{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:07:29Z","timestamp":1790870849170,"version":"4.1.0"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"DOI":"10.3389\/fmed.2020.606824","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T01:06:26Z","timestamp":1610931986000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":202,"title":["Will COVID-19 Lead to Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome?"],"prefix":"10.3389","volume":"7","author":[{"given":"Anthony L.","family":"Komaroff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucinda","family":"Bateman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"993","DOI":"10.15585\/mmwr.mm6930e1","article-title":"Symptom duration and risk factors for delayed return to usual health among outpatients with COVID-19 in a multistate health care systems network","volume":"69","author":"Tenforde","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep."},{"key":"B2","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1001\/jama.2020.12603","article-title":"Persistent symptoms in patients after acute COVID-19","volume":"324","author":"Carfi","year":"2020","journal-title":"JAMA."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e0240784","DOI":"10.1371\/journal.pone.0240784","article-title":"Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection","volume":"15","author":"Townsend","year":"2020","journal-title":"PLoS ONE."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1101\/2020.12.24.20248802","article-title":"Symptomatic description of long COVID through 7 months in an international cohort","author":"Davis","year":"2020","journal-title":"medRxiv."},{"key":"B5","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/1471-2377-11-37","article-title":"Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study","volume":"11","author":"Moldofsky","year":"2011","journal-title":"BMC Neurol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7326\/0003-4819-102-1","article-title":"Evidence for active Epstein-Barr virus infection in patients with persistent, unexplained illnesses: elevated anti-early antigen antibodies","volume":"102","author":"Jones","year":"1985","journal-title":"Ann Intern Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1192\/bjp.173.6.475","article-title":"Incidence, risk and prognosis of acute and chronic fatigue syndromes and psychiatric disorders after glandular fever","volume":"173","author":"White","year":"1998","journal-title":"Br J Psychiatry."},{"key":"B8","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1136\/bmj.38933.585764.AE","article-title":"Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study","volume":"333","author":"Hickie","year":"2006","journal-title":"BMJ."},{"key":"B9","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1136\/jcp.2007.050054","article-title":"Chronic fatigue syndrome is associated with chronic enterovirus infection of the stomach","volume":"61","author":"Chia","year":"2008","journal-title":"J Clin Pathol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"S39","DOI":"10.1016\/S1386-6532(06)70010-5","article-title":"Is human herpesvirus-6 a trigger for chronic fatigue syndrome?","volume":"37","author":"Komaroff","year":"2006","journal-title":"J Clin Virol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1056\/NEJMc1506576","article-title":"Post-Ebola signs and symptoms in U.S. survivors","volume":"373","author":"Epstein","year":"2015","journal-title":"N Engl J Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1348\/174866407X218312","article-title":"Neurocognitive and functional outcomes in persons recovering from West Nile virus illness","volume":"2","author":"Sejvar","year":"2008","journal-title":"J Neuropsychol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jcv.2006.10.011","article-title":"Post-infectious fatigue syndrome in dengue infection","volume":"38","author":"Seet","year":"2007","journal-title":"J Clin Virol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1099\/vir.0.017590-0","article-title":"Antibody to parvovirus B19 nonstructural protein is associated with chronic arthralgia in patients with chronic fatigue syndrome\/myalgic encephalomyelitis","volume":"91","author":"Kerr","year":"2010","journal-title":"J Gen Virol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/0002-9343(90)90520-N","article-title":"Summary of the first 100 patients seen at a Lyme disease referral center","volume":"88","author":"Sigal","year":"1990","journal-title":"Am J Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e0155884","DOI":"10.1371\/journal.pone.0155884","article-title":"Fatigue following acute Q-fever: a systematic literature review","volume":"11","author":"Morroy","year":"2016","journal-title":"PLoS ONE."},{"key":"B17","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1034\/j.1600-0463.2003.1110504.x","article-title":"Multiple co-infections (mycoplasma, chlamydia, human herpes virus-6) in blood of chronic fatigue syndrome patients: association with signs and symptoms","volume":"111","author":"Nicolson","year":"2003","journal-title":"APMIS."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1016\/j.cgh.2018.01.022","article-title":"Prevalence of irritable bowel syndrome and chronic fatigue 10 years after giardia infection","volume":"16","author":"Litleskare","year":"2018","journal-title":"Clin Gastroenterol Hepatol."},{"key":"B19","unstructured":"TopolE\n            VergheseA\n            FauciA\n          MedscapeFauci to Medscape: \u2018We're All In It Together and We're Gonna Get Through It'2020"},{"key":"B20","volume-title":"Beyond Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: Redefining an Illness","year":"2015"},{"key":"B21","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/1477-7525-1-49","article-title":"A population-based study of the clinical course of chronic fatigue syndrome","volume":"1","author":"Nisenbaum","year":"2003","journal-title":"Health Qual Life Outcomes."},{"key":"B22","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1093\/occmed\/kqi013","article-title":"A systematic review describing the prognosis of chronic fatigue syndrome","volume":"55","author":"Cairns","year":"2005","journal-title":"Occup Med (Lond)."},{"key":"B23","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1542\/peds.107.5.994","article-title":"Thirteen-year follow-up of children and adolescents with chronic fatigue syndrome","volume":"107","author":"Bell","year":"2001","journal-title":"Pediatrics."},{"key":"B24","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1001\/jama.2019.8312","article-title":"Advances in understanding the pathophysiology of chronic fatigue syndrome","volume":"322","author":"Komaroff","year":"2019","journal-title":"JAMA."},{"key":"B25","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1007\/s11682-018-0029-4","article-title":"Evidence of widespread metabolite abnormalities in myalgic encephalomyelitis\/chronic fatigue syndrome: assessment with whole-brain magnetic resonance spectroscopy","volume":"14","author":"Mueller","year":"2019","journal-title":"Brain Imaging Behav."},{"key":"B26","doi-asserted-by":"publisher","first-page":"15902","DOI":"10.1073\/pnas.2003432117","article-title":"Oligodendrocytes that survive acute coronavirus infection induce prolonged inflammatory responses in the CNS","volume":"117","author":"Pan","year":"2020","journal-title":"Proc Natl Acad Sci USA."},{"key":"B27","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.neubiorev.2015.07.015","article-title":"Sickness: from the focus on cytokines, prostaglandins, and complement factors to the perspectives of neurons","volume":"57","author":"Poon","year":"2015","journal-title":"Neurosci Biobehav Rev."},{"key":"B28","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.mehy.2013.05.034","article-title":"Chronic fatigue syndrome from vagus nerve infection: a psychoneuroimmunological hypothesis","volume":"81","author":"VanElzakker","year":"2013","journal-title":"Med Hypotheses."},{"key":"B29","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.tins.2013.10.003","article-title":"The neuroimmune basis of fatigue","volume":"37","author":"Dantzer","year":"2014","journal-title":"Trends Neurosci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"E5472","DOI":"10.1073\/pnas.1607571113","article-title":"Metabolic features of chronic fatigue syndrome","volume":"113","author":"Naviaux","year":"2016","journal-title":"Proc Natl Acad Sci USA."},{"key":"B31","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.freeradbiomed.2005.04.020","article-title":"Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms","volume":"39","author":"Kennedy","year":"2005","journal-title":"Free Radic Biol Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1186\/s12967-019-02155-4","article-title":"Transient receptor potential melastatin 2 channels are overexpressed in myalgic encephalomyelitis\/chronic fatigue syndrome patients","volume":"17","author":"Balinas","year":"2019","journal-title":"J Transl Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3390\/healthcare8040394","article-title":"Reductions in cerebral blood flow can be provoked by sitting in severe myalgic encephalomyelitis\/chronic fatigue syndrome patients","volume":"8","author":"Campen","year":"2020","journal-title":"Healthcare (Basel)."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2020.606824\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T01:06:34Z","timestamp":1610931994000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2020.606824\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,18]]},"references-count":33,"alternative-id":["10.3389\/fmed.2020.606824"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2020.606824","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,18]]},"article-number":"606824"}}