{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:17:37Z","timestamp":1787026657777,"version":"build-2736575974"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    The mRNA-destabilizing protein tristetraprolin (TTP), encoded by the\n                    <jats:italic>ZFP36<\/jats:italic>\n                    gene, is known to be able to end inflammatory responses by directly targeting and destabilizing mRNAs encoding pro-inflammatory cytokines. We analyzed its role in psoriasis, a disease characterized by chronic inflammation. We observed that TTP is downregulated in fibroblasts deriving from psoriasis patients compared to those deriving from healthy individuals and that psoriatic fibroblasts exhibit abnormal inflammasome activity compared to their physiological counterpart. This phenomenon depends on TTP downregulation. In fact, following restoration, TTP is capable of directly targeting for degradation NLRP3 mRNA, thereby drastically decreasing inflammasome activation. Moreover, we provide evidence that\n                    <jats:italic>ZFP36<\/jats:italic>\n                    undergoes methylation in psoriasis, by virtue of the presence of long stretches of CpG dinucleotides both in the promoter and the coding region. Besides confirming that a perturbation of TTP expression might underlie the pathogenesis of psoriasis, we suggest that deregulated inflammasome activity might play a role in the disease alongside deregulated cytokine expression.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2020.579383","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T03:44:03Z","timestamp":1611287043000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Promoter Methylation Leads to Decreased ZFP36 Expression and Deregulated NLRP3 Inflammasome Activation in Psoriatic Fibroblasts"],"prefix":"10.3389","volume":"7","author":[{"given":"Matteo","family":"Bertesi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Fantini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Alecci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Lotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Martello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Parenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Carretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Marconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Grande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Pincelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Zanocco-Marani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,1,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/nri1689","article-title":"Getting under the skin: the immunogenetics of psoriasis","volume":"5","author":"Bowcock","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1038\/jid.2010.103","article-title":"Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions","volume":"130","author":"Davidovici","year":"2010","journal-title":"J Invest Dermatol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/j.1365-2133.1983.tb07075.x","article-title":"Hyperactivity of fibroblasts cultured from psoriatic skin: i faster proliferation and effect of serum withdrawal","volume":"109","author":"Priestley","year":"1983","journal-title":"Br J Dermatol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"56S","DOI":"10.1111\/1523-1747.ep12505791","article-title":"Experimental models for psoriasis","volume":"95","author":"Krueger","year":"1990","journal-title":"J Invest Dermatol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"536","DOI":"10.3389\/fimmu.2019.00536","article-title":"Defective induction of COX-2 expression by psoriatic fibroblasts promotes pro-inflammatory activation of macrophages","volume":"10","author":"Arasa","year":"2019","journal-title":"Front Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"566","DOI":"10.3390\/antiox8110566","article-title":"Fibroblasts to keratinocytes redox signaling: the possible role of ROS in psoriatic plaque formation","volume":"8","author":"Barygina","year":"2019","journal-title":"Antioxidants."},{"key":"B7","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.tibs.2016.12.003","article-title":"An ancient family of RNA-binding proteins: still important! 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