{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:06:26Z","timestamp":1789387586787,"version":"build-2803163510"},"reference-count":303,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"\n Gastric cancer remains a leading cause of cancer-related mortality worldwide. The classical\n Helicobacter pylori<\/jats:italic>\n -centric paradigm of gastric carcinogenesis is being progressively expanded, as it is now recognized that the stomach harbors a complex and metabolically active microbial ecosystem whose compositional shifts fundamentally influence oncogenic progression. This review proposes a unifying dysbiosis-carcinogenesis-immune remodeling-therapeutic intervention (DCIT) framework to integrate the rapidly growing body of evidence linking gastric microbiota dysbiosis to malignancy. We survey the compositional landscape of the gastric microbiota across the Correa cascade, from healthy homeostasis through atrophic gastritis, intestinal metaplasia, and adenocarcinoma, and examine the ecological succession that releases niche constraints for oral commensals and nitrate-reducing taxa in advanced disease stages. We systematically evaluate four complementary mechanistic axes of microbial carcinogenesis: genotoxicity driven by bacterial effectors, chronic inflammation sustained by pattern recognition receptor signaling, epithelial barrier disruption facilitating bacterial translocation, and metabolic reprogramming of the gastric niche generating carcinogenic\n N<\/jats:italic>\n -nitroso compounds and secondary bile acids. The review further examines how gastric microbiota remodels the tumor immune microenvironment through immune cell reprogramming, metabolite-mediated signaling, and checkpoint modulation, with direct implications for the efficacy of immune checkpoint inhibitor immunotherapy. The translational pipeline is evaluated from established\n H. pylori<\/jats:italic>\n eradication regimens through probiotics, phage therapy, and fecal microbiota transplantation to emerging strategies that integrate microbiota modulation with chemotherapy and immunotherapy. Finally, we assess the methodological challenges of low-biomass gastric microbiome research, the integration of multi-omics platforms, and the critical evidence gaps that need to be addressed to realize the clinical potential of microbiota-targeted strategies for gastric cancer prevention and treatment.\n <\/jats:p>","DOI":"10.3389\/fimmu.2026.1953049","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:41:30Z","timestamp":1789386090000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gastric bacterial microbiota and gastric carcinogenesis: from dysbiosis to immune remodeling and therapeutic opportunities"],"prefix":"10.3389","volume":"17","author":[{"given":"Shengyu","family":"Huang","sequence":"first","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangtian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of Nantong University, Medical School of Nantong University","place":["Nantong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Huludao Central Hospital","place":["Huludao, Liaoning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of Nantong University, Medical School of Nantong University","place":["Nantong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of Nantong University, Medical School of Nantong University","place":["Nantong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingbin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Lishui Second People\u2019s Hospital","place":["Lishui, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongxin","family":"Ling","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Lishui Second People\u2019s Hospital","place":["Lishui, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(25)00052-2","article-title":"Gastric cancer","volume":"405","author":"Sundar","year":"2025","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16183163","article-title":"Gastric cancer: An up-to-date review with new insights into early-onset gastric cancer","volume":"16","author":"Mazurek","year":"2024","journal-title":"Cancers (Basel)"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2022.103841","article-title":"Characteristics of gastric cancer around the world","volume":"181","author":"L\u00f3pez","year":"2023","journal-title":"Crit Rev Oncol Hematol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1111\/apt.15650","article-title":"Systematic review: gastric microbiota in health and disease","volume":"51","author":"Rajilic-Stojanovic","year":"2020","journal-title":"Aliment Pharmacol Ther"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176451","article-title":"Pathways of gastric carcinogenesis, Helicobacter pylori virulence and interactions with antioxidant systems, vitamin C and phytochemicals","volume":"21","author":"Toh","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12739","article-title":"Review: Gastric cancer: Basic aspects","volume":"25","author":"Resende","year":"2020","journal-title":"Helicobacter"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10120-021-01260-y","article-title":"Interdisciplinary insights into the link between gut microbiome and gastric carcinogenesis-what is currently known","volume":"25","author":"Ka\u017amierczak-Siedlecka","year":"2022","journal-title":"Gastric Cancer"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1353094","article-title":"Cross-talk between Helicobacter pylori and gastric cancer: a scientometric analysis","volume":"14","author":"Yang","year":"2024","journal-title":"Front Cell Infect Microbiol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10163473","article-title":"Clinical relevance of Helicobacter pylori infection","volume":"10","author":"Mladenova","year":"2021","journal-title":"J Clin Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"3992","DOI":"10.1002\/cam4.2277","article-title":"Prevention of gastric cancer by Helicobacter pylori eradication: A review from Japan","volume":"8","author":"Uno","year":"2019","journal-title":"Cancer Med"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11050593","article-title":"Efficacy and long-term safety of H. pylori eradication for gastric cancer prevention","volume":"11","author":"Liou","year":"2019","journal-title":"Cancers (Basel)"},{"key":"B12","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1111\/hel.12260","article-title":"Gastric microbiota","volume":"20","author":"Ianiro","year":"2015","journal-title":"Helicobacter"},{"key":"B13","doi-asserted-by":"publisher","first-page":"15957","DOI":"10.1038\/s41598-017-16289-2","article-title":"Dysbiosis of the microbiome in gastric carcinogenesis","volume":"7","author":"Casta\u00f1o-Rodr\u00edguez","year":"2017","journal-title":"Sci Rep"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-022-02377-9","article-title":"Meta-analysis of mucosal microbiota reveals universal microbial signatures and dysbiosis in gastric carcinogenesis","volume":"41","author":"Liu","year":"2022","journal-title":"Oncogene"},{"key":"B15","doi-asserted-by":"publisher","first-page":"4285","DOI":"10.1038\/s41598-022-08288-9","article-title":"Dysbiotic change in gastric microbiome and its functional implication in gastric carcinogenesis","volume":"12","author":"Park","year":"2022","journal-title":"Sci Rep"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1138928","article-title":"Alterations in bacterial community dynamics from noncancerous to gastric cancer","volume":"14","author":"Peng","year":"2023","journal-title":"Front Microbiol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-024-03034-7","article-title":"Unveiling the gastric microbiota: implications for gastric carcinogenesis, immune responses, and clinical prospects","volume":"43","author":"Liu","year":"2024","journal-title":"J Exp Clin Cancer Res"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2022.05.001","article-title":"Microbiota and gastric cancer","volume":"86","author":"Bess\u00e8de","year":"2022","journal-title":"Semin Cancer Biol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1130001","article-title":"Gastric microbiota: an emerging player in gastric cancer","volume":"14","author":"Zhou","year":"2023","journal-title":"Front Microbiol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-026-03052-9","article-title":"The dual role of gastric microbiota dysbiosis in gastric cancer progression and therapy","volume":"31","author":"Liu","year":"2026","journal-title":"Int J Clin Oncol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-024-01021-x","article-title":"Role of the microbiome in the diagnosis and management of gastroesophageal cancers","volume":"55","author":"Mascaretti","year":"2024","journal-title":"J Gastrointest Cancer"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3390\/life15070999","article-title":"Gastric cancer and microbiota: Exploring the microbiome's role in carcinogenesis and treatment strategies","volume":"15","author":"Laz\u0103r","year":"2025","journal-title":"Life (Basel)"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25031679","article-title":"Microbiota-gastric cancer interactions and the potential influence of nutritional therapies","volume":"25","author":"Raoul","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327209","article-title":"Cancer as microenvironmental, systemic and environmental diseases: opportunity for transdisciplinary microbiomics science","author":"Inamura","year":"2022","journal-title":"Gut"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-023-00594-2","article-title":"Bacteria in cancer initiation, promotion and progression","volume":"23","author":"El Tekle","year":"2023","journal-title":"Nat Rev Cancer"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1301506","article-title":"Intratumoral microbiota: implications for cancer onset, progression, and therapy","volume":"14","author":"Wu","year":"2023","journal-title":"Front Immunol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2023.11.053","article-title":"The influence of Helicobacter pylori, proton pump inhibitor, and obesity on the gastric microbiome in relation to gastric cancer development","volume":"23","author":"Zhou","year":"2024","journal-title":"Comput Struct Biotechnol J"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9060617","article-title":"Impact of environmental and pharmacologic changes on the upper gastrointestinal microbiome","volume":"9","author":"Bilello","year":"2021","journal-title":"Biomedicines"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1218395","article-title":"The role of gastric microecological dysbiosis in gastric carcinogenesis","volume":"14","author":"Huang","year":"2023","journal-title":"Front Microbiol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1224669","article-title":"The role of microbiota in the development and treatment of gastric cancer","volume":"13","author":"Wang","year":"2023","journal-title":"Front Oncol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13070584","article-title":"Helicobacter pylori and the human gastrointestinal microbiota: A multifaceted relationship","volume":"13","author":"Tohumcu","year":"2024","journal-title":"Antibiotics (Basel)"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-023-01534-w","article-title":"Mucin-microbiome signatures shape the tumor microenvironment in gastric cancer","volume":"11","author":"Oosterlinck","year":"2023","journal-title":"Microbiome"},{"key":"B33","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/s12943-024-02016-9","article-title":"OLFM4 promotes the progression of intestinal metaplasia through activation of the MYH9\/GSK3\u03b2\/\u03b2-catenin pathway","volume":"23","author":"Wei","year":"2024","journal-title":"Mol Cancer"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000191","article-title":"Gastric microbiota in a low-Helicobacter pylori prevalence general population and their associations with gastric lesions","volume":"11","author":"Ndegwa","year":"2020","journal-title":"Clin Transl Gastroenterol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10112206","article-title":"Oral microbiota and tumor-a new perspective of tumor pathogenesis","volume":"10","author":"Li","year":"2022","journal-title":"Microorganisms"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.914418","article-title":"The interactions between oral-gut axis microbiota and Helicobacter pylori","volume":"12","author":"Chen","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s12866-024-03219-2","article-title":"Microbiome signatures associated with clinical stages of gastric cancer: whole metagenome shotgun sequencing study","volume":"24","author":"Jeong","year":"2024","journal-title":"BMC Microbiol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.754959","article-title":"Alterations in gastric mucosal microbiota in gastric carcinogenesis: A systematic review and meta-analysis","volume":"8","author":"Yang","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"B39","doi-asserted-by":"publisher","first-page":"17866","DOI":"10.1038\/s41598-021-97261-z","article-title":"The gastric microbiota in patients with Crohn's disease; a preliminary study","volume":"11","author":"Ostrowski","year":"2021","journal-title":"Sci Rep"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1010465","article-title":"A literature review on the potential clinical implications of streptococci in gastric cancer","volume":"13","author":"Zi","year":"2022","journal-title":"Front Microbiol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2024.02.004","article-title":"A tough act to swallow: Streptococcusanginosus and gastric cancer","volume":"32","author":"Wong","year":"2024","journal-title":"Cell Host Microbe"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2019.101585","article-title":"Duration of use of proton pump inhibitors and the risk of gastric and oesophageal cancer","volume":"62","author":"Brusselaers","year":"2019","journal-title":"Cancer Epidemiol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/nyas.14428","article-title":"Potential proton pump inhibitor-related adverse effects","volume":"1481","author":"Perry","year":"2020","journal-title":"Ann N Y Acad Sci"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10070875","article-title":"Impact of dietary patterns on H. pylori infection and the modulation of microbiota to counteract its effect. A narrative review","volume":"10","author":"Rueda-Robles","year":"2021","journal-title":"Pathogens"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1153269","article-title":"Gastric microbiota dysbiosis and Helicobacter pylori infection","volume":"14","author":"Zhang","year":"2023","journal-title":"Front Microbiol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13099-025-00708-1","article-title":"Anti-urease therapy: a targeted approach to mitigating antibiotic resistance in Helicobacter pylori while preserving the gut microflora","volume":"17","author":"Almarmouri","year":"2025","journal-title":"Gut Pathog"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.953718","article-title":"The interplay between Helicobacter pylori and the gut microbiota: An emerging driver influencing the immune system homeostasis and gastric carcinogenesis","volume":"12","author":"Fakharian","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11050725","article-title":"Western-type Helicobacter pylori CagA are the most frequent type in Mongolian patients","volume":"11","author":"Tserentogtokh","year":"2019","journal-title":"Cancers (Basel)"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13081878","article-title":"Role of bacterial and viral pathogens in gastric carcinogenesis","volume":"13","author":"Palrasu","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37095-4","article-title":"VacA promotes CagA accumulation in gastric epithelial cells during Helicobacter pylori infection","volume":"9","author":"Abdullah","year":"2019","journal-title":"Sci Rep"},{"key":"B51","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s11010-014-2138-8","article-title":"Role of vacuolating cytotoxin VacA and cytotoxin-associated antigen CagA of Helicobacter pylori in the progression of gastric cancer","volume":"396","author":"Ki","year":"2014","journal-title":"Mol Cell Biochem"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.004879","article-title":"Helicobacter pylori CagA inhibits endocytosis of cytotoxin VacA in host cells","volume":"3","author":"Akada","year":"2010","journal-title":"Dis Model Mech"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-011-9512-8","article-title":"Iron trafficking system in Helicobacter pylori","volume":"25","author":"Ge","year":"2012","journal-title":"Biometals"},{"key":"B54","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/hel.12087","article-title":"Host cell contact induces fur-dependent expression of virulence factors CagA and VacA in Helicobacter pylori","volume":"19","author":"Raghwan","year":"2014","journal-title":"Helicobacter"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-15138-6_5","article-title":"Crosstalk between DNA damage and inflammation in the multiple steps of gastric carcinogenesis","volume":"421","author":"Sokolova","year":"2019","journal-title":"Curr Top Microbiol Immunol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9342563","article-title":"Immune response in H. pylori-associated gastritis and gastric cancer","volume":"2020","author":"Niu","year":"2020","journal-title":"Gastroenterol Res Pract"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.960281","article-title":"Alterations in the gastric microbiota and metabolites in gastric cancer: An update review","volume":"12","author":"Lei","year":"2022","journal-title":"Front Oncol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/978-3-030-51652-9_20","article-title":"Metabolomics of gastric cancer","volume":"1280","author":"Kadam","year":"2021","journal-title":"Adv Exp Med Biol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12092619","article-title":"Alterations in gastric microbial communities are associated with risk of gastric cancer in a Korean population: A case-control study","volume":"12","author":"Gunathilake","year":"2020","journal-title":"Cancers (Basel)"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-020-01130-z","article-title":"Molecular alterations in gastric cancer and the surrounding intestinal metaplastic mucosa: an analysis of isolated glands","volume":"24","author":"Sugimoto","year":"2021","journal-title":"Gastric Cancer"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1134785","article-title":"Linking dysbiosis to precancerous stomach through inflammation: Deeper than and beyond imaging","volume":"14","author":"Lopes","year":"2023","journal-title":"Front Immunol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2021.08.013","article-title":"The role of microbiota in gastrointestinal cancer and cancer treatment: Chance or curse","volume":"13","author":"Smet","year":"2022","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13060484","article-title":"Exploring the link between Helicobacter pylori, gastric microbiota and gastric cancer","volume":"13","author":"Sgamato","year":"2024","journal-title":"Antibiotics (Basel)"},{"key":"B64","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/s41598-017-18596-0","article-title":"Increased abundance of Clostridium and Fusobacterium in gastric microbiota of patients with gastric cancer in Taiwan","volume":"8","author":"Hsieh","year":"2018","journal-title":"Sci Rep"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-020-06415-y","article-title":"A comparison of tumor-associated and non-tumor-associated gastric microbiota in gastric cancer patients","volume":"66","author":"Wu","year":"2021","journal-title":"Dig Dis Sci"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1159\/000512833","article-title":"Gastric cancer microbiome","volume":"88","author":"Barra","year":"2021","journal-title":"Pathobiology"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.641322","article-title":"Role of the gastric microbiome in gastric cancer: From carcinogenesis to treatment","volume":"12","author":"Yang","year":"2021","journal-title":"Front Microbiol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16203547","article-title":"Gastrointestinal microbiota in gastric cancer: Potential mechanisms and clinical applications-a literature review","volume":"16","author":"Wu","year":"2024","journal-title":"Cancers (Basel)"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v30.i35.3972","article-title":"Fusobacterium nucleatum: Unraveling its potential role in gastric carcinogenesis","volume":"30","author":"Petkevicius","year":"2024","journal-title":"World J Gastroenterol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15010269","article-title":"Fusobacterium nucleatum-induced tumor mutation burden predicts poor survival of gastric cancer patients","volume":"15","author":"Hsieh","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-023-00612-7","article-title":"Analysis of bacterial diversity and community structure in gastric juice of patients with advanced gastric cancer","volume":"14","author":"Wei","year":"2023","journal-title":"Discov Oncol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-024-00965-3","article-title":"Comprehensive multiomics analysis of the signatures of gastric mucosal bacteria and plasma metabolites across different stomach microhabitats in the development of gastric cancer","volume":"48","author":"Wang","year":"2025","journal-title":"Cell Oncol (Dordr)"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00433","article-title":"The gastric microbiome is perturbed in advanced gastric adenocarcinoma identified through shotgun metagenomics","volume":"8","author":"Hu","year":"2018","journal-title":"Front Cell Infect Microbiol"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2186677","article-title":"Shotgun metagenomics of gastric biopsies reveals compositional and functional microbiome shifts in high- and low-gastric-cancer-risk populations from Colombia, South America","volume":"15","author":"Mannion","year":"2023","journal-title":"Gut Microbes"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241813786","article-title":"Microbiomes, their function, and cancer: How metatranscriptomics can close the knowledge gap","volume":"24","author":"Aitmanait\u0117","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14194886","article-title":"Bacterial involvement in progression and metastasis of adenocarcinoma of the stomach","volume":"14","author":"Morgan","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15204993","article-title":"Exploring the microbiome in gastric cancer: Assessing potential implications and contextualizing microorganisms beyond H. pylori and Epstein-Barr virus","volume":"15","author":"Shin","year":"2023","journal-title":"Cancers (Basel)"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241411855","article-title":"How can the microbiome induce carcinogenesis and modulate drug resistance in cancer therapy","volume":"24","author":"Mendes","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrad071","article-title":"Radiation-induced gastric injury during radiotherapy: molecular mechanisms and clinical treatment","volume":"64","author":"Chen","year":"2023","journal-title":"J Radiat Res"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2024.2306676","article-title":"Fusobacterium nucleatum in tumors: from tumorigenesis to tumor metastasis and tumor resistance","volume":"25","author":"Ye","year":"2024","journal-title":"Cancer Biol Ther"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.Can-24-2580","article-title":"Intratumoral Fusobacterium nucleatum recruits tumor-associated neutrophils to promote gastric cancer progression and immune evasion","volume":"85","author":"Zhang","year":"2025","journal-title":"Cancer Res"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241713503","article-title":"Inflammation and digestive cancer","volume":"24","author":"Waldum","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-024-01103-4","article-title":"Bacterial small molecule metabolites implicated in gastrointestinal cancer development","volume":"23","author":"Turocy","year":"2025","journal-title":"Nat Rev Microbiol"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1002\/ygh2.488","article-title":"Helicobacter pylori virulence factors and host genetic polymorphisms in a low gastric cancer incidence and high H pylori prevalence country","volume":"3","author":"Rush","year":"2021","journal-title":"GastroHep"},{"key":"B85","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/978-3-319-75241-9_8","article-title":"The Helicobacter pylori type IV secretion system encoded by the cag pathogenicity island: Architecture, function, and signaling","volume":"413","author":"Backert","year":"2017","journal-title":"Curr Top Microbiol Immunol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwy095","article-title":"Helicobacter pylori induces intracellular galectin-8 aggregation around damaged lysosomes within gastric epithelial cells in a host O-glycan-dependent manner","volume":"29","author":"Li","year":"2019","journal-title":"Glycobiology"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14174316","article-title":"Nrf2 downregulation contributes to epithelial-to-mesenchymal transition in Helicobacter pylori-infected cells","volume":"14","author":"Bacon","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2015.00077","article-title":"Transforming growth factor-\u03b2: an important mediator in Helicobacter pylori-associated pathogenesis","volume":"5","author":"Li","year":"2015","journal-title":"Front Cell Infect Microbiol"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2013.09.004","article-title":"Modulation of autophagy by Helicobacter pylori and its role in gastric carcinogenesis","volume":"21","author":"Greenfield","year":"2013","journal-title":"Trends Microbiol"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911706","article-title":"The role of cyclomodulins and some microbial metabolites in bacterial microecology and macroorganism carcinogenesis","volume":"23","author":"Markelova","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.699015","article-title":"CEACAM1 activation by CbpF-expressing E. coli","volume":"11","author":"Shhadeh","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1093\/femsmc\/xtag002","article-title":"The role of Fusobacterium nucleatum in the tumour microenvironment and carcinogenesis of oral and colonic Malignancies","volume":"7","author":"Larionova","year":"2026","journal-title":"FEMS Microbes"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2025.2544169","article-title":"Microbial manipulators: Fusobacterium nucleatum modulates the tumor immune microenvironment in colorectal cancer","volume":"17","author":"Li","year":"2025","journal-title":"J Oral Microbiol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-019-0621-2","article-title":"Impact of the gut microbiome on the genome and epigenome of colon epithelial cells: contributions to colorectal cancer development","volume":"11","author":"Allen","year":"2019","journal-title":"Genome Med"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20225697","article-title":"Upgrading the repertoire of miRNAs in gastric adenocarcinoma to provide a new resource for biomarker discovery","volume":"20","author":"Pewarchuk","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9080870","article-title":"NF-\u03baB in gastric cancer development and therapy","volume":"9","author":"Chaithongyot","year":"2021","journal-title":"Biomedicines"},{"key":"B97","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1186\/s12967-023-04473-0","article-title":"Transcriptome profiling of patient-derived tumor xenografts suggests novel extracellular matrix-related signatures for gastric cancer prognosis prediction","volume":"21","author":"Deng","year":"2023","journal-title":"J Transl Med"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i30.3313","article-title":"MicroRNAs as non-invasive diagnostic biomarkers for gastric cancer: Current insights and future perspectives","volume":"24","author":"Link","year":"2018","journal-title":"World J Gastroenterol"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.09.019","article-title":"Epstein-Barr virus-associated gastric cancer: A distinct subtype","volume":"495","author":"Yang","year":"2020","journal-title":"Cancer Lett"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1358511","article-title":"The viral etiology of EBV-associated gastric cancers contributes to their unique pathology, clinical outcomes, treatment responses and immune landscape","volume":"15","author":"Salnikov","year":"2024","journal-title":"Front Immunol"},{"key":"B101","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/s41568-022-00462-5","article-title":"Context-dependent functions of pattern recognition receptors in cancer","volume":"22","author":"Man","year":"2022","journal-title":"Nat Rev Cancer"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.611444","article-title":"TLRs as a promise target along with immune checkpoint against gastric cancer","volume":"8","author":"Cui","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7927054","article-title":"The role of gastric mucosal immunity in gastric diseases","volume":"2020","author":"Nie","year":"2020","journal-title":"J Immunol Res"},{"key":"B104","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.canlet.2022.01.014","article-title":"Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression via the NOD1\/RIPK2\/NF-\u03baB pathway","volume":"530","author":"Nomoto","year":"2022","journal-title":"Cancer Lett"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112185","article-title":"NF-\u03baB activation enhances STING signaling by altering microtubule-mediated STING trafficking","volume":"42","author":"Zhang","year":"2023","journal-title":"Cell Rep"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28647","article-title":"The influence of the Chuyou Yuyang granule on the Toll-like receptor\/nuclear factor-\u03baB signal pathway in Helicobacter pylori-positive peptic ulcer patients","volume":"120","author":"Yang","year":"2019","journal-title":"J Cell Biochem"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2020.112315","article-title":"Tumor-associated macrophages induce PD-L1 expression in gastric cancer cells through IL-6 and TNF-\u03b1 signaling","volume":"396","author":"Ju","year":"2020","journal-title":"Exp Cell Res"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1159\/000512326","article-title":"Immune system efficiency in cancer and the microbiota influence","volume":"88","author":"Barbosa","year":"2021","journal-title":"Pathobiology"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12426","article-title":"Fusobacterium nucleatum and cancer","volume":"89","author":"Alon-Maimon","year":"2022","journal-title":"Periodontol 2000"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00436-22","article-title":"DNA transport through the dynamic type IV secretion system","volume":"91","author":"Ryan","year":"2023","journal-title":"Infect Immun"},{"key":"B111","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s11658-024-00538-0","article-title":"Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development","volume":"29","author":"Rayan","year":"2024","journal-title":"Cell Mol Biol Lett"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.718710","article-title":"The influence of nutrition on intestinal permeability and the microbiome in health and disease","volume":"9","author":"Inczefi","year":"2022","journal-title":"Front Nutr"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10123117","article-title":"The gut microbiome and its implication in the mucosal digestive disorders","volume":"10","author":"Bozomitu","year":"2022","journal-title":"Biomedicines"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2026-338505","article-title":"Gastric microbiota-mediated immune remodelling in gastric cancer","author":"Gao","year":"2026","journal-title":"Gut"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.Cir-22-0107","article-title":"Gastric microbiome alterations are associated with decreased CD8+ tissue-resident memory T cells in the tumor microenvironment of gastric cancer","volume":"10","author":"Peng","year":"2022","journal-title":"Cancer Immunol Res"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1291117","article-title":"Research progress on the immune microenvironment and immunotherapy in gastric cancer","volume":"14","author":"Mou","year":"2023","journal-title":"Front Immunol"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15184594","article-title":"The gum-gut axis: Periodontitis and the risk of gastrointestinal cancers","volume":"15","author":"Baima","year":"2023","journal-title":"Cancers (Basel)"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065978","article-title":"Gut microbiome composition and its metabolites are a key regulating factor for Malignant transformation, metastasis and antitumor immunity","volume":"24","author":"Lozenov","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2017.09.010","article-title":"The gastrointestinal microbiota and its role in oncogenesis","volume":"31","author":"Lam","year":"2017","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.603086","article-title":"Colon carcinogenesis: The interplay between diet and gut microbiota","volume":"10","author":"Loke","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1155\/agm3\/1095370","article-title":"Gut microbiota and gastric cancer: The immunoregulatory mechanism and the preventive role of microbiota\u2010derived short\u2010chain fatty acids","volume":"2025","author":"Chakraborty","year":"2025","journal-title":"Advanced Gut Microbiome Res"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107373","article-title":"Gut microbial metabolites: Shaping future diagnosis and treatment against gastrointestinal cancer","volume":"208","author":"Gou","year":"2024","journal-title":"Pharmacol Res"},{"key":"B123","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.nutres.2024.01.012","article-title":"Molecular crosstalk between polyphenols and gut microbiota in cancer prevention","volume":"124","author":"Zeb","year":"2024","journal-title":"Nutr Res"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1647740","article-title":"Gut microbiome-mediated health effects of fiber and polyphenol-rich dietary interventions","volume":"12","author":"Meiners","year":"2025","journal-title":"Front Nutr"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.06.019","article-title":"Thioproline prevents carcinogenesis in the remnant stomach induced by duodenal reflux","volume":"237","author":"Suo","year":"2006","journal-title":"Cancer Lett"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2348441","article-title":"Commensal microbiota-derived metabolite agmatine triggers inflammation to promote colorectal tumorigenesis","volume":"16","author":"Lu","year":"2024","journal-title":"Gut Microbes"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15123065","article-title":"Distinct signatures of tumor-associated microbiota and metabolome in low-grade vs. high-grade dysplastic colon polyps: Inference of their role in tumor initiation and progression","volume":"15","author":"Clavenna","year":"2023","journal-title":"Cancers (Basel)"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319188","article-title":"Influence of gastrectomy for gastric cancer treatment on faecal microbiome and metabolome profiles","volume":"69","author":"Erawijantari","year":"2020","journal-title":"Gut"},{"key":"B129","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1038\/s41591-022-01779-2","article-title":"Targeting the gut and tumor microbiota in cancer","volume":"28","author":"Park","year":"2022","journal-title":"Nat Med"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2025.189350","article-title":"Tumor immune microenvironment remodeling after neoadjuvant therapy in gastric cancer: Update and new challenges","volume":"1880","author":"Sun","year":"2025","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"B131","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1038\/s41467-026-68612-z","article-title":"A spatially resolved atlas of gastric cancer characterises a lymphocyte-aggregated region","volume":"17","author":"Gao","year":"2026","journal-title":"Nat Commun"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.7150\/thno.71833","article-title":"Single-cell landscape reveals active cell subtypes and their interaction in the tumor microenvironment of gastric cancer","volume":"12","author":"Li","year":"2022","journal-title":"Theranostics"},{"key":"B133","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1186\/s13059-022-02828-2","article-title":"Parallel single-cell and bulk transcriptome analyses reveal key features of the gastric tumor microenvironment","volume":"23","author":"Kang","year":"2022","journal-title":"Genome Biol"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.Cd-21-0683","article-title":"Single-cell atlas of lineage states, tumor microenvironment, and subtype-specific expression programs in gastric cancer","volume":"12","author":"Kumar","year":"2022","journal-title":"Cancer Discov"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2024.2301801","article-title":"The critical role of tumor microbiome in cancer immunotherapy","volume":"25","author":"Yang","year":"2024","journal-title":"Cancer Biol Ther"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-023-2634-7","article-title":"The gut microbiome modulate response to immunotherapy in cancer","volume":"68","author":"Jiang","year":"2025","journal-title":"Sci China Life Sci"},{"key":"B137","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1186\/s12967-024-05709-3","article-title":"Influence of the gut microbiota on immune cell interactions and cancer treatment","volume":"22","author":"Liu","year":"2024","journal-title":"J Transl Med"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1758763","article-title":"The most comprehensive study at single-cell resolution: A giant step toward understanding gastric cancer","volume":"9","author":"Diao","year":"2022","journal-title":"Glob Med Genet"},{"key":"B139","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s00262-024-03820-4","article-title":"Single-cell RNA sequencing to map tumor heterogeneity in gastric carcinogenesis paving roads to individualized therapy","volume":"73","author":"Xu","year":"2024","journal-title":"Cancer Immunol Immunother"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-21-2935","article-title":"Location matters: Profiling diffuse type gastric cancer at the single-cell level","volume":"27","author":"Huang","year":"2021","journal-title":"Clin Cancer Res"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-021-01607-3","article-title":"TIM3(+) cells in gastric cancer: Clinical correlates and association with immune context","volume":"126","author":"Chen","year":"2022","journal-title":"Br J Cancer"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4180517","article-title":"PD-L1 expression and CD8(+) T cell infiltration predict a favorable prognosis in advanced gastric cancer","volume":"2018","author":"Wang","year":"2018","journal-title":"J Immunol Res"},{"key":"B143","doi-asserted-by":"publisher","first-page":"4851","DOI":"10.1038\/s41467-022-32570-z","article-title":"Predicting response to immunotherapy in gastric cancer via multi-dimensional analyses of the tumour immune microenvironment","volume":"13","author":"Chen","year":"2022","journal-title":"Nat Commun"},{"key":"B144","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/s41416-020-01138-3","article-title":"Trastuzumab upregulates programmed death ligand-1 expression through interaction with NK cells in gastric cancer","volume":"124","author":"Yamashita","year":"2021","journal-title":"Br J Cancer"},{"key":"B145","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/s12967-023-04688-1","article-title":"Potential crosstalk between SPP1\u2009+\u2009TAMs and CD8\u2009+\u2009exhausted T cells promotes an immunosuppressive environment in gastric metastatic cancer","volume":"22","author":"Du","year":"2024","journal-title":"J Transl Med"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108551","article-title":"The impaired anti-tumoral effect of immune surveillance cells in the immune microenvironment of gastric cancer","volume":"219","author":"Fan","year":"2020","journal-title":"Clin Immunol"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1282176","article-title":"The role of macrophages in gastric cancer","volume":"14","author":"Zhang","year":"2023","journal-title":"Front Immunol"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.216618","article-title":"IKZF4\/NONO-RAB11FIP3 axis promotes immune evasion in gastric cancer via facilitating PD-L1 endosome recycling","volume":"584","author":"Weng","year":"2024","journal-title":"Cancer Lett"},{"key":"B149","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/s41419-024-06875-4","article-title":"IL-4\/IL-4R axis signaling drives resistance to immunotherapy by inducing the upregulation of Fc\u03b3 receptor IIB in M2 macrophages","volume":"15","author":"Zhang","year":"2024","journal-title":"Cell Death Dis"},{"key":"B150","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/s41392-023-01450-3","article-title":"TRIM28 promotes the escape of gastric cancer cells from immune surveillance by increasing PD-L1 abundance","volume":"8","author":"Ma","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2020.111846","article-title":"Lactic acid promotes macrophage polarization through MCT-HIF1\u03b1 signaling in gastric cancer","volume":"388","author":"Zhang","year":"2020","journal-title":"Exp Cell Res"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114601","article-title":"Metabolic codependencies in the tumor microenvironment and gastric cancer: Difficulties and opportunities","volume":"162","author":"Zhao","year":"2023","journal-title":"BioMed Pharmacother"},{"key":"B153","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s00262-024-03735-0","article-title":"Inhibition of glycolysis enhances the efficacy of immunotherapy via PDK-mediated upregulation of PD-L1","volume":"73","author":"Zhang","year":"2024","journal-title":"Cancer Immunol Immunother"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-023-01456-4","article-title":"Tumor-infiltrating monocytic myeloid-derived suppressor cells contribute to the development of an immunosuppressive tumor microenvironment in gastric cancer","volume":"27","author":"Tsutsumi","year":"2024","journal-title":"Gastric Cancer"},{"key":"B155","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1186\/s12885-021-09065-z","article-title":"Immune landscape of advanced gastric cancer tumor microenvironment identifies immunotherapeutic relevant gene signature","volume":"21","author":"Zhang","year":"2021","journal-title":"BMC Cancer"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.980986","article-title":"Identifying immune cells-related phenotype to predict immunotherapy and clinical outcome in gastric cancer","volume":"13","author":"Jiang","year":"2022","journal-title":"Front Immunol"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1173524","article-title":"Clinical significance of CD155 expression and correlation with cellular components of tumor microenvironment in gastric adenocarcinoma","volume":"14","author":"Liu","year":"2023","journal-title":"Front Immunol"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.06.024","article-title":"CCL2 promotes colorectal carcinogenesis by enhancing polymorphonuclear myeloid-derived suppressor cell population and function","volume":"12","author":"Chun","year":"2015","journal-title":"Cell Rep"},{"key":"B159","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s12935-020-01173-3","article-title":"Identification and validation of stromal-tumor microenvironment-based subtypes tightly associated with PD-1\/PD-L1 immunotherapy and outcomes in patients with gastric cancer","volume":"20","author":"Ren","year":"2020","journal-title":"Cancer Cell Int"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010488","article-title":"The impact of the microbiome on resistance to cancer treatment with chemotherapeutic agents and immunotherapy","volume":"23","author":"Sevcikova","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00533","article-title":"Regulatory T cells and plasmacytoid dendritic cells within the tumor microenvironment in gastric cancer are correlated with gastric microbiota dysbiosis: A preliminary study","volume":"10","author":"Ling","year":"2019","journal-title":"Front Immunol"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1162938","article-title":"TNF+ regulatory T cells regulate the stemness of gastric cancer cells through the IL13\/STAT3 pathway","volume":"13","author":"Zhao","year":"2023","journal-title":"Front Oncol"},{"key":"B163","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s13000-020-00979-z","article-title":"Prognostic perspectives of PD-L1 combined with tumor-infiltrating lymphocytes, Epstein-Barr virus, and microsatellite instability in gastric carcinomas","volume":"15","author":"Choi","year":"2020","journal-title":"Diagn Pathol"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.833584","article-title":"The prognostic value of gastric immune prognostic index in gastric cancer patients treated with PD-1\/PD-L1 inhibitors","volume":"13","author":"Chen","year":"2022","journal-title":"Front Pharmacol"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2023.11.027","article-title":"The role of gut microbiota and metabolites in cancer chemotherapy","volume":"64","author":"Li","year":"2024","journal-title":"J Adv Res"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9071469","article-title":"Nutritional interventions targeting gut microbiota during cancer therapies","volume":"9","author":"Rinninella","year":"2021","journal-title":"Microorganisms"},{"key":"B167","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1080\/01635581.2024.2367266","article-title":"Exploring the relationship between diet, lifestyle and gut microbiome in colorectal cancer development: A recent update","volume":"76","author":"Saha","year":"2024","journal-title":"Nutr Cancer"},{"key":"B168","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/s41522-025-00786-8","article-title":"Gut microbiota shapes cancer immunotherapy responses","volume":"11","author":"Lei","year":"2025","journal-title":"NPJ Biofilms Microbiomes"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-020-01090-4","article-title":"Current status of immune checkpoint inhibitors for gastric cancer","volume":"23","author":"Kono","year":"2020","journal-title":"Gastric Cancer"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-020-09925-3","article-title":"Gastric cancer: a comprehensive review of current and future treatment strategies","volume":"39","author":"Sexton","year":"2020","journal-title":"Cancer Metastasis Rev"},{"key":"B171","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.semcancer.2023.04.009","article-title":"Application of artificial intelligence for improving early detection and prediction of therapeutic outcomes for gastric cancer in the era of precision oncology","volume":"93","author":"Wang","year":"2023","journal-title":"Semin Cancer Biol"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1471273","article-title":"Gut microbiota as a biomarker and modulator of anti-tumor immunotherapy outcomes","volume":"15","author":"Yan","year":"2024","journal-title":"Front Immunol"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-022-00513-x","article-title":"Targeting the gut microbiota for cancer therapy","volume":"22","author":"Fernandes","year":"2022","journal-title":"Nat Rev Cancer"},{"key":"B174","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s40164-023-00442-x","article-title":"Role of gut microbiome in cancer immunotherapy: from predictive biomarker to therapeutic target","volume":"12","author":"Zhang","year":"2023","journal-title":"Exp Hematol Oncol"},{"key":"B175","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.it.2022.11.002","article-title":"The heightened importance of the microbiome in cancer immunotherapy","volume":"44","author":"Villemin","year":"2023","journal-title":"Trends Immunol"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1833138","article-title":"The relationship between gut microbiota and cancer immune response and immunotherapy","volume":"17","author":"Jia","year":"2026","journal-title":"Front Immunol"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.987763","article-title":"Relationships among microbiota, gastric cancer, and immunotherapy","volume":"13","author":"Li","year":"2022","journal-title":"Front Microbiol"},{"key":"B178","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1038\/s41467-023-37636-0","article-title":"Antimicrobial exposure is associated with decreased survival in triple-negative breast cancer","volume":"14","author":"Ransohoff","year":"2023","journal-title":"Nat Commun"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29359","article-title":"Gut microbiome and cancer immunotherapy","volume":"235","author":"Sun","year":"2020","journal-title":"J Cell Physiol"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15184426","article-title":"The influence of the microbiome on immunotherapy for gastroesophageal cancer","volume":"15","author":"Dadgar","year":"2023","journal-title":"Cancers (Basel)"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2024.102737","article-title":"The tumor immune composition of mismatch repair deficient and Epstein-Barr virus-positive gastric cancer: A systematic review","volume":"127","author":"Bos","year":"2024","journal-title":"Cancer Treat Rev"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens13090728","article-title":"Unlocking the potential: Epstein-Barr virus (EBV) in gastric cancer and future treatment prospects, a literature review","volume":"13","author":"Corallo","year":"2024","journal-title":"Pathogens"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1208044","article-title":"The gut dysbiosis-cancer axis: illuminating novel insights and implications for clinical practice","volume":"14","author":"Asseri","year":"2023","journal-title":"Front Pharmacol"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115040","article-title":"Gut microbiota interactions with antitumor immunity in colorectal cancer: From understanding to application","volume":"165","author":"Zhuang","year":"2023","journal-title":"BioMed Pharmacother"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.104967","article-title":"Fecal microbiota transplantation: no longer cinderella in tumour immunotherapy","volume":"100","author":"Yang","year":"2024","journal-title":"EBioMedicine"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abo2003","article-title":"Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity","volume":"8","author":"Choi","year":"2023","journal-title":"Sci Immunol"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-022-01027-2","article-title":"Cancer immunotherapy: Fecal microbiota transplantation brings light","volume":"23","author":"Zhang","year":"2022","journal-title":"Curr Treat Options Oncol"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.949490","article-title":"Antitumor effects of fecal microbiota transplantation: Implications for microbiome modulation in cancer treatment","volume":"13","author":"Xu","year":"2022","journal-title":"Front Immunol"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-024-00901-8","article-title":"Live bacterial therapeutics for detection and treatment of colorectal cancer","volume":"21","author":"Zhang","year":"2024","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111935","article-title":"Progress of engineered bacteria for tumour therapy","volume":"132","author":"Xia","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2023.09.006","article-title":"Build-a-bug workshop: Using microbial-host interactions and synthetic biology tools to create cancer therapies","volume":"31","author":"Raman","year":"2023","journal-title":"Cell Host Microbe"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-031620-031509","article-title":"Engineering the microbiome to prevent adverse events: Challenges and opportunities","volume":"61","author":"Khan","year":"2021","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-324489","article-title":"Human gastric microbiota transplantation recapitulates premalignant lesions in germ-free mice","volume":"71","author":"Kwon","year":"2022","journal-title":"Gut"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-0386-0","article-title":"Gastrointestinal tract modeling using organoids engineered with cellular and microbiota niches","volume":"52","author":"Min","year":"2020","journal-title":"Exp Mol Med"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-024-01240-z","article-title":"Regulation of metaplasia and dysplasia in the stomach by the stromal microenvironment","volume":"56","author":"Rhodes","year":"2024","journal-title":"Exp Mol Med"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12597","article-title":"Guidelines for the management of Helicobacter pylori infection in Japan: 2016 revised edition","volume":"24","author":"Kato","year":"2019","journal-title":"Helicobacter"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002968","article-title":"ACG clinical guideline: Treatment of Helicobacter pylori infection","volume":"119","author":"Chey","year":"2024","journal-title":"Am J Gastroenterol"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1128\/aac.02188-21","article-title":"A survey of Helicobacter pylori antibiotic-resistant genotypes and strain lineages by whole-genome sequencing in China","volume":"66","author":"Zhou","year":"2022","journal-title":"Antimicrob Agents Chemother"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1097\/mog.0000000000000578","article-title":"Treatment of helicobacter pylori","volume":"35","author":"Argueta","year":"2019","journal-title":"Curr Opin Gastroenterol"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i16.1907","article-title":"Development of Helicobacter pylori treatment: How do we manage antimicrobial resistance","volume":"25","author":"Suzuki","year":"2019","journal-title":"World J Gastroenterol"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12698","article-title":"Helicobacter pylori eradication therapy outcome according to clarithromycin susceptibility testing in Japan","volume":"25","author":"Horie","year":"2020","journal-title":"Helicobacter"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2021.03.001","article-title":"Fourteen-day sequential therapy is superior to 7-day triple therapy as first-line regimen for Helicobacter pylori infected children","volume":"121","author":"Su","year":"2022","journal-title":"J Formos Med Assoc"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2012.05.010","article-title":"Different Antibiotic No Culture Eradicating (DANCE) strategy: an easy way to manage H. pylori eradication","volume":"44","author":"Roccarina","year":"2012","journal-title":"Dig Liver Dis"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2021.10.019","article-title":"Levofloxacin-based therapy as an efficient alternative for eradicating Helicobacter pylori infection in Iran: a systematic review and meta-analysis","volume":"29","author":"Keikha","year":"2022","journal-title":"J Glob Antimicrob Resist"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmni.2021.100904","article-title":"Rescue effects of Lactobacillus-containing bismuth regimens after Helicobacter pylori treatment failure","volume":"42","author":"Karbalaei","year":"2021","journal-title":"New Microbes New Infect"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1080\/1040841x.2024.2364194","article-title":"Rapid diagnosis and precision treatment of Helicobacter pylori infection in clinical settings","volume":"51","author":"Umar","year":"2025","journal-title":"Crit Rev Microbiol"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-023-01991-5","article-title":"Vonoprazan: A review in Helicobacter pylori infection","volume":"84","author":"Shirley","year":"2024","journal-title":"Drugs"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12495","article-title":"Systematic review with meta-analysis: Vonoprazan, a potent acid blocker, is superior to proton-pump inhibitors for eradication of clarithromycin-resistant strains of Helicobacter pylori","volume":"23","author":"Li","year":"2018","journal-title":"Helicobacter"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.3390\/ph13100276","article-title":"The potential benefits of Vonoprazan as Helicobacter pylori infection therapy","volume":"13","author":"Miftahussurur","year":"2020","journal-title":"Pharm (Basel)"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14130","article-title":"Systematic review with meta-analysis: the efficacy of vonoprazan-based triple therapy on Helicobacter pylori eradication","volume":"46","author":"Jung","year":"2017","journal-title":"Aliment Pharmacol Ther"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.05.055","article-title":"Vonoprazan triple and dual therapy for Helicobacter pylori infection in the United States and Europe: Randomized clinical trial","volume":"163","author":"Chey","year":"2022","journal-title":"Gastroenterology"},{"key":"B212","doi-asserted-by":"publisher","first-page":"8986","DOI":"10.1038\/s41598-024-59621-3","article-title":"Fourteen-day vonoprazan-based bismuth quadruple therapy for H. pylori eradication in an area with high clarithromycin and levofloxacin resistance: a prospective randomized study (VQ-HP trial)","volume":"14","author":"Tungtrongchitr","year":"2024","journal-title":"Sci Rep"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4305-0","article-title":"Helicobacter pylori eradication with proton pump inhibitors or potassium-competitive acid blockers: The effect of clarithromycin resistance","volume":"61","author":"Matsumoto","year":"2016","journal-title":"Dig Dis Sci"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12788","article-title":"Impact of body size on first-line Helicobacter pylori eradication success using vonoprazan and amoxicillin dual therapy","volume":"26","author":"Eto","year":"2021","journal-title":"Helicobacter"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14992","article-title":"Treatment of Helicobacter pylori infection and its long-term impacts on gut microbiota","volume":"35","author":"Liou","year":"2020","journal-title":"J Gastroenterol Hepatol"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12871","article-title":"Dynamic changes in antibiotic resistance genes and gut microbiota after Helicobacter pylori eradication therapies","volume":"27","author":"Wang","year":"2022","journal-title":"Helicobacter"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1288920","article-title":"Diversity recovery and probiotic shift of gastric microbiota in functional dyspepsia patients after Helicobacter pylori eradication therapy","volume":"14","author":"Wang","year":"2023","journal-title":"Front Microbiol"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16122254","article-title":"Non-Invasive markers for the detection of gastric precancerous conditions","volume":"16","author":"Roma\u0144czyk","year":"2024","journal-title":"Cancers (Basel)"},{"key":"B219","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1007\/s00203-022-03314-w","article-title":"The impacts of probiotics in eradication therapy of Helicobacter pylori","volume":"204","author":"Bai","year":"2022","journal-title":"Arch Microbiol"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-024-10396-z","article-title":"Effects of Lactobacillus spp. on Helicobacter pylori: A promising frontier in the era of antibiotic resistance","volume":"17","author":"Dash","year":"2025","journal-title":"Probiotics Antimicrob Proteins"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6237239","article-title":"Helicobacter pylori infection and gastric dysbiosis: Can probiotics administration be useful to treat this condition","volume":"2018","author":"Bruno","year":"2018","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i37.10644","article-title":"Are probiotics useful in Helicobacter pylori eradication","volume":"21","author":"Homan","year":"2015","journal-title":"World J Gastroenterol"},{"key":"B223","doi-asserted-by":"publisher","first-page":"1600240","DOI":"10.1002\/mnfr.201600240","article-title":"Probiotics, gut microbiota, and their influence on host health and disease","volume":"61","author":"S\u00e1nchez","year":"2017","journal-title":"Mol Nutr Food Res"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13051436","article-title":"Unraveling the puzzle: Health benefits of probiotics-a comprehensive review","volume":"13","author":"Gul","year":"2024","journal-title":"J Clin Med"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2019.1673725","article-title":"Microbiota modulation-based therapy for luminal GI disorders: current applications of probiotics and fecal microbiota transplantation","volume":"19","author":"Elangovan","year":"2019","journal-title":"Expert Opin Biol Ther"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.16.4.658-672.2003","article-title":"Potential uses of probiotics in clinical practice","volume":"16","author":"Reid","year":"2003","journal-title":"Clin Microbiol Rev"},{"key":"B227","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1097\/MCG.0b013e318266f6cf","article-title":"Meta-analysis of the efficacy and safety of Lactobacillus-containing and Bifidobacterium-containing probiotic compound preparation in Helicobacter pylori eradication therapy","volume":"47","author":"Wang","year":"2013","journal-title":"J Clin Gastroenterol"},{"key":"B228","doi-asserted-by":"publisher","first-page":"13152","DOI":"10.1038\/s41598-024-63894-z","article-title":"Saccharomyces boulardii combined with triple therapy alter the microbiota in the eradication of Helicobacter pylori infection","volume":"14","author":"Zhang","year":"2024","journal-title":"Sci Rep"},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06985.x","article-title":"Effect of pretreatment with Lactobacillus gasseri OLL2716 on first-line Helicobacter pylori eradication therapy","volume":"27","author":"Deguchi","year":"2012","journal-title":"J Gastroenterol Hepatol"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2010-3274","article-title":"Bifidobacterium bifidum BF-1 suppresses Helicobacter pylori-induced genes in human epithelial cells","volume":"93","author":"Shirasawa","year":"2010","journal-title":"J Dairy Sci"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-010-1119-4","article-title":"Evaluation of Helicobacter pylori eradication by triple therapy plus Lactobacillus acidophilus compared to triple therapy alone","volume":"30","author":"Medeiros","year":"2011","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"B232","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.coph.2005.06.009","article-title":"Probiotics and nutraceuticals: non-medicinal treatments of gastrointestinal diseases","volume":"5","author":"Penner","year":"2005","journal-title":"Curr Opin Pharmacol"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03480.x","article-title":"Review article: Probiotics in gastrointestinal and liver diseases","volume":"26","author":"Jonkers","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.3390\/foods10061261","article-title":"Impact of the gut microbiota balance on the health-disease relationship: The importance of consuming probiotics and prebiotics","volume":"10","author":"Olvera-Rosales","year":"2021","journal-title":"Foods"},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.3390\/nu13010081","article-title":"The impact of whole grain intake on gastrointestinal tumors: A focus on colorectal, gastric, and esophageal cancers","volume":"13","author":"Tullio","year":"2020","journal-title":"Nutrients"},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030625","article-title":"Interplay between dietary polyphenols and oral and gut microbiota in the development of colorectal cancer","volume":"12","author":"Cueva","year":"2020","journal-title":"Nutrients"},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155540","article-title":"Studies on the mechanisms of Helicobacter pylori inhibition by Syzygium aromaticum aqueous extract","volume":"130","author":"Peng","year":"2024","journal-title":"Phytomedicine"},{"key":"B238","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2019.105584","article-title":"Confirmation by solid-state NMR spectroscopy of a strong complex phenol-dietary fiber with retention of antioxidant activity in vitro","volume":"102","author":"Berm\u00fadez-Oria","year":"2020","journal-title":"Food Hydrocolloids"},{"key":"B239","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2019.05.002","article-title":"Syzygium aromaticum L.: Traditional herbal medicine against cagA and vacA toxin genes-producing drug resistant Helicobacter pylori","volume":"10","author":"El-Shouny","year":"2020","journal-title":"J Tradit Complement Med"},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116618","article-title":"Coptisine inhibits Helicobacter pylori and reduces the expression of CagA to alleviate host inflammation in vitro and in vivo","volume":"314","author":"Tang","year":"2023","journal-title":"J Ethnopharmacol"},{"key":"B241","doi-asserted-by":"publisher","DOI":"10.3390\/nu11010032","article-title":"Olive oil effects on colorectal cancer","volume":"11","author":"Borz\u00ec","year":"2018","journal-title":"Nutrients"},{"key":"B242","doi-asserted-by":"publisher","DOI":"10.3390\/foods9091279","article-title":"Modifications of gut microbiota after grape pomace supplementation in subjects at cardiometabolic risk: A randomized cross-over controlled clinical trial","volume":"9","author":"Ramos-Romero","year":"2020","journal-title":"Foods"},{"key":"B243","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8218","article-title":"The health benefits of dietary polyphenols on pediatric intestinal diseases: Mechanism of action, clinical evidence and future research progress","volume":"38","author":"Jiang","year":"2024","journal-title":"Phytother Res"},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1087755","article-title":"The effects of traditional Chinese medicine and dietary compounds on digestive cancer immunotherapy and gut microbiota modulation: A review","volume":"14","author":"Feng","year":"2023","journal-title":"Front Immunol"},{"key":"B245","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7068","article-title":"Potential therapeutic applications of phytoconstituents as immunomodulators: Pre-clinical and clinical evidences","volume":"35","author":"Ali","year":"2021","journal-title":"Phytother Res"},{"key":"B246","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.725821","article-title":"Dietary patterns and associated microbiome changes that promote oncogenesis","volume":"9","author":"Ibragimova","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2025.105085","article-title":"Phage therapy in cancer treatment: Mechanisms, emerging innovations, and translational progress","volume":"218","author":"Hsu","year":"2026","journal-title":"Crit Rev Oncol Hematol"},{"key":"B248","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10080999","article-title":"Bacteriophage technology and modern medicine","volume":"10","author":"Azam","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"B249","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2020.11.003","article-title":"Enhancing phage therapy through synthetic biology and genome engineering","volume":"68","author":"Lenneman","year":"2021","journal-title":"Curr Opin Biotechnol"},{"key":"B250","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioteChadv.2023.108116","article-title":"Genetic engineering of bacteriophages: Key concepts, strategies, and applications","volume":"64","author":"Hussain","year":"2023","journal-title":"Biotechnol Adv"},{"key":"B251","doi-asserted-by":"publisher","DOI":"10.1080\/1040841x.2023.2274849","article-title":"The potential for bacteriophages and prophage elements in fighting and preventing the gonorrhea","volume":"50","author":"Adamczyk-Pop\u0142awska","year":"2024","journal-title":"Crit Rev Microbiol"},{"key":"B252","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2022.127155","article-title":"The resurgence of phage-based therapy in the era of increasing antibiotic resistance: From research progress to challenges and prospects","volume":"264","author":"Anyaegbunam","year":"2022","journal-title":"Microbiol Res"},{"key":"B253","doi-asserted-by":"publisher","first-page":"24404","DOI":"10.1038\/s41598-024-76427-5","article-title":"Current and future directions in bacteriophage research for developing therapeutic innovations","volume":"14","author":"Cui","year":"2024","journal-title":"Sci Rep"},{"key":"B254","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2206739119","article-title":"Synthetic engineering and biological containment of bacteriophages","volume":"119","author":"Mitsunaka","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"key":"B255","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1016\/j.celrep.2019.09.062","article-title":"Reprogramming bacteriophage host range through structure-guided design of chimeric receptor binding proteins","volume":"29","author":"Dunne","year":"2019","journal-title":"Cell Rep"},{"key":"B256","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12282","article-title":"The presence of phage orthologous genes in Helicobacter pylori correlates with the presence of the virulence factors CagA and VacA","volume":"21","author":"Kyrillos","year":"2016","journal-title":"Helicobacter"},{"key":"B257","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.coisb.2017.05.009","article-title":"Advances in bacterial cancer therapies using synthetic biology","volume":"5","author":"Chien","year":"2017","journal-title":"Curr Opin Syst Biol"},{"key":"B258","doi-asserted-by":"publisher","DOI":"10.1126\/science.1206843","article-title":"Synthetic biology moving into the clinic","volume":"333","author":"Ruder","year":"2011","journal-title":"Science"},{"key":"B259","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11144119","article-title":"Fecal microbiota transplantation as new therapeutic avenue for human diseases","volume":"11","author":"Biazzo","year":"2022","journal-title":"J Clin Med"},{"key":"B260","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1333864","article-title":"Mechanism-guided fine-tuned microbiome potentiates anti-tumor immunity in HCC","volume":"14","author":"Liu","year":"2023","journal-title":"Front Immunol"},{"key":"B261","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1158\/0008-5472.Can-20-2629","article-title":"The microbiome and cancer: Creating friendly neighborhoods and removing the foes within","volume":"81","author":"Parida","year":"2021","journal-title":"Cancer Res"},{"key":"B262","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2023.103797","article-title":"Drug and gut microbe relationships: Moving beyond antibiotics","volume":"28","author":"Kumbhare","year":"2023","journal-title":"Drug Discov Today"},{"key":"B263","doi-asserted-by":"publisher","DOI":"10.1002\/ags3.12439","article-title":"History and emerging trends in chemotherapy for gastric cancer","volume":"5","author":"Yamashita","year":"2021","journal-title":"Ann Gastroenterol Surg"},{"key":"B264","doi-asserted-by":"publisher","DOI":"10.1080\/1040841x.2023.2247493","article-title":"Mechanisms underlying the effects, and clinical applications, of oral microbiota in lung cancer: current challenges and prospects","volume":"50","author":"Ma","year":"2024","journal-title":"Crit Rev Microbiol"},{"key":"B265","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2019.12.003","article-title":"Immunotherapy for Malignant glioma: Current status and future directions","volume":"41","author":"Wang","year":"2020","journal-title":"Trends Pharmacol Sci"},{"key":"B266","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2023.103988","article-title":"Clinical and molecular overview of immunotherapeutic approaches for Malignant skin melanoma: Past, present and future","volume":"186","author":"Venzel","year":"2023","journal-title":"Crit Rev Oncol Hematol"},{"key":"B267","doi-asserted-by":"publisher","DOI":"10.1126\/science.abl7070","article-title":"Gut bacteria enable prostate cancer growth","volume":"374","author":"Mcculloch","year":"2021","journal-title":"Science"},{"key":"B268","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9080436","article-title":"Best Helicobacter pylori eradication strategy in the era of antibiotic resistance","volume":"9","author":"Kim","year":"2020","journal-title":"Antibiotics (Basel)"},{"key":"B269","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a023879","article-title":"Phage therapy in the era of synthetic biology","volume":"8","author":"Barbu","year":"2016","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B270","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11112930","article-title":"Fecal microbiota transplantation in liver cirrhosis","volume":"11","author":"Boicean","year":"2023","journal-title":"Biomedicines"},{"key":"B271","doi-asserted-by":"publisher","DOI":"10.2174\/0109298673284520240112055108","article-title":"Multi-omics combined with machine learning facilitating the diagnosis of gastric cancer","volume":"31","author":"Li","year":"2024","journal-title":"Curr Med Chem"},{"key":"B272","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2026.102756","article-title":"A 15-layer multi-omics analysis of gastric cancer ecotypes provides therapeutic insights","volume":"7","author":"Wang","year":"2026","journal-title":"Cell Rep Med"},{"key":"B273","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1680517","article-title":"Integrative multi-omics analysis of gastric cancer evolution from precancerous lesions to metastasis identifies a deep learning-based prognostic model","volume":"16","author":"Ren","year":"2025","journal-title":"Front Immunol"},{"key":"B274","doi-asserted-by":"publisher","DOI":"10.1039\/d2mo00288d","article-title":"Multi-omics insights into the interplay between gut microbiota and colorectal cancer in the \"microworld\" age","volume":"19","author":"Wang","year":"2023","journal-title":"Mol Omics"},{"key":"B275","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.3c00894","article-title":"Multiomics analysis revealed colorectal cancer pathogenesis","volume":"23","author":"Xu","year":"2024","journal-title":"J Proteome Res"},{"key":"B276","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms12030484","article-title":"Gut microbiome-colorectal cancer relationship","volume":"12","author":"Yadav","year":"2024","journal-title":"Microorganisms"},{"key":"B277","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13020420","article-title":"From the colon to the liver: How gut microbiota may influence colorectal cancer metastatic potential","volume":"13","author":"Mignini","year":"2024","journal-title":"J Clin Med"},{"key":"B278","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-21-0792","article-title":"Spatially distinct reprogramming of the tumor microenvironment based on tumor invasion in diffuse-type gastric cancers","volume":"27","author":"Jeong","year":"2021","journal-title":"Clin Cancer Res"},{"key":"B279","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.18159","article-title":"Exploring the current landscape of single-cell RNA sequencing applications in gastric cancer research","volume":"28","author":"Awuah","year":"2024","journal-title":"J Cell Mol Med"},{"key":"B280","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104371","article-title":"Impacts of neoadjuvant chemoradiotherapy on the immune landscape of esophageal squamous cell carcinoma","volume":"86","author":"Wen","year":"2022","journal-title":"EBioMedicine"},{"key":"B281","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1186\/s12967-023-04600-x","article-title":"Unraveling temporal and spatial biomarkers of epithelial-mesenchymal transition in colorectal cancer: Insights into the crucial role of immunosuppressive cells","volume":"21","author":"Wang","year":"2023","journal-title":"J Transl Med"},{"key":"B282","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2024.101080","article-title":"Circumventing drug resistance in gastric cancer: A spatial multi-omics exploration of chemo and immuno-therapeutic response dynamics","volume":"74","author":"Che","year":"2024","journal-title":"Drug Resist Update"},{"key":"B283","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-320368","article-title":"Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing","volume":"70","author":"Zhang","year":"2021","journal-title":"Gut"},{"key":"B284","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v17.i2.97125","article-title":"Landscape of four different stages of human gastric cancer revealed by single-cell sequencing","volume":"17","author":"Tang","year":"2025","journal-title":"World J Gastrointest Oncol"},{"key":"B285","doi-asserted-by":"publisher","first-page":"2692","DOI":"10.1038\/s41467-023-38360-5","article-title":"Spatially resolved multi-omics highlights cell-specific metabolic remodeling and interactions in gastric cancer","volume":"14","author":"Sun","year":"2023","journal-title":"Nat Commun"},{"key":"B286","doi-asserted-by":"publisher","DOI":"10.1038\/s41435-024-00297-0","article-title":"Combined single cell and spatial transcriptome analysis reveals cellular heterogeneity of hedgehog pathway in gastric cancer","volume":"25","author":"Zhang","year":"2024","journal-title":"Genes Immun"},{"key":"B287","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2023.9","article-title":"Fusobacterium nucleatum: a novel immune modulator in breast cancer","volume":"25","author":"Little","year":"2023","journal-title":"Expert Rev Mol Med"},{"key":"B288","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2024.105317","article-title":"Paired qualitative and quantitative analysis of bacterial microcolonies in the tonsils of patients with tonsillar hyperplasia","volume":"26","author":"Teh","year":"2024","journal-title":"Microbes Infect"},{"key":"B289","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/jgh.15042","article-title":"Intestinal microbiota and its association with colon cancer and red\/processed meat consumption","volume":"36","author":"Abu-Ghazaleh","year":"2021","journal-title":"J Gastroenterol Hepatol"},{"key":"B290","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/bs.pmbts.2020.03.004","article-title":"Mucosa microbiome of gastric lesions: Fungi and bacteria interactions","volume":"171","author":"Wang","year":"2020","journal-title":"Prog Mol Biol Transl Sci"},{"key":"B291","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1016\/j.celrep.2019.04.052","article-title":"Dissecting the single-cell transcriptome network underlying gastric premalignant lesions and early gastric cancer","volume":"27","author":"Zhang","year":"2019","journal-title":"Cell Rep"},{"key":"B292","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.946995","article-title":"Mycobiota and C-type lectin receptors in cancers: Know thy neighbors","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Microbiol"},{"key":"B293","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-020-02235-2","article-title":"The microbiome, genetics, and gastrointestinal neoplasms: the evolving field of molecular pathological epidemiology to analyze the tumor-immune-microbiome interaction","volume":"140","author":"Mima","year":"2021","journal-title":"Hum Genet"},{"key":"B294","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11061476","article-title":"A putative role of Candida albicans in promoting cancer development: A current state of evidence and proposed mechanisms","volume":"11","author":"Talapko","year":"2023","journal-title":"Microorganisms"},{"key":"B295","doi-asserted-by":"publisher","DOI":"10.7150\/thno.55209","article-title":"Candida albicans disorder is associated with gastric carcinogenesis","volume":"11","author":"Zhong","year":"2021","journal-title":"Theranostics"},{"key":"B296","doi-asserted-by":"publisher","first-page":"3807","DOI":"10.1016\/j.cell.2022.09.015","article-title":"A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors","volume":"185","author":"Dohlman","year":"2022","journal-title":"Cell"},{"key":"B297","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6011632","article-title":"Dysbiosis of gastric mucosal fungal microbiota in the gastric cancer microenvironment","volume":"2022","author":"Zhang","year":"2022","journal-title":"J Immunol Res"},{"key":"B298","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.09.013","article-title":"The tumor mycobiome: A paradigm shift in cancer pathogenesis","volume":"185","author":"Li","year":"2022","journal-title":"Cell"},{"key":"B299","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/s41579-022-00816-8","article-title":"Spotlight on the cancer mycobiome","volume":"20","author":"Du Toit","year":"2022","journal-title":"Nat Rev Microbiol"},{"key":"B300","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ctrv.2018.03.006","article-title":"Outlooks on Epstein-Barr virus associated gastric cancer","volume":"66","author":"Naseem","year":"2018","journal-title":"Cancer Treat Rev"},{"key":"B301","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2023.109238","article-title":"CD47-targeted immunotherapy unleashes antitumour immunity in Epstein-Barr virus-associated gastric cancer","volume":"247","author":"Duan","year":"2023","journal-title":"Clin Immunol"},{"key":"B302","doi-asserted-by":"publisher","DOI":"10.1186\/1750-9378-7-21","article-title":"Epstein-barr virus infected gastric adenocarcinoma expresses latent and lytic viral transcripts and has a distinct human gene expression profile","volume":"7","author":"Tang","year":"2012","journal-title":"Infect Agent Cancer"},{"key":"B303","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.36408","article-title":"Prediction of epstein-barr virus status in gastric cancer biopsy specimens using a deep learning algorithm","volume":"5","author":"Vuong","year":"2022","journal-title":"JAMA Netw Open"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1953049\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:41:33Z","timestamp":1789386093000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1953049\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,14]]},"references-count":303,"alternative-id":["10.3389\/fimmu.2026.1953049"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1953049","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,14]]},"article-number":"1953049"}}