{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:14:45Z","timestamp":1784265285092,"version":"3.55.0"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Schistosomiasis is a major public health problem in tropical areas of the world. Health-related quality of life (HRQOL) measurement is being widely used to evaluate the impact of a disease or treatment in several aspects of daily life. However, few studies evaluated the impact of severe forms of schistosomiasis on HRQOL of affected individuals and compared them to healthy controls with a similar socio-demographic background. Our aims were to evaluate the HRQOL in patients with hepatosplenic schistosomiasis (HS) and schistosomal myeloradiculopathy (SMR) and healthy volunteers (HV) and determine if clinical complications of the disease are associated with HRQOL scores. We interviewed and evaluated the HRQOL in 49 patients with HS, 22 patients with SMR, and 26 HV from an outpatient clinic of the Federal University of Minas Gerais University Hospital using the WHOQOL-BREF questionnaire. SMR and HS patients had a significantly lower overall quality of life score when comparing with the HV control group (<jats:italic>p<\/jats:italic> = 0.003 and <jats:italic>p<\/jats:italic> = 0.005, respectively). Multivariate ordinal regression model adjusted for sex, age, and educational level indicated that HS and SMR patients have three and five times more chances of having a lower quality of life than healthy volunteers (Odds Ratio 3.13 and 5.04, respectively). There was no association between complications of HS disease and quality of life scores. In contrast, worse quality of life was observed in SMR patients that presented back or leg pain, leg paresthesia, and bladder dysfunction. In conclusion, HS and SMR significantly impact the overall quality of life of the affected individuals, reinforcing the importance of efforts to control and eradicate this debilitating disease and suggesting that multidisciplinary clinical management of schistosomiasis patients would be more appropriate and could potentially improve patient's quality of life.<\/jats:p>","DOI":"10.3389\/fmed.2021.629484","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T05:46:43Z","timestamp":1622526403000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Quality of Life Assessment Among Patients Living With Hepatosplenic Schistosomiasis and Schistosomal Myeloradiculopathy"],"prefix":"10.3389","volume":"8","author":[{"given":"Silvana J\u00fania","family":"Roriz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Almeida","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Vaz de Melo Trindade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia Fonseca de Morais","family":"Caporali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Roberto","family":"Lambertucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41572-018-0013-8","article-title":"Schistosomiasis","volume":"4","author":"McManus","year":"2018","journal-title":"Nat Rev Dis Primers."},{"key":"B2","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1590\/S0037-86822000000300009","article-title":"Critical analysis of the estimated number of Schistosomiasis mansoni carriers in Brazil","volume":"33","author":"Katz","year":"2000","journal-title":"Rev Soc Bras Med Trop."},{"key":"B3","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.actatropica.2013.12.007","article-title":"Predictive risk mapping of schistosomiasis in Brazil using Bayesian geostatistical models","volume":"132","author":"Scholte","year":"2014","journal-title":"Acta Trop."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e0006232","DOI":"10.1371\/journal.pntd.0006232","article-title":"Evaluation of diagnostic methods for the detection of intestinal schistosomiasis in endemic areas with low parasite loads: Saline gradient, Helmintex, Kato-Katz and rapid urine test","volume":"12","author":"Oliveira","year":"2018","journal-title":"PLoS Negl Trop Dis."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e180478","DOI":"10.1590\/0074-02760180478","article-title":"Diagnosis of Schistosoma mansoni infections: what are the choices in Brazilian low-endemic areas?","volume":"114","author":"Silva-Moraes","year":"2019","journal-title":"Mem Inst Oswaldo Cruz."},{"key":"B6","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1590\/S0074-02762010000400012","article-title":"Acute schistosomiasis mansoni: revisited and reconsidered","volume":"105","author":"Lambertucci","year":"2010","journal-title":"Mem Inst Oswaldo Cruz."},{"key":"B7","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1590\/0037-8682-0186-2013","article-title":"Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools","volume":"47","author":"Lambertucci","year":"2014","journal-title":"Rev Soc Bras Med Trop."},{"key":"B8","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1590\/S0037-86822007000500016","article-title":"Guidelines for the diagnosis and treatment of schistosomal myeloradiculopathy","volume":"40","author":"Lambertucci","year":"2007","journal-title":"Rev Soc Bras Med Trop."},{"key":"B9","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1097\/NRL.0b013e3182704d1e","article-title":"Neuroschistosomiasis mansoni: literature review and guidelines","volume":"18","author":"Vale","year":"2012","journal-title":"Neurologist."},{"key":"B10","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.actatropica.2008.05.027","article-title":"Human schistosomiasis mansoni: immune responses during acute and chronic phases of the infection","volume":"108","author":"Caldas","year":"2008","journal-title":"Acta Trop."},{"key":"B11","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1111\/j.1365-3024.2009.01157.x","article-title":"Schistosomiasis and liver fibrosis","volume":"31","author":"Andrade","year":"2009","journal-title":"Parasite Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1017\/S0033291798006667","article-title":"Development of the World Health Organization WHOQOL-BREF quality of life assessment. 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