{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:16:15Z","timestamp":1787166975888,"version":"build-2736575974"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2016A020216013"],"award-info":[{"award-number":["2016A020216013"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010843","name":"Guangzhou Science, Technology and Innovation Commission","doi-asserted-by":"publisher","award":["201604120013"],"award-info":[{"award-number":["201604120013"]}],"id":[{"id":"10.13039\/501100010843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["5010"],"award-info":[{"award-number":["5010"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    HLA-B27 has an established relationship with the development of ankylosing spondylitis (AS). After reviewing the HLA-B genotype from 407 Chinese subjects (318 patients and 89 sex-matched controls), we found that 252 patients and 32 controls were HLA-B27(+) and that HLA-B\n                    <jats:sup>*<\/jats:sup>\n                    27:04 was the dominant HLA-B27 subtype (\n                    <jats:italic>N<\/jats:italic>\n                    = 224). In all participants, HLA\n                    <jats:sup>*<\/jats:sup>\n                    27:04 homozygous were only detected in two patients. In the HLA-B27(+) group, HLA-B40 was observed in 51 cases and one control (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.05, OR = 7.87, 95% CI 1.05\u201359.0); of these, the most genotype was HLA-B\n                    <jats:sup>*<\/jats:sup>\n                    27:04\/B\n                    <jats:sup>*<\/jats:sup>\n                    40:01(\n                    <jats:italic>N<\/jats:italic>\n                    = 38). Two hundred thirty-nine patients' clinical information was recorded. Cases with HLA-B27\/B46 had more peripheral joint involvement (OR = 3.95, 95% CI 1.77\u20138.79) in HLA-B27(+) AS. HLA-B\n                    <jats:sup>*<\/jats:sup>\n                    15:02 may be a significant risk element to peripheral joint involvement (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.05) in HLA-B27(\u2212) patients. Therefore, we believe HLA-B\n                    <jats:sup>*<\/jats:sup>\n                    40:01, HLA-B\n                    <jats:sup>*<\/jats:sup>\n                    46:01, and HLA-B\n                    <jats:sup>*<\/jats:sup>\n                    15:02 can be the test indicators for AS diagnostic value.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2020.568790","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T08:11:36Z","timestamp":1610093496000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["The Clinical Characteristics of Other HLA-B Types in Chinese Ankylosing Spondylitis Patients"],"prefix":"10.3389","volume":"7","author":[{"given":"Xinyu","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiujing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuqi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zena","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangyan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liudan","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieruo","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,1,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1002\/1529-0131(199801)41:1<58::AID-ART8>3.0.CO;2-G","article-title":"Prevalence of spondylarthropathies in HLA-B27 positive and negative blood donors, Arthritis Rheum","volume":"41","author":"Braun","year":"1998"},{"key":"B2","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.semarthrit.2007.01.003","article-title":"Epidemiology of spondyloarthritis in the People's Republic of China: review of the literature and commentary","volume":"37","author":"Ng","year":"2007","journal-title":"Semin Arthritis Rheum"},{"key":"B3","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/j.0105-2896.2009.00852.x","article-title":"Genomics of ankylosing spondylitis","volume":"10","author":"Thomas","year":"2010","journal-title":"Discov Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1111\/j.1365-2249.1993.tb05885.x","article-title":"HLA-B27 subtypes in the spondarthropathies","volume":"91","author":"MacLean","year":"1993","journal-title":"Clin Exp Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1034\/j.1399-0039.2001.580407.x","article-title":"New insights regarding HLA-B27 diversity in the Asian population","volume":"58","author":"Garc\u00eda-Fern\u00e1ndez","year":"2001","journal-title":"Tissue Antigens"},{"key":"B6","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1399-0039.1995.tb02436.x","article-title":"HLA-B27 subtypes in Asian patients with ankylosing spondylitis. 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