{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:53:23Z","timestamp":1792461203379,"version":"4.5.0"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T00:00:00Z","timestamp":1625788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Chronic venous disorder (CVeD) has a high prevalence, being commonly diagnosed by the presence of varicose veins. In fact, the development of varicose veins in lower extremities and\/or pelvic venous insufficiency (LEPVI) is frequent. However, its potential impact on fetal health has not been investigated. This study aimed to examine whether the presence of varicose veins in women's LEPVI is related to an intrapartum fetal compromise event.<\/jats:p><jats:p><jats:bold>Materials:<\/jats:bold> A cross-sectional, national study was conducted using medical administrative records (CMBD) of all vaginal births (<jats:italic>n<\/jats:italic> = 256,531) recorded in 2015 in Spain. The independent variable was defined as the presence of varicose veins in the legs, vulva, and perineum or hemorrhoids. A logistic regression model was used to assess the association of interest.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Among women with vaginal deliveries, those with varicose veins in their LEPVI have a significantly greater odds of intrapartum fetal compromise (OR = 1.30, 99.55%CI = 1.08\u20131.54) than their counterparts without varicose veins. After adjustment, this association remained significant (OR = 1.25, 99.5%CI = 1.05\u20131.50).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Our findings of an association between varicose veins in women's lower extremities and\/or pelvis and intrapartum fetal compromise suggest that varicose veins may be a novel and important clinical risk factor for fetal well-being and health.<\/jats:p>","DOI":"10.3389\/fmed.2021.577096","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T14:03:08Z","timestamp":1625839388000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Association Between Lower Extremity Venous Insufficiency and Intrapartum Fetal Compromise: A Nationwide Cross-Sectional Study"],"prefix":"10.3389","volume":"8","author":[{"given":"\u00c1ngel","family":"As\u00fansolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chaowen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Ortega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Coca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa N.","family":"Borrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"De Le\u00f3n-Luis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalio","family":"Garc\u00eda-Honduvilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melchor","family":"\u00c1lvarez-Mon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Buj\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,7,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1159\/000500449","article-title":"Unravelling the role of MAPKs (ERK1\/2) in venous reflux in patients with chronic venous disorder","volume":"206","author":"Ortega","year":"2018","journal-title":"Cells Tissues Organs."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2869","DOI":"10.1161\/CIRCULATIONAHA.118.035584","article-title":"Clinical and genetic determinants of varicose veins","volume":"138","author":"Fukaya","year":"2018","journal-title":"Circulation."},{"key":"B3","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.jvsv.2016.06.003","article-title":"A systematic review and meta-analysis of the risk for development of varicose veins in women with a history of pregnancy","volume":"4","author":"Ismail","year":"2016","journal-title":"J Vasc Surg Venous Lymphat Disord."},{"key":"B4","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.humpath.2018.03.022","article-title":"Placentas from women with pregnancy-associated venous insufficiency show vital damage with evidence of hypoxic cellular stress","volume":"77","author":"Garcia-Honduvilla","year":"2018","journal-title":"Hum Pathol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"567","DOI":"10.14670\/HH-11-948","article-title":"Remodeling of collagen fibers in placentas of pregnant women with venous insufficiency","volume":"33","author":"Ortega","year":"2018","journal-title":"Histol Histopathol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ajog.2019.07.032","article-title":"The physiology of intrapartumfetal compromise at term","volume":"222","author":"Turner","year":"2020","journal-title":"Am J Obstet Gynecol."},{"key":"B7","unstructured":"Hospital Discharge Records in the National Health System. 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Disponible en"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1097\/01.mlr.0000182534.19832.83","article-title":"Coding algorithms for defining Comorbidities in ICD-9-CM and ICD-10 administrative data","volume":"43","author":"Quan","year":"2005","journal-title":"Med Care."},{"key":"B9","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.placenta.2017.02.016","article-title":"Maternal vascular malperfusion of the placental bed associated with hypertensive disorders in the Boston Birth Cohort","volume":"52","author":"Bustamante Helfrich","year":"2017","journal-title":"Placenta."},{"key":"B10","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.jash.2017.09.001","article-title":"The relationship between hypertensive disorders in pregnancy and placental maternal and fetal vascular circulation","volume":"11","author":"Kovo","year":"2017","journal-title":"J Am Soc Hypertens."},{"key":"B11","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.placenta.2016.11.004","article-title":"Placental maternal vascular malperfusion and adverse pregnancy outcomes in gestational diabetes mellitus","volume":"49","author":"Scifres","year":"2017","journal-title":"Placenta."},{"key":"B12","doi-asserted-by":"publisher","first-page":"4157","DOI":"10.1111\/jcmm.15077","article-title":"Pregnancy-associated venous insufficiency course with placental and systemic oxidative stress","volume":"24","author":"Ortega","year":"2020","journal-title":"J Cell Mol Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.3390\/ijms21072487","article-title":"Increased angiogenesis and lymphangiogenesis in the placental villi of women with chronic venous disease during pregnancy","volume":"21","author":"Ortega","year":"2020","journal-title":"Int J Mol Sci."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2021.577096\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T14:03:12Z","timestamp":1625839392000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2021.577096\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,9]]},"references-count":13,"alternative-id":["10.3389\/fmed.2021.577096"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2021.577096","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,9]]},"article-number":"577096"}}