{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T06:23:47Z","timestamp":1772519027971,"version":"3.50.1"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:bold>Aims:<\/jats:bold> To evaluate both donor and recipient features involved in visual acuity restoring and complication insurgence in eyes that have undergone Descemet stripping automated endothelial keratoplasty (DSAEK).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> In this retrospective study, charts of 111 eyes of 96 patients (mean age 70.25 \u00b1 8.58 years) that underwent DSAEK were evaluated. Only Fuch's Distrophy (FD) or Bullous Keratopathy (BK) due to cataract surgery eyes were included. A complete ophthalmic check with endothelial cell density (ECD) and central corneal thickness (CCT) measurement was performed before surgery and at 1, 3, 6, and 12 months follow-up. Each DSAEK was performed by the same well-trained surgeon; only pre-cut lenticules, provided by same Eye Bank, were implanted.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A total of 48 (43%) complications have been observed (most of them were 22 partial graft detachments and 17 IOP spikes). At the last follow-up (mean: 8.58 \u00b1 4.09 months), a significant increase (<jats:italic>p<\/jats:italic> &amp;lt; 0.05) of best corrected visual acuity (BCVA) was detected. Overall mean BCVA of the eyes evaluated was 0.40 \u00b1 0.43 LogMAR with BK eyes showing a significantly higher improvement (<jats:italic>p<\/jats:italic> &amp;lt; 0.05) compared to FD eyes. The only factor showing a significant correlation (<jats:italic>p<\/jats:italic> &amp;lt; 0.05) with visual acuity enhancement was the implant of a lenticule thinner than 100 \u03bcm. Recipient features significantly (<jats:italic>p<\/jats:italic> &amp;lt; 0.05) associated with complications observed after surgery were glaucoma and diabetes mellitus.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The use of a graft thinner than 100 \u03bcm can provide better visual acuity recovery while recipients affected by glaucoma or diabetes mellitus are more prone to develop complications after surgery.<\/jats:p>","DOI":"10.3389\/fmed.2021.605160","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T05:04:10Z","timestamp":1618203850000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of Donor and Recipient Characteristics Involved in Descemet Stripping Automated Endothelial Keratoplasty Outcomes"],"prefix":"10.3389","volume":"8","author":[{"given":"Michele","family":"Lanza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Boccia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano","family":"Ruggiero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Melillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Bifani Sconocchia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Simonelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Sbordone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,4,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1016\/j.ophtha.2016.04.049","article-title":"Five-year graft survival comparing Descemet stripping automated endothelial keratoplasty and penetrating keratoplasty","volume":"123","author":"Ang","year":"2016","journal-title":"Ophthalmology."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1016\/j.ophtha.2009.06.021","article-title":"Descemet's stripping endothelial keratoplasty: safety and outcomes: a report by the American Academy of Ophthalmology","volume":"116","author":"Lee","year":"2009","journal-title":"Ophthalmology."},{"key":"B3","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1097\/ICU.0000000000000575","article-title":"Ultrathin descemet stripping automated endothelial keratoplasty","volume":"30","author":"Durrani","year":"2019","journal-title":"Curr Opin Ophthalmol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1016\/j.ophtha.2020.02.029","article-title":"Descemet membrane endothelial keratoplasty vs. ultrathin Descemet stripping automated endothelial keratoplasty: a multicenter randomized controlled clinical trial","volume":"127","author":"Dunker","year":"2020","journal-title":"Ophthalmology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.ophtha.2018.05.019","article-title":"Descemet endothelial thickness comparison trial: a randomized trial comparing ultrathin Descemet stripping automated endothelial keratoplasty with Descemet membrane endothelial keratoplasty","volume":"126","author":"Chamberlain","year":"2019","journal-title":"Ophthalmology."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1016\/j.ophtha.2011.12.037","article-title":"Three-year visual acuity outcomes after Descemet's stripping automated endothelial keratoplasty","volume":"119","author":"Li","year":"2012","journal-title":"Ophthalmology."},{"key":"B7","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.ophtha.2015.09.023","article-title":"Descemet stripping endothelial keratoplasty for Fuchs' endothelial corneal dystrophy: five-year results of a prospective study","volume":"123","author":"Wacker","year":"2016","journal-title":"Ophthalmology."},{"key":"B8","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.ajo.2019.02.029","article-title":"Effect of graft attachment status and intraocular pressure on Descemet stripping automated endothelial keratoplasty outcomes in the cornea preservation time study","volume":"203","author":"Aldave","year":"2019","journal-title":"Am J Ophthalmol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2276","DOI":"10.1016\/j.ophtha.2016.07.036","article-title":"A Randomized multicenter clinical trial of ultrathin Descemet stripping automated endothelial keratoplasty (DSAEK) versus DSAEK","volume":"123","author":"Dickman","year":"2016","journal-title":"Ophthalmology."},{"key":"B10","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.ajo.2016.07.024","article-title":"Changing practice patterns and long-term outcomes of endothelial versus penetrating keratoplasty: a prospective Dutch registry study","volume":"170","author":"Dickman","year":"2016","journal-title":"Am J Ophthalmol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1016\/j.ophtha.2012.11.030","article-title":"Ultrathin Descemet's stripping automated endothelial keratoplasty with the microkeratome double-pass technique: two-year outcomes","volume":"120","author":"Busin","year":"2013","journal-title":"Ophthalmology."},{"key":"B12","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/s0886-3350(96)80003-4","article-title":"Stop, chop, chop, and stuff","volume":"22","author":"Vasavada","year":"1996","journal-title":"J Cataract Refr Surg."},{"key":"B13","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.2307\/2531734","article-title":"Models for longitudinal data: a generalized estimating equation approach","volume":"44","author":"Zeger","year":"1988","journal-title":"Biometrics."},{"key":"B14","first-page":"161","article-title":"Generalized estimating equation. In: Springer, editor","volume-title":"Analysis of Repeated Measures Data","author":"Islam","year":"2011"},{"key":"B15","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1167\/iovs.11-7753","article-title":"Microkeratome-assisted preparation of ultrathin grafts for descemet stripping automated endothelial keratoplasty","volume":"53","author":"Busin","year":"2012","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1016\/j.ophtha.2019.02.011","article-title":"Cornea Preservation Time Study Group. Postoperative endothelial cell density is associated with late endothelial graft failure after Descemet Stripping Automated Endothelial Keratoplasty","volume":"126","author":"Patel","year":"2019","journal-title":"Ophthalmology."},{"key":"B17","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1001\/jamaophthalmol.2018.5669","article-title":"Cornea Preservation Time Study Group. Donor, recipient, and operative factors associated with increased endothelial cell loss in the Cornea Preservation Time Study","volume":"137","author":"Lass","year":"2019","journal-title":"JAMA Ophthalmol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.ajo.2018.10.005","article-title":"Cornea Preservation Time Study Group. Factors associated with graft rejection in the Cornea Preservation Time Study","volume":"196","author":"Stulting","year":"2018","journal-title":"Am J Ophthalmol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1016\/j.ophtha.2018.08.002","article-title":"Cornea Preservation Time Study Group. Donor, recipient, and operative factors associated with graft success in the Cornea Preservation Time Study","volume":"125","author":"Terry","year":"2018","journal-title":"Ophthalmology."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1001\/jamaophthalmol.2017.4970","article-title":"Cornea Preservation Time Study Group. Corneal endothelial cell loss 3 years after successful Descemet stripping automated endothelial keratoplasty in the Cornea Preservation Time Study: a Randomized clinical trial","volume":"135","author":"Lass","year":"2017","journal-title":"JAMA Ophthalmol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1097\/ICO.0000000000001999","article-title":"Five-year outcomes of ultrathin Descemet stripping automated endothelial keratoplasty","volume":"3","author":"Madi","year":"2019","journal-title":"Cornea"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1016\/j.ophtha.2008.01.024","article-title":"Complications of Descemet's stripping with automated endothelial keratoplasty: survey of 118 eyes at One Institute","volume":"11","author":"Suh","year":"2008","journal-title":"Ophthalmology."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2021.605160\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T05:04:13Z","timestamp":1618203853000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2021.605160\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,12]]},"references-count":22,"alternative-id":["10.3389\/fmed.2021.605160"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2021.605160","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,12]]},"article-number":"605160"}}