{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:59:47Z","timestamp":1790600387554,"version":"4.1.0"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Mechanical high-intensity focused ultrasound releases tumor antigens and danger signals. It provides a potential substrate for immune checkpoint blockade. However, antigen release does not necessarily generate productive dendritic cell priming. In colorectal cancer, this transition occurs within a mucosal microenvironment shaped by epithelial barrier integrity, microbial exposure and myeloid clearance. Neutrophils can support epithelial repair or reinforce tumor-associated suppression. Macrophages remove apoptotic granulocytes and regulate inflammatory resolution. They can also restrain dendritic cell cytokine production. These context-dependent functions may determine whether mechanically released antigens initiate cytotoxic immunity or enter a nonproductive clearance response. This mini review integrates intestinal myeloid homeostasis with experimental evidence for mechanical ultrasound ablation and PD-1\/PD-L1 blockade. It distinguishes antigen uptake from cross-presentation, protective resolution from tumor-permissive suppression, and colorectal evidence from observations in other tumor models. Functional dendritic cell readouts, lineage-resolved checkpoint measurements and concurrent barrier assessment provide a framework for evaluating combination therapy. The therapeutic objective is to preserve mucosal protection while sustaining antigen-specific immunity.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1998296","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:21:16Z","timestamp":1790598076000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Myeloid control of dendritic cell priming after mechanical HIFU in colorectal cancer: implications for PD-1\/PD-L1 blockade"],"prefix":"10.3389","volume":"17","author":[{"given":"Yao","family":"Liao","sequence":"first","affiliation":[{"name":"Sichuan Clinical Research Center for Radiation and Therapy, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China","place":["Mianyang, China"]},{"name":"Department of Oncology, Mianyang Central Hospital,School of Medicine, University of Electronic Science and Technology of China","place":["Mianyang, 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