{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:07:07Z","timestamp":1792652827280,"version":"4.5.0"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>The animal model is an important tool to study the mechanism of disease formation. Different animal models of pruritus have been adopted based on the purpose of researchers in the study of the itching mechanism. Although the symptoms of various models are quite different, scratching behavior is a key indicator. Therefore, it is necessary to find an animal model that can quickly induce animal scratching and maintain the stability of scratching behavior. In this study, we compared animal models of pruritus induced by four substances and found that the scratching behavior of mice induced by urushiol not only reached the plateau stage quickly but also showed more stability in the plateau phase than that induced by 2,4-dinitrofluorobenzene, oxazolone, and imiquimod. Meanwhile, in the animal model induced by urushiol, the changes of epidermal thickening and inflammatory cell aggregation were also more obvious. In addition, pruritus induced by urushiol is prevalent all over the world, especially in the United States and Europe, involving outdoor groups such as firefighters, forest loggers, and farmers. Therefore, we believe that the urushiol-induced animal model is an ideal choice for the study of the itch formation mechanism and the development of antipruritic drugs.<\/jats:p>","DOI":"10.3389\/fmed.2021.630237","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T05:05:52Z","timestamp":1614056752000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparative Study on Different Skin Pruritus Mouse Models"],"prefix":"10.3389","volume":"8","author":[{"given":"Guan","family":"Donglang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Tongtong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Dan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Changming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Guang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tang","family":"Zongxiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1007\/s00105-016-3829-8","article-title":"Chronic pruritus care in daily practice","volume":"67","author":"Stander","year":"2016","journal-title":"Hautarzt."},{"key":"B2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1093\/qjmed\/hcg002","article-title":"Itch: scratching more than the surface","volume":"96","author":"Twycross","year":"2003","journal-title":"Qjm-Int J Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.clindermatol.2019.07.031","article-title":"Pruritus as a sign of systemic disease","volume":"37","author":"Welz-Kubiak","year":"2019","journal-title":"Clinics Dermatol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.iac.2016.08.009","article-title":"Differential diagnosis of atopic dermatitis","volume":"37","author":"Barrett","year":"2017","journal-title":"Immunol Allergy Clin."},{"key":"B5","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.det.2019.08.008","article-title":"Phototherapy for Itch","volume":"38","author":"Zhong","year":"2020","journal-title":"Dermatol Clin."},{"key":"B6","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jgr.2018.12.012","article-title":"Medicinal potential of Panax ginseng and its ginsenosides in atopic dermatitis treatment","volume":"44","author":"Lorz","year":"2020","journal-title":"J Ginseng Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/6981386","article-title":"Antipruritic effect of ethyl acetate extract from fructus cnidii in mice with 2,4-dinitrofluorobenzene-induced atopic dermatitis","volume":"2020","author":"Chen","year":"2020","journal-title":"Evid Based Complement Alternat Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/npr2.12120","article-title":"Critical role of GRP receptor-expressing neurons in the spinal transmission of imiquimod-induced psoriatic itch","volume":"3","author":"Kiguchi","year":"2020","journal-title":"Neuropsychopharmacol Rep."},{"key":"B9","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1097\/01.LAB.0000018827.78602.F4","article-title":"Chymase participates in chronic dermatitis by inducing eosinophil infiltration","volume":"82","author":"Tomimori","year":"2002","journal-title":"Lab Invest."},{"key":"B10","first-page":"405","article-title":"Contact and delayed hypersensitivity in the mouse. 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