{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:56:19Z","timestamp":1790571379190,"version":"4.1.0"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Latent tuberculosis infection (LTBI) affects nearly a quarter of the world\u2019s population, yet current diagnostic tools are suboptimal. Interferon-\u03b3-inducible protein 10 (IP-10) has been proposed as a candidate biomarker, but its diagnostic value for LTBI among high-risk groups is unclear. To address this, we performed a systematic review and meta-analysis to assess the accuracy of\n                      <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                      (Mtb) antigen-induced IP-10 for detecting LTBI among high-risk groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Web of Science, Embase, Scopus, and the Cochrane Library were searched up to April 2026. Cohort and cross-sectional studies evaluating Mtb antigen-induced IP-10 for LTBI diagnosis in high-risk groups were included. A bivariate random-effects model and a hierarchical summary receiver operating characteristic model were used to estimate and summarize the overall diagnostic performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nineteen articles comprising 24 studies (2,014 participants) were included. The pooled sensitivity, specificity, positive and negative likelihood ratios, diagnostic odds ratio, and area under the curve of Mtb antigen-induced IP-10 were 0.81, 0.88, 6.93, 0.21, 32.56, and 0.91, respectively, indicating good diagnostic performance of Mtb antigen-induced IP-10 for detecting LTBI among high-risk groups. The bivariate boxplot, meta-regression and subgroup analysis identified no significant source of heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Mtb antigen-induced IP-10 is a promising biomarker for detecting LTBI among high-risk groups. It may serve as a useful adjunct to IGRAs and TST, although its clinical utility requires further validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.crd.york.ac.uk\/prospero\/<\/jats:ext-link>\n                      , identifier CRD420261388089.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1951983","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:29:21Z","timestamp":1790569761000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic accuracy of Mycobacterium tuberculosis antigen-induced interferon-\u03b3-inducible protein 10 for latent tuberculosis infection among high-risk groups: a systematic review and 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Sichuan University","place":["Chengdu, China"]},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Social Medicine and Health Management, School of Public Health, Lanzhou University","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, West China Second University Hospital, Sichuan University","place":["Chengdu, China"]},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education","place":["Chengdu, 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