{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:53:42Z","timestamp":1791179622266,"version":"4.1.0"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several intraneuronal antibodies have been identified in association with paraneoplastic encephalitis, including anti-Ma and anti-Yo antibodies. There is a pure case of narcolepsy associated with anti-Ma2 antibody positivity with concomitant anti-Yo antibody.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report a 42-year-old male patient who presented with recurrent cataplexy as the primary and dominant symptom without typical hyperphagia in the early stages of narcolepsy associated with anti-Ma2 antibody positivity. Despite extensive screening, no underlying malignancy was detected over a 3-year disease duration. The patient exhibited significant clinical improvement following immunotherapy at the beginning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is a rare report of an isolated clinical manifestation of narcolepsy associated with anti-Ma2 antibody positivity with concomitant anti-Yo antibody. This case reminds clinicians to notice that cataplexy could be the only early symptom of narcolepsy associated with anti-Ma2 antibody positivity with concomitant anti-Yo antibody, which can easily lead to misdiagnoses. Autoimmune mechanisms may play an important role in the pathogenesis of narcolepsy associated with anti-Ma2 antibody positivity, and prompt immunotherapy offers a promising approach for its management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1942979","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:31:44Z","timestamp":1791178304000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Narcolepsy associated with anti-Ma2 antibody positivity"],"prefix":"10.3389","volume":"17","author":[{"given":"Yefan","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Neurology, Xiangya Hospital, Central South University","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital, Central South University","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yike","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital, Central South University","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital, Central South University","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fifth Affiliated Hospital of Sun Yat-Sen University","place":["Zhuhai, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13152589","article-title":"Autoimmune encephalitis with antibodies: Anti-NMDAR, anti-AMPAR, anti-GQ1b, anti-DPPX, anti-CASPR2, anti-LGI1, anti-RI, anti-Yo, anti-Hu, anti-CV2 and anti-GABAAR, in the course of psychoses, neoplastic diseases, and paraneoplastic syndromes","volume":"13","author":"Braczkowski","year":"2023","journal-title":"Diagnostics (Basel)"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1288.abs","article-title":"Molecular and clinical diversity in paraneoplastic immunity to Ma proteins","volume":"50","author":"Rosenfeld","year":"2001","journal-title":"Ann Neurol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh203","article-title":"Clinical analysis of anti-Ma2-associated 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diagnostic criteria for paraneoplastic neurologic syndromes","volume":"8","author":"Graus","year":"2021","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1212\/nxi.0000000000200538","article-title":"Relative frequency and distinctive features of anti-Ma2 nonparaneoplastic neurologic disorders: A French cohort study","volume":"13","author":"Vaisvilas","year":"2026","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/30.6.767","article-title":"REM sleep behavior disorder and narcoleptic features in anti-Ma2-associated encephalitis","volume":"30","author":"Compta","year":"2007","journal-title":"Sleep"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2021.101546","article-title":"Neurobiology of cataplexy","volume":"60","author":"Seifinejad","year":"2021","journal-title":"Sleep Med 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Psychiatry"},{"key":"B14","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.nrleng.2016.05.004","article-title":"Anti-Ma and anti-Ma2-associated paraneoplastic neurological syndromes","volume":"33","author":"Ortega Suero","year":"2018","journal-title":"Neurologia (Engl Ed)"}],"container-title":["Frontiers in 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