{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:42:19Z","timestamp":1790847739201,"version":"4.1.0"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> To evaluate the serum lipid levels of patients with primary angle-closure glaucoma (PACG) and to investigate the relationship between serum lipid levels and PACG.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> In this cross-sectional, case\u2013control study, a total of 320 PACG subjects and 242 age- and sex-matched control subjects were recruited. Serum high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), small dense LDL-C (SDLDL-C), triglyceride (TRIG), and cholesterol (CHOL) levels were measured using enzymatic colorimetry. Serum apolipoprotein A (APOA), apolipoprotein B (APOB), apolipoprotein E (APOE), and lipoprotein(a) (LPa) levels were measured by immunoturbidimetry.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The serum LDL-C, TRIG, HDL-C, APOE, LPa, CHOL, APOB, and APOA levels were significantly higher (<jats:italic>p<\/jats:italic> &amp;lt; 0.05) in the PACG group than in the control group. Multiple liner regression analyses revealed that there was a statistically correlation between HDL-C levels and mean deviation MD (<jats:italic>B<\/jats:italic> = 0.389, <jats:italic>P<\/jats:italic> = 0.002, 95% confidence interval [CI] = \u22121.249 to \u22120.624); LDL-C levels and MD (<jats:italic>B<\/jats:italic> = 0.190, <jats:italic>P<\/jats:italic> = 0.019, 95% CI = \u22125.632 to \u22121.306); and CHOL levels and MD (<jats:italic>B<\/jats:italic> = 0.364, <jats:italic>P<\/jats:italic> = 0.27, 95% CI = \u22127.727 to \u22121.839). Logistic regression analyses showed that high serum HDL-C (odds ratio [OR] = 11.01, 95% CI = 5.616\u201321.587), LDL-C (OR = 1.330, 95% CI = 1.079\u20131.640), SDLDL-C (OR = 1.007, 95% CI = 1.005\u20131.008), APOA (OR = 13.621, 95% CI = 7.251\u201325.591), APOB (OR = 2.243, 95% CI = 1.060\u20134.732), LPa (OR = 0.999, 95% CI = 0.998\u20131.00), and CHOL (OR = 1.131, 95% CI = 1.005\u20131.326) levels were significantly associated with PACG.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> High serum HDL-C, LDL-C, APOA, APOB, LPa, and CHOL levels were associated with PACG.<\/jats:p>","DOI":"10.3389\/fmed.2021.618970","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T05:52:31Z","timestamp":1612245151000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Association Between Serum Lipid Levels and Patients With Primary Angle-Closure Glaucoma in China: A Cross Sectional, 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