{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:17:14Z","timestamp":1790471834789,"version":"4.1.0"},"reference-count":224,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"DOI":"10.3389\/fmed.2017.00103","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T05:39:02Z","timestamp":1500874742000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":113,"title":["Bidirectional Mast Cell\u2013Eosinophil Interactions in Inflammatory Disorders and Cancer"],"prefix":"10.3389","volume":"4","author":[{"given":"Maria Rosaria","family":"Galdiero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilda","family":"Varricchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansour","family":"Seaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Marone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Levi-Schaffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Marone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,7,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1111\/cea.12675","article-title":"Mast cells in asthma \u2013 state of the art","volume":"46","author":"Bradding","year":"2016","journal-title":"Clin Exp Allergy"},{"key":"B2","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.it.2004.10.010","article-title":"Mast cells and basophils: friends as well as foes in bronchial asthma?","volume":"26","author":"Marone","year":"2005","journal-title":"Trends Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1097\/ACI.0000000000000251","article-title":"Interleukin-5 pathway inhibition in the treatment of eosinophilic respiratory disorders: evidence and unmet needs","volume":"16","author":"Varricchi","year":"2016","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1002\/art.39192","article-title":"Ability of interleukin-33- and immune complex-triggered activation of human mast cells to down-regulate monocyte-mediated immune responses","volume":"67","author":"Rivellese","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1136\/annrheumdis-2014-205562","article-title":"Toll-like receptor triggering augments activation of human mast cells by anti-citrullinated protein antibodies","volume":"74","author":"Suurmond","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"B6","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1002\/iid3.94","article-title":"Prostaglandin D2 metabolites as a biomarker of in vivo mast cell activation in systemic mastocytosis and rheumatoid arthritis","volume":"4","author":"Cho","year":"2016","journal-title":"Immun Inflamm Dis"},{"key":"B7","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1038\/ni.3326","article-title":"Self-reactive IgE exacerbates interferon responses associated with autoimmunity","volume":"17","author":"Henault","year":"2016","journal-title":"Nat Immunol"},{"key":"B8","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.4049\/jimmunol.157.3.1219","article-title":"Eosinophil granule proteins activate human heart mast cells","volume":"157","author":"Patella","year":"1996","journal-title":"J Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1159\/000237546","article-title":"Eosinophil granule proteins are selective activators of human heart mast cells","volume":"113","author":"Patella","year":"1997","journal-title":"Int Arch Allergy Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1161\/01.CIR.92.5.1084","article-title":"Infiltrates of activated mast cells at the site of coronary atheromatous erosion or rupture in myocardial infarction","volume":"92","author":"Kovanen","year":"1995","journal-title":"Circulation"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1161\/01.ATV.0000140820.51174.8d","article-title":"Mast cells in neovascularized human coronary plaques store and secrete basic fibroblast growth factor, a potent angiogenic mediator","volume":"24","author":"Lappalainen","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1172\/JCI25713","article-title":"Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia\/reperfusion","volume":"116","author":"Mackins","year":"2006","journal-title":"J Clin Invest"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1161\/CIRCRESAHA.108.173682","article-title":"Adventitial mast cells contribute to pathogenesis in the progression of abdominal aortic aneurysm","volume":"102","author":"Tsuruda","year":"2008","journal-title":"Circ Res"},{"key":"B14","doi-asserted-by":"publisher","first-page":"3359","DOI":"10.1172\/JCI31311","article-title":"Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice","volume":"117","author":"Sun","year":"2007","journal-title":"J Clin Invest"},{"key":"B15","doi-asserted-by":"publisher","first-page":"21093","DOI":"10.1073\/pnas.1015166107","article-title":"Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm","volume":"107","author":"Di Gennaro","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B16","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/ni.3159","article-title":"Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8(+) T cells","volume":"16","author":"Carretero","year":"2015","journal-title":"Nat Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"7443","DOI":"10.4049\/jimmunol.1000446","article-title":"Human eosinophils exert TNF-alpha and granzyme A-mediated tumoricidal activity toward colon carcinoma cells","volume":"185","author":"Legrand","year":"2010","journal-title":"J Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.ejphar.2015.03.088","article-title":"Mast cells and basophils in inflammatory and tumor angiogenesis and lymphangiogenesis","volume":"778","author":"Marone","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e1168556","DOI":"10.1080\/2162402X.2016.1168556","article-title":"The immune network in thyroid cancer","volume":"5","author":"Galdiero","year":"2016","journal-title":"Oncoimmunology"},{"key":"B20","volume-title":"Beitrage zur Theorie und Praxis der histologischen Farbung","author":"Ehrlich","year":"1878"},{"key":"B21","first-page":"166","article-title":"Beitrage zur Kenntnis der granulierten Bindegewbszellen und der eosinophilen Leukocyten","author":"Ehrlich","year":"1879","journal-title":"Arch Anat Physiol (Leipzig)"},{"key":"B22","first-page":"571","article-title":"Uber die specifischen Granulationen des Blutes","author":"Ehrlich","year":"1879","journal-title":"Arch Anat Physiol (Leipzig)"},{"key":"B23","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.coph.2014.07.002","article-title":"Immunopharmacological modulation of mast cells","volume":"17","author":"Borriello","year":"2014","journal-title":"Curr Opin Pharmacol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.pharmthera.2016.10.010","article-title":"Mast cell and eosinophil surface receptors as targets for anti-allergic therapy","volume":"170","author":"Gangwar","year":"2017","journal-title":"Pharmacol Ther"},{"key":"B25","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/164_2017_18","article-title":"Histamine release from mast cells and basophils","volume":"241","author":"Borriello","year":"2017","journal-title":"Handb Exp Pharmacol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1038\/ni.3445","article-title":"Expression profiling of constitutive mast cells reveals a unique identity within the immune system","volume":"17","author":"Dwyer","year":"2016","journal-title":"Nat Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/ni.3412","article-title":"Distinct myeloid progenitor-differentiation pathways identified through single-cell RNA sequencing","volume":"17","author":"Drissen","year":"2016","journal-title":"Nat Immunol"},{"key":"B28","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1182\/blood.V94.7.2333.419k30_2333_2342","article-title":"Demonstration that human mast cells arise from a progenitor cell population that is CD34(+), c-kit(+), and expresses aminopeptidase N (CD13)","volume":"94","author":"Kirshenbaum","year":"1999","journal-title":"Blood"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.04.001","article-title":"Rheostatic functions of mast cells in the control of innate and adaptive immune responses","author":"Frossi","year":"2017","journal-title":"Trends Immunol"},{"key":"B30","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1182\/blood.V79.4.958.bloodjournal794958","article-title":"The c-kit receptor ligand functions as a mast cell chemoattractant","volume":"79","author":"Meininger","year":"1992","journal-title":"Blood"},{"key":"B31","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1084\/jem.20081756","article-title":"Identification of the human eosinophil lineage-committed progenitor: revision of phenotypic definition of the human common myeloid progenitor","volume":"206","author":"Mori","year":"2009","journal-title":"J Exp Med"},{"key":"B32","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1111\/j.1365-2222.2011.03854.x","article-title":"Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor","volume":"42","author":"Molfino","year":"2012","journal-title":"Clin Exp Allergy"},{"key":"B33","doi-asserted-by":"publisher","first-page":"3445","DOI":"10.4049\/jimmunol.1600611","article-title":"IL-33 precedes IL-5 in regulating eosinophil commitment and is required for eosinophil homeostasis","volume":"197","author":"Johnston","year":"2016","journal-title":"J Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1007\/s11894-006-0024-6","article-title":"Eosinophils in the gastrointestinal tract","volume":"8","author":"Lamouse-Smith","year":"2006","journal-title":"Curr Gastroenterol Rep"},{"key":"B35","doi-asserted-by":"publisher","first-page":"999","DOI":"10.4049\/jimmunol.1400413","article-title":"Roles and regulation of gastrointestinal eosinophils in immunity and disease","volume":"193","author":"Jung","year":"2014","journal-title":"J Immunol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.jaci.2012.07.025","article-title":"Human versus mouse eosinophils: \u201cthat which we call an eosinophil, by any other name would stain as red\u201d","volume":"130","author":"Lee","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S0065-2776(08)01003-1","article-title":"Biology of the eosinophil","volume":"101","author":"Blanchard","year":"2009","journal-title":"Adv Immunol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1034\/j.1600-065X.2001.790117.x","article-title":"Elemental signals regulating eosinophil accumulation in the lung","volume":"179","author":"Foster","year":"2001","journal-title":"Immunol Rev"},{"key":"B39","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/S1471-4906(02)02274-3","article-title":"Probing the roles of mast cells and basophils in natural and acquired immunity, physiology and disease","volume":"23","author":"Marone","year":"2002","journal-title":"Trends Immunol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/nm.2755","article-title":"IgE and mast cells in allergic disease","volume":"18","author":"Galli","year":"2012","journal-title":"Nat Med"},{"key":"B41","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1159\/000069515","article-title":"Mast cells in basal cell carcinoma express VEGF, IL-8 and RANTES","volume":"130","author":"Aoki","year":"2003","journal-title":"Int Arch Allergy Immunol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1097\/DAD.0b013e31815c932a","article-title":"Mast cells have prognostic value in Merkel cell carcinoma","volume":"30","author":"Beer","year":"2008","journal-title":"Am J Dermatopathol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1111\/1523-1747.ep12523627","article-title":"Melanoma. An ultrastructural study of the host inflammatory and vascular responses","volume":"75","author":"Dvorak","year":"1980","journal-title":"J Invest Dermatol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1172\/JCI79840","article-title":"Mast cells mediate malignant pleural effusion formation","volume":"125","author":"Giannou","year":"2015","journal-title":"J Clin Invest"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.2353\/ajpath.2010.100070","article-title":"Mast cells are novel independent prognostic markers in prostate cancer and represent a target for therapy","volume":"177","author":"Johansson","year":"2010","journal-title":"Am J Pathol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"3927","DOI":"10.1158\/0008-5472.CAN-12-4479","article-title":"Dynamic mast cell-stromal cell interactions promote growth of pancreatic cancer","volume":"73","author":"Ma","year":"2013","journal-title":"Cancer Res"},{"key":"B47","doi-asserted-by":"publisher","first-page":"6203","DOI":"10.1038\/onc.2010.348","article-title":"Mast cells have a protumorigenic role in human thyroid cancer","volume":"29","author":"Melillo","year":"2010","journal-title":"Oncogene"},{"key":"B48","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1097\/DAD.0b013e318172364d","article-title":"Vascular density has prognostic value in Merkel cell carcinoma","volume":"30","author":"Ng","year":"2008","journal-title":"Am J Dermatopathol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"5987","DOI":"10.1158\/0008-5472.CAN-11-1637","article-title":"Mast cell targeting hampers prostate adenocarcinoma development but promotes the occurrence of highly malignant neuroendocrine cancers","volume":"71","author":"Pittoni","year":"2011","journal-title":"Cancer Res"},{"key":"B50","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/S0959-8049(02)00150-8","article-title":"Neovascularisation, expression of fibroblast growth factor-2, and mast cells with tryptase activity increase simultaneously with pathological progression in human malignant melanoma","volume":"39","author":"Ribatti","year":"2003","journal-title":"Eur J Cancer"},{"key":"B51","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1046\/j.1365-2362.2003.01152.x","article-title":"Tumor vascularity and tryptase-positive mast cells correlate with a poor prognosis in melanoma","volume":"33","author":"Ribatti","year":"2003","journal-title":"Eur J Clin Invest"},{"key":"B52","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1097\/CMR.0000000000000192","article-title":"Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma","volume":"25","author":"Siiskonen","year":"2015","journal-title":"Melanoma Res"},{"key":"B53","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1172\/JCI117241","article-title":"Cellular markers that distinguish the phases of hemangioma during infancy and childhood","volume":"93","author":"Takahashi","year":"1994","journal-title":"J Clin Invest"},{"key":"B54","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1053\/hupa.2000.16658","article-title":"Cutaneous malignant melanoma: correlation between neovascularization and peritumor accumulation of mast cells overexpressing vascular endothelial growth factor","volume":"31","author":"Toth-Jakatics","year":"2000","journal-title":"Hum Pathol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.ajpath.2015.09.016","article-title":"Inhibition of mast cell-derived histamine decreases human cholangiocarcinoma growth and differentiation via c-kit\/stem cell factor-dependent signaling","volume":"186","author":"Johnson","year":"2016","journal-title":"Am J Pathol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/sj.bjc.6690070","article-title":"Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma","volume":"79","author":"Ribatti","year":"1999","journal-title":"Br J Cancer"},{"key":"B57","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1182\/blood-2012-03-415638","article-title":"Mast cells play a protumorigenic role in primary cutaneous lymphoma","volume":"120","author":"Rabenhorst","year":"2012","journal-title":"Blood"},{"key":"B58","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1159\/000443275","article-title":"The impact of mast cell density on the progression of bone disease in multiple myeloma patients","volume":"168","author":"Vyzoukaki","year":"2015","journal-title":"Int Arch Allergy Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"792","DOI":"10.2353\/ajpath.2010.091286","article-title":"Mast cells and Th17\u2009cells contribute to the lymphoma-associated pro-inflammatory microenvironment of angioimmunoblastic T-cell lymphoma","volume":"177","author":"Tripodo","year":"2010","journal-title":"Am J Pathol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"4664","DOI":"10.1182\/blood-2007-11-125823","article-title":"Prognostic influence of tumor-infiltrating mast cells in patients with follicular lymphoma treated with rituximab and CHOP","volume":"111","author":"Taskinen","year":"2008","journal-title":"Blood"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1182\/blood-2013-04-497271","article-title":"Bone marrow stroma CD40 expression correlates with inflammatory mast cell infiltration and disease progression in splenic marginal zone lymphoma","volume":"123","author":"Franco","year":"2014","journal-title":"Blood"},{"key":"B62","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1046\/j.1365-2141.2002.03768.x","article-title":"Mast cell infiltration correlates with poor prognosis in Hodgkin\u2019s lymphoma","volume":"119","author":"Molin","year":"2002","journal-title":"Br J Haematol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1111\/ejh.12583","article-title":"Tumour-associated mast cells in classical Hodgkin\u2019s lymphoma: correlation with histological subtype, other tumour-infiltrating inflammatory cell subsets and outcome","volume":"96","author":"Andersen","year":"2016","journal-title":"Eur J Haematol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1111\/ejh.12747","article-title":"The role of tumour-infiltrating eosinophils, mast cells and macrophages in classical and nodular lymphocyte predominant Hodgkin lymphoma in children","volume":"97","author":"Englund","year":"2016","journal-title":"Eur J Haematol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s00441-010-1010-8","article-title":"Ultrastructural evidence for human mast cell-eosinophil interactions in vitro","volume":"341","author":"Minai-Fleminger","year":"2010","journal-title":"Cell Tissue Res"},{"key":"B66","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1111\/j.1398-9995.2010.02494.x","article-title":"Physical interactions between mast cells and eosinophils: a novel mechanism enhancing eosinophil survival in vitro","volume":"66","author":"Elishmereni","year":"2011","journal-title":"Allergy"},{"key":"B67","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1111\/all.12059","article-title":"Interacting mast cells and eosinophils acquire an enhanced activation state in vitro","volume":"68","author":"Elishmereni","year":"2013","journal-title":"Allergy"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1124\/jpet.102.046581","article-title":"Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells","volume":"305","author":"Hofstra","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"B69","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.molimm.2014.05.007","article-title":"Functional characterization of histamine H4 receptor on human mast cells","volume":"62","author":"Jemima","year":"2014","journal-title":"Mol Immunol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"6192","DOI":"10.1073\/pnas.81.19.6192","article-title":"Adenosine release from stimulated mast cells","volume":"81","author":"Marquardt","year":"1984","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B71","doi-asserted-by":"publisher","first-page":"134","DOI":"10.3389\/fimmu.2012.00134","article-title":"Mast cell adenosine receptors function: a focus on the a3 adenosine receptor and inflammation","volume":"3","author":"Rudich","year":"2012","journal-title":"Front Immunol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/j.1365-2125.1983.tb01481.x","article-title":"Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects","volume":"15","author":"Cushley","year":"1983","journal-title":"Br J Clin Pharmacol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1164\/ajrccm\/138.5.1143","article-title":"Adenosine potentiates mediator release from human lung mast cells","volume":"138","author":"Peachell","year":"1988","journal-title":"Am Rev Respir Dis"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.4049\/jimmunol.1001563","article-title":"Adenosine potentiates human lung mast cell tissue plasminogen activator activity","volume":"186","author":"Sereda","year":"2011","journal-title":"J Immunol"},{"key":"B75","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1111\/j.1476-5381.2011.01446.x","article-title":"Reciprocal modulation of anti-IgE induced histamine release from human mast cells by A(1) and A(2B) adenosine receptors","volume":"164","author":"Yip","year":"2011","journal-title":"Br J Pharmacol"},{"key":"B76","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1007\/s000110050644","article-title":"Studies on the effects of adenosine A3 receptor stimulation on human eosinophils isolated from non-asthmatic or asthmatic donors","volume":"49","author":"Reeves","year":"2000","journal-title":"Inflamm Res"},{"key":"B77","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/S0006-291X(02)02910-8","article-title":"Positive coupling of atypical adenosine A3 receptors on human eosinophils to adenylyl cyclase","volume":"300","author":"Ezeamuzie","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"B78","doi-asserted-by":"publisher","first-page":"2662","DOI":"10.4049\/jimmunol.169.5.2662","article-title":"Tryptase activates the mitogen-activated protein kinase\/activator protein-1 pathway in human peripheral blood eosinophils, causing cytokine production and release","volume":"169","author":"Temkin","year":"2002","journal-title":"J Immunol"},{"key":"B79","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1097\/MD.0b013e3181af35a5","article-title":"Cardiac involvement in Churg-Strauss syndrome: impact of endomyocarditis","volume":"88","author":"Neumann","year":"2009","journal-title":"Medicine (Baltimore)"},{"key":"B80","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1002\/art.27263","article-title":"Cardiac involvement in Churg-Strauss syndrome","volume":"62","author":"Dennert","year":"2010","journal-title":"Arthritis Rheum"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00005792-197501000-00001","article-title":"The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature","volume":"54","author":"Chusid","year":"1975","journal-title":"Medicine (Baltimore)"},{"key":"B82","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/0002-9343(79)90227-4","article-title":"The cardiovascular manifestations of the hypereosinophilic syndrome. Prospective study of 26 patients, with review of the literature","volume":"67","author":"Parrillo","year":"1979","journal-title":"Am J Med"},{"key":"B83","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/0002-9149(83)90131-5","article-title":"Noncardiovascular findings associated with heart disease in the idiopathic hypereosinophilic syndrome","volume":"52","author":"Harley","year":"1983","journal-title":"Am J Cardiol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1161\/01.CIR.67.3.572","article-title":"Two-dimensional echocardiographic assessment of the idiopathic hypereosinophilic syndrome. Anatomic basis of mitral regurgitation and peripheral embolization","volume":"67","author":"Gottdiener","year":"1983","journal-title":"Circulation"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1182\/blood-2002-05-1488","article-title":"Non-IgE-dependent activation of human lung- and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factor","volume":"101","author":"Piliponsky","year":"2003","journal-title":"Blood"},{"key":"B86","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.jaci.2014.05.004","article-title":"Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria","volume":"134","author":"Fujisawa","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"B87","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.jaci.2016.04.051","article-title":"Roles of Mas-related G protein-coupled receptor X2 on mast cell-mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases","volume":"138","author":"Subramanian","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"B88","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1111\/all.12232","article-title":"Eosinophil major basic protein activates human cord blood mast cells primed with fibroblast membranes by integrin-beta1","volume":"68","author":"Ben-Zimra","year":"2013","journal-title":"Allergy"},{"key":"B89","doi-asserted-by":"crossref","first-page":"599","DOI":"10.4049\/jimmunol.149.2.599","article-title":"The human recombinant c-kit receptor ligand, rhSCF, induces mediator release from human cutaneous mast cells and enhances IgE-dependent mediator release from both skin mast cells and peripheral blood basophils","volume":"149","author":"Columbo","year":"1992","journal-title":"J Immunol"},{"key":"B90","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.4049\/jimmunol.163.5.2799","article-title":"Stem cell factor is localized in, released from, and cleaved by human mast cells","volume":"163","author":"de Paulis","year":"1999","journal-title":"J Immunol"},{"key":"B91","doi-asserted-by":"publisher","first-page":"4291","DOI":"10.1182\/blood.V100.13.4291","article-title":"Stem cell factor induces eosinophil activation and degranulation: mediator release and gene array analysis","volume":"100","author":"Oliveira","year":"2002","journal-title":"Blood"},{"key":"B92","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1182\/blood.V97.4.1086","article-title":"Human peripheral blood eosinophils express stem cell factor","volume":"97","author":"Hartman","year":"2001","journal-title":"Blood"},{"key":"B93","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1084\/jem.186.2.313","article-title":"Human peripheral blood eosinophils express a functional c-kit receptor for stem cell factor that stimulates very late antigen 4 (VLA-4)-mediated cell adhesion to fibronectin and vascular cell adhesion molecule 1 (VCAM-1)","volume":"186","author":"Yuan","year":"1997","journal-title":"J Exp Med"},{"key":"B94","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1111\/j.1398-9995.2009.02148.x","article-title":"Osteopontin is expressed and functional in human eosinophils","volume":"65","author":"Puxeddu","year":"2010","journal-title":"Allergy"},{"key":"B95","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1002\/eji.200737057","article-title":"Osteopontin is produced by mast cells and affects IgE-mediated degranulation and migration of mast cells","volume":"38","author":"Nagasaka","year":"2008","journal-title":"Eur J Immunol"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1111\/j.1398-9995.2004.00606.x","article-title":"Human mast cells express receptors for IL-3, IL-5 and GM-CSF; a partial map of receptors on human mast cells cultured in vitro","volume":"59","author":"Dahl","year":"2004","journal-title":"Allergy"},{"key":"B97","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/nature12526","article-title":"Type 2 innate lymphoid cells control eosinophil homeostasis","volume":"502","author":"Nussbaum","year":"2013","journal-title":"Nature"},{"key":"B98","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1111\/cea.12509","article-title":"Differential TLR-induced cytokine production by human mast cells is amplified by FcvarepsilonRI triggering","volume":"45","author":"Suurmond","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"B99","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.cyto.2015.02.005","article-title":"The betac receptor family \u2013 structural insights and their functional implications","volume":"74","author":"Broughton","year":"2015","journal-title":"Cytokine"},{"key":"B100","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.jaad.2015.03.041","article-title":"Angiogenesis and lymphangiogenesis in inflammatory skin disorders","volume":"73","author":"Varricchi","year":"2015","journal-title":"J Am Acad Dermatol"},{"key":"B101","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1067\/mai.2002.125000","article-title":"The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjects","volume":"110","author":"Braccioni","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"B102","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1067\/mai.2002.124269","article-title":"Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils","volume":"109","author":"Bandeira-Melo","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"B103","doi-asserted-by":"publisher","first-page":"6518","DOI":"10.4049\/jimmunol.1101806","article-title":"Eosinophils as a novel cell source of prostaglandin D2: autocrine role in allergic inflammation","volume":"187","author":"Luna-Gomes","year":"2011","journal-title":"J Immunol"},{"key":"B104","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1126\/science.287.5460.2013","article-title":"Prostaglandin D2 as a mediator of allergic asthma","volume":"287","author":"Matsuoka","year":"2000","journal-title":"Science"},{"key":"B105","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1111\/cea.12280","article-title":"Role of prostaglandin D2 and CRTH2 blockade in early- and late-phase nasal responses","volume":"44","author":"Shiraishi","year":"2014","journal-title":"Clin Exp Allergy"},{"key":"B106","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0022-3565(25)24901-1","article-title":"Effect of PGD2 on cardiac contractility: a negative inotropism secondary to coronary vasoconstriction conceals a primary positive inotropic action","volume":"237","author":"Hattori","year":"1986","journal-title":"J Pharmacol Exp Ther"},{"key":"B107","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1067\/mai.2001.119919","article-title":"Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP","volume":"108","author":"Gervais","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"B108","doi-asserted-by":"publisher","first-page":"4792","DOI":"10.4049\/jimmunol.179.7.4792","article-title":"The role of the prostaglandin D2 receptor, DP, in eosinophil trafficking","volume":"179","author":"Schratl","year":"2007","journal-title":"J Immunol"},{"key":"B109","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.4049\/jimmunol.162.5.2982","article-title":"Endogenous platelet-activating factor is critically involved in effector functions of eosinophils stimulated with IL-5 or IgG","volume":"162","author":"Bartemes","year":"1999","journal-title":"J Immunol"},{"key":"B110","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.4049\/jimmunol.144.12.4773","article-title":"Synthesis of 1-acyl-2-acetyl-sn-glycero-3-phosphocholine by an enriched preparation of the human lung mast cell","volume":"144","author":"Triggiani","year":"1990","journal-title":"J Immunol"},{"key":"B111","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1164\/ajrccm.156.1.9608084","article-title":"Characterization of platelet-activating factor acetylhydrolase in human bronchoalveolar lavage","volume":"156","author":"Triggiani","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"B112","doi-asserted-by":"publisher","first-page":"5252","DOI":"10.4049\/jimmunol.169.9.5252","article-title":"Platelet-activating factor activates two distinct effector pathways in human eosinophils","volume":"169","author":"Kato","year":"2002","journal-title":"J Immunol"},{"key":"B113","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.4049\/jimmunol.161.6.3064","article-title":"Triple role of platelet-activating factor in eosinophil migration across monolayers of lung epithelial cells: eosinophil chemoattractant and priming agent and epithelial cell activator","volume":"161","author":"Liu","year":"1998","journal-title":"J Immunol"},{"key":"B114","doi-asserted-by":"publisher","first-page":"3739","DOI":"10.1073\/pnas.91.9.3739","article-title":"Mast cells synthesize, store, and release nerve growth factor","volume":"91","author":"Leon","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B115","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1002\/eji.1830270925","article-title":"Human mast cells express functional TrkA and are a source of nerve growth factor","volume":"27","author":"Nilsson","year":"1997","journal-title":"Eur J Immunol"},{"key":"B116","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/S0091-6749(98)70135-6","article-title":"Nerve growth factor is preformed in and activates human peripheral blood eosinophils","volume":"102","author":"Solomon","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"B117","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.1182\/blood.V99.6.2214","article-title":"Human eosinophils produce neurotrophins and secrete nerve growth factor on immunologic stimuli","volume":"99","author":"Kobayashi","year":"2002","journal-title":"Blood"},{"key":"B118","doi-asserted-by":"publisher","first-page":"10955","DOI":"10.1073\/pnas.93.20.10955","article-title":"Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma","volume":"93","author":"Bonini","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B119","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/j.1398-9995.2003.00442.x","article-title":"Eosinophils: \u2019new\u2019 roles for \u2019old\u2019 cells","volume":"59","author":"Munitz","year":"2004","journal-title":"Allergy"},{"key":"B120","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.4049\/jimmunol.172.2.1227","article-title":"Prostaglandin E2 induces degranulation-independent production of vascular endothelial growth factor by human mast cells","volume":"172","author":"Abdel-Majid","year":"2004","journal-title":"J Immunol"},{"key":"B121","doi-asserted-by":"publisher","first-page":"4448","DOI":"10.1073\/pnas.1000803107","article-title":"IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin","volume":"107","author":"Theoharides","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B122","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1084\/jem.188.6.1135","article-title":"Mast cells can secrete vascular permeability factor\/vascular endothelial cell growth factor and exhibit enhanced release after immunoglobulin E-dependent upregulation of fc epsilon receptor I expression","volume":"188","author":"Boesiger","year":"1998","journal-title":"J Exp Med"},{"key":"B123","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1111\/j.1398-9995.2010.02372.x","article-title":"Angiogenesis and lymphangiogenesis in bronchial asthma","volume":"65","author":"Detoraki","year":"2010","journal-title":"Allergy"},{"key":"B124","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.jaci.2009.01.044","article-title":"Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects","volume":"123","author":"Detoraki","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"B125","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1091\/mbc.9.4.875","article-title":"Synthesis, storage, and release of vascular endothelial growth factor\/vascular permeability factor (VEGF\/VPF) by human mast cells: implications for the biological significance of VEGF206","volume":"9","author":"Grutzkau","year":"1998","journal-title":"Mol Biol Cell"},{"key":"B126","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1016\/j.biocel.2004.09.001","article-title":"Human peripheral blood eosinophils induce angiogenesis","volume":"37","author":"Puxeddu","year":"2005","journal-title":"Int J Biochem Cell Biol"},{"key":"B127","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1165\/ajrcmb.17.1.2796","article-title":"Expression of vascular endothelial growth factor by human eosinophils: upregulation by granulocyte macrophage colony-stimulating factor and interleukin-5","volume":"17","author":"Horiuchi","year":"1997","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B128","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1476-7961-8-10","article-title":"Hypoxia modulates human eosinophil function","volume":"8","author":"Nissim Ben-Efraim","year":"2010","journal-title":"Clin Mol Allergy"},{"key":"B129","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1111\/j.1398-9995.2008.01822.x","article-title":"The role of eosinophil major basic protein in angiogenesis","volume":"64","author":"Puxeddu","year":"2009","journal-title":"Allergy"},{"key":"B130","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/ni.3049","article-title":"The immunology of asthma","volume":"16","author":"Lambrecht","year":"2015","journal-title":"Nat Immunol"},{"key":"B131","doi-asserted-by":"publisher","first-page":"242","DOI":"10.3389\/fimmu.2017.00242","article-title":"Reslizumab and eosinophilic asthma: one step closer to precision medicine?","volume":"8","author":"Varricchi","year":"2017","journal-title":"Front Immunol"},{"key":"B132","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.intimp.2017.04.027","article-title":"Innate immunity as the orchestrator of allergic airway inflammation and resolution in asthma","volume":"48","author":"Thiriou","year":"2017","journal-title":"Int Immunopharmacol"},{"key":"B133","doi-asserted-by":"publisher","first-page":"685","DOI":"10.2174\/138161211795428975","article-title":"The role of mast cells in the structural alterations of the airways as a potential mechanism in the pathogenesis of severe asthma","volume":"17","author":"Carter","year":"2011","journal-title":"Curr Pharm Des"},{"key":"B134","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.chest.2016.06.009","article-title":"New developments in mast cell biology: clinical implications","volume":"150","author":"Arthur","year":"2016","journal-title":"Chest"},{"key":"B135","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1056\/NEJMoa1613125","article-title":"KIT inhibition by imatinib in patients with severe refractory asthma","volume":"376","author":"Cahill","year":"2017","journal-title":"N Engl J Med"},{"key":"B136","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1111\/j.1398-9995.2009.02122.x","article-title":"Masitinib, a c-kit\/PDGF receptor tyrosine kinase inhibitor, improves disease control in severe corticosteroid-dependent asthmatics","volume":"64","author":"Humbert","year":"2009","journal-title":"Allergy"},{"key":"B137","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1111\/imr.12340","article-title":"Structure and dynamics of IgE-receptor interactions: FcepsilonRI and CD23\/FcepsilonRII","volume":"268","author":"Sutton","year":"2015","journal-title":"Immunol Rev"},{"key":"B138","doi-asserted-by":"publisher","first-page":"CD003559","DOI":"10.1002\/14651858.CD003559.pub4","article-title":"Omalizumab for asthma in adults and children","volume":"1","author":"Normansell","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"B139","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jaci.2013.05.013","article-title":"Omalizumab in patients with symptomatic chronic idiopathic\/spontaneous urticaria despite standard combination therapy","volume":"132","author":"Kaplan","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"B140","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1111\/j.1398-9995.2004.00770.x","article-title":"The effect of treatment with omalizumab, an anti-IgE antibody, on asthma exacerbations and emergency medical visits in patients with severe persistent asthma","volume":"60","author":"Bousquet","year":"2005","journal-title":"Allergy"},{"key":"B141","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/j.1398-9995.2004.00772.x","article-title":"Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE","volume":"60","author":"Humbert","year":"2005","journal-title":"Allergy"},{"key":"B142","doi-asserted-by":"publisher","first-page":"611","DOI":"10.2169\/internalmedicine.50.4640","article-title":"Omalizumab treatment of systemic mast cell activation disease: experiences from four cases","volume":"50","author":"Molderings","year":"2011","journal-title":"Intern Med"},{"key":"B143","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1183\/13993003.01501-2015","article-title":"Omalizumab reduces bronchial mucosal IgE and improves lung function in non-atopic asthma","volume":"48","author":"Pillai","year":"2016","journal-title":"Eur Respir J"},{"key":"B144","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.rmed.2009.09.011","article-title":"Effect of omalizumab on peripheral blood eosinophilia in allergic asthma","volume":"104","author":"Massanari","year":"2010","journal-title":"Respir Med"},{"key":"B145","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1164\/rccm.200312-1651OC","article-title":"Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma","volume":"170","author":"Djukanovic","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"B146","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1016\/j.jaci.2006.02.028","article-title":"Effect of omalizumab treatment on peripheral eosinophil and T-lymphocyte function in patients with allergic asthma","volume":"117","author":"Noga","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"B147","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1159\/000070434","article-title":"Immunological and clinical changes in allergic asthmatics following treatment with omalizumab","volume":"131","author":"Noga","year":"2003","journal-title":"Int Arch Allergy Immunol"},{"key":"B148","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/j.1398-9995.2008.01881.x","article-title":"Eosinophils in bronchial mucosa of asthmatics after allergen challenge: effect of anti-IgE treatment","volume":"64","author":"van Rensen","year":"2009","journal-title":"Allergy"},{"key":"B149","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1177\/039463201202500217","article-title":"Omalizumab modulates bronchial reticular basement membrane thickness and eosinophil infiltration in severe persistent allergic asthma patients","volume":"25","author":"Riccio","year":"2012","journal-title":"Int J Immunopathol Pharmacol"},{"key":"B150","doi-asserted-by":"publisher","first-page":"305","DOI":"10.5114\/pdia.2014.40973","article-title":"Changes in blood eosinophilia during omalizumab therapy as a predictor of asthma exacerbation","volume":"31","author":"Skiepko","year":"2014","journal-title":"Postepy dermatologii i alergologii"},{"key":"B151","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/00325481.2017.1321945","article-title":"Predictors of response to therapy with omalizumab in patients with severe allergic asthma \u2013 a real life study","author":"Kallieri","year":"2017","journal-title":"Postgrad Med"},{"key":"B152","doi-asserted-by":"publisher","first-page":"318","DOI":"10.2478\/v10039-011-0024-0","article-title":"Airway inflammation and eotaxin in exhaled breath condensate of patients with severe persistent allergic asthma during omalizumab therapy","volume":"56","author":"Zietkowski","year":"2011","journal-title":"Adv Med Sci"},{"key":"B153","doi-asserted-by":"crossref","first-page":"6893","DOI":"10.4049\/jimmunol.162.11.6893","article-title":"Intracellular expression and release of Fc epsilon RI alpha by human eosinophils","volume":"162","author":"Seminario","year":"1999","journal-title":"J Immunol"},{"key":"B154","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nri3807","article-title":"Type 2 inflammation in asthma \u2013 present in most, absent in many","volume":"15","author":"Fahy","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"B155","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1056\/NEJMoa1403290","article-title":"Mepolizumab treatment in patients with severe eosinophilic asthma","volume":"371","author":"Ortega","year":"2014","journal-title":"N Engl J Med"},{"key":"B156","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.1056\/NEJMoa1403291","article-title":"Glucocorticoids and mepolizumab in eosinophilic asthma","volume":"371","author":"Bel","year":"2014","journal-title":"N Engl J Med"},{"key":"B157","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.chest.2016.03.032","article-title":"Reslizumab for inadequately controlled asthma with elevated blood eosinophil levels: a randomized phase 3 study","volume":"150","author":"Bjermer","year":"2016","journal-title":"Chest"},{"key":"B158","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.chest.2016.03.018","article-title":"Phase 3 study of reslizumab in patients with poorly controlled asthma: effects across a broad range of eosinophil counts","volume":"150","author":"Corren","year":"2016","journal-title":"Chest"},{"key":"B159","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1016\/S0140-6736(16)31324-1","article-title":"Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting beta2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial","volume":"388","author":"Bleecker","year":"2016","journal-title":"Lancet"},{"key":"B160","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1016\/S0140-6736(16)31322-8","article-title":"Benralizumab, an anti-interleukin-5 receptor alpha monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial","volume":"388","author":"FitzGerald","year":"2016","journal-title":"Lancet"},{"key":"B161","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jaci.2011.02.040","article-title":"Eosinophilic esophagitis: updated consensus recommendations for children and adults","volume":"128","author":"Liacouras","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"B162","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/ajg.2010.412","article-title":"Tryptase staining of mast cells may differentiate eosinophilic esophagitis from gastroesophageal reflux disease","volume":"106","author":"Dellon","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"B163","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1016\/j.jaci.2010.08.050","article-title":"Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-beta1, and increase esophageal smooth muscle contraction","volume":"126","author":"Aceves","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"B164","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1111\/j.1399-3038.2008.00798.x","article-title":"The role of mast cells in eosinophilic esophagitis","volume":"20","author":"Lucendo","year":"2009","journal-title":"Pediatr Allergy Immunol"},{"key":"B165","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1053\/j.gastro.2006.08.033","article-title":"A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis","volume":"131","author":"Konikoff","year":"2006","journal-title":"Gastroenterology"},{"key":"B166","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1016\/S1542-3565(05)00885-2","article-title":"Eosinophilic esophagitis: a 10-year experience in 381 children","volume":"3","author":"Liacouras","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"key":"B167","doi-asserted-by":"publisher","first-page":"e0113483","DOI":"10.1371\/journal.pone.0113483","article-title":"A pilot study of omalizumab in eosinophilic esophagitis","volume":"10","author":"Loizou","year":"2015","journal-title":"PLoS One"},{"key":"B168","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1136\/gut.2009.178558","article-title":"Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial","volume":"59","author":"Straumann","year":"2010","journal-title":"Gut"},{"key":"B169","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jaci.2010.04.029","article-title":"Mepolizumab does not alter levels of eosinophils, T cells, and mast cells in the duodenal mucosa in eosinophilic esophagitis","volume":"126","author":"Conus","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"B170","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1016\/j.jaci.2013.02.042","article-title":"Anti-IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis","volume":"131","author":"Otani","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"B171","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.jaci.2011.11.044","article-title":"Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial","volume":"129","author":"Spergel","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"B172","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1093\/rheumatology\/kes171","article-title":"Increased production of IL-5 and dominant Th2-type response in airways of Churg-Strauss syndrome patients","volume":"51","author":"Jakiela","year":"2012","journal-title":"Rheumatology (Oxford)"},{"key":"B173","doi-asserted-by":"publisher","first-page":"201","DOI":"10.3109\/02770903.2015.1081700","article-title":"Omalizumab in patients with eosinophilic granulomatosis with polyangiitis: a 36-month follow-up study","volume":"53","author":"Detoraki","year":"2016","journal-title":"J Asthma"},{"key":"B174","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.jaci.2009.10.014","article-title":"Sustained response to mepolizumab in refractory Churg-Strauss syndrome","volume":"125","author":"Kahn","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"B175","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1056\/NEJMoa1702079","article-title":"Mepolizumab or placebo for eosinophilic granulomatosis with polyangiitis","volume":"376","author":"Wechsler","year":"2017","journal-title":"N Engl J Med"},{"key":"B176","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1002\/art.40012","article-title":"The role of omalizumab in patients with eosinophilic granulomatosis with polyangiitis: comment on the article by Jachiet et al","volume":"69","author":"Detoraki","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"B177","first-page":"817","article-title":"Endocarditis parietalis fibroplastica mit Blut-eosinophilie, ein eigenartiges Krankheitsbild","volume":"66","author":"Loeffler","year":"1936","journal-title":"Schweiz Med Wochen"},{"key":"B178","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1182\/blood.V82.5.1553.1553","article-title":"Synthesis of interleukin-5 by activated eosinophils in patients with eosinophilic heart diseases","volume":"82","author":"Desreumaux","year":"1993","journal-title":"Blood"},{"key":"B179","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S0140-6736(87)90412-0","article-title":"Deposits of eosinophil granule proteins in cardiac tissues of patients with eosinophilic endomyocardial disease","volume":"1","author":"Tai","year":"1987","journal-title":"Lancet"},{"key":"B180","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.jaci.2015.08.026","article-title":"Association of eosinophilic esophagitis and hypertrophic cardiomyopathy","volume":"137","author":"Davis","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"B181","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0162-3109(95)00037-3","article-title":"Immunological characterization and functional importance of human heart mast cells","volume":"31","author":"Marone","year":"1995","journal-title":"Immunopharmacology"},{"key":"B182","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1111\/j.1749-6632.1988.tb38555.x","article-title":"Cardiovascular and metabolic effects of peptide leukotrienes in man","volume":"524","author":"Marone","year":"1988","journal-title":"Ann N Y Acad Sci"},{"key":"B183","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1161\/01.CIR.73.6.1175","article-title":"Effect of activation of the H1 receptor on coronary hemodynamics in man","volume":"73","author":"Vigorito","year":"1986","journal-title":"Circulation"},{"key":"B184","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1084\/jem.172.4.1271","article-title":"Activation of platelets by eosinophil granule proteins","volume":"172","author":"Rohrbach","year":"1990","journal-title":"J Exp Med"},{"key":"B185","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1124\/jpet.103.063974","article-title":"A specific chymase inhibitor, 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-2-heptyl]acetamide (NK3201), suppresses development of abdominal aortic aneurysm in hamsters","volume":"309","author":"Tsunemi","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"B186","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1161\/CIRCULATIONAHA.109.849679","article-title":"Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation","volume":"120","author":"Sun","year":"2009","journal-title":"Circulation"},{"key":"B187","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/S0140-6736(12)61140-4","article-title":"Pemphigoid diseases","volume":"381","author":"Schmidt","year":"2013","journal-title":"Lancet"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13382","article-title":"Analysis of serum markers of cellular immune activation in patients with bullous pemphigoid","author":"Bieber","year":"2017","journal-title":"Exp Dermatol"},{"key":"B189","doi-asserted-by":"publisher","first-page":"15003","DOI":"10.1074\/jbc.M111.221036","article-title":"The C5a receptor on mast cells is critical for the autoimmune skin-blistering disease bullous pemphigoid","volume":"286","author":"Heimbach","year":"2011","journal-title":"J Biol Chem"},{"key":"B190","doi-asserted-by":"publisher","first-page":"464","DOI":"10.2340\/00015555-2581","article-title":"Increased activity and apoptosis of eosinophils in blister fluids, skin and peripheral blood of patients with bullous pemphigoid","volume":"97","author":"Engmann","year":"2017","journal-title":"Acta Derm Venereol"},{"key":"B191","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1111\/all.13131","article-title":"Evidence for a role of eosinophils in blister formation in bullous pemphigoid","volume":"72","author":"de Graauw","year":"2017","journal-title":"Allergy"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15358","article-title":"IL-17A localizes in the exocytic compartment of mast cells in psoriatic skin","author":"Brembilla","year":"2017","journal-title":"Br J Dermatol"},{"key":"B193","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.jaci.2015.01.033","article-title":"Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis","volume":"136","author":"Mashiko","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"B194","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1111\/j.1365-2613.2009.00669.x","article-title":"Angiogenesis drives psoriasis pathogenesis","volume":"90","author":"Heidenreich","year":"2009","journal-title":"Int J Exp Pathol"},{"key":"B195","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0065-2776(09)01203-6","article-title":"Cellular and molecular mechanisms in atopic dermatitis","volume":"102","author":"Oyoshi","year":"2009","journal-title":"Adv Immunol"},{"key":"B196","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1067\/mai.2002.120553","article-title":"Mast cells regulate IFN-gamma expression in the skin and circulating IgE levels in allergen-induced skin inflammation","volume":"109","author":"Alenius","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"B197","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1016\/j.jaci.2011.01.054","article-title":"Contrasting pathogenesis of atopic dermatitis and psoriasis \u2013 part II: immune cell subsets and therapeutic concepts","volume":"127","author":"Guttman-Yassky","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"B198","first-page":"486","article-title":"Ueber das Verhalten der Leucocyten bei malignen Tumoren","volume":"46","author":"Rheinbach","year":"1893","journal-title":"Arch Klin Chir"},{"key":"B199","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1002\/1097-0142(19870201)59:3<466::AID-CNCR2820590319>3.0.CO;2-P","article-title":"Tumor-associated tissue eosinophilia in nasopharyngeal carcinoma. A pathologic study of 422 primary and 138 metastatic tumors","volume":"59","author":"Looi","year":"1987","journal-title":"Cancer"},{"key":"B200","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1002\/(SICI)1096-9896(199912)189:4<487::AID-PATH484>3.0.CO;2-I","article-title":"Independent prognostic value of eosinophil and mast cell infiltration in colorectal cancer tissue","volume":"189","author":"Nielsen","year":"1999","journal-title":"J Pathol"},{"key":"B201","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1046\/j.1365-2559.2002.01437.x","article-title":"Tumour-associated tissue eosinophilia as a prognostic factor in oral squamous cell carcinomas","volume":"41","author":"Dorta","year":"2002","journal-title":"Histopathology"},{"key":"B202","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1182\/blood.V93.8.2463","article-title":"Differential chemokine expression in tissues involved by Hodgkin\u2019s disease: direct correlation of eotaxin expression and tissue eosinophilia","volume":"93","author":"Teruya-Feldstein","year":"1999","journal-title":"Blood"},{"key":"B203","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1182\/blood.V95.6.1911","article-title":"Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases","volume":"95","author":"Kampen","year":"2000","journal-title":"Blood"},{"key":"B204","doi-asserted-by":"publisher","first-page":"5023","DOI":"10.4049\/jimmunol.0900504","article-title":"Eosinophils oxidize damage-associated molecular pattern molecules derived from stressed cells","volume":"183","author":"Lotfi","year":"2009","journal-title":"J Immunol"},{"key":"B205","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1189\/jlb.0106027","article-title":"Pivotal advance: eosinophil infiltration of solid tumors is an early and persistent inflammatory host response","volume":"79","author":"Cormier","year":"2006","journal-title":"J Leukoc Biol"},{"key":"B206","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1158\/2326-6066.CIR-13-0196","article-title":"Eosinophils and cancer","volume":"2","author":"Davis","year":"2014","journal-title":"Cancer Immunol Res"},{"key":"B207","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1007\/s00262-012-1288-3","article-title":"Involvement of eosinophils in the anti-tumor response","volume":"61","author":"Gatault","year":"2012","journal-title":"Cancer Immunol Immunother"},{"key":"B208","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1097\/01.cji.0000211324.53396.f6","article-title":"Eosinophilic granulocytes and damage-associated molecular pattern molecules (DAMPs): role in the inflammatory response within tumors","volume":"30","author":"Lotfi","year":"2007","journal-title":"J Immunother"},{"key":"B209","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1182\/blood.V95.4.1207.004k34_1207_1213","article-title":"Tissue eosinophilia correlates strongly with poor prognosis in nodular sclerosing Hodgkin\u2019s disease, allowing for known prognostic factors","volume":"95","author":"von Wasielewski","year":"2000","journal-title":"Blood"},{"key":"B210","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.4287","article-title":"Towards the introduction of the \u2019Immunoscore\u2019 in the classification of malignant tumours","volume":"232","author":"Galon","year":"2014","journal-title":"J Pathol"},{"key":"B211","doi-asserted-by":"publisher","first-page":"650","DOI":"10.2174\/0929867323666160119094313","article-title":"Eosinophils in cancer: favourable or unfavourable?","volume":"23","author":"Sakkal","year":"2016","journal-title":"Curr Med Chem"},{"key":"B212","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1177\/41.11.8409368","article-title":"Ultrastructural immunogold localization of tumor necrosis factor-alpha to the matrix compartment of eosinophil secondary granules in patients with idiopathic hypereosinophilic syndrome","volume":"41","author":"Beil","year":"1993","journal-title":"J Histochem Cytochem"},{"key":"B213","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1159\/000353251","article-title":"Roles of eosinophils in the modulation of angiogenesis","volume":"99","author":"Nissim Ben-Efraim","year":"2014","journal-title":"Chem Immunol Allergy"},{"key":"B214","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/exd.13107","article-title":"Controversial role of mast cells in skin cancers","volume":"26","author":"Varricchi","year":"2017","journal-title":"Exp Dermatol"},{"key":"B215","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/S0145-2126(01)00038-8","article-title":"Diagnostic criteria and classification of mastocytosis: a consensus proposal","volume":"25","author":"Valent","year":"2001","journal-title":"Leuk Res"},{"key":"B216","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1056\/NEJMra1409760","article-title":"Mast cells, mastocytosis, and related disorders","volume":"373","author":"Theoharides","year":"2015","journal-title":"N Engl J Med"},{"key":"B217","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1038\/jid.2009.281","article-title":"Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations","volume":"130","author":"Bodemer","year":"2010","journal-title":"J Invest Dermatol"},{"key":"B218","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.jaci.2007.03.015","article-title":"Eosinophilia in systemic mastocytosis: clinical and molecular correlates and prognostic significance","volume":"120","author":"Bohm","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"B219","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1016\/j.jaci.2011.05.032","article-title":"IL-5 receptor alpha levels in patients with marked eosinophilia or mastocytosis","volume":"128","author":"Wilson","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"B220","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1002\/cncr.25036","article-title":"Evaluation of the prognostic significance of eosinophilia and basophilia in a larger cohort of patients with myelodysplastic syndromes","volume":"116","author":"Wimazal","year":"2010","journal-title":"Cancer"},{"key":"B221","doi-asserted-by":"publisher","first-page":"4660","DOI":"10.1182\/blood-2003-01-0006","article-title":"Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness","volume":"101","author":"Klion","year":"2003","journal-title":"Blood"},{"key":"B222","doi-asserted-by":"publisher","first-page":"3038","DOI":"10.1182\/blood-2004-03-0787","article-title":"FIP1L1-PDGFRA fusion: prevalence and clinicopathologic correlates in 89 consecutive patients with moderate to severe eosinophilia","volume":"104","author":"Pardanani","year":"2004","journal-title":"Blood"},{"key":"B223","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1158\/0008-5472.CAN-16-2234","article-title":"Advances in the classification and treatment of mastocytosis: current status and outlook toward the future","volume":"77","author":"Valent","year":"2017","journal-title":"Cancer Res"},{"key":"B224","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1053\/j.seminhematol.2012.01.007","article-title":"Mast cells and eosinophils in mastocytosis, chronic eosinophilic leukemia, and non-clonal disorders","volume":"49","author":"Gotlib","year":"2012","journal-title":"Semin Hematol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmed.2017.00103\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T13:33:18Z","timestamp":1750771998000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmed.2017.00103\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,24]]},"references-count":224,"alternative-id":["10.3389\/fmed.2017.00103"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2017.00103","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,24]]},"article-number":"103"}}