{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:38:18Z","timestamp":1779323898348,"version":"3.51.4"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T00:00:00Z","timestamp":1618272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> To investigate the clinical characteristics of patients with dizziness\/vertigo accompanied by loss of the posterior canal(s) (LPC).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Clinical data of 23 patients with LPC were collected. We determined video-head-impulse test (vHIT) gains of all six semicircular canals and correlated vHIT findings with other vestibulo-cochlear tests, including caloric test, ocular and cervical vestibular-evoked myogenic potentials (oVEMP, cVEMP), pure tone audiometry (PTA), and analyzed the differences in clinical manifestations of patients with LPC with different etiologies.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> LPC was identified in 23 patients. At the time of disease onset, most patients presented with dizziness (47.8%) and vertigo (30.4%) only, and some patients (21.7%) complained of unsteadiness. Among these 23 patients with LPC, there were 14 (60.9%) patients of isolated LPC (ILPC), 21 (91.3%) patients of unilateral LPC (ULPC), and 2 (8.7%) patients of bilateral LPC (BLPC). (1) Among 14 patients with ILPC, 13 (92.9%) patients had unilateral ILPC, the rate of ipsilesional impairment on caloric test, or oVEMP\/cVEMP test or PTA ipsilesionally was 53.8% (7\/13) in patients with unilateral ILPC. The causes of unilateral ILPC were vertigo\/dizziness of unclear origin (38.5%), labyrinthine infarction (15.4%), vestibular migraine (15.4%), and other diseases (30.8%); (2) among 21 patients with ULPC, 7 patients (33.3%) were accompanied with horizontal semicircular canal hypofunction ipsilesionally, the abnormal rate of caloric test, or oVEMP\/cVEMP tests or PTA ipsilesionally was 57.1%. The causes of ULPC were vertigo\/dizziness of unclear origin (33.3%), autoimmune inner ear disease (14.3%), labyrinthine infarction (14.3%), vestibular neuritis (9.5%), vestibular migraine (9.5%), and other diseases (19.0%); (3) among two patients with BLPC, one patient presented with unsteadiness, the causes of BLPC were vestibular paroxysmia and autoimmune inner ear disease.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> vHIT is a fast and effective method for assessing LPC, which can be used to detect isolated PC dysfunction. The causes of ILPC were peripheral origin or central origin. Patients with ILPC and ULPC mostly presented with dizziness\/vertigo, and ULPC was often accompanied by ipsilateral vestibulo-cochlear impairment.<\/jats:p>","DOI":"10.3389\/fmed.2021.589969","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T04:31:31Z","timestamp":1618288291000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Characteristics of Patients With Dizziness\/Vertigo Accompanied by Posterior Semicircular Canal Hypofunction"],"prefix":"10.3389","volume":"8","author":[{"given":"Zheyuan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongli","family":"Si","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangzhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e61488","DOI":"10.1371\/journal.pone.0061488","article-title":"The video Head Impulse Test (vHIT) detects vertical semicircular canal dysfunction","volume":"8","author":"Macdougall","year":"2013","journal-title":"PLoS ONE"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1016\/j.clinph.2017.04.029","article-title":"Association of posterior semicircular canal hypofunction on video-head-impulse testing with other vestibulo-cochlear deficits","volume":"128","author":"Tarnutzer","year":"2017","journal-title":"Clin Neurophysiol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1093\/brain\/119.3.755","article-title":"Vestibular neuritis spares the inferior division of the vestibular nerve","volume":"119","author":"Fetter","year":"1996","journal-title":"Brain"},{"key":"B4","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1097\/01.mao.0000169787.99835.9f","article-title":"Anatomic differences in the lateral vestibular nerve channels and their implications in vestibular neuritis","volume":"26","author":"Gianoli","year":"2005","journal-title":"Otol Neurotol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1097\/MAO.0000000000000758","article-title":"Superior versus inferior vestibular neuritis: are there intrinsic differences in infection, reactivation, or production of infectious particles between the vestibular ganglia?","volume":"36","author":"Nayak","year":"2015","journal-title":"Otol Neurotol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2378","DOI":"10.1212\/01.wnl.0000314685.01433.0d","article-title":"Normal head impulse test differentiates acute cerebellar strokes from vestibular neuritis","volume":"70","author":"Newman-Toker","year":"2008","journal-title":"Neurology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"154","DOI":"10.3389\/fneur.2015.00154","article-title":"The Video Head Impulse Test (vHIT) of semicircular canal function - 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