{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:22:20Z","timestamp":1759990940898,"version":"3.41.2"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG056769"],"award-info":[{"award-number":["R01AG056769"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006937","name":"National Center for Medical Rehabilitation Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"DOI":"10.3389\/fmed.2019.00327","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T12:30:11Z","timestamp":1579696211000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Angiotensin Converting Enzyme Inhibitors Combined with Exercise for Hypertensive Seniors (The ACES Trial): Study Protocol of a Randomized Controlled Trial"],"prefix":"10.3389","volume":"6","author":[{"given":"Sara A.","family":"Harper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana C.","family":"Baptista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah J.","family":"Wherry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca S.","family":"Boxer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerry L.","family":"Hildreth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina S.","family":"Seay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. Hunter","family":"Allman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christy S.","family":"Carter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Aban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy M.","family":"Kohrt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas W.","family":"Buford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,1,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1001\/jama.295.17.2018","article-title":"Association of long-distance corridor walk performance with mortality, cardiovascular disease, mobility limitation, and disability","volume":"295","author":"Newman","year":"2006","journal-title":"JAMA."},{"key":"B2","doi-asserted-by":"publisher","first-page":"S36","DOI":"10.1016\/j.jacc.2005.03.080","article-title":"The value of estimated functional capacity in estimating outcome: results from the NHBLI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) study","volume":"47","author":"Shaw","year":"2006","journal-title":"J Am Coll Cardiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1001\/jama.2010.1923","article-title":"Gait speed and survival in older adults","volume":"305","author":"Studenski","year":"2011","journal-title":"JAMA."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1161\/STROKEAHA.107.500850","article-title":"Walking speed and risk of incident ischemic stroke among postmenopausal women","volume":"39","author":"McGinn","year":"2008","journal-title":"Stroke."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1016\/j.jacc.2010.06.039","article-title":"Gait speed as an incremental predictor of mortality and major morbidity in elderly patients undergoing cardiac surgery","volume":"56","author":"Afilalo","year":"2010","journal-title":"J Am Coll Cardiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"b4460","DOI":"10.1136\/bmj.b4460","article-title":"Slow walking speed and cardiovascular death in well functioning older adults: prospective cohort study","volume":"339","author":"Dumurgier","year":"2009","journal-title":"BMJ."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1097\/HJH.0b013e328338bbec","article-title":"Hypertension and lower walking speed in the elderly: the Three-City study","volume":"28","author":"Dumurgier","year":"2010","journal-title":"J Hypertens."},{"key":"B8","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1111\/j.1532-5415.2010.03282.x","article-title":"High blood pressure accelerates gait slowing in well-functioning older adults over 18-years of follow-up","volume":"59","author":"Rosano","year":"2011","journal-title":"J Am Geriatr Soc."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1161\/HYPERTENSIONAHA.107.097667","article-title":"Association between concurrent and remote blood pressure and disability in older adults","volume":"50","author":"Hajjar","year":"2007","journal-title":"Hypertension."},{"key":"B10","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1093\/ageing\/afp209","article-title":"Risk factors for disability in older persons over 3-year follow-up","volume":"39","author":"Balzi","year":"2010","journal-title":"Age Ageing."},{"key":"B11","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1001\/jama.1997.03540250033028","article-title":"A randomized trial comparing aerobic exercise and resistance exercise with a health education program in older adults with knee osteoarthritis. The Fitness Arthritis and Seniors Trial (FAST)","volume":"277","author":"Ettinger","year":"1997","journal-title":"JAMA."},{"key":"B12","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1053\/apmr.2000.4425","article-title":"Low-intensity exercise as a modifier of physical frailty in older adults","volume":"81","author":"Brown","year":"2000","journal-title":"Arch Phys Med Rehabil."},{"key":"B13","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1097\/00008483-200407000-00005","article-title":"Effects of cardiac rehabilitation on the recovery outcomes of older adults after coronary artery bypass surgery","volume":"24","author":"Dolansky","year":"2004","journal-title":"J Cardiopulm Rehabil."},{"key":"B14","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1093\/gerona\/59.2.M154","article-title":"The effects of multidimensional home-based exercise on functional performance in elderly people","volume":"59","author":"Nelson","year":"2004","journal-title":"J Gerontol A Biol Sci Med Sci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1093\/gerona\/60.11.1437","article-title":"Angiotensin-converting enzyme inhibition intervention in elderly persons: effects on body composition and physical performance","volume":"60","author":"Carter","year":"2005","journal-title":"J Gerontol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"9753","DOI":"10.1007\/s11357-015-9753-5","article-title":"The renin-angiotensin system and prevention of age-related functional decline: where are we now?","volume":"37","author":"Simon","year":"2015","journal-title":"Age."},{"key":"B17","first-page":"127","article-title":"Perindopril: do randomised, controlled trials support an ACE inhibitor class effect? A meta-analysis of clinical trials","volume":"20","author":"Snyman","year":"2009","journal-title":"Cardiovasc J Afr."},{"key":"B18","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1136\/heart.88.4.373","article-title":"Perindopril improves six minute walking distance in older patients with left ventricular systolic dysfunction: a randomised double blind placebo controlled trial","volume":"88","author":"Hutcheon","year":"2002","journal-title":"Heart."},{"key":"B19","doi-asserted-by":"publisher","first-page":"21","DOI":"10.2165\/00003495-200059002-00003","article-title":"Diuretics as a basis of antihypertensive therapy","volume":"59","author":"Kaplan","year":"2000","journal-title":"Drugs."},{"key":"B20","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/S0140-6736(02)08024-8","article-title":"Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study","volume":"359","author":"Onder","year":"2002","journal-title":"Lancet."},{"key":"B21","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1111\/j.1532-5415.2004.52265.x","article-title":"Antihypertensive medications and differences in muscle mass in older persons: the health, aging and body composition study","volume":"52","author":"Di Bari","year":"2004","journal-title":"J Am Geriatr Soc"},{"key":"B22","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s11357-010-9196-y","article-title":"Differential effects of enalapril and losartan on body composition and indices of muscle quality in aged male Fischer 344 x Brown Norway rats","volume":"33","author":"Carter","year":"2011","journal-title":"Age."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1111\/j.1532-5415.2012.04045.x","article-title":"Angiotensin-converting enzyme inhibitor use by older adults is associated with greater functional responses to exercise","volume":"60","author":"Buford","year":"2012","journal-title":"J Am Geriatr Soc."},{"key":"B24","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1093\/gerona\/glr042","article-title":"Usefulness of preclinical models for assessing the efficacy of late-life interventions for sarcopenia","volume":"67","author":"Carter","year":"2012","journal-title":"J Gerontol A Biol Sci Med Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1093\/gerona\/glv222","article-title":"Antihypertensive use and the effect of a physical activity intervention in the prevention of major mobility disability among older adults: the LIFE study","volume":"71","author":"Buford","year":"2016","journal-title":"J Gerontol A Biol Sci Med Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1503\/cmaj.071062","article-title":"Is there a new role for angiotensin-converting-enzyme inhibitors in elderly patients?","volume":"177","author":"Cranney","year":"2007","journal-title":"CMAJ."},{"key":"B27","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/j.1559-4572.2008.07117.x","article-title":"Effects of angiotensin-converting enzyme inhibitor therapy on levels of inflammatory markers in response to exercise-induced stress: studies in the metabolic syndrome","volume":"3","author":"Vaccari","year":"2008","journal-title":"J Cardiometab Syndr."},{"key":"B28","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1093\/eurheartj\/ehr400","article-title":"Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers are beneficial in normotensive atherosclerotic patients: a collaborative meta-analysis of randomized trials","volume":"33","author":"McAlister","year":"2012","journal-title":"Eur Heart J."},{"key":"B29","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.cct.2015.06.019","article-title":"Multi-modal intervention to reduce cardiovascular risk among hypertensive older adults: Design of a randomized clinical trial","volume":"43","author":"Buford","year":"2015","journal-title":"Contemp Clin Trials."},{"key":"B30","doi-asserted-by":"publisher","first-page":"E196","DOI":"10.3390\/jcm8020196","article-title":"Multimodal intervention to improve functional status in hypertensive older adults: a pilot randomized controlled trial","volume":"8","author":"Baptista","year":"2019","journal-title":"J Clin Med"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1097\/00005768-200107000-00010","article-title":"CHAMPS physical activity questionnaire for older adults: outcomes for interventions","volume":"33","author":"Stewart","year":"2001","journal-title":"Med Sci Sports Exerc."},{"key":"B32","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1111\/j.1532-5415.2004.52267.x","article-title":"Reliability of the 400-m usual-pace walk test as an assessment of mobility limitation in older adults","volume":"52","author":"Rolland","year":"2004","journal-title":"J Am Geriatr Soc."},{"key":"B33","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1046\/j.1532-5415.2001.00496.x","article-title":"Exercise prescription for older adults with osteoarthritis pain: consensus practice recommendations. A supplement to the AGS Clinical Practice Guidelines on the management of chronic pain in older adults","volume":"49","year":"2001","journal-title":"J Am Geriatr Soc"},{"key":"B34","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1503\/cmaj.061339","article-title":"Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial","volume":"177","author":"Sumukadas","year":"2007","journal-title":"CMAJ."},{"volume-title":"ACSM's Guidelines for Exercise Testing and Prescription","year":"2014","key":"B35"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1161\/HYP.0000000000000066","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: executive summary: a report of the American College of Cardiology\/American Heart Association task force on clinical practice guidelines","volume":"71","author":"Whelton","year":"2018","journal-title":"Hypertension."},{"volume-title":"Borg's Perceived Exertion and Pain Scales.","year":"1998","author":"Borg","key":"B37"},{"key":"B38","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1378\/chest.123.2.387","article-title":"The 6-min walk test: a quick measure of functional status in elderly adults","volume":"123","author":"Enright","year":"2003","journal-title":"Chest."},{"key":"B39","doi-asserted-by":"publisher","first-page":"e000257","DOI":"10.1161\/JAHA.113.000257","article-title":"Ankle brachial index values, leg symptoms, and functional performance among community-dwelling older men and women in the lifestyle interventions and independence for elders study","volume":"2","author":"McDermott","year":"2013","journal-title":"J Am Heart Assoc."},{"key":"B40","doi-asserted-by":"publisher","first-page":"M85","DOI":"10.1093\/geronj\/49.2.M85","article-title":"A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission","volume":"49","author":"Guralnik","year":"1994","journal-title":"J Gerontol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0895-4356(01)00434-6","article-title":"A stroke prediction score in the elderly: validation and Web-based application","volume":"55","author":"Lumley","year":"2002","journal-title":"J Clin Epidemiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1016\/j.jacc.2010.07.021","article-title":"Frailty, aging, and cardiac surgery outcomes: the stopwatch tells the story","volume":"56","author":"Cleveland","year":"2010","journal-title":"J Am Coll Cardiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jada.2003.10.017","article-title":"Additional self-monitoring tools in the dietary modification component of The Women's Health Initiative","volume":"104","author":"Mossavar-Rahmani","year":"2004","journal-title":"J Am Diet Assoc."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1016\/j.jand.2012.06.002","article-title":"Evaluation of three short dietary instruments to assess fruit and vegetable intake: the National Cancer Institute's food attitudes and behaviors survey","volume":"112","author":"Yaroch","year":"2012","journal-title":"J Acad Nutr Diet."},{"key":"B45","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J Chronic Dis."},{"key":"B46","first-page":"e232","article-title":"Quality of life in hypertension: the SF-12 compared to the SF-36","volume":"11","author":"Cote","year":"2004","journal-title":"Can J Clin Pharmacol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1093\/gerona\/glp196","article-title":"Effects of age and sedentary lifestyle on skeletal muscle NF-kappaB signaling in men","volume":"65","author":"Buford","year":"2010","journal-title":"J Gerontol A Biol Sci Med Sci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"E265","DOI":"10.3390\/jcm8020265","article-title":"Blood-flow restriction resistance exercise for older adults with knee osteoarthritis: a pilot randomized clinical trial","volume":"8","author":"Harper","year":"2019","journal-title":"J Clin Med"},{"key":"B49","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/BF03324957","article-title":"Differential gene expression of FoxO1, ID1, and ID3 between young and older men and associations with muscle mass and function","volume":"23","author":"Buford","year":"2011","journal-title":"Aging Clin Exp Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1249\/MSS.0b013e3182625928","article-title":"Blood flow restriction enhances post-resistance exercise angiogenic gene expression","volume":"44","author":"Larkin","year":"2012","journal-title":"Med Sci Sports Exerc."},{"key":"B51","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1139\/apnm-2016-0224","article-title":"Effects of blood flow restriction on biomarkers of myogenesis in response to resistance exercise","volume":"42","author":"Layne","year":"2017","journal-title":"Appl Physiol Nutr Metab."},{"key":"B52","first-page":"4","article-title":"Validation of the OMRON M6 Comfort (HEM-7321-E) upper arm blood pressure monitor, in oscillometry mode, for clinic use and self measurement in a general population, according to the European Society of Hypertension International Protocol revision 2010","author":"Takahashi","year":"2014","journal-title":"dablEducational Trust"},{"key":"B53","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1111\/j.1532-5415.2006.00701.x","article-title":"Meaningful change and responsiveness in common physical performance measures in older adults","volume":"54","author":"Perera","year":"2006","journal-title":"J Am Geriatr Soc."},{"key":"B54","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1007\/s12603-009-0104-z","article-title":"What is a meaningful change in physical performance? Findings from a clinical trial in older adults (the LIFE-P study)","volume":"13","author":"Kwon","year":"2009","journal-title":"J Nutr Health Aging"},{"key":"B55","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1080\/00031305.1980.10483031","article-title":"Population marginal means in the linear model: an alternative to least squares means","volume":"34","author":"Searle","year":"1980","journal-title":"Am Stat."},{"volume-title":"Applied Longitudinal Analysis","year":"2012","author":"Fitzmaurice","key":"B56"},{"key":"B57","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1093\/gerona\/gls174","article-title":"Gait speed as a measure in geriatric assessment in clinical settings: a systematic review","volume":"68","author":"Peel","year":"2013","journal-title":"J Gerontol A Biol Sci Med Sci."},{"key":"B58","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/ageing\/afz046","article-title":"Sarcopenia: revised European consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1113\/JP270536","article-title":"Exercise: the lifelong supplement for healthy ageing and slowing down the onset of frailty","volume":"594","author":"Vina","year":"2016","journal-title":"J Physiol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s40520-016-0705-4","article-title":"Physical activity and exercise as countermeasures to physical frailty and sarcopenia","volume":"29","author":"Marzetti","year":"2017","journal-title":"Aging Clin Exp Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s40279-013-0018-0","article-title":"Toward exercise as personalized medicine","volume":"43","author":"Buford","year":"2013","journal-title":"Sports Med."},{"key":"B62","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.pmrj.2013.11.009","article-title":"Optimizing the benefits of exercise on physical function in older adults","volume":"6","author":"Buford","year":"2014","journal-title":"PM R."},{"key":"B63","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1097\/BOR.0b013e3283432c41","article-title":"Exercise: necessary but not sufficient for improving function and preventing disability?","volume":"23","author":"Keysor","year":"2011","journal-title":"Curr Opin Rheumatol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1056\/NEJM200001203420301","article-title":"Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients","volume":"342","author":"Yusuf","year":"2000","journal-title":"N Engl J Med."},{"key":"B65","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1111\/j.1751-7176.2011.00450.x","article-title":"Are there pleiotropic effects of antihypertensive medications or is it all about the blood pressure in the patient with diabetes and hypertension?","volume":"13","author":"Sica","year":"2011","journal-title":"J Clin Hypertens."},{"key":"B66","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1093\/gerona\/glt142","article-title":"Do ACE inhibitors improve the response to exercise training in functionally impaired older adults? A randomized controlled trial","volume":"69","author":"Sumukadas","year":"2014","journal-title":"J Gerontol A Biol Sci Med Sci."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmed.2019.00327\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T12:30:15Z","timestamp":1579696215000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmed.2019.00327\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,22]]},"references-count":66,"alternative-id":["10.3389\/fmed.2019.00327"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2019.00327","relation":{},"ISSN":["2296-858X"],"issn-type":[{"type":"electronic","value":"2296-858X"}],"subject":[],"published":{"date-parts":[[2020,1,22]]},"article-number":"327"}}