{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:37:30Z","timestamp":1777592250958,"version":"3.51.4"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"DOI":"10.3389\/fmed.2020.583943","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T06:25:48Z","timestamp":1604643948000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["CML\/RAGE Signal Bridges a Common Pathogenesis Between Atherosclerosis and Non-alcoholic Fatty Liver"],"prefix":"10.3389","volume":"7","author":[{"given":"Qiwen","family":"Pang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honghua","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengyang","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lele","family":"Jing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongqun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3377","DOI":"10.3748\/wjg.v17.i29.3377","article-title":"Nutrition and physical activity in NAFLD: an overview of the epidemiological evidence","volume":"17","author":"Zelber-Sagi","year":"2011","journal-title":"World J Gastroenterol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/460190","article-title":"Genetic factors in the pathogenesis of nonalcoholic fatty liver and steatohepatitis","volume":"2015","author":"Dongiovanni","year":"2015","journal-title":"Biomed Res Int."},{"key":"B3","doi-asserted-by":"publisher","first-page":"5031","DOI":"10.1021\/acs.jmedchem.9b01701","article-title":"The race to bash NASH: emerging targets and drug development in a complex liver disease","volume":"63","author":"Romero","year":"2020","journal-title":"J Med Chem."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1007\/s10620-016-4143-0","article-title":"Global epidemiology of non-alcoholic fatty liver disease and perspectives on US minority populations","volume":"61","author":"Sherif","year":"2016","journal-title":"Dig Dis Sci"},{"key":"B5","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1097\/MAJ.0b013e3182018598","article-title":"Nonalcoholic fatty liver disease and type 2 diabetes mellitus: the hidden epidemic","volume":"341","author":"Ismail","year":"2011","journal-title":"Am J Med Sci Jun"},{"key":"B6","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.jhep.2019.06.021","article-title":"The global epidemiology of NAFLD NASH in patients with type 2 diabetes: a systematic review meta-analysis","volume":"71","author":"Younossi","year":"2019","journal-title":"J Hepatol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1002\/hep.22429","article-title":"Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes","volume":"48","author":"Fracanzani","year":"2008","journal-title":"Hepatology."},{"key":"B8","doi-asserted-by":"publisher","first-page":"165","DOI":"10.2337\/dc07-1463","article-title":"Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects","volume":"31","author":"Kotronen","year":"2008","journal-title":"Diabetes Care."},{"key":"B9","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1053\/j.gastro.2007.04.068","article-title":"Relationship between hepatic\/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects","volume":"133","author":"Gastaldelli","year":"2007","journal-title":"Gastroenterology."},{"key":"B10","doi-asserted-by":"publisher","first-page":"134","DOI":"10.14218\/JCTH.2017.00005","article-title":"Nonalcoholic Fatty Liver Disease (NAFLD) and risk of cardiac arrhythmias: a new aspect of the liver-heart axis","volume":"5","author":"Mantovani","year":"2017","journal-title":"J Clin Transl Hepatol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"3104","DOI":"10.3390\/ijerph16173104","article-title":"Cardiovascular risk in non-alcoholic fatty liver disease: mechanisms and therapeutic implications","volume":"16","author":"Tana","year":"2019","journal-title":"Int J Environ Res Public Health."},{"key":"B12","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.jhep.2008.06.012","article-title":"Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: a systematic review","volume":"49","author":"Sookoian","year":"2008","journal-title":"J Hepatol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/S0016-5085(98)70599-2","article-title":"Steatohepatitis: a tale of two \u201chits\u201d?","volume":"114","author":"Day","year":"1998","journal-title":"Gastroenterology."},{"key":"B14","doi-asserted-by":"publisher","first-page":"189813","DOI":"10.1155\/2019\/4189813","article-title":"The role of oxidative stress in the development of diabetes mellitus and its complications","volume":"2019","author":"Dos Santos","year":"2019","journal-title":"J Diabetes Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2337\/diabetes.48.1.1","article-title":"Role of oxidative stress in diabetic complications: a new perspective on an old paradigm","volume":"48","author":"Baynes","year":"1999","journal-title":"Diabetes."},{"key":"B16","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1586\/eem.10.68","article-title":"The N\u03b5-(carboxymethyl)lysine -RAGE axis: putative implications for the pathogenesis of obesity-related complications","volume":"5","author":"Gaens","year":"2010","journal-title":"Endocrinol Metab."},{"key":"B17","doi-asserted-by":"publisher","first-page":"9982","DOI":"10.1074\/jbc.271.17.9982","article-title":"The advanced glycation end product, Nepsilon-(carboxymethyl)lysine, is a product of both lipid peroxidation and glycoxidation reactions","volume":"271","author":"Fu","year":"1996","journal-title":"J Biol Chem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.atherosclerosis.2012.01.019","article-title":"Advanced glycation end-product N\u03b5-carboxymethyl-Lysine accelerates progression of atherosclerotic calcification in diabetes","volume":"221","author":"Wang","year":"2012","journal-title":"Atherosclerosis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"18070","DOI":"10.3748\/wjg.v20.i48.18070","article-title":"Adipokines proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease","volume":"20","author":"Stojsavljevi\u0107","year":"2014","journal-title":"World J Gastroenterol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1111\/jre.12518","article-title":"Advanced glycation end-products increase IL-6 and ICAM-1 expression via RAGE, MAPK and NF-\u03baB pathways in human gingival fibroblasts","volume":"53","author":"Nonaka","year":"2018","journal-title":"J Periodontal Res."},{"key":"B21","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/path.4045","article-title":"Advanced glycation end product N\u03b5 - carboxymethyllysine induces endothelial cell injury: the involvement of SHP-1-regulated VEGFR-2 dephosphorylation","volume":"230","author":"Liu","year":"2013","journal-title":"Pathology."},{"key":"B22","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1152\/ajplung.00185.2014","article-title":"Acute secondhand smoke-induced pulmonary inflammation is diminished in RAGE knockout mice","volume":"307","author":"Wood","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.ijcard.2014.01.031","article-title":"Effects of N\u03b5 -carboxymethyl-lysine on ERS-mediated apoptosis in diabetic atherosclerosis","volume":"172","author":"Wang","year":"2014","journal-title":"Int J Cardiol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/j.2040-1124.2010.00013.x","article-title":"Oxidative stress: a cause and therapeutic target of diabetic complications","volume":"1","author":"Araki","year":"2010","journal-title":"J Diabetes Investig."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1161\/CIRCULATIONAHA.113.005015","article-title":"Contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis","volume":"129","author":"Allahverdian","year":"2014","journal-title":"Circulation."},{"key":"B26","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1136\/jcp.2005.032391","article-title":"Hepaticex-pressionofgalectin-3 and receptor for advanced glycationend products inpatients with liver disease","volume":"60","author":"Butscheid","year":"2007","journal-title":"J Clin Pathol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.3389\/fimmu.2019.02893","article-title":"Macrophage function in the pathogenesis of non-alcoholic fatty liver disease: the mac attack","volume":"10","author":"Oates","year":"2019","journal-title":"Front Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1002\/hep.21496","article-title":"The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD","volume":"45","author":"Angulo","year":"2007","journal-title":"Hepatology."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1053\/j.gastro.2012.04.001","article-title":"The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American gastroenterological association, American Association for the study of liver diseases, and American College of Gastroenterology","volume":"142","author":"Chalasani","year":"2012","journal-title":"Gastroenterology."},{"key":"B30","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.jhep.2008.06.018","article-title":"Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease","volume":"49","author":"Ong","year":"2008","journal-title":"J Hepatol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1002\/hep.23314","article-title":"Decreased survival of subjects with elevated liver function tests during a 28-year follow-up","volume":"51","author":"S\u00f6derberg","year":"2010","journal-title":"Hepatology."},{"key":"B32","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/s10620-019-05996-7","article-title":"Cardiovascular risk in NAFLD: an intimate relationship?","volume":"5","author":"Lonardo","year":"2019","journal-title":"Dig Dis Sci"},{"key":"B33","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cgh.2011.12.039","article-title":"Independent association between nonalcoholic fatty liver disease and cardiovascular disease in the US population","volume":"10","author":"Stepanova","year":"2012","journal-title":"Clin Gastroenterol Hepatol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.jhep.2016.05.013","article-title":"Nonalcoholic fatty liver disease and risk of incident cardiovascular disease: a meta-analysis of observational studies","volume":"65","author":"Targher","year":"2016","journal-title":"J Hepatol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1016\/j.cgh.2019.12.026","article-title":"Nonalcoholic fatty liver disease and fibrosis associated with increased risk of cardiovascular events in a prospective study","volume":"18","author":"Baratta","year":"2020","journal-title":"Clin Gastroenterol Hepatol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"5826","DOI":"10.3748\/wjg.v12.i36.5826","article-title":"Fatty liver, carotid disease and gallstones: a study of age related associations","volume":"12","author":"Lonardo","year":"2006","journal-title":"World J Gastroenterol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.atherosclerosis.2019.01.029","article-title":"Does nonalcoholic fatty liver disease cause cardiovascular disease? Current knowledge and gaps","volume":"282","author":"Santos","year":"2019","journal-title":"Atherosclerosis."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/275867","article-title":"MicroRNAs involved in the lipid metabolism and their possible implications for atherosclerosis development and treatment","volume":"2014","author":"Nov\u00e1k","year":"2014","journal-title":"Mediat Inflamm."},{"key":"B39","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis an inflamrnatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N Engl J Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/jfbc.13200","article-title":"Nutraceuticals for prevention of atherosclerosis: targeting monocyte infiltration to the vascular endotheliu","volume":"446","author":"Kim","year":"2020","journal-title":"J Food Biochem."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1111\/1440-1681.13316","article-title":"MiR-599 regulates LPS-mediated apoptosis and inflammatory responses through the JAK2\/STAT3 signaling pathway via targeting ROCK1 in human umbilical vein endothelial cells","volume":"478","author":"Wang","year":"2020","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"4266","DOI":"10.2174\/138161212802481237","article-title":"Atherosclerosis as an inflammatory disease","volume":"18","author":"Tuttolomondo","year":"2012","journal-title":"Curr Pharm Des."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1007\/s10620-006-9262-6","article-title":"Association among C-reactive protein, fatty liver disease, and cardiovascular risk","volume":"52","author":"Lizardi-Cervera","year":"2007","journal-title":"Curr Pharm Des."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1002\/hep.30887","article-title":"Vitamin D receptor activation in liver macrophages protects against hepatic endoplasmic reticulum stress in mice","volume":"71","author":"Zhou","year":"2020","journal-title":"Hepatology."},{"key":"B45","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1002\/hep.23280","article-title":"Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications","volume":"51","author":"Fabbrini","year":"2010","journal-title":"Hepatology."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1042\/CS20200446","article-title":"Non-alcoholic fatty liver disease: a metabolic burden promoting atherosclerosis","volume":"134","author":"Zhang","year":"2020","journal-title":"Clin Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s40200-018-0378-y","article-title":"Life-style-induced metabolic derangement and epigenetic changes promote diabetes and oxidative stress leading to NASH and atherosclerosis severity","volume":"17","author":"Srivastava","year":"2018","journal-title":"J Diabetes Metab Disord."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/j.jhep.2006.02.011","article-title":"Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2","volume":"44","author":"Haukeland","year":"2006","journal-title":"Hepatology."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1016\/j.dld.2019.05.015","article-title":"Brain involvement in non-alcoholic fatty liver disease (NAFLD): a systematic review","volume":"51","author":"Lombardi","year":"2019","journal-title":"Dig Liver Dis."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molmet.2020.101092","article-title":"Dysregulated lipid metabolism links NAFLD to cardiovascular disease","volume":"30","author":"Deprince","year":"2020","journal-title":"Mol Metab."},{"key":"B51","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1159\/000282080","article-title":"Epidemiology of non-alcoholic fatty liver disease","volume":"28","author":"Bellentani","year":"2010","journal-title":"Digest Dis."},{"key":"B52","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0169-409X(97)00128-2","article-title":"Interactions of liposomes and lipid-based carrier systems with blood proteins: relation to clearance behaviour in vivo","volume":"32","author":"Cullis","year":"1998","journal-title":"Adv Drug Deliver Rev"},{"key":"B53","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1111\/liv.12226","article-title":"Predictive value of ALT levels for non- alcoholic steatohepatitis (NASH) and advanced fibrosis in non-alcoholic fatty liver disease (NAFLD)","volume":"33","author":"Verma","year":"2013","journal-title":"Liver Int."},{"key":"B54","doi-asserted-by":"publisher","first-page":"31740","DOI":"10.1074\/jbc.274.44.31740","article-title":"N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression","volume":"274","author":"Kislinger","year":"1999","journal-title":"J Biol Chem."},{"key":"B55","doi-asserted-by":"publisher","first-page":"401","DOI":"10.2174\/1570161116666171205105402","article-title":"Editorial: arterial stiffness, central haemodynamics and nonalcoholic fatty liver disease: links with cardiovascular risk and effects of drug treatment","volume":"16","author":"Katsiki","year":"2018","journal-title":"Curr Vasc Pharmacol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s00592-018-1266-0","article-title":"A round trip from nonalcoholic fatty liver disease to diabetes: molecular targets to the rescue?","volume":"56","author":"Lonardo","year":"2019","journal-title":"Acta Diabetol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.2174\/0929867043365369","article-title":"Oxidative stress, antioxidants, and endothelial function","volume":"11","author":"Schulz","year":"2004","journal-title":"Curr Med Chem."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2020.583943\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T06:25:50Z","timestamp":1604643950000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2020.583943\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,6]]},"references-count":57,"alternative-id":["10.3389\/fmed.2020.583943"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2020.583943","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,6]]},"article-number":"583943"}}