-\u03b2 has a domain swapped architecture","volume":"16","author":"Jin","year":"2025","journal-title":"Nat Commun"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2020-0066","article-title":"Overcoming stromal barriers to immuno-oncological responses via fibroblast activation protein-targeted therapy","volume":"13","author":"Brennen","year":"2021","journal-title":"Immunotherapy"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1080\/03008207.2025.2543383","article-title":"Latent TGF-\u03b2 content of articular cartilage with development and age","volume":"67","author":"Dogru","year":"2026","journal-title":"Connect Tissue Res"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2017.1422850","article-title":"TGFB1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators","volume":"14","author":"N\u00fcchel","year":"2018","journal-title":"Autophagy"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9258(18)32345-7","article-title":"Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization","volume":"258","author":"Assoian","year":"1983","journal-title":"J Biol Chem"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-377648","article-title":"Platelet TGF-\u03b21 contributions to plasma TGF-\u03b21, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload","volume":"119","author":"Meyer","year":"2012","journal-title":"Blood"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/nm0995-932","article-title":"Release and activation of platelet latent TGF-beta in blood clots during dissolution with plasmin","volume":"1","author":"Grainger","year":"1995","journal-title":"Nat Med"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2009.04.001","article-title":"Platelet \u03b1-granules: Basic biology and clinical correlates","volume":"23","author":"Blair","year":"2009","journal-title":"Blood Rev"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1584059","article-title":"The winding road to platelet \u03b1-granules","volume":"13","author":"Ambrosio","year":"2025","journal-title":"Front Cell Dev Biol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20180458","article-title":"Sorting machineries: how platelet-dense granules differ from \u03b1-granules","volume":"38","author":"Chen","year":"2018","journal-title":"Biosci Rep"},{"key":"B40","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/0268-960X(93)90024-X","article-title":"Platelet \u03b1-granules","volume":"7","author":"Harrison","year":"1993","journal-title":"Blood Rev"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2014.10.003","article-title":"Platelet secretion: From haemostasis to wound healing and beyond","volume":"29","author":"Golebiewska","year":"2015","journal-title":"Blood Rev"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0049-3848(99)00015-8","article-title":"Platelet dense granules: Structure, function and implications for haemostasis","volume":"95","author":"McNicol","year":"1999","journal-title":"Thromb Res"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V120.21.SCI-34.SCI-34","article-title":"Molecular triggers of granule formation in megakaryocytes and platelets","volume":"120","author":"Kahr","year":"2012","journal-title":"Blood"},{"key":"B44","doi-asserted-by":"publisher","first-page":"9060143","DOI":"10.1155\/2016\/9060143","article-title":"Platelet activation: The mechanisms and potential biomarkers","author":"Yun","year":"2016","journal-title":"BioMed Res Int"},{"key":"B45","unstructured":"The Clotting Cascade | Nbdf\n          \n          \n          \n          2026"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-12-1067","article-title":"The role of platelets in inflammation","volume":"114","author":"Thomas","year":"2015","journal-title":"Thromb Haemost"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.11.036","article-title":"Platelets and primary haemostasis","volume":"129","author":"Clemetson","year":"2012","journal-title":"Thromb Res"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201304054","article-title":"The incredible journey: From megakaryocyte development to platelet formation","volume":"201","author":"Machlus","year":"2013","journal-title":"J Cell Biol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00077","article-title":"Platelet granule exocytosis: a comparison with chromaffin cells","volume":"4","author":"Fitch-Tewfik","year":"2013","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B50","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1152\/physrev.1982.62.1.185","article-title":"Human platelet size, shape, and related functions in health and disease","volume":"62","author":"Frojmovic","year":"1982","journal-title":"Physiol Rev"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000053559.46158.ad","article-title":"Inhibitory effects of glycoprotein IIb\/IIIa antagonists and aspirin on the release of soluble CD40 ligand during platelet stimulation","volume":"107","author":"Nannizzi-Alaimo","year":"2003","journal-title":"Circulation"},{"key":"B52","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/pl00000776","article-title":"The CD40\/CD154 receptor\/ligand dyad","volume":"58","author":"Sch\u00f6nbeck","year":"2001","journal-title":"Cell Mol Life Sci"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3390\/ijms151222342","article-title":"The signaling role of CD40 ligand in platelet biology and in platelet component transfusion","volume":"15","author":"Aloui","year":"2014","journal-title":"Int J Mol Sci"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/35393","article-title":"CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells","volume":"391","author":"Henn","year":"1998","journal-title":"Nature"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.825892","article-title":"Platelets as key factors in inflammation: Focus on CD40L\/CD40","volume":"13","author":"Cognasse","year":"2022","journal-title":"Front Immunol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/s1050-1738(01)00142-6","article-title":"CD40-CD40L interactions in atherosclerosis","volume":"12","author":"Lutgens","year":"2002","journal-title":"Trends Cardiovasc Med"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000070111.98158.6C","article-title":"CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation","volume":"92","author":"Inwald","year":"2003","journal-title":"Circ Res"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.4.2011","article-title":"Cutting edge: T cells trigger CD40-dependent platelet activation and granular RANTES release: a novel pathway for immune response amplification","volume":"172","author":"Danese","year":"2004","journal-title":"J Immunol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1002\/path.1425","article-title":"CD40 ligand is selectively expressed on CD4+ T cells and platelets: implications for CD40-CD40L signalling in atherosclerosis","volume":"201","author":"B\u00fcchner","year":"2003","journal-title":"J Pathol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/s1074-7613(03)00177-8","article-title":"Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments","volume":"19","author":"Elzey","year":"2003","journal-title":"Immunity"},{"key":"B61","doi-asserted-by":"publisher","first-page":"9466","DOI":"10.1038\/s41598-018-27710-9","article-title":"CXCL4\/Platelet factor 4 is an agonist of CCR1 and drives human monocyte migration","volume":"8","author":"Fox","year":"2018","journal-title":"Sci Rep"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.4.1158.004k31_1158_1166","article-title":"The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages","volume":"95","author":"Scheuerer","year":"2000","journal-title":"Blood"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.4.2584","article-title":"Platelet factor 4 (CXC chemokine ligand 4) differentially regulates respiratory burst, survival, and cytokine expression of human monocytes by using distinct signaling pathways","volume":"179","author":"Kasper","year":"2007","journal-title":"J Immunol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.1.134","article-title":"Platelet-derived interleukin-1 induces cytokine production, but not proliferation of human vascular smooth muscle cells","volume":"91","author":"Loppnow","year":"1998","journal-title":"Blood"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200105058","article-title":"Activated platelets mediate inflammatory signaling by regulated interleukin 1\u03b2 synthesis","volume":"154","author":"Lindemann","year":"2001","journal-title":"J Cell Biol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.5AB0521-621RR","article-title":"Decreased levels of immune-regulatory cytokines in patients with immune thrombocytopenia and long-lasting overexpression of these cytokines in the splenectomized patients","volume":"110","author":"Wang","year":"2021","journal-title":"J Leukoc Biol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1048.2002.03345.x","article-title":"Reduced transforming growth factor-\u03b21 production by mononuclear cells from patients with active chronic idiopathic thrombocytopenic purpura","volume":"116","author":"Andersson","year":"2002","journal-title":"Br J Haematol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000966","article-title":"American Society of Hematology 2019 guidelines for immune thrombocytopenia","volume":"3","author":"Neunert","year":"2019","journal-title":"Blood Adv"},{"key":"B69","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1182\/blood.2023022738","article-title":"Platelet-derived TGF-\u03b21 induces functional reprogramming of myeloid-derived suppressor cells in immune thrombocytopenia","volume":"144","author":"Wang","year":"2024","journal-title":"Blood"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.317119","article-title":"\u03b22M signals monocytes through non-canonical TGF\u03b2 receptor signal transduction","volume":"128","author":"Hilt","year":"2021","journal-title":"Circ Res"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.122943","article-title":"Platelet-derived \u03b22M regulates monocyte inflammatory responses","volume":"4","author":"Hilt","year":"2019","journal-title":"JCI Insight"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/742719","article-title":"Platelet function in patients with diabetes mellitus: From a theoretical to a practical perspective","volume":"2011","author":"Kakouros","year":"2011","journal-title":"Int J Endocrinol"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6404438","article-title":"Understanding the activation of platelets in diabetes and its modulation by allyl methyl sulfide, an active metabolite of garlic","volume":"2021","author":"Malladi","year":"2021","journal-title":"J Diabetes Res"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2026.109626","article-title":"Obesity and type 2 diabetes mellitus add up to induce platelet hyperreactivity and platelet activation","volume":"259","author":"Guglielmini","year":"2026","journal-title":"Thromb Res"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2026.02.002","article-title":"Platelet activation and platelet-monocyte interaction amplify thromboinflammation in obesity through adhesion molecules and endothelial IL-1R signaling","volume":"24","author":"Dib","year":"2026","journal-title":"J Thromb Haemostasis"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/834153","article-title":"Platelet counts and platelet activation markers in obese subjects","volume":"2008","author":"Samocha-Bonet","year":"2008","journal-title":"Mediators Inflammation"},{"key":"B77","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.thromres.2022.10.008","article-title":"Obesity: Effects on bone marrow homeostasis and platelet activation","volume":"231","author":"Vauclard","year":"2023","journal-title":"Thromb Res"},{"key":"B78","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.bcmd.2008.07.003","article-title":"Platelet function in hypertension","volume":"42","author":"El Haouari","year":"2009","journal-title":"Blood Cells Mol Dis"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2009.247","article-title":"Platelet activation in essential hypertension: Implications for antiplatelet treatment","volume":"23","author":"Gkaliagkousi","year":"2010","journal-title":"Am J Hypertens"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1999.tb01288.x","article-title":"Platelet hyperactivity in hypertensive older patients is controlled by lowering blood pressure","volume":"47","author":"Riondino","year":"1999","journal-title":"J Am Geriatrics Soc"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.317959","article-title":"Hyperglycemia in acute ischemic stroke: Physiopathological and therapeutic complexity","volume":"17","author":"Ferrari","year":"2021","journal-title":"Neural Regener Res"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000115297.92132.84","article-title":"Hyperglycemia in acute stroke","volume":"35","author":"Lindsberg","year":"2004","journal-title":"Stroke"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.9346","article-title":"Intensive vs standard treatment of hyperglycemia and functional outcome in patients with acute ischemic stroke: The SHINE randomized clinical trial","volume":"322","author":"Johnston","year":"2019","journal-title":"JAMA"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15154","article-title":"Hyperglycemia exacerbates ischemic stroke outcome independent of platelet glucose uptake","volume":"19","author":"Denorme","year":"2021","journal-title":"J Thromb Haemostasis"},{"key":"B85","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s40842-025-00247-3","article-title":"Chronic hyperglycemia and cardiovascular dysfunction: An in-depth exploration of metabolic and cellular pathways in type 2 diabetes mellitus","volume":"11","author":"Hussain","year":"2025","journal-title":"Cardiovasc Diabetol Endocrinol Rep"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.065090","article-title":"Addressing cardiovascular risk in diabetes: It\u2019s more than the sugar","volume":"147","author":"Ozkan","year":"2023","journal-title":"Circulation"},{"key":"B87","first-page":"2200","article-title":"Diabetes: Hyperglycemia and cardiovascular risk","volume":"71","author":"Sadovsky","year":"2005","journal-title":"AFP"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.2337\/dcS13-2044","article-title":"Cardiovascular importance of hyperglycemia and hypoglycemia","volume":"36","author":"Tk\u00e1\u010d","year":"2013","journal-title":"Diabetes Care"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2013.37.6.423","article-title":"Clinical marker of platelet hyperreactivity in diabetes mellitus","volume":"37","author":"Kim","year":"2013","journal-title":"Diabetes Metab J"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1352-4","article-title":"Enhanced P-selectin expression and increased soluble CD40 ligand in patients with type 1 diabetes mellitus and microangiopathy: Evidence for platelet hyperactivity and chronic inflammation","volume":"47","author":"Yngen","year":"2004","journal-title":"Diabetologia"},{"key":"B91","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/s0049-3848(01)00348-6","article-title":"Insulin enhances platelet activation in vitro","volume":"104","author":"Yngen","year":"2001","journal-title":"Thromb Res"},{"key":"B92","unstructured":"Diabetes, Heart Disease, & Stroke - Niddk\n          \n          \n          \n          2026"},{"key":"B93","doi-asserted-by":"publisher","first-page":"e984","DOI":"10.1161\/CIR.0000000000000973","article-title":"Obesity and cardiovascular disease","volume":"143","author":"Powell-Wiley","year":"2021","journal-title":"Circulation"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.99863","article-title":"Hypertension and risk of stroke: A systematic review and meta-analysis","volume":"17","author":"Mohammad","year":"2023","journal-title":"Cureus"},{"key":"B95","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.cmet.2012.11.012","article-title":"Vascular complications of diabetes: Mechanisms of injury and protective factors","volume":"17","author":"Rask-Madsen","year":"2013","journal-title":"Cell Metab"},{"key":"B96","unstructured":"Diabetes and Your Heart\n          \n          \n          \n          2024"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000116389.61864.DE","article-title":"Cardiovascular events in diabetic and nondiabetic adults with or without history of myocardial infarction","volume":"109","author":"Lee","year":"2004","journal-title":"Circulation"},{"key":"B98","doi-asserted-by":"crossref","DOI":"10.1017\/UPO9781922064004.012","article-title":"Platelets in the pathogenesis of vascular disease and their role as a therapeutic target","volume-title":"Mechanisms of Vascular Disease: A Reference Book for Vascular Specialists","author":"Prabhu","year":"2011"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.3390\/cells11061014","article-title":"Platelets, a key cell in inflammation and atherosclerosis progression","volume":"11","author":"Huilcaman","year":"2022","journal-title":"Cells"},{"key":"B100","unstructured":"Arteriosclerosis \/ Atherosclerosis - Symptoms and Causes\n          \n          \n          \n          2026"},{"key":"B101","unstructured":"Atherosclerosis - What is Atherosclerosis\n          \n          \n          NHLBI, NIH\n          \n          2024"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2019.00132","article-title":"Platelets are at the nexus of vascular diseases","volume":"6","author":"Lebas","year":"2019","journal-title":"Front Cardiovasc Med"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.06.004","article-title":"Neutrophil and platelet complexes and their relevance to neutrophil recruitment and activation","volume":"17","author":"Page","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2018.1430358","article-title":"Measuring and interpreting platelet-leukocyte aggregates","volume":"29","author":"Finsterbusch","year":"2018","journal-title":"Platelets"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.04.005","article-title":"Macrophages in the pathogenesis of atherosclerosis","volume":"145","author":"Moore","year":"2011","journal-title":"Cell"},{"key":"B106","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/nrcardio.2009.228","article-title":"Monocytes in atherosclerosis: subsets and functions","volume":"7","author":"Woollard","year":"2010","journal-title":"Nat Rev Cardiol"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02711.x","article-title":"Platelet and leukocyte activation, atherosclerosis and inflammation in European and South Asian men","volume":"5","author":"Dotsenko","year":"2007","journal-title":"J Thromb Haemost"},{"key":"B108","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1053\/ejvs.2002.1795","article-title":"The role of platelets in peripheral vascular disease","volume":"25","author":"Cassar","year":"2003","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/s0008-6363(97)00033-3","article-title":"Circulating transforming growth factor beta 1 and coronary artery disease","volume":"34","author":"Wang","year":"1997","journal-title":"Cardiovasc Res"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1007\/s10016-001-0159-8","article-title":"The role of platelets in peripheral arterial disease: therapeutic implications","volume":"16","author":"Matsagas","year":"2002","journal-title":"Ann Vasc Surg"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(79)90154-1","article-title":"Role of blood platelets in coronary artery disease","volume":"43","author":"Haft","year":"1979","journal-title":"Am J Cardiol"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.09.026","article-title":"Platelet dysfunction in vascular pathologies and how can it be treated","volume":"129","author":"Alexandru","year":"2012","journal-title":"Thromb Res"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000001232","article-title":"Diagnosis and management of cerebral small vessel disease","volume":"29","author":"Sharrief","year":"2023","journal-title":"Continuum (Minneap Minn)"},{"key":"B114","unstructured":"What is cerebral small vessel disease\n          \n          \n          American Brain Foundation"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007654","article-title":"CNS small vessel disease","volume":"92","author":"Cannistraro","year":"2019","journal-title":"Neurology"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.70771","article-title":"Association between platelet and cerebral small vessel disease: a secondary analysis based on a retrospective cross\u2010sectional study in Korean adults","volume":"15","author":"Huang","year":"2025","journal-title":"Brain Behav"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e328340147c","article-title":"Activation of platelets and cellular coagulation in cerebral small-vessel disease","volume":"21","author":"Oberheiden","year":"2010","journal-title":"Blood Coagul Fibrinolysis"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.595463","article-title":"Pathomechanisms of HIV-associated cerebral small vessel disease: a comprehensive clinical and neuroimaging protocol and analysis pipeline","volume":"11","author":"Murray","year":"2020","journal-title":"Front Neurol"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.17863\/CAM.50869","article-title":"Blood-brain barrier permeability and inflammation in cerebral small vessel disease","author":"Walsh","year":"2020"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2013.84","article-title":"Associations between surface markers on blood monocytes and carotid atherosclerosis in HIV-positive individuals","volume":"92","author":"Westhorpe","year":"2014","journal-title":"Immunol Cell Biol"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302318","article-title":"Characterization of platelet-monocyte complexes in HIV-1-infected individuals: possible role in HIV-associated neuroinflammation","volume":"192","author":"Singh","year":"2014","journal-title":"J Immunol"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1405431","article-title":"Non-classical monocyte levels correlate negatively with HIV-associated cerebral small vessel disease and cognitive performance","volume":"14","author":"Singh","year":"2024","journal-title":"Front Cell Infect Microbiol"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.3390\/life14050545","article-title":"Vascular alterations following COVID-19 infection: a comprehensive literature review","volume":"14","author":"Karakasis","year":"2024","journal-title":"Life (Basel)"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-024-02208-x","article-title":"Sustained vascular inflammatory effects of SARS-CoV-2 spike protein on human endothelial cells","volume":"48","author":"Gultom","year":"2025","journal-title":"Inflammation"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf430","article-title":"Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study","volume":"46","author":"Bruno","year":""},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvssci.2024.100278","article-title":"The impact of platelets and antiplatelets medications on immune mediation","volume":"6","author":"Morena","year":"2025","journal-title":"JVS-Vascular Sci"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26010049","article-title":"Complex pattern of platelet activation\/reactivity after SARS-CoV-2 infection","volume":"26","author":"Luzak","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.317703","article-title":"Platelets can associate with SARS-CoV-2 RNA and are hyperactivated in COVID-19","volume":"127","author":"Zaid","year":"2020","journal-title":"Circ Res"},{"key":"B129","unstructured":"Long COVID\n          \n          \n          Cdc\n          \n          2026"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.4082\/kjfm.24.0085","article-title":"Long COVID: a comprehensive overview of the signs and symptoms across multiple organ systems","volume":"45","author":"Merhavy","year":"2024","journal-title":"Korean J Fam Med"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106935","article-title":"Biological mechanisms underpinning the development of long COVID","volume":"26","author":"Perumal","year":"2023","journal-title":"iScience"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2025.103882","article-title":"Chronic inflammation in long COVID relationship to autoimmune diseases","volume":"24","author":"Chen","year":"2025","journal-title":"Autoimmun Rev"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-01778-0","article-title":"Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease","volume":"25","author":"Liew","year":"2024","journal-title":"Nat Immunol"},{"key":"B134","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/s41590-025-02353-x","article-title":"Long COVID involves activation of proinflammatory and immune exhaustion pathways","volume":"27","author":"Aid","year":"2026","journal-title":"Nat Immunol"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X231224383","article-title":"Dysregulated platelet function in patients with postacute sequelae of COVID-19","volume":"29","author":"Aggarwal","year":"2024","journal-title":"Vasc Med"},{"key":"B136","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.jacbts.2024.09.007","article-title":"Low-grade inflammation in long COVID syndrome sustains a persistent platelet activation associated with lung impairment","volume":"10","author":"Brambilla","year":"2025","journal-title":"JACC: Basic to Trans Sci"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.321659","article-title":"Persisting platelet activation and hyperactivity in COVID-19 survivors","volume":"131","author":"Martins-Gon\u00e7alves","year":"2022","journal-title":"Circ Res"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000004470","article-title":"Circulating activated platelets in children with long COVID: a case-controlled preliminary observation","volume":"43","author":"Buonsenso","year":"2024","journal-title":"Pediatr Infect Dis J"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abh2434","article-title":"Platelets amplify endotheliopathy in COVID-19","volume":"7","author":"Barrett","year":"2021","journal-title":"Sci Adv"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1126\/science.adg7942","article-title":"Persistent complement dysregulation with signs of thromboinflammation in active long Covid","volume":"383","author":"Cervia-Hasler","year":"2024","journal-title":"Science"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12709","article-title":"Platelet\u2010leukocyte interactions in COVID\u201019: contributions to hypercoagulability, inflammation, and disease severity","volume":"6","author":"Hottz","year":"2022","journal-title":"Res Pract Thromb Haemostasis"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1498491","article-title":"Unveiling the hidden link: elevated platelets and T cell subsets in 5% of moderate COVID-19 patients 48 days post-onset","volume":"14","author":"An","year":"2024","journal-title":"Front Cell Infect Microbiol"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2022.03.022","article-title":"Platelet-leukocyte crosstalk in COVID-19: how might the reciprocal links between thrombotic events and inflammatory state affect treatment strategies and disease prognosis","volume":"213","author":"Ghasemzadeh","year":"2022","journal-title":"Thromb Res"},{"key":"B144","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1186\/s12916-020-01801-9","article-title":"Platelet activation in adult HIV-infected patients on antiretroviral therapy: a systematic review and meta-analysis","volume":"18","author":"Nkambule","year":"2020","journal-title":"BMC Med"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.3390\/v11030200","article-title":"Immune activation, inflammation, and non-AIDS co-morbidities in HIV-infected patients under long-term ART","volume":"11","author":"Zicari","year":"2019","journal-title":"Viruses"},{"key":"B146","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s11904-017-0356-x","article-title":"Inflammation, immune activation, and antiretroviral therapy in HIV","volume":"14","author":"Hileman","year":"2017","journal-title":"Curr HIV\/AIDS Rep"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14589","article-title":"Pharmacological impact of antiretroviral therapy on platelet function to investigate human immunodeficiency virus\u2010associated cardiovascular risk","volume":"176","author":"Taylor","year":"2019","journal-title":"Br J Pharmacol"},{"key":"B148","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.thromres.2018.07.003","article-title":"The HIV protease inhibitor, ritonavir, dysregulates human platelet function in vitro","volume":"169","author":"Loelius","year":"2018","journal-title":"Thromb Res"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty","volume":"15","author":"Ferrucci","year":"2018","journal-title":"Nat Rev Cardiol"},{"key":"B150","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1111\/cei.12814","article-title":"Ageing and inflammation in patients with HIV infection","volume":"187","author":"Nasi","year":"2017","journal-title":"Clin Exp Immunol"},{"key":"B151","article-title":"HIV and inflamm-aging: How do we reach the summit of healthy aging","volume":"32","author":"Sheets","year":"2024"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging. An evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"B153","article-title":"Aging, inflammation, and HIV infection","volume":"20","author":"Aberg","year":"2016","journal-title":"Top Antivir Med"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.124.323891","article-title":"Inflammation in HIV and its impact on atherosclerotic cardiovascular disease","volume":"134","author":"Obare","year":"2024","journal-title":"Circ Res"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000035652","article-title":"HIV-related neurocognitive disorders: Diagnosis, treatment, and mental health implications: A review","volume":"102","author":"Elendu","year":"2023","journal-title":"Med (Baltimore)"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32834695fb","article-title":"Current understanding of HIV-associated neurocognitive disorders pathogenesis","volume":"24","author":"Gannon","year":"2011","journal-title":"Curr Opin Neurol"},{"key":"B157","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1186\/s12982-025-00608-4","article-title":"Osteoporosis and fracture risk among individuals with HIV: A systematic review and meta-analysis","volume":"22","author":"Afraie","year":"2025","journal-title":"Discov Public Health"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1584022","article-title":"The unexplored relationship between spontaneous osteoclastogenesis and platelets in osteoporosis","volume":"12","author":"Salamanna","year":"2025","journal-title":"Front Med"},{"key":"B159","unstructured":"The role of platelet-activating factor in chronic inflammation, immune activation, and comorbidities associated with HIV infection\n          \n          \n            \n              Fragopoulou\n              E\n            \n            \n              Chini\n              M\n            \n            \n              Lazanas\n              MC\n            \n            \n              Detopoulou\n              P\n            \n            \n              Antonopoulou\n              S\n            \n            \n              Kelesidis\n              T\n            \n          \n          Aids Reviews\n          \n          2015"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25094697","article-title":"HIV-associated neurocognitive disorder: A look into cellular and molecular pathology","volume":"25","author":"Thompson","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B161","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1093\/cid\/ciae609","article-title":"HIV is associated with subclinical coronary atherosclerosis: A prospective matched cohort study","volume":"81","author":"Knudsen","year":"2025","journal-title":"Clin Infect Dis"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1621765","article-title":"Persistent inflammatory activation in people living with HIV. Involvement in atherosclerosis","volume":"12","author":"Illanes-\u00c1lvarez","year":"2025","journal-title":"Front Med (Lausanne)"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002420","article-title":"Platelets function as an acute viral reservoir during HIV-1 infection by harboring virus and T-cell complex formation","volume":"4","author":"Simpson","year":"2020","journal-title":"Blood Adv"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.21.8321","article-title":"Transforming growth factor beta and noncytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection","volume":"87","author":"Kekow","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"B165","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s12929-018-0490-9","article-title":"The effects of highly active antiretroviral therapy on the serum levels of pro-inflammatory and anti-inflammatory cytokines in HIV infected subjects","volume":"25","author":"Osuji","year":"2018","journal-title":"J BioMed Sci"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115196","article-title":"Association of circulating receptor Fc gamma RIII-positive monocytes in AIDS patients with elevated levels of transforming growth factor-beta","volume":"87","author":"Allen","year":"1991","journal-title":"J Clin Invest"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1016\/s0046-8177(96)90392-5","article-title":"Distribution of transforming growth factor-beta isoforms in human immunodeficiency virus-1 encephalitis","volume":"27","author":"Johnson","year":"1996","journal-title":"Hum Pathol"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.215","article-title":"Renal TGF-beta in HIV-associated kidney diseases","volume":"51","author":"B\u00f3di","year":"1997","journal-title":"Kidney Int"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.3390\/cells10040806","article-title":"Enhanced intestinal TGF-\u03b2\/SMAD-dependent signaling in simian immunodeficiency virus infected rhesus macaques","volume":"10","author":"Boby","year":"2021","journal-title":"Cells"},{"key":"B170","year":""},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003977","article-title":"Aspirin and antiplatelet treatments in cancer","volume":"137","author":"Tao","year":"2021","journal-title":"Blood"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23163","article-title":"Preoperative thrombocytosis is associated with survival after surgery for colorectal cancer","volume":"106","author":"Ishizuka","year":"2012","journal-title":"J Surg Oncol"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09091826","article-title":"Prognostic significance of thrombocytosis in patients with primary lung cancer","volume":"9","author":"Pedersen","year":"1996","journal-title":"Eur Respir J"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110352","article-title":"Paraneoplastic thrombocytosis in ovarian cancer","volume":"366","author":"Stone","year":"2012","journal-title":"N Engl J Med"},{"key":"B175","doi-asserted-by":"publisher","first-page":"023001","DOI":"10.1088\/2057-1739\/aa6c05","article-title":"Platelet count as a predictor of metastasis and venous thromboembolism in patients with cancer","volume":"3","author":"Sylman","year":"2017","journal-title":"Converg Sci Phys Oncol"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1267\/THRO03061098","article-title":"Impact of pretreatment thrombocytosis on survival in primary breast cancer","volume":"89","author":"Taucher","year":"2003","journal-title":"Thromb Haemost"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0216","article-title":"Identification of luminal breast cancers that establish a tumor-supportive macroenvironment defined by proangiogenic platelets and bone marrow-derived cells","volume":"2","author":"Kuznetsov","year":"2012","journal-title":"Cancer Discov"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.09.009","article-title":"Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis","volume":"20","author":"Labelle","year":"2011","journal-title":"Cancer Cell"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1411082111","article-title":"Platelets guide the formation of early metastatic niches","volume":"111","author":"Labelle","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v96.5.1789","article-title":"Immobilized platelets support human colon carcinoma cell tethering, rolling, and firm adhesion under dynamic flow conditions","volume":"96","author":"McCarty","year":"2000","journal-title":"Blood"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-1872","article-title":"Platelet-derived MHC class I confers a pseudonormal phenotype to cancer cells that subverts the antitumor reactivity of natural killer immune cells","volume":"72","author":"Placke","year":"2012","journal-title":"Cancer Res"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.321861","article-title":"Mechanism of tumor-platelet communications in cancer","volume":"132","author":"Dudiki","year":"2023","journal-title":"Circ Res"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.04131.x","article-title":"The platelet contribution to cancer progression","volume":"9","author":"Bambace","year":"2011","journal-title":"J Thromb Haemostasis"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-023-02184-3","article-title":"TGF\u03b2 carrying exosomes in plasma: Potential biomarkers of cancer progression in patients with head and neck squamous cell carcinoma","volume":"128","author":"Ludwig","year":"2023","journal-title":"Br J Cancer"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-019-0082-5","article-title":"A plasma protein derived TGF\u03b2 signature is a prognostic indicator in triple negative breast cancer","volume":"3","author":"Katayama","year":"2019","journal-title":"NPJ Precis Oncol"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1038\/359693a0","article-title":"Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease","volume":"359","author":"Shull","year":"1992","journal-title":"Nature"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.10.6413","article-title":"Genetic regulation of autoimmune disease: BALB\/c background TGF-beta 1-deficient mice develop necroinflammatory IFN-gamma-dependent hepatitis","volume":"166","author":"Gorham","year":"2001","journal-title":"J Immunol"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2007.02.024","article-title":"TGF-\u03b21 inhibition of IFN-\u03b3-induced signaling and Th1 gene expression in CD4+ T cells is Smad3 independent but MAP kinase dependent","volume":"44","author":"Park","year":"2007","journal-title":"Mol Immunol"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20012076","article-title":"Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation","volume":"195","author":"Gorelik","year":"2002","journal-title":"J Exp Med"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.9.5666","article-title":"TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1","volume":"175","author":"Park","year":"2005","journal-title":"J Immunol"},{"key":"B191","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/82_2010_96","article-title":"The role of IL-10 in regulating immunity to persistent viral infections","volume":"350","author":"Wilson","year":"2011","journal-title":"Curr Top Microbiol Immunol"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000288","article-title":"TGF-\u03b2 enhances effector Th1 cell activation but promotes self-regulation via IL-10","volume":"184","author":"Huss","year":"2010","journal-title":"J Immunol"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01364","article-title":"Transforming growth factor-\u03b2 and interleukin-10 synergistically regulate humoral immunity via modulating metabolic signals","volume":"9","author":"Komai","year":"2018","journal-title":"Front Immunol"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2014.45","article-title":"Regulatory T cells and immune regulation of allergic diseases: Roles of IL-10 and TGF-\u03b2","volume":"15","author":"Palomares","year":"2014","journal-title":"Genes Immun"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1038\/srep42186","article-title":"A critical role of platelet TGF-\u03b2 release in podoplanin-mediated tumour invasion and metastasis","volume":"7","author":"Takemoto","year":"2017","journal-title":"Sci Rep"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.7150\/jca.103757","article-title":"TGF-\u03b2 secreted by cancer cells-platelets interaction activates cancer metastasis potential by inducing metabolic reprogramming and bioenergetic adaptation","volume":"16","author":"Zhong","year":"2025","journal-title":"J Cancer"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12123653","article-title":"Platelet-derived GARP induces peripheral regulatory T cells\u2014potential impact on T cell suppression in patients with melanoma-associated thrombocytosis","volume":"12","author":"Zimmer","year":"2020","journal-title":"Cancers (Basel)"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1111\/febs.70279","article-title":"TGF\u03b2 enhances platelet\u2013breast-cancer-cell interaction and promotes platelet aggregation","volume":"293","author":"Genitoni","year":"2026","journal-title":"FEBS J"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12464","article-title":"Platelets promote osteosarcoma cell growth through activation of the platelet-derived growth factor receptor-Akt signaling axis","volume":"105","author":"Takagi","year":"2014","journal-title":"Cancer Sci"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.2147\/BCTT.S135665","article-title":"High glucose levels promote the proliferation of breast cancer cells through GTPases","volume":"9","author":"Hou","year":"2017","journal-title":"Breast Cancer (Dove Med Press)"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027074","article-title":"High glucose promotes pancreatic cancer cell proliferation via the induction of EGF expression and transactivation of EGFR","volume":"6","author":"Han","year":"2011","journal-title":"PloS One"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3537","article-title":"Platelet-derived TGF-\u03b2 induces tissue factor expression via the Smad3 pathway in osteosarcoma cells","volume":"33","author":"Saito","year":"2018","journal-title":"J Bone Miner Res"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aai7911","article-title":"Platelets subvert T cell immunity against cancer via GARP-TGF\u03b2 axis","volume":"2","author":"Rachidi","year":"2017","journal-title":"Sci Immunol"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2012.02.005","article-title":"Detection of circulating platelet-monocyte complexes in persons infected with human immunodeficiency virus type-1","volume":"181","author":"Singh","year":"2012","journal-title":"J Virol Methods"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2014.66","article-title":"Higher levels of circulating monocyte-platelet aggregates are correlated with viremia and increased sCD163 levels in HIV-1 infection","volume":"12","author":"Liang","year":"2015","journal-title":"Cell Mol Immunol"},{"key":"B206","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1186\/s12967-025-06591-3","article-title":"Over-activation and dysfunction of platelet-NK cell aggregates in HIV-infected individuals","volume":"23","author":"Deng","year":"2025","journal-title":"J Transl Med"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.799124","article-title":"Increased platelet-CD4+ T cell aggregates are correlated with HIV-1 permissiveness and CD4+ T cell loss","volume":"12","author":"Dai","year":"2021","journal-title":"Front Immunol"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-433946","article-title":"Shared monocyte subset phenotypes in HIV-1 infection and in uninfected subjects with acute coronary syndrome","volume":"120","author":"Funderburg","year":"2012","journal-title":"Blood"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3A0620-460RR","article-title":"Monocytes complexed to platelets differentiate into functionally deficient dendritic cells","volume":"109","author":"Singh","year":"2021","journal-title":"J Leukocyte Biol"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1738092","article-title":"Double, double toil and trouble: transforming growth factor beta (TGF-\u03b2) in HIV infection","volume":"16","author":"Harrison-Gleason","year":"2025","journal-title":"Front Immunol"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1093\/jimmun\/vkaf283.1485","article-title":"Combinatorial action of TGF\u03b2 and IL-10 induces monocyte and monocyte-derived dendritic cell dysfunction in people living with HIV 3717","volume":"214","author":"Karli Sutton","year":"2025","journal-title":"J Immunol"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.3390\/jdb4020021","article-title":"Signalling by transforming growth factor beta isoforms in wound healing and tissue regeneration","volume":"4","author":"Gilbert","year":"2016","journal-title":"J Dev Biol"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1038\/nature07039","article-title":"Wound repair and regeneration","volume":"453","author":"Gurtner","year":"2008","journal-title":"Nature"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2011.00089","article-title":"Transforming growth factor-\u03b2 and endoglin signaling orchestrate wound healing","volume":"2","author":"Valluru","year":"2011","journal-title":"Front Physiol"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.147.5.1600","article-title":"Type I transforming growth factor-beta receptors on neutrophils mediate chemotaxis to transforming growth factor-beta","volume":"147","author":"Brandes","year":"1991","journal-title":"J Immunol"},{"key":"B216","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev.immunol.24.021605.090737","article-title":"Transforming growth factor-beta regulation of immune responses","volume":"24","author":"Li","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.15.6805","article-title":"Transforming growth factor beta 1, a potent chemoattractant for human neutrophils, bypasses classic signal-transduction pathways","volume":"88","author":"Reibman","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2011.01.001","article-title":"Macrophages in skin injury and repair","volume":"216","author":"Mahdavian Delavary","year":"2011","journal-title":"Immunobiology"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.16.5788","article-title":"Transforming growth factor type beta induces monocyte chemotaxis and growth factor production","volume":"84","author":"Wahl","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"B220","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/s0006-291x(88)80319-x","article-title":"Transforming growth factor-beta (TGF beta) is chemotactic for human monocytes and induces their expression of angiogenic activity","volume":"157","author":"Wiseman","year":"1988","journal-title":"Biochem Biophys Res Commun"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2013.0466","article-title":"The role of TGF\u03b2 signaling in wound epithelialization","volume":"3","author":"Ramirez","year":"2014","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"B222","first-page":"18","article-title":"The role of the TGF-\u03b2 family in wound healing, burns and scarring: a review","volume":"2","author":"Penn","year":"2012","journal-title":"Int J Burns Trauma"},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.12.4167","article-title":"Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro","volume":"83","author":"Roberts","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1996.01890140057011","article-title":"Transforming growth factor beta 1 improves wound healing and random flap survival in normal and irradiated rats","volume":"122","author":"Nall","year":"1996","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"B225","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1159\/000339613","article-title":"Wound repair and regeneration","volume":"49","author":"Reinke","year":"2012","journal-title":"Eur Surg Res"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700613","article-title":"Formation and function of the myofibroblast during tissue repair","volume":"127","author":"Hinz","year":"2007","journal-title":"J Invest Dermatol"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-1273rev","article-title":"TGF-beta signaling and the fibrotic response","volume":"18","author":"Leask","year":"2004","journal-title":"FASEB J"},{"key":"B228","unstructured":"Wound healing phases\n          \n          \n            \n              Wallace\n              HA\n            \n            \n              Basehore\n              BM\n            \n            \n              Zito\n              PM\n            \n          \n          Treasure Island (FL)\n          StatPearls Publishing\n          Statpearls [Internet]\n          \n          2026"},{"key":"B229","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/s41580-024-00715-1","article-title":"Cellular and molecular mechanisms of skin wound healing","volume":"25","author":"Pe\u00f1a","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041237","article-title":"Epithelial-mesenchymal plasticity and endothelial-mesenchymal transition in cutaneous wound healing","volume":"15","author":"Vu","year":"2023","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e34269","article-title":"Epithelial-mesenchymal plasticity (EMP) in wound healing: Exploring EMT mechanisms, regulatory network, and therapeutic opportunities","volume":"10","author":"Yao","year":"2024","journal-title":"Heliyon"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2012.04.002","article-title":"Induction of epithelial-mesenchymal transition by transforming growth factor \u03b2","volume":"22","author":"Moustakas","year":"2012","journal-title":"Semin Cancer Biol"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209019200","article-title":"Epithelial to mesenchymal transition in Madin-Darby canine kidney cells is accompanied by down-regulation of Smad3 expression, leading to resistance to transforming growth factor-beta-induced growth arrest","volume":"278","author":"Nicol\u00e1s","year":"2003","journal-title":"J Biol Chem"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.1038\/12971","article-title":"Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response","volume":"1","author":"Ashcroft","year":"1999","journal-title":"Nat Cell Biol"},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509341798","article-title":"Acceleration of palatal wound healing in Smad3-deficient mice","volume":"88","author":"Jinno","year":"2009","journal-title":"J Dent Res"},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111192","article-title":"Temporal control of PDGFR\u03b1 regulates the fibroblast-to-myofibroblast transition in wound healing","volume":"40","author":"Yao","year":"2022","journal-title":"Cell Rep"},{"key":"B237","first-page":"75","article-title":"The role of myofibroblasts in wound healing, contraction and its clinical implications in cleft palate repair","volume":"7","author":"Chitturi","year":"2015","journal-title":"J Int Oral Health"},{"key":"B238","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S50046","article-title":"Fibroblasts and myofibroblasts in wound healing","volume":"7","author":"Darby","year":"2014","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"B239","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.451336","article-title":"Transforming growth factor-\u03b21 (TGF-\u03b21)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts","volume":"288","author":"Midgley","year":"2013","journal-title":"J Biol Chem"},{"key":"B240","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1097\/BOR.0000000000000963","article-title":"The contribution of endothelial cells to tissue fibrosis","volume":"36","author":"Romano","year":"2024","journal-title":"Curr Opin Rheumatol"},{"key":"B241","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-022-00887-5","article-title":"EndMT: New findings on the origin of myofibroblasts in endometrial fibrosis of intrauterine adhesions","volume":"20","author":"Xu","year":"2022","journal-title":"Reprod Biol Endocrinol"},{"key":"B242","doi-asserted-by":"publisher","DOI":"10.3390\/ijms262311724","article-title":"Endothelial-to-mesenchymal transition in health and disease: molecular insights and therapeutic implications","volume":"26","author":"Kim","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B243","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00021.2018","article-title":"Endothelial to mesenchymal transition: role in physiology and in the pathogenesis of human diseases","volume":"99","author":"Piera-Velazquez","year":"2019","journal-title":"Physiol Rev"},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2025.2483990","article-title":"TGF-\u03b2: elusive target in diabetic kidney disease","volume":"47","author":"Rani","year":"2025","journal-title":"Ren Fail"},{"key":"B245","doi-asserted-by":"publisher","DOI":"10.3390\/biom12030373","article-title":"Role of TGF-beta signaling in beta cell proliferation and function in diabetes","volume":"12","author":"Wang","year":"2022","journal-title":"Biomolecules"},{"key":"B246","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2019.11.010","article-title":"TGF-\u03b2 and diabetic nephropathy: lessons learned over the past 20 years","volume":"359","author":"Gewin","year":"2020","journal-title":"Am J Med Sci"},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200003000-00002","article-title":"Transcriptional regulation of transforming growth factor beta1 by glucose: investigation into the role of the hexosamine biosynthesis pathway","volume":"319","author":"Daniels","year":"2000","journal-title":"Am J Med Sci"},{"key":"B248","doi-asserted-by":"publisher","DOI":"10.1369\/0022155419849388","article-title":"Extracellular matrix in kidney fibrosis: More than just a scaffold","volume":"67","author":"B\u00fclow","year":"2019","journal-title":"J Histochem Cytochem"},{"key":"B249","doi-asserted-by":"publisher","first-page":"25338","DOI":"10.1038\/s41598-025-10143-6","article-title":"TGF\u03b21 accelerated the progression of diabetic nephropathy via up-regulating BRD4\/Notch1\/YAP signaling induced fibrosis and proliferation in fibroblasts","volume":"15","author":"Li","year":"2025","journal-title":"Sci Rep"},{"key":"B250","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2015.0635","article-title":"Challenges in the treatment of chronic wounds","volume":"4","author":"Frykberg","year":"2015","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"B251","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1186\/s12964-024-01623-9","article-title":"Targeting Wnt\/\u03b2-catenin signaling and its interplay with TGF-\u03b2 and Notch signaling pathways for the treatment of chronic wounds","volume":"22","author":"Gumede","year":"2024","journal-title":"Cell Commun Signal"},{"key":"B252","doi-asserted-by":"publisher","first-page":"265sr6","DOI":"10.1126\/scitranslmed.3009337","article-title":"Wound repair and regeneration: Mechanisms, signaling, and translation","volume":"6","author":"Eming","year":"2014","journal-title":"Sci Transl Med"},{"key":"B253","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","article-title":"Perspective article: Growth factors and cytokines in wound healing","volume":"16","author":"Barrientos","year":"2008","journal-title":"Wound Repair Regener"},{"key":"B254","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2013.132","article-title":"Expression of cytokines, growth factors and apoptosis-related signal molecules in chronic pressure ulcer wounds healing","volume":"52","author":"Jiang","year":"2014","journal-title":"Spinal Cord"},{"key":"B255","doi-asserted-by":"publisher","DOI":"10.3390\/ijms150916257","article-title":"FOXO1, TGF-\u03b2 regulation and wound healing","volume":"15","author":"Hameedaldeen","year":"2014","journal-title":"Int J Mol Sci"},{"key":"B256","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25168992","article-title":"OxInflammation affects transdifferentiation to myofibroblasts, prolonging wound healing in diabetes: A systematic review","volume":"25","author":"Silveira","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B257","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12954","article-title":"Diabetic wound healing: The impact of diabetes on myofibroblast activity and its potential therapeutic treatments","volume":"29","author":"Wan","year":"2021","journal-title":"Wound Repair Regener"},{"key":"B258","doi-asserted-by":"publisher","DOI":"10.1039\/c0mb00317d","article-title":"Impaired TGF-\u03b2 signaling and a defect in resolution of inflammation contribute to delayed wound healing in a female rat model of type 2 diabetes","volume":"7","author":"Al-Mulla","year":"2011","journal-title":"Mol Biosyst"},{"key":"B259","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpaic.2012.12.001","article-title":"Haemostasis, blood platelets and coagulation","author":"Jobling","year":"2013","journal-title":"Anaesthesia Intensive Care Med"},{"key":"B260","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4684-4880-1_8","article-title":"Secreted alpha granule proteins","volume-title":"Platelet Membrane Glycoproteins","author":"Mosher","year":"1985"},{"key":"B261","doi-asserted-by":"publisher","DOI":"10.1126\/science.2442813","article-title":"Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta","volume":"237","author":"Mustoe","year":"1987","journal-title":"Science"},{"key":"B262","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(91)90119-7","article-title":"Effect of topical recombinant TGF-beta on healing of partial thickness injuries","volume":"51","author":"Jones","year":"1991","journal-title":"J Surg Res"},{"key":"B263","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1242\/jcs.108.3.985","article-title":"Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring","volume":"108","author":"Shah","year":"1995","journal-title":"J Cell Sci"},{"key":"B264","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084753","article-title":"Effect of platelet lysate on human cells involved in different phases of wound healing","volume":"8","author":"Barsotti","year":"2013","journal-title":"PloS One"},{"key":"B265","doi-asserted-by":"publisher","DOI":"10.1155\/jdr\/1254597","article-title":"Mechanism of platelet\u2010rich plasma in promoting diabetic wound healing via the PI3K\/AKT signaling pathway to regulate collagen synthesis and angiogenesis","volume":"2026","author":"Liu","year":"2026","journal-title":"J Diabetes Res"},{"key":"B266","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1764429","article-title":"An in-vivo study of effects of platelet-rich plasma on transforming growth factor-\u03b21 and matrix metalloprotein 9 expression in traumatic ulcers with diabetes mellitus","volume":"18","author":"Radithia","year":"2024","journal-title":"Eur J Dent"},{"key":"B267","doi-asserted-by":"publisher","first-page":"79","DOI":"10.4142\/jvs.2016.17.1.79","article-title":"Effect of autologous platelet-rich plasma application on cutaneous wound healing in dogs","volume":"17","author":"Jee","year":"2016","journal-title":"J Vet Sci"},{"key":"B268","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010212","article-title":"Comparative analysis of different platelet lysates and platelet rich preparations to stimulate tendon cell biology: An in vitro study","volume":"19","author":"Klatte-Schulz","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B269","doi-asserted-by":"publisher","DOI":"10.1002\/term.3022","article-title":"Platelet\u2010derived transforming growth factor\u2010\u03b21 promotes keratinocyte proliferation in cutaneous wound healing","volume":"14","author":"Chong","year":"2020","journal-title":"J Tissue Eng Regener Med"},{"key":"B270","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.jacc.2018.09.089","article-title":"Endothelial to mesenchymal transition in cardiovascular disease: JACC state-of-the-art review","volume":"73","author":"Kovacic","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"B271","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008050513","article-title":"Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition","volume":"19","author":"Zeisberg","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"B272","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/s41419-022-04888-5","article-title":"Endothelial ETS1 inhibition exacerbate blood-brain barrier dysfunction in multiple sclerosis through inducing endothelial-to-mesenchymal transition","volume":"13","author":"Luo","year":"2022","journal-title":"Cell Death Dis"},{"key":"B273","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2020.03.020","article-title":"Platelets induce endothelial-mesenchymal transition and subsequent fibrogenesis in endometriosis","volume":"41","author":"Yan","year":"2020","journal-title":"Reprod BioMed Online"},{"key":"B274","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604662","article-title":"The role of endothelial-to-mesenchymal transition in cancer progression","volume":"99","author":"Potenta","year":"2008","journal-title":"Br J Cancer"},{"key":"B275","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008476","article-title":"Plasma levels of transforming growth factor-beta1 reflect left ventricular remodeling in aortic stenosis","volume":"4","author":"Villar","year":"2009","journal-title":"PloS One"},{"key":"B276","doi-asserted-by":"publisher","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis","volume":"13","author":"Zeisberg","year":"2007","journal-title":"Nat Med"},{"key":"B277","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.734550","article-title":"Endothelial to mesenchymal transition: An insight in atherosclerosis","volume":"8","author":"Huang","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"B278","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.065768","article-title":"Endothelial-to-mesenchymal transition contributes to accelerated atherosclerosis in Hutchinson-Gilford progeria syndrome","volume":"150","author":"Hamczyk","year":"2024","journal-title":"Circulation"},{"key":"B279","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.cellsig.2018.09.004","article-title":"TGF\u03b2, smooth muscle cells and coronary artery disease: A review","volume":"53","author":"Low","year":"2019","journal-title":"Cell Signal"},{"key":"B280","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000140739.45472.9c","article-title":"Increased expression of transforming growth factor-beta1 as a stabilizing factor in human atherosclerotic plaques","volume":"35","author":"Cipollone","year":"2004","journal-title":"Stroke"},{"key":"B281","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040990","article-title":"Overexpression of TGF-\u00df1 in macrophages reduces and stabilizes atherosclerotic plaques in ApoE-deficient mice","volume":"7","author":"Reifenberg","year":"2012","journal-title":"PloS One"},{"key":"B282","doi-asserted-by":"publisher","DOI":"10.1055\/a-2694-1383","article-title":"Platelet-specific TGF\u03b2 deficiency aggravates atherosclerosis, vascular inflammation, and hypercholesterolemia in mice","volume":"126","author":"Tan","year":"2026","journal-title":"Thromb Haemost"},{"key":"B283","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0219-9","article-title":"HIV infection and coronary heart disease: Mechanisms and management","volume":"16","author":"Hsue","year":"2019","journal-title":"Nat Rev Cardiol"},{"key":"B284","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.carpath.2007.12.011","article-title":"Coronary atherosclerotic lesions in human immunodeficiency virus-infected patients: A histopathologic study","volume":"18","author":"Micheletti","year":"2009","journal-title":"Cardiovasc Pathol"},{"key":"B285","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-011-1189-3","article-title":"Transforming growth factor-\u03b2 and atherosclerosis: Interwoven atherogenic and atheroprotective aspects","volume":"347","author":"Toma","year":"2012","journal-title":"Cell Tissue Res"},{"key":"B286","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.596841","article-title":"Dynamics of transforming growth factor (TGF)-\u03b2 superfamily cytokine induction during HIV-1 infection are distinct from other innate cytokines","volume":"11","author":"Dickinson","year":"2020","journal-title":"Front Immunol"},{"key":"B287","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2024.111397","article-title":"Platelets could be key regulators of epithelial\/endothelial-to- mesenchymal transition in atherosclerosis and wound healing","volume":"189","author":"Tian","year":"2024","journal-title":"Med Hypotheses"},{"key":"B288","doi-asserted-by":"publisher","DOI":"10.21542\/gcsp.2025.hvbte.19","article-title":"Activated platelets are molecular drivers of endothelial-to-mesenchymal transition in calcific aortic valve disease","volume":"2025","author":"Weiss","year":"2025","journal-title":"Global Cardiol Sci Pract"},{"key":"B289","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00294","article-title":"Endothelial to mesenchymal transition represents a key link in the interaction between inflammation and endothelial dysfunction","volume":"9","author":"Cho","year":"2018","journal-title":"Front Immunol"},{"key":"B290","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15016","article-title":"Platelets promote Ang II (angiotensin II)-induced atrial fibrillation by releasing TGF-\u03b21 (transforming growth factor-\u03b21) and interacting with fibroblasts","volume":"76","author":"Liu","year":"2020","journal-title":"Hypertension"},{"key":"B291","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.198647","article-title":"Atorvastatin suppresses HIV\/antiretroviral drug-induced cardiac fibrosis and dysfunction in mice by blocking platelet TGF-\u03b21 signaling","volume":"11","author":"Subramani","year":"2026","journal-title":"JCI Insight"},{"key":"B292","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1097\/QAD.0000000000002516","article-title":"HIV protease inhibitor ritonavir induces renal fibrosis and dysfunction: Role of platelet-derived TGF-\u03b21 and intervention via anti-oxidant pathways","volume":"34","author":"Laurence","year":"2020","journal-title":"AIDS"},{"key":"B293","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187185","article-title":"HIV protease inhibitor-induced cardiac dysfunction and fibrosis is mediated by platelet-derived TGF-\u03b21 and can be suppressed by exogenous carbon monoxide","volume":"12","author":"Laurence","year":"2017","journal-title":"PloS One"},{"key":"B294","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.125.046482","article-title":"Monocytes defined by platelet interactions and oxidative stress signaling underlie HIV-associated atherosclerosis","volume":"15","author":"Wang","year":"2026","journal-title":"JAHA"},{"key":"B295","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.216902","article-title":"Direct contact between tumor cells and platelets initiates a FAK-dependent F3\/TGF-\u03b2 positive feedback loop that promotes tumor progression and EMT in osteosarcoma","volume":"591","author":"Shi","year":"2024","journal-title":"Cancer Lett"},{"key":"B296","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217161","article-title":"Platelets promote primary hepatocellular carcinoma metastasis through TGF-\u03b21-mediated cancer cell autophagy","volume":"600","author":"Lu","year":"2024","journal-title":"Cancer Lett"},{"key":"B297","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5114\/wo.2021.103938","article-title":"Platelet-derived growth factor-B signalling might promote epithelial-mesenchymal transition in gastric carcinoma cells through activation of the MAPK\/ERK pathway","volume":"25","author":"Yin","year":"2021","journal-title":"Contemp Oncol (Pozn)"},{"key":"B298","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1186\/s10020-025-01355-7","article-title":"Platelets induce epithelial to mesenchymal transition in renal proximal tubular epithelial cells through TGF-\u03b2 signaling pathway","volume":"31","author":"Rustiasari","year":"2025","journal-title":"Mol Med"},{"key":"B299","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017010868","article-title":"Platelet TGF-\u03b21 deficiency decreases liver fibrosis in a mouse model of liver injury","volume":"2","author":"Ghafoory","year":"2018","journal-title":"Blood Adv"},{"key":"B300","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-024-01235-6","article-title":"Transforming growth factor-\u03b2 receptors: versatile mechanisms of ligand activation","volume":"45","author":"Chia","year":"2024","journal-title":"Acta Pharmacol Sin"},{"key":"B301","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1489701","article-title":"Recent advances in therapeutic use of transforming growth factor-beta inhibitors in cancer and fibrosis","volume":"15","author":"Jing","year":"2025","journal-title":"Front Oncol"},{"key":"B302","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1038\/s41467-026-69456-3","article-title":"Triple targeting of STING, TGF-\u03b2, and PD-L1 boosts CXCL16-CXCR6 signaling for potent antitumor response","volume":"17","author":"Yi","year":"2026","journal-title":"Nat Commun"},{"key":"B303","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2025-011824","article-title":"Potent antitumor activity through dual targeting of PD-L1 and TGF-\u03b2 pathways in the glioma tumor microenvironment","volume":"14","author":"Silginer","year":"2026","journal-title":"J Immunother Cancer"},{"key":"B304","doi-asserted-by":"publisher","DOI":"10.1177\/003335491513000614","article-title":"Preventive aspirin and other antiplatelet medication use among U.S. Adults aged \u2265 40 years: data from the national health and nutrition examination survey, 2011-2012","volume":"130","author":"Gu","year":"2015","journal-title":"Public Health Rep"},{"key":"B305","unstructured":"Antiplatelet Drugs: Types, Uses & Side Effects\n          \n          \n          \n          2025"},{"key":"B306","unstructured":"6. Antiplatelet Therapy for Ischemic Stroke and Transient Ischemic Attack\n          \n          \n          \n          2025"},{"key":"B307","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.16-2-152","article-title":"Antiplatelet therapy \u2013 a summary for the general physicians","volume":"16","author":"Thachil","year":"2016","journal-title":"Clin Med (Lond)"},{"key":"B308","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e32807f2ad9","article-title":"Antiplatelet therapy in type 2 diabetes mellitus","volume":"14","author":"Angiolillo","year":"2007","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"B309","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1267856","article-title":"Review of currently available GP IIb\/IIIa inhibitors and their role in peripheral vascular interventions","volume":"27","author":"Stangl","year":"2010","journal-title":"Semin Intervent Radiol"},{"key":"B310","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-021-06983-3","article-title":"A survey of aspirin knowledge among the general public","volume":"37","author":"Owen","year":"2022","journal-title":"J Gen Intern Med"},{"key":"B311","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.101.10.1206","article-title":"Aspirin","volume":"101","author":"Awtry","year":"2000","journal-title":"Circulation"},{"key":"B312","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-869523","article-title":"Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis","volume":"31","author":"Savi","year":"2005","journal-title":"Semin Thromb Hemost"},{"key":"B313","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3283385420","article-title":"Clopidogrel pathway","volume":"20","author":"Sangkuhl","year":"2010","journal-title":"Pharmacogenet Genomics"},{"key":"B314","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-2064","article-title":"Antiplatelet therapy in diabetes: efficacy and limitations of current treatment strategies and future directions","volume":"32","author":"Angiolillo","year":"2009","journal-title":"Diabetes Care"},{"key":"B315","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.047830","article-title":"Can an old ally defeat a new enemy","volume":"142","author":"Gurbel","year":"2020","journal-title":"Circulation"},{"key":"B316","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2020.12.073","article-title":"Meta-analysis of the effect of aspirin on mortality in COVID-19","volume":"142","author":"Salah","year":"2021","journal-title":"Am J Cardiol"},{"key":"B317","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.23605","article-title":"Effect of P2Y12 inhibitors on survival free of organ support among non-critically ill hospitalized patients with COVID-19: A randomized clinical trial","volume":"327","author":"Berger","year":"2022","journal-title":"JAMA"},{"key":"B318","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2021-001785","article-title":"Combined anticoagulant and antiplatelet therapy is associated with an improved outcome in hospitalised patients with COVID-19: a propensity matched cohort study","volume":"8","author":"Matli","year":"2021","journal-title":"Open Heart"},{"key":"B319","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.989903","article-title":"Associations between the use of aspirin or other antiplatelet drugs and all-cause mortality among patients with COVID-19: A meta-analysis","volume":"13","author":"Su","year":"2022","journal-title":"Front Pharmacol"},{"key":"B320","doi-asserted-by":"publisher","first-page":"4832","DOI":"10.1038\/s41598-024-55407-9","article-title":"Antiplatelet therapy prior to COVID-19 infection impacts on patients mortality: a propensity score-matched cohort study","volume":"14","author":"Sokolski","year":"2024","journal-title":"Sci Rep"},{"key":"B321","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.802566","article-title":"Platelets and antiplatelet medication in COVID-19-related thrombotic complications","volume":"8","author":"Schrottmaier","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"B322","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2022.100025","article-title":"Early SARS-CoV-2 infection: Platelet-neutrophil complexes and platelet function","volume":"7","author":"Rieder","year":"2023","journal-title":"Res Pract Thromb Haemostasis"},{"key":"B323","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2022.06.002","article-title":"Antiplatelet effects of clopidogrel vs aspirin in virologically controlled HIV","volume":"7","author":"Marcantoni","year":"2022","journal-title":"JACC: Basic to Trans Sci"},{"key":"B324","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-018-0637-6","article-title":"Impact of boosted antiretroviral therapy on the pharmacokinetics and efficacy of clopidogrel and prasugrel active metabolites","volume":"57","author":"Marsousi","year":"2018","journal-title":"Clin Pharmacokinet"},{"key":"B325","doi-asserted-by":"publisher","first-page":"8","DOI":"10.4103\/jpcs.jpcs_19_25","article-title":"Role of the CYP450 enzymatic pathway in drug metabolism: focus on proton-pump inhibitors and antiplatelet therapy","volume":"11","author":"Mehta","year":"2025","journal-title":"J Pract Cardiovasc Sci"},{"key":"B326","unstructured":"Aspirin Uses and Side-Effects. NHS Inform\n          \n          \n          2026"},{"key":"B327","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw278","article-title":"A randomized placebo controlled trial of aspirin effects on immune activation in chronically human immunodeficiency virus-infected adults on virologically suppressive antiretroviral therapy","volume":"4","author":"O\u2019Brien","year":"2017","journal-title":"Open Forum Infect Dis"},{"key":"B328","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2011.550573","article-title":"Beyond efficacy: pharmacokinetic differences between clopidogrel, prasugrel and ticagrelor","volume":"12","author":"Giorgi","year":"2011","journal-title":"Expert Opin Pharmacother"},{"key":"B329","unstructured":"Aspirin \u2013 Pharmacokinetics\n          \n          \n          2026"},{"key":"B330","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00196.2016","article-title":"Aspirin therapy reduces the ability of platelets to promote colon and pancreatic cancer cell proliferation: Implications for the oncoprotein c-MYC","volume":"312","author":"Mitrugno","year":"2017","journal-title":"Am J Physiol Cell Physiol"},{"key":"B331","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2504650","article-title":"Low-dose aspirin for PI3K-altered localized colorectal cancer","volume":"393","author":"Martling","year":"2025","journal-title":"N Engl J Med"},{"key":"B332","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067208","article-title":"Aspirin and the risk of colorectal cancer in relation to the expression of COX-2","volume":"356","author":"Chan","year":"2007","journal-title":"N Engl J Med"},{"key":"B333","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018033","article-title":"Aspirin use and pancreatic cancer risk","volume":"98","author":"Sun","year":"2019","journal-title":"Med (Baltimore)"},{"key":"B334","doi-asserted-by":"publisher","DOI":"10.14309\/01.ajg.0001028600.78778.31","article-title":"S58 impact of long-term aspirin use on pancreatic cancer outcomes: insights from national inpatient sample","volume":"119","author":"Singh","year":"2024","journal-title":"Am J Gastroenterol"},{"key":"B335","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.269811","article-title":"Engagement of \u03b1IIb\u03b23 (GPIIb\/IIIa) with \u03b1\u03bd\u03b23 integrin mediates interaction of melanoma cells with platelets: a connection to hematogenous metastasis","volume":"287","author":"Lonsdorf","year":"2012","journal-title":"J Biol Chem"},{"key":"B336","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00367.2018","article-title":"The role of coagulation and platelets in colon cancer-associated thrombosis","volume":"316","author":"Mitrugno","year":"2019","journal-title":"Am J Physiol Cell Physiol"},{"key":"B337","doi-asserted-by":"publisher","DOI":"10.1177\/1076029620977906","article-title":"Relationship of platelet glycoprotein IIb\/IIIa and CD62P with hypercoagulable state after oncologic surgery","volume":"26","author":"Zhong","year":"2020","journal-title":"Clin Appl Thromb Hemost"},{"key":"B338","doi-asserted-by":"publisher","DOI":"10.2174\/1389450115666140804220441","article-title":"\u03b1IIb\u03b23-integrin ligands: abciximab and eptifibatide as proapoptotic factors in MCF-7 human breast cancer cells","volume":"16","author":"Kononczuk","year":"2015","journal-title":"Curr Drug Targets"},{"key":"B339","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0215(19970117)70:2<201::aid-ijc11>3.0.co;2-l","article-title":"Platelets mediate tumor cell adhesion to the subendothelium under flow conditions: involvement of platelet GPIIb-IIIa and tumor cell alpha(v) integrins","volume":"70","author":"Dardik","year":"1997","journal-title":"Int J Cancer"},{"key":"B340","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.10.5892","article-title":"Role of beta3 integrins in melanoma cell adhesion to activated platelets under flow","volume":"271","author":"Felding-Habermann","year":"1996","journal-title":"J Biol Chem"},{"key":"B341","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s40164-025-00723-7","article-title":"Targeting platelet-tumor cell interactions via thromboxane A2-prostanoid receptor blockade to reduce metastasis in triple negative breast cancer","volume":"14","author":"Toragall","year":"2025","journal-title":"Exp Hematol Oncol"},{"key":"B342","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2021.107057","article-title":"A novel murine model of pulmonary fibrosis: the role of platelets in chronic changes induced by bleomycin","volume":"109","author":"Carrington","year":"2021","journal-title":"J Pharmacol Toxicol Methods"},{"key":"B343","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.molimm.2020.01.017","article-title":"Cangrelor alleviates bleomycin-induced pulmonary fibrosis by inhibiting platelet activation in mice","volume":"120","author":"Zhan","year":"2020","journal-title":"Mol Immunol"},{"key":"B344","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305655","article-title":"Ticagrelor protects the heart against reperfusion injury and improves remodeling after myocardial infarction","volume":"35","author":"Ye","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B345","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-013-6471-z","article-title":"Inhibition of platelet activation by clopidogrel prevents hypertension-induced cardiac inflammation and fibrosis","volume":"27","author":"Jia","year":"2013","journal-title":"Cardiovasc Drugs Ther"},{"key":"B346","doi-asserted-by":"publisher","DOI":"10.1159\/000487972","article-title":"Aspirin reduces cardiac interstitial fibrosis by inhibiting erk1\/2-serpine2 and P-akt signalling pathways","volume":"45","author":"Li","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"B347","doi-asserted-by":"publisher","DOI":"10.33594\/000000189","article-title":"Ticagrelor improves remodeling, reduces apoptosis, inflammation and fibrosis and increases the number of progenitor stem cells after myocardial infarction in a rat model of ischemia reperfusion","volume":"53","author":"Birnbaum","year":"2019","journal-title":"Cell Physiol Biochem"},{"key":"B348","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1254","article-title":"Use of antiplatelet agents is inversely associated with liver fibrosis in patients with cardiovascular disease","volume":"2","author":"Schwarzkopf","year":"2018","journal-title":"Hepatol Commun"},{"key":"B349","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2014.07.004","article-title":"Aspirin may reduce liver fibrosis progression: Evidence from a multicenter retrospective study of recurrent hepatitis C after liver transplantation","volume":"38","author":"Poujol-Robert","year":"2014","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"B350","doi-asserted-by":"publisher","first-page":"2776","DOI":"10.1016\/j.cgh.2019.04.061","article-title":"Daily aspirin use associated with reduced risk for fibrosis progression in patients with nonalcoholic fatty liver disease","volume":"17","author":"Simon","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"key":"B351","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13515","article-title":"Aspirin use is associated with lower indices of liver fibrosis among adults in the United States","volume":"43","author":"Jiang","year":"2016","journal-title":"Aliment Pharmacol Ther"},{"key":"B352","doi-asserted-by":"publisher","DOI":"10.1177\/0363546519827294","article-title":"Effects of aspirin on growth factor release from freshly isolated leukocyte-rich platelet-rich plasma in healthy men: A prospective fixed-sequence controlled laboratory study","volume":"47","author":"Jayaram","year":"2019","journal-title":"Am J Sports Med"},{"key":"B353","doi-asserted-by":"publisher","DOI":"10.1080\/20565623.2024.2413827","article-title":"Effect of aspirin on platelet-rich plasma of diabetes mellitus with lower extremity atherosclerosis","volume":"10","author":"Zhang","year":"2024","journal-title":"Future Sci OA"},{"key":"B354","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3109\/08977194.2014.977437","article-title":"Effects of anti-aggregant, anti-inflammatory and anti-coagulant drug consumption on the preparation and therapeutic potential of plasma rich in growth factors (PRGF)","volume":"33","author":"Anitua","year":"2015","journal-title":"Growth Factors"},{"key":"B355","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1177\/0267659107077950","article-title":"Quality assessment of platelet rich plasma during anti-platelet therapy","volume":"22","author":"Smith","year":"2007","journal-title":"Perfusion"},{"key":"B356","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000049686","article-title":"Effect of indobufen combined with clopidogrel on efficacy and blood TGF-\u03b2 and IL-6 expression after percutaneous transluminal angioplasty of arteriovenous fistula","volume":"105","author":"Feng","year":"2026","journal-title":"Med (Baltimore)"},{"key":"B357","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1057331","article-title":"Antiplatelet efficacy of ticagrelor versus clopidogrel in Mediterranean patients with diabetes mellitus and chronic coronary syndromes: A crossover pharmacodynamic investigation","volume":"9","author":"Marcano","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"B358","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-026-03290-1","article-title":"Comparative effectiveness of dual antiplatelet therapy after revascularization in diabetes and chronic limb-threatening ischemia: a target trial emulation study","author":"Lin","year":"2026","journal-title":"Cardiovasc Diabetol"},{"key":"B359","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-151753","article-title":"In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1","volume":"112","author":"Ahamed","year":"2008","journal-title":"Blood"},{"key":"B360","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006608","article-title":"In vitro and in vivo evidence that thrombospondin-1 (TSP-1) contributes to stirring- and shear-dependent activation of platelet-derived TGF-beta1","volume":"4","author":"Ahamed","year":"2009","journal-title":"PloS One"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1938898\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:22:40Z","timestamp":1791195760000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1938898\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,5]]},"references-count":360,"alternative-id":["10.3389\/fimmu.2026.1938898"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1938898","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,5]]},"article-number":"1938898"}}