{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:25:54Z","timestamp":1784204754800,"version":"3.55.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T00:00:00Z","timestamp":1518739200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA164719"],"award-info":[{"award-number":["CA164719"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"DOI":"10.3389\/fmed.2018.00030","type":"journal-article","created":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T12:54:50Z","timestamp":1518785690000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Granulin Secreted by the Food-Borne Liver Fluke Opisthorchis viverrini Promotes Angiogenesis in Human Endothelial Cells"],"prefix":"10.3389","volume":"5","author":[{"given":"Brandon","family":"Haugen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon E.","family":"Karinshak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria H.","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastas","family":"Popratiloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Loukas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Brindley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Smout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,2,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1039\/c0mb00295j","article-title":"Infection with the carcinogenic human liver fluke, Opisthorchis viverrini","volume":"7","author":"Smout","year":"2011","journal-title":"Mol Biosyst"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e1005209","DOI":"10.1371\/journal.ppat.1005209","article-title":"Carcinogenic parasite secretes growth factor that accelerates wound healing and potentially promotes neoplasia","volume":"11","author":"Smout","year":"2015","journal-title":"PLoS Pathog"},{"key":"B3","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.exppara.2014.11.004","article-title":"Suppression of Ov-grn-1 encoding granulin of Opisthorchis viverrini inhibits proliferation of biliary epithelial cells","volume":"148","author":"Papatpremsiri","year":"2015","journal-title":"Exp Parasitol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e1000611","DOI":"10.1371\/journal.ppat.1000611","article-title":"A granulin-like growth factor secreted by the carcinogenic liver fluke, Opisthorchis viverrini, promotes proliferation of host cells","volume":"5","author":"Smout","year":"2009","journal-title":"PLoS Pathog"},{"key":"B5","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.pt.2012.07.006","article-title":"The tumorigenic liver fluke Opisthorchis viverrini \u2013 multiple pathways to cancer","volume":"28","author":"Sripa","year":"2012","journal-title":"Trends Parasitol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e201","DOI":"10.1371\/journal.pmed.0040201","article-title":"Liver fluke induces cholangiocarcinoma","volume":"4","author":"Sripa","year":"2007","journal-title":"PLoS Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"4258","DOI":"10.1021\/acs.jmedchem.7b00047","article-title":"Development of a potent wound healing agent based on the liver fluke granulin structural fold","volume":"60","author":"Bansal","year":"2017","journal-title":"J Med Chem"},{"key":"B8","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1177\/2211068213495204","article-title":"Automated image analysis of in vitro angiogenesis assay","volume":"18","author":"Boizeau","year":"2013","journal-title":"J Lab Autom"},{"key":"B9","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/nrc2868","article-title":"Targeting the tumour vasculature: insights from physiological angiogenesis","volume":"10","author":"Chung","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"B10","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1146\/annurev-cellbio-092910-154002","article-title":"Developmental and pathological angiogenesis","volume":"27","author":"Chung","year":"2011","journal-title":"Annu Rev Cell Dev Biol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1387\/ijdb.103215ac","article-title":"A brief history of angiogenesis assays","volume":"55","author":"Cimpean","year":"2011","journal-title":"Int J Dev Biol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e51312","DOI":"10.3791\/51312","article-title":"Endothelial cell tube formation assay for the in vitro study of angiogenesis","volume":"91","author":"DeCicco-Skinner","year":"2014","journal-title":"J Vis Exp"},{"key":"B13","doi-asserted-by":"publisher","first-page":"14973","DOI":"10.1002\/anie.201708927","article-title":"Conotoxin Phi-MiXXVIIA from the superfamily G2 employs a novel cysteine framework that mimics granulin and displays anti-apoptotic activity","volume":"56","author":"Jin","year":"2017","journal-title":"Angew Chem Int Ed Engl"},{"key":"B14","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/nprot.2010.6","article-title":"In vitro angiogenesis: endothelial cell tube formation on gelled basement membrane extract","volume":"5","author":"Arnaoutova","year":"2010","journal-title":"Nat Protoc"},{"key":"B15","unstructured":"Angiogenesis analyzer\n            CarpentierG\n          Image J News2012"},{"key":"B16","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1177\/1087057107300646","article-title":"The use of strictly standardized mean difference for hit selection in primary RNA interference high-throughput screening experiments","volume":"12","author":"Zhang","year":"2007","journal-title":"J Biomol Screen"},{"key":"B17","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.pep.2011.06.018","article-title":"Expression, refolding and purification of Ov-GRN-1, a granulin-like growth factor from the carcinogenic liver fluke, that causes proliferation of mammalian host cells","volume":"79","author":"Smout","year":"2011","journal-title":"Protein Expr Purif"},{"key":"B18","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1158\/1535-7163.MCT-05-0324","article-title":"Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention","volume":"5","author":"Bertl","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"B19","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s13287-016-0305-4","article-title":"Role of VEGF-A in angiogenesis promoted by umbilical cord-derived mesenchymal stromal\/stem cells: in vitro study","volume":"7","author":"Arutyunyan","year":"2016","journal-title":"Stem Cell Res Ther"},{"key":"B20","doi-asserted-by":"publisher","first-page":"39256","DOI":"10.18632\/oncotarget.9684","article-title":"Dendritic cell-derived VEGF-A plays a role in inflammatory angiogenesis of human secondary lymphoid organs and is driven by the coordinated activation of multiple transcription factors","volume":"7","author":"Salvi","year":"2016","journal-title":"Oncotarget"},{"key":"B21","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s10456-013-9341-1","article-title":"Naturally derived factors and their role in the promotion of angiogenesis for the healing of chronic wounds","volume":"16","author":"Morgan","year":"2013","journal-title":"Angiogenesis"},{"key":"B22","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1111\/j.1600-0463.2004.apm11207-0808.x","article-title":"The chemokine system \u2013 a major regulator of angiogenesis in health and disease","volume":"112","author":"Rosenkilde","year":"2004","journal-title":"APMIS"},{"key":"B23","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1007\/s10522-017-9709-5","article-title":"Angiogenesis is VEGF-independent in the aged striatum of male rats exposed to acute hypoxia","volume":"18","author":"Molina","year":"2017","journal-title":"Biogerontology"},{"key":"B24","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1038\/onc.2016.226","article-title":"Progranulin and granulin-like protein as novel VEGF-independent angiogenic factors derived from human mesothelioma cells","volume":"36","author":"Eguchi","year":"2017","journal-title":"Oncogene"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.2174\/138161212800626184","article-title":"Novel VEGF-independent strategies targeting tumor vasculature: clinical aspects","volume":"18","author":"Petrillo","year":"2012","journal-title":"Curr Pharm Des"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e34758","DOI":"10.1371\/journal.pone.0034758","article-title":"Genetic polymorphism in a VEGF-independent angiogenesis gene ANGPT1 and overall survival of colorectal cancer patients after surgical resection","volume":"7","author":"Dai","year":"2012","journal-title":"PLoS One"},{"key":"B27","first-page":"3085","article-title":"Progranulin promotes colorectal cancer proliferation and angiogenesis through TNFR2\/Akt and ERK signaling pathways","volume":"5","author":"Yang","year":"2015","journal-title":"Am J Cancer Res"},{"key":"B28","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1110\/ps.073295308","article-title":"Structure dissection of human progranulin identifies well-folded granulin\/epithelin modules with unique functional activities","volume":"17","author":"Tolkatchev","year":"2008","journal-title":"Protein Sci"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1002\/hep.22191","article-title":"Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma","volume":"47","author":"Ho","year":"2008","journal-title":"Hepatology"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e1005479","DOI":"10.1371\/journal.ppat.1005838","article-title":"Modulation of host angiogenesis as a microbial survival strategy and therapeutic target","volume":"12","author":"Osherov","year":"2016","journal-title":"PLoS Pathog"},{"key":"B31","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S1937-6448(08)01405-6","article-title":"Chick embryo chorioallantoic membrane as a useful tool to study angiogenesis","volume":"270","author":"Ribatti","year":"2008","journal-title":"Int Rev Cell Mol Biol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"6709","DOI":"10.1182\/blood-2011-06-359141","article-title":"Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds","volume":"118","author":"Chan","year":"2011","journal-title":"Blood"},{"key":"B33","doi-asserted-by":"publisher","first-page":"377","DOI":"10.4067\/S0716-97602009000300012","article-title":"A semi-quantitative assay to screen for angiogenic compounds and compounds with angiogenic potential using the EA.hy926 endothelial cell line","volume":"42","author":"Aranda","year":"2009","journal-title":"Biol Res"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2824","DOI":"10.4049\/jimmunol.1201114","article-title":"The chemokine receptors CXCR1 and CXCR2 couple to distinct G protein-coupled receptor kinases to mediate and regulate leukocyte functions","volume":"189","author":"Raghuwanshi","year":"2012","journal-title":"J Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"e1006393","DOI":"10.1371\/journal.ppat.1006393","article-title":"Helminth infection-induced malignancy","volume":"13","author":"Brindley","year":"2017","journal-title":"PLoS Pathog"},{"key":"B36","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1017\/S0031182010001642","article-title":"Angiogenesis and parasitic helminth-associated neovascularization","volume":"138","author":"Dennis","year":"2011","journal-title":"Parasitology"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmed.2018.00030\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T12:54:53Z","timestamp":1518785693000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmed.2018.00030\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,16]]},"references-count":36,"alternative-id":["10.3389\/fmed.2018.00030"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2018.00030","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,16]]},"article-number":"30"}}