{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T13:28:13Z","timestamp":1771075693353,"version":"3.50.1"},"reference-count":33,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 102-2911-I-008-001, 105-2218-E-008-003"],"award-info":[{"award-number":["MOST 102-2911-I-008-001, 105-2218-E-008-003"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"DOI":"10.3389\/fmed.2017.00161","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T04:22:30Z","timestamp":1506572550000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Exploring the Abnormal Modulation of the Autonomic Systems during Nasal Flow Limitation in Upper Airway Resistance Syndrome by Hilbert\u2013Huang Transform"],"prefix":"10.3389","volume":"4","author":[{"given":"Chen","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Men-Tzung","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Guilleminault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,9,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1164\/ajrccm.157.5.9708008","article-title":"Detection of flow limitation with a nasal cannula\/pressure transducer system","volume":"157","author":"Hosselet","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1183\/09031936.01.00053501","article-title":"Inspiratory flow limitation during sleep in pre-eclampsia: comparison with normal pregnant and nonpregnant women","volume":"18","author":"Connolly","year":"2001","journal-title":"Eur Respir J"},{"key":"B3","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S1389-9457(99)00011-8","article-title":"A clinical investigation of obstructive sleep apnea syndrome (OSAS) and upper airway resistance syndrome (UARS) patients","volume":"1","author":"Guilleminault","year":"2000","journal-title":"Sleep Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1097\/01.mcp.0000143689.86819.c2","article-title":"Upper airway resistance syndrome \u2013 one decade later","volume":"10","author":"Bao","year":"2004","journal-title":"Curr Opin Pulm Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1093\/sleep\/30.5.641","article-title":"The cyclic alternating pattern demonstrates increased sleep instability and correlates with fatigue and sleepiness in adults with upper airway resistance syndrome","volume":"30","author":"Guilleminault","year":"2007","journal-title":"Sleep"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.5665\/sleep.3122","article-title":"Inspiratory flow limitation in a normal population of adults in Sao Paulo, Brazil","volume":"36","author":"Palombini","year":"2013","journal-title":"Sleep"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1164\/ajrccm.161.5.16158a","article-title":"Upper airway resistance syndrome is a distinct syndrome","volume":"161","author":"Guilleminault","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1056\/NEJM199302043280502","article-title":"Sympathetic-nerve activity during sleep in normal subjects","volume":"328","author":"Somers","year":"1993","journal-title":"N Engl J Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1161\/01.CIR.98.11.1071","article-title":"Altered cardiovascular variability in obstructive sleep apnea","volume":"98","author":"Narkiewicz","year":"1998","journal-title":"Circulation"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1152\/japplphysiol.01095.2002","article-title":"Cardiovascular variability after arousal from sleep: time-varying spectral analysis","volume":"95","author":"Blasi","year":"2003","journal-title":"J Appl Physiol (1985)"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1164\/ajrccm.164.7.2011036","article-title":"Sleep-disordered breathing and hypotension","volume":"164","author":"Guilleminault","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.sleep.2005.03.014","article-title":"Heart rate variability, sympathetic and vagal balance and EEG arousals in upper airway resistance and mild obstructive sleep apnea syndromes","volume":"6","author":"Guilleminault","year":"2005","journal-title":"Sleep Med"},{"key":"B13","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1161\/01.RES.72.2.440","article-title":"Respiratory modulation of muscle sympathetic nerve activity in intact and lung denervated humans","volume":"72","author":"Seals","year":"1993","journal-title":"Circ Res"},{"key":"B14","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1161\/01.RES.85.5.457","article-title":"Role of respiratory motor output in within-breath modulation of muscle sympathetic nerve activity in humans","volume":"85","author":"St Croix","year":"1999","journal-title":"Circ Res"},{"key":"B15","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1152\/japplphysiol.01214.2007","article-title":"Upper airway neuromuscular compensation during sleep is defective in obstructive sleep apnea","volume":"105","author":"McGinley","year":"2008","journal-title":"J Appl Physiol (1985)"},{"key":"B16","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events","author":"Iber","year":"2007"},{"key":"B17","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1098\/rspa.1998.0193","article-title":"The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis","volume":"454","author":"Huang","year":"1998","journal-title":"Proc R Soc Lond A Math Phys Eng Sci"},{"key":"B18","doi-asserted-by":"publisher","first-page":"785243","DOI":"10.1155\/2008\/785243","article-title":"Multimodal pressure-flow analysis: application of Hilbert Huang transform in cerebral blood flow regulation","volume":"2008","author":"Lo","year":"2008","journal-title":"EURASIP J Adv Signal Process"},{"key":"B19","doi-asserted-by":"publisher","first-page":"061924","DOI":"10.1103\/PhysRevE.79.061924","article-title":"Nonlinear phase interaction between nonstationary signals: a comparison study of methods based on Hilbert-Huang and Fourier transforms","volume":"79","author":"Lo","year":"2009","journal-title":"Phys Rev E Stat Nonlin Soft Matter Phys"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1142\/S1793536909000187","article-title":"Ensemble empirical mode decomposition: a noise-assisted data analysis method","volume":"1","author":"Wu","year":"2009","journal-title":"Adv Adapt Data Anal"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1161\/01.CIR.93.5.1043","article-title":"Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology","volume":"93","year":"1996","journal-title":"Circulation"},{"key":"B22","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.sleep.2011.04.004","article-title":"Current hypopnea scoring criteria underscore pediatric sleep disordered breathing","volume":"12","author":"Lin","year":"2011","journal-title":"Sleep Med"},{"key":"B23","volume-title":"R: A Language and Environment for Statistical Computing","year":"2011"},{"key":"B24","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s11325-005-0017-y","article-title":"Obstructive sleep apnea syndrome: effect of respiratory events and arousal on pulse wave amplitude measured by photoplethysmography in NREM sleep","volume":"9","author":"Haba-Rubio","year":"2005","journal-title":"Sleep Breath"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1093\/sleep\/33.12.1687","article-title":"Pulse wave amplitude drops during sleep are reliable surrogate markers of changes in cortical activity","volume":"33","author":"Delessert","year":"2010","journal-title":"Sleep"},{"key":"B26","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1161\/01.CIR.90.1.121","article-title":"Circadian rhythms of frequency domain measures of heart rate variability in healthy subjects and patients with coronary artery disease. Effects of arousal and upright posture","volume":"90","author":"Huikuri","year":"1994","journal-title":"Circulation"},{"key":"B27","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1164\/ajrccm.162.2.9901026","article-title":"Upper airway resistance syndrome. Central electroencephalographic power and changes in breathing effort","volume":"162","author":"Black","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"B28","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1183\/09031936.01.17508380","article-title":"Sleep and daytime sleepiness in upper airway resistance syndrome compared to obstructive sleep apnoea syndrome","volume":"17","author":"Guilleminault","year":"2001","journal-title":"Eur Respir J"},{"key":"B29","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1164\/ajrccm.157.2.96-06049","article-title":"Histological indications of a progressive snorers disease in an upper airway muscle","volume":"157","author":"Friberg","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"B30","doi-asserted-by":"publisher","first-page":"H826","DOI":"10.1152\/ajpheart.00970.2011","article-title":"Spontaneous fluctuations in the peripheral photoplethysmographic waveform: roles of arterial pressure and muscle sympathetic nerve activity","volume":"302","author":"Chan","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.jsmc.2007.05.005","article-title":"Variability of respiratory effort in relation to sleep stages in normal controls and upper airway resistance syndrome patients","volume":"2","author":"Guilleminault","year":"2001","journal-title":"Sleep Med"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1109\/TPWRS.2007.907542","article-title":"An improved Hilbert-Huang method for analysis of time-varying waveforms in power quality","volume":"22","author":"Senroy","year":"2007","journal-title":"IEEE Trans Power Syst"},{"key":"B33","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1002\/ana.24432","article-title":"Suprachiasmatic neuron numbers and rest-activity circadian rhythms in older humans","volume":"78","author":"Wang","year":"2015","journal-title":"Ann Neurol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmed.2017.00161\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T04:22:36Z","timestamp":1506572556000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmed.2017.00161\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,28]]},"references-count":33,"alternative-id":["10.3389\/fmed.2017.00161"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2017.00161","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,28]]},"article-number":"161"}}