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Med."],"abstract":"<jats:p>Here the hypothesis is advanced that maladaptive mechanisms that prevent recovery in some intensive care unit (ICU) patients may also underlie Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS). Specifically, these mechanisms are: (a) suppression of the pituitary gland's<jats:italic>pulsatile<\/jats:italic>secretion of tropic hormones, and (b) a \u201cvicious circle\u201d between inflammation, oxidative and nitrosative stress (O&amp;amp;NS), and low thyroid hormone<jats:italic>function<\/jats:italic>. 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