{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:26:02Z","timestamp":1790342762839,"version":"4.1.0"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:00:00Z","timestamp":1592956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"DOI":"10.3389\/fmed.2020.00217","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T08:48:11Z","timestamp":1592988491000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":43,"title":["The Disordered Vaginal Microbiota Is a Potential Indicator for a Higher Failure of in vitro Fertilization"],"prefix":"10.3389","volume":"7","author":[{"given":"Yao","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyao","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cihua","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingtao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,6,24]]},"reference":[{"key":"B1","author":"Turchi","year":"2015","journal-title":"Prevalence, Definition, and Classification of Infertility"},{"key":"B2","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.fertnstert.2015.06.025","article-title":"Ectopic pregnancy rate increases with the number of retrieved oocytes in autologous in vitro fertilization with non-tubal infertility but not donor\/recipient cycles: An analysis of 109,140 clinical pregnancies from the society for assisted reproductive technology registry","volume":"104","author":"Acharya","year":"2015","journal-title":"Fertil Steril."},{"key":"B3","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1089\/acu.2017.1265","article-title":"Positive effect of acupuncture and cupping in infertility treatment","volume":"30","author":"Wang","year":"2018","journal-title":"Med Acupunct."},{"key":"B4","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.jare.2013.05.002","article-title":"Prediction models in in vitro fertilization; where are we: a mini review","volume":"5","author":"Loendersloot","year":"2014","journal-title":"J Adv Res"},{"key":"B5","unstructured":"Evaluation of uterine biophysical profile and to assess its role in predicting conception among unexplained primary infertility patients404\n            GuptaP\n            JainPK\n            KaushikA\n            ChandraS\n          J Epidemiol Commun.262014"},{"key":"B6","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1007\/s00404-018-5034-8","article-title":"Only women's age and the duration of infertility are the prognostic factors for the success rate of natural cycle ivf","volume":"299","author":"Wolff","year":"2019","journal-title":"Arch Gynecol Obste."},{"key":"B7","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1530\/REP-17-0566","article-title":"The impact of infertility diagnosis on embryo-endometrial dialogue","volume":"155","author":"Parks","year":"2018","journal-title":"Reproduction."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1016\/s0015-0282(00)01624-1","article-title":"Bacteria in the transfer catheter tip influence the live-birth rate after in vitro fertilization","volume":"74","author":"Moore","year":"2000","journal-title":"Fertil Steril."},{"key":"B9","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1080\/09513590.2017.1302420","article-title":"Transferring two grades i cleavage-stage embryo might not be a good protocol","volume":"33","author":"Li","year":"2017","journal-title":"Gynecol Endocrinol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s10815-018-01398-2","article-title":"Cumulus-corona gene expression analysis combined with morphological embryo scoring in single embryo transfer cycles increases live birth after fresh transfer and decreases time to pregnancy","volume":"36","author":"Adriaenssens","year":"2019","journal-title":"J Assist Reprod Genet."},{"key":"B11","first-page":"34","article-title":"Hpv\/chlamydia trachomatis co-infection: metagenomic analysis of cervical microbiota in asymptomatic women","volume":"41","author":"Di","year":"2018","journal-title":"New Microbiol."},{"key":"B12","first-page":"331","article-title":"Unraveling the dynamics of the human vaginal microbiome","volume":"89","author":"Nunn","year":"2016","journal-title":"Yale J Biol Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2884","DOI":"10.3892\/etm.2018.5778","article-title":"Seminal bacterial composition in patients with obstructive and nonobstructive azoospermia","volume":"15","author":"Chen","year":"2018","journal-title":"Exp Ther Mbd."},{"key":"B14","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1111\/j.1471-0528.2010.02840.x","article-title":"The vaginal microbiome: new information about genital tract flora using molecular based techniques","volume":"118","author":"Lamont","year":"2011","journal-title":"Bjog-int J Obstet Gy."},{"key":"B15","first-page":"S91","article-title":"Biological control of vaginosis to improve reproductive health","volume":"140","author":"Mastromarino","year":"2014","journal-title":"Indian J Med Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s12958-015-0028-x","article-title":"Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring","volume":"13","author":"Sharma","year":"2015","journal-title":"Reprod Biol Endocrin."},{"key":"B17","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.placenta.2018.04.005","article-title":"Utility of metabolic profiling of serum in the diagnosis of pregnancy complications","volume":"66","author":"Powell","year":"2018","journal-title":"Placenta."},{"key":"B18","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1034\/j.1600-0897.2003.00095.x","article-title":"Pre-conceptional natural killer cell activity and percentage as predictors of biochemical pregnancy and spontaneous abortion with normal chromosome karyotype","volume":"50","author":"Yamada","year":"2015","journal-title":"Am J Reprod Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.3389\/fmicb.2016.01479","article-title":"Evaluation of the microbial diversity in amyotrophic lateral sclerosis using high-throughput sequencing","volume":"7","author":"Fang","year":"2016","journal-title":"Front Microbiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat Methods."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2460","DOI":"10.1093\/bioinformatics\/btq461","article-title":"Search and clustering orders of magnitude faster than BLAST","volume":"6","author":"Edgar","year":"2010","journal-title":"Bioinformatics."},{"key":"B22","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.fertnstert.2018.06.036","article-title":"Cervicovaginal microbiota, women's health, reproductive outcomes","volume":"110","author":"Kroon","year":"2018","journal-title":"Fertil Steril."},{"key":"B23","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.chom.2018.01.013","article-title":"Cervicovaginal microbiota and reproductive health: the virtue of simplicity","volume":"23","author":"Anahtar","year":"2018","journal-title":"Cell Host Microbe."},{"key":"B24","doi-asserted-by":"publisher","first-page":"534","DOI":"10.4103\/ijmr.IJMR_774_16","article-title":"Vaginal lactobacilli profile in pregnant women with normal & abnormal vaginal flora","volume":"146","author":"Yeruva","year":"2017","journal-title":"Indian J Med Ras."},{"key":"B25","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1038\/ismej.2011.109","article-title":"Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers","volume":"6","author":"Wang","year":"2011","journal-title":"ISME"},{"key":"B26","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/nature22318","article-title":"Corrigendum: Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota","volume":"545","author":"Forslund","year":"2017","journal-title":"Nature."},{"key":"B27","doi-asserted-by":"publisher","first-page":"e0172456","DOI":"10.1371\/journal.pone.0172456","article-title":"Effect of women's age on embryo morphology, cleavage rate and competence-a multicenter cohort study","volume":"12","author":"Gr\u00f8ndahl","year":"2017","journal-title":"PLoS ONE."},{"key":"B28","doi-asserted-by":"publisher","first-page":"501","DOI":"10.29252\/ijrm.14.8.501","article-title":"Analysis of ovarian reserve markers (amh, fsh, afc) in different age strata in ivf\/icsi patients","volume":"14","author":"Tehraninezhad","year":"2016","journal-title":"Int J Reprod Biomed."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1113\/JP271694","article-title":"The vaginal microbiota, host defence and reproductive physiology","volume":"595","author":"Smith","year":"2017","journal-title":"J Physiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1172\/JCI97043","article-title":"Group b streptococcus exploits vaginal epithelial exfoliation for ascending infection","volume":"128","author":"Vornhagen","year":"2018","journal-title":"J Clin Invest."},{"key":"B31","doi-asserted-by":"publisher","first-page":"116","DOI":"10.4274\/tjod.34651","article-title":"Non-invasive prediction of implantation window in controlled hyperstimulation cycles: Can the time from the menstrual day at embryo transfer to expected menstrual cycle give a clue?","volume":"13","author":"Sanverdi","year":"2016","journal-title":"Turk J Obstet Gynecol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"305","DOI":"10.3233\/npm-17111","article-title":"The relationship of cervical microbiota diversity with race and disparities in preterm birth","volume":"11","author":"Wheeler","year":"2018","journal-title":"J Neonatal Perinatal Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.fertnstert.2018.04.041","article-title":"Relevance of assessing the uterine microbiota in infertility","volume":"110","author":"Moreno","year":"2018","journal-title":"Fertil Steril."},{"key":"B34","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1007\/BF02212584","article-title":"Ureaplasma urealyticum and mycoplasma hominis detected by the polymerase chain reaction in the cervices of women undergoing in vitro fertilization: prevalence and consequences","volume":"12","author":"Witkin","year":"1995","journal-title":"J Assist Reprod Genet."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1093\/oxfordjournals.humrep.a019470","article-title":"Fertilization and early embryology: Incidence of microbial growth from the tip of the embryo transfer catheter after embryo transfer in relation to clinical pregnancy rate following in-vitro fertilization and embryo transfer","volume":"11","author":"Egbase","year":"1996","journal-title":"Hum Reprod."},{"key":"B36","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.ajog.2016.09.075","article-title":"Evidence that the endometrial microbiota has an effect on implantation success or failure","volume":"215","author":"Moreno","year":"2016","journal-title":"Am J Obstet Gynecol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1093\/humrep\/17.2.337","article-title":"Bacterial colonization of the uterine cervix and success rate in assisted reproduction: results of a prospective survey","volume":"17","author":"Raed","year":"2002","journal-title":"Hum Reprod."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1097\/MAJ.0b013e31823ea228","article-title":"The microbiota of the vagina and its influence on women's health and disease","volume":"343","author":"Martin","year":"2012","journal-title":"Am J Med Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1016\/s0015-0282(98)00277-5","article-title":"Microbial flora of the cervix assessed at the time of embryo transfer adversely affects in vitro fertilization outcome","volume":"70","author":"Fanchin","year":"1998","journal-title":"Fertil Steril."},{"key":"B40","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1111\/aogs.12933","article-title":"Treatment of bacterial vaginosis in pregnancy in order to reduce the risk of spontaneous preterm delivery - a clinical recommendation","volume":"95","author":"Haahr","year":"2016","journal-title":"Acta Obstet Gyn Scan."},{"key":"B41","doi-asserted-by":"publisher","first-page":"738","DOI":"10.23736\/s0026-4784.18.04247-8","article-title":"Assisted reproductive technique in women of advanced fertility age","volume":"70","author":"Artini","year":"2018","journal-title":"Minerva Chir."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e60670","DOI":"10.1371\/journal.pone.0060670","article-title":"Composition of the vaginal microbiota in women of reproductive age - sensitive and specific molecular diagnosis of bacterial vaginosis is possible?","volume":"8","author":"Shipitsyna","year":"2013","journal-title":"PLoS ONE."},{"key":"B43","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/2049-2618-1-29","article-title":"Daily temporal dynamics of vaginal microbiota before, during and after episodes of bacterial vaginosis","volume":"1","author":"Ravel","year":"2013","journal-title":"Microbiome."},{"key":"B44","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1080\/19396368.2018.1482030","article-title":"Association of estrogen, progesterone and follicle stimulating hormone receptor polymorphisms with in vitro fertilization outcomes","volume":"64","author":"Ganesh","year":"2018","journal-title":"Front Endocrinol."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmed.2020.00217\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T08:48:16Z","timestamp":1592988496000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmed.2020.00217\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,24]]},"references-count":44,"alternative-id":["10.3389\/fmed.2020.00217"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2020.00217","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,24]]},"article-number":"217"}}