{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:46:14Z","timestamp":1776872774647,"version":"3.51.2"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T00:00:00Z","timestamp":1524441600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI12\/00523, PI16\/001136"],"award-info":[{"award-number":["PI12\/00523, PI16\/001136"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["FJCI-2015-23849"],"award-info":[{"award-number":["FJCI-2015-23849"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"DOI":"10.3389\/fmed.2018.00114","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T10:09:51Z","timestamp":1524478191000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Anti-High-Density Lipoprotein Antibodies and Antioxidant Dysfunction in Immune-Driven Diseases"],"prefix":"10.3389","volume":"5","author":[{"given":"Javier","family":"Rodr\u00edguez-Carrio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Mozo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Nikiphorou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Su\u00e1rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,4,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/nrrheum.2011.75","article-title":"Epidemiology of CVD in rheumatic disease, with a focus on RA and SLE","volume":"7","author":"Symmons","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1385\/CRIAI:23:3:247","article-title":"Cardiac involvement in systemic autoimmune diseases","volume":"23","author":"Riboldi","year":"2002","journal-title":"Clin Rev Allergy Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1002\/1529-0131(200110)44:10<2331::AID-ART395>3.0.CO;2-I","article-title":"Traditional Framingham risk factors fail to fully account for accelerated atherosclerosis in systemic lupus erythematosus","volume":"44","author":"Esdaile","year":"2001","journal-title":"Arthritis Rheum"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1002\/1529-0131(200112)44:12<2737::AID-ART460>3.0.CO;2-#","article-title":"High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditional cardiac risk factors","volume":"44","author":"del Rinc\u00f3n","year":"2001","journal-title":"Arthritis Rheum"},{"key":"B5","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/ncprheum0092","article-title":"Mechanisms of disease: atherosclerosis in autoimmune diseases","volume":"2","author":"Sherer","year":"2006","journal-title":"Nat Clin Pract Rheumatol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1002\/acr.20322","article-title":"Inflammatory and autoimmune mechanisms in the induction of atherosclerotic damage in systemic rheumatic diseases: two faces of the same coin","volume":"63","author":"Bartoloni","year":"2011","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0021-9150(01)00651-7","article-title":"Review article HDL and arteriosclerosis : beyond reverse cholesterol transport","volume":"161","author":"Nofer","year":"2002","journal-title":"Atherosclerosis"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1136\/annrheumdis-2013-204933","article-title":"Inflammation and lipid profile in rheumatoid arthritis: bridging an apparent paradox","volume":"73","author":"Gonz\u00e1lez-Gay","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"B9","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/nrrheum.2013.91","article-title":"Changes in lipid levels with inflammation and therapy in RA: a maturing paradigm","volume":"9","author":"Robertson","year":"2013","journal-title":"Nat Rev Rheumatol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1002\/art.21889","article-title":"Relationship of serum paraoxonase 1 activity and paraoxonase 1 genotype to risk of systemic lupus erythematosus","volume":"54","author":"Tripi","year":"2006","journal-title":"Arthritis Rheum"},{"key":"B11","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1093\/intimm\/dxq045","article-title":"Decreased human paraoxonase-1 activity in patients with Sj\u00f6gren\u2019s syndrome","volume":"22","author":"Sz\u00e1nt\u00f3","year":"2010","journal-title":"Int Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jaut.2007.02.004","article-title":"The pathogenesis of atherosclerosis in autoimmune rheumatic diseases: roles of inflammation and dyslipidemia","volume":"28","author":"Hahn","year":"2007","journal-title":"J Autoimmun"},{"key":"B13","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/RHU.0000000000000413","article-title":"Asymptomatic atherosclerosis in primary Sj\u00f6gren syndrome: correlation between low ankle brachial index and autoantibodies positivity","volume":"22","author":"Garcia","year":"2016","journal-title":"J Clin Rheumatol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2845","DOI":"10.1002\/art.39267","article-title":"Risk factors for the rapid increase in risk of acute coronary events in patients with new-onset rheumatoid arthritis: a nested case-control study","volume":"67","author":"Mantel","year":"2015","journal-title":"Arthritis Rheumatol (Hoboken)"},{"key":"B15","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1002\/art.24390","article-title":"Association between anti-cyclic citrullinated peptide antibodies and ischemic heart disease in patients with rheumatoid arthritis","volume":"61","author":"L\u00f3pez-Longo","year":"2009","journal-title":"Arthritis Rheum"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.3899\/jrheum.090188","article-title":"Autoantibodies and the risk of cardiovascular events","volume":"36","author":"Liang","year":"2009","journal-title":"J Rheumatol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.atherosclerosis.2013.02.009","article-title":"Antibodies to citrullinated peptides and risk of coronary heart disease","volume":"228","author":"Cambridge","year":"2013","journal-title":"Atherosclerosis"},{"key":"B18","doi-asserted-by":"publisher","first-page":"2311","DOI":"10.1002\/art.39198","article-title":"Rheumatoid arthritis, anti-cyclic citrullinated peptide positivity, and cardiovascular disease risk in the women\u2019s health initiative","volume":"67","author":"Mackey","year":"2015","journal-title":"Arthritis Rheumatol (Hoboken)"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2861","DOI":"10.1002\/art.39302","article-title":"Brief report: lack of replication of an association between anti-citrullinated fibrinogen and subclinical atherosclerosis in patients with rheumatoid arthritis","volume":"67","author":"Montes","year":"2015","journal-title":"Arthritis Rheumatol (Hoboken)"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2686","DOI":"10.1002\/art.10542","article-title":"Antibodies to high-density lipoprotein and beta2-glycoprotein I are inversely correlated with paraoxonase activity in systemic lupus erythematosus and primary antiphospholipid syndrome","volume":"46","author":"Delgado Alves","year":"2002","journal-title":"Arthritis Rheum"},{"key":"B21","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1093\/rheumatology\/ken397","article-title":"Anti-atherogenic and anti-inflammatory properties of high-density lipoprotein are affected by specific antibodies in systemic lupus erythematosus","volume":"48","author":"Batuca","year":"2009","journal-title":"Rheumatology"},{"key":"B22","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.trsl.2015.07.004","article-title":"Antibodies to high-density lipoproteins are associated with inflammation and cardiovascular disease in rheumatoid arthritis patients","volume":"166","author":"Rodr\u00edguez-Carrio","year":"2015","journal-title":"Transl Res"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1002\/art.39609","article-title":"PON activity is modulated by rs662 polymorphism and IgG anti-HDL antibodies in rheumatoid arthritis patients: potential implications for CV disease","volume":"68","author":"Rodr\u00edguez-Carrio","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.1160\/TH17-03-0221","article-title":"Serum levels of anti-PON1 and anti-HDL antibodies as potential biomarkers of premature atherosclerosis in systemic lupus erythematosus","volume":"117","author":"L\u00f3pez","year":"2017","journal-title":"Thromb Haemost"},{"key":"B25","first-page":"33","article-title":"Classification and diagnostic criteria for mixed connective tissue disease","volume-title":"Mixed Connective Tissue Disease and Anti-Nuclear Antibodies","author":"Alarc\u00f3n-Segovia","year":"1987"},{"key":"B26","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1136\/ard.61.6.554","article-title":"Classification criteria for Sj\u00f6gren\u2019s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group","volume":"61","author":"Vitali","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"B27","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1002\/art.38098","article-title":"2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European League against Rheumatism collaborative initiative","volume":"65","author":"van den Hoogen","year":"2013","journal-title":"Arthritis Rheum"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1002\/art.1780330802","article-title":"The American College of Rheumatology 1990 criteria for the classification of vasculitis. Introduction","volume":"33","author":"Hunder","year":"1990","journal-title":"Arthritis Rheum"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1056\/NEJMra043898","article-title":"Primary biliary cirrhosis","volume":"353","author":"Kaplan","year":"2005","journal-title":"N Engl J Med"},{"key":"B30","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.2337\/dc13-S011","article-title":"Standards of medical care in diabetes \u2013 2013","volume":"36","year":"2013","journal-title":"Diabetes Care"},{"key":"B31","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.autrev.2014.01.042","article-title":"Diagnosis and classification of pernicious anemia","volume":"13","author":"Bizzaro","year":"2014","journal-title":"Autoimmun Rev"},{"key":"B32","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1136\/gut.2005.082909","article-title":"The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications","volume":"55","author":"Satsangi","year":"2006","journal-title":"Gut"},{"key":"B33","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3109\/00365528909091339","article-title":"Classification of inflammatory bowel disease","author":"Lennard-Jones","year":"1989","journal-title":"Scand J Gastroenterol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1097\/MCG.0b013e31827a6f83","article-title":"World Gastroenterology Organisation global guidelines on celiac disease","volume":"47","author":"Bai","year":"2013","journal-title":"J Clin Gastroenterol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1093\/rheumatology\/keu345","article-title":"Red cell distribution width is associated with cardiovascular risk and disease parameters in rheumatoid arthritis","volume":"54","author":"Rodr\u00edguez-Carrio","year":"2015","journal-title":"Rheumatology (Oxford)"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1161\/ATVBAHA.112.300133","article-title":"High-density lipoprotein function, dysfunction, and reverse cholesterol transport","volume":"32","author":"Fisher","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"78","DOI":"10.2174\/1874091X01206010078","article-title":"High density lipoprotein and it\u2019s dysfunction","volume":"6","author":"Eren","year":"2012","journal-title":"Open Biochem J"},{"key":"B38","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.berh.2012.01.009","article-title":"Mixed connective tissue disease: an overview of clinical manifestations, diagnosis and treatment","volume":"26","author":"Ortega-Hernandez","year":"2012","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"R78","DOI":"10.1186\/ar2999","article-title":"Endothelial cell markers reflecting endothelial cell dysfunction in patients with mixed connective tissue disease","volume":"12","author":"Soltesz","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"B40","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1007\/s12026-014-8552-x","article-title":"Increased levels of anti-heat-shock protein 60 (anti-Hsp60) indicate endothelial dysfunction, atherosclerosis and cardiovascular diseases in patients with mixed connective tissue disease","volume":"60","author":"Bodolay","year":"2014","journal-title":"Immunol Res"},{"key":"B41","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.autrev.2011.01.004","article-title":"Comparative assessment of vascular function in autoimmune rheumatic diseases: considerations of prevention and treatment","volume":"10","author":"Solt\u00e9sz","year":"2011","journal-title":"Autoimmun Rev"},{"key":"B42","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1186\/s13075-015-0756-5","article-title":"Associations between circulating endostatin levels and vascular organ damage in systemic sclerosis and mixed connective tissue disease: an observational study","volume":"17","author":"Reiseter","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"B43","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/nrgastro.2014.202","article-title":"Epidemiology, risk factors and management of cardiovascular diseases in IBD","volume":"12","author":"Singh","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"e56944","DOI":"10.1371\/journal.pone.0056944","article-title":"Disease activity in inflammatory bowel disease is associated with increased risk of myocardial infarction, stroke and cardiovascular death \u2013 a Danish nationwide cohort study","volume":"8","author":"Kristensen","year":"2013","journal-title":"PLoS One"},{"key":"B45","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.jacl.2010.08.021","article-title":"Dyslipidemia and lipoprotein profiles in patients with inflammatory bowel disease","volume":"4","author":"Sappati Biyyani","year":"2010","journal-title":"J Clin Lipidol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1002\/ibd.20582","article-title":"Paraoxonase-1 status in Crohn\u2019s disease and ulcerative colitis","volume":"15","author":"Boehm","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"B47","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1177\/0003319716652031","article-title":"Subclinical atherosclerosis in patients with inflammatory bowel diseases: a systematic review and meta-analysis","volume":"68","author":"Wu","year":"2016","journal-title":"Angiology"},{"key":"B48","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1097\/MOG.0000000000000212","article-title":"Role of type 2 immunity in intestinal inflammation","volume":"31","author":"Bamias","year":"2015","journal-title":"Curr Opin Gastroenterol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"4846","DOI":"10.3748\/wjg.v20.i17.4846","article-title":"Inflammatory bowel disease and celiac disease: overlaps and differences","volume":"20","author":"Pascual","year":"2014","journal-title":"World J Gastroenterol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.dld.2013.04.001","article-title":"Impact of gluten-free diet on cardiovascular risk factors. A retrospective analysis in a large cohort of coeliac patients","volume":"45","author":"Zanini","year":"2013","journal-title":"Dig Liver Dis"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1136\/heartjnl-2016-310111","article-title":"Cardiovascular risk assessment and treatment in chronic inflammatory disorders in primary care","volume":"102","author":"Emanuel","year":"2016","journal-title":"Heart"},{"key":"B52","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.berh.2016.03.003","article-title":"Cardiovascular risk and its modification in patients with connective tissue diseases","volume":"30","author":"O\u2019Sullivan","year":"2016","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.1002\/art.27546","article-title":"Anti-apolipoprotein A-1 IgG predicts major cardiovascular events in patients with rheumatoid arthritis","volume":"62","author":"Vuilleumier","year":"2010","journal-title":"Arthritis Rheum"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmed.2018.00114\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T10:09:54Z","timestamp":1524478194000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmed.2018.00114\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,23]]},"references-count":53,"alternative-id":["10.3389\/fmed.2018.00114"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2018.00114","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,23]]},"article-number":"114"}}