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This review elaborates on the mechanisms through which cancer cells utilize metabolic reprogramming, mechanical stress, and neural control to shape the microenvironment conducive to tumor growth. It also describes the metastatic cascade of their active dissemination and colonization processes of cancer cells within the peritoneal cavity. Finally, on the basis of these mechanistic insights, we propose a three-step strategy that dismantle physical barriers, blocks nutrient supply, and reverses immune suppression. 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