{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:06:04Z","timestamp":1753891564090,"version":"3.41.2"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T00:00:00Z","timestamp":1623283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The morbidity and mortality of coronavirus disease 2019 (COVID-19) are still increasing. This study aimed to assess the quality of relevant COVID-19 clinical practice guidelines (CPGs) and to compare the similarities and differences between recommendations.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A comprehensive search was conducted using electronic databases (PubMed, Embase, and Web of Science) and representative guidelines repositories from December 1, 2019, to August 11, 2020 (updated to April 5, 2021), to obtain eligible CPGs. The Appraisal of Guidelines for Research and Evaluation (AGREE II) tool was used to evaluate the quality of CPGs. Four authors extracted relevant information and completed data extraction forms. All data were analyzed using R version 3.6.0 software.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> In total, 39 CPGs were identified and the quality was not encouragingly high. The median score (interquartile range, IQR) of every domain from AGREE II for evidence-based CPGs (EB-CPGs) versus (vs.) consensus-based CPG (CB-CPGs) was 81.94% (75.00\u201384.72) vs. 58.33% (52.78\u201368.06) in scope and purpose, 59.72% (38.89\u201375.00) vs. 36.11% (33.33\u201336.11) in stakeholder involvement, 64.58% (32.29\u201371.88) vs. 22.92% (16.67\u201326.56) in rigor of development, 75.00% (52.78\u201386.81) vs. 52.78% (50.00\u201363.89) in clarity of presentation, 40.63% (22.40\u201362.50) vs. 20.83% (13.54\u201325.00) in applicability, and 58.33% (50.00\u2013100.00) vs. 50.00% (50.00\u201377.08) in editorial independence, respectively. The methodological quality of EB-CPGs were significantly superior to the CB-CPGs in the majority of domains (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). There was no agreement on diagnosis criteria of COVID-19. But a few guidelines show Remdesivir may be beneficial for the patients, hydroxychloroquine +\/\u2013 azithromycin may not, and there were more consistent suggestions regarding discharge management. For instance, after discharge, isolation management and health status monitoring may be continued.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> In general, the methodological quality of EB-CPGs is greater than CB-CPGs. However, it is still required to be further improved. Besides, the consistency of COVID-19 recommendations on topics such as diagnosis criteria is different. Of them, hydroxychloroquine +\/\u2013 azithromycin may be not beneficial to treat patients with COVID-19, but remdesivir may be a favorable risk-benefit in severe COVID-19 infection; isolation management and health status monitoring after discharge may be still necessary. Chemoprophylaxis, including SARS-CoV 2 vaccines and antiviral drugs of COVID-19, still require more trials to confirm this.<\/jats:p>","DOI":"10.3389\/fmed.2021.630765","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T06:26:25Z","timestamp":1623306385000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Quality of and Recommendations for Relevant Clinical Practice Guidelines for COVID-19 Management: A Systematic Review and Critical Appraisal"],"prefix":"10.3389","volume":"8","author":[{"given":"Yun-Yun","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing-Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Zhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao-Hua","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian-Tao","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomei","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Hui","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,10]]},"reference":[{"key":"B1","unstructured":"WHOWHO Coronavirus Disease (COVID-19) Dashboard2021"},{"key":"B2","doi-asserted-by":"crossref","DOI":"10.17226\/13058","volume-title":"Committee on Standards for Developing Trustworthy Clinical Practice Guidelines. Clinical Practice Guidelines We Can Trust","author":"Graham","year":"2011"},{"key":"B3","doi-asserted-by":"publisher","first-page":"500","DOI":"10.21037\/atm.2020.03.130","article-title":"A quality evaluation of guidelines on five different viruses causing public health emergencies of international concern","volume":"8","author":"Zhao","year":"2020","journal-title":"Ann Transl Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"m1936","DOI":"10.1136\/bmj.m1936","article-title":"Scope, quality, and inclusivity of clinical guidelines produced early in the covid-19 pandemic: rapid review","volume":"369","author":"Dagens","year":"2020","journal-title":"BMJ."},{"key":"B5","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s40779-020-00251-x","article-title":"Role of adjunctive treatment strategies in COVID-19 and a review of international and national clinical guidelines","volume":"7","author":"Xu","year":"2020","journal-title":"Mil Med Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/jebm.12419","article-title":"Consistency of recommendations and methodological quality of guidelines for the diagnosis and treatment of COVID-19","volume":"14","author":"Luo","year":"2021","journal-title":"J Evid Based Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1001\/jama.2020.2783","article-title":"Positive RT-PCR test results in patients recovered from COVID-19","volume":"323","author":"Lan","year":"2020","journal-title":"JAMA."},{"key":"B8","doi-asserted-by":"publisher","first-page":"101619","DOI":"10.1016\/j.tmaid.2020.101619","article-title":"Positive result of Sars-Cov-2 in sputum from a cured patient with COVID-19","volume":"34","author":"Qu","year":"2020","journal-title":"Travel Med Infect Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1177\/0009922820928057","article-title":"Characteristics of children with reactivation of SARS-CoV-2 infection after hospital discharge","volume":"59","author":"Zhao","year":"2020","journal-title":"Clin Pediatr."},{"key":"B10","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ."},{"key":"B11","unstructured":"The AGREE II Instrument."},{"key":"B12","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s40779-020-00238-8","article-title":"Methodological quality (risk of bias) assessment tools for primary and secondary medical studies: what are they and which is better?","volume":"7","author":"Ma","year":"2020","journal-title":"Mil Med Res."},{"volume-title":"Statistical Methods for Rates and Proportions","year":"1981","author":"Fleiss","key":"B13"},{"key":"B14","unstructured":"IDSA Guidelines on the Treatment and Management of Patients With COVID-19."},{"key":"B15","unstructured":"Australian Guidelines for the Clinical Care of People With COVID-19"},{"key":"B16","unstructured":"COVID-19 Rapid Guideline: Managing COVID-19."},{"key":"B17","article-title":"American college of rheumatology guidance for covid-19 vaccination in patients with rheumatic and musculoskeletal diseases - version 1","volume-title":"Arthritis Rheumatol.","author":"Curtis","year":"2021"},{"key":"B18","doi-asserted-by":"publisher","first-page":"2100048","DOI":"10.1183\/13993003.00048-2021","article-title":"Management of hospitalised adults with coronavirus disease-19 (COVID-19): a European respiratory society living guideline","volume":"57","author":"Chalmers","year":"2021","journal-title":"Eur Respir J."},{"key":"B19","unstructured":"WHO Living Guideline: Drugs to Prevent COVID-19."},{"key":"B20","unstructured":"Coronavirus Disease 2019 (COVID-19) Treatment Guidelines."},{"key":"B21","doi-asserted-by":"publisher","first-page":"e219","DOI":"10.1097\/CCM.0000000000004899","article-title":"Surviving Sepsis campaign guidelines on the management of adults with Coronavirus disease 2019 (COVID-19) in the ICU: first update","volume":"49","author":"Alhazzani","year":"2021","journal-title":"Crit Care Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1111\/trf.16328","article-title":"COVID-19 convalescent plasma: interim recommendations from the AABB","volume":"61","author":"Cohn","year":"2021","journal-title":"Transfusion."},{"key":"B23","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1093\/jpids\/piaa115","article-title":"Multicenter interim guidance on use of antivirals for children with coronavirus disease 2019\/severe acute respiratory syndrome coronavirus 2","volume":"10","author":"Chiotos","year":"2021","journal-title":"J Pediatric Infect Dis Soc."},{"key":"B24","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.ejca.2021.01.033","article-title":"2021 update of the AGIHO guideline on evidence-based management of COVID-19 in patients with cancer regarding diagnostics, viral shedding, vaccination and therapy","volume":"147","author":"Giesen","year":"2021","journal-title":"Eur J Cancer."},{"key":"B25","doi-asserted-by":"publisher","first-page":"M20","DOI":"10.7326\/M20-8101","article-title":"Should remdesivir be used for the treatment of patients with COVID-19? Rapid, living practice points from the American college of physicians (version 2)","volume":"174","author":"Qaseem","year":"2021","journal-title":"Ann Intern Med."},{"key":"B26","unstructured":"Clinical management of COVID-19 patients: living guidance."},{"key":"B27","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1136\/gutjnl-2020-324000","article-title":"SARS-CoV-2 vaccination for patients with inflammatory bowel diseases: recommendations from an international consensus meeting","volume":"70","author":"Siegel","year":"2021","journal-title":"Gut."},{"key":"B28","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.cmi.2020.12.011","article-title":"Therapeutic strategies for severe COVID-19: a position paper from the Italian society of infectious and tropical diseases (SIMIT)","volume":"27","author":"Mussini","year":"2021","journal-title":"Clin Microbiol Infect."},{"key":"B29","doi-asserted-by":"publisher","first-page":"110","DOI":"10.4269\/ajtmh.20-1173","article-title":"Pragmatic recommendations for tracheostomy, discharge, and rehabilitation measures in hospitalized patients recovering from severe COVID-19 in low- and middle-income countries","volume":"104","author":"Schultz","year":"2021","journal-title":"Am J Trop Med Hyg."},{"key":"B30","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3238\/arztebl.m2021.0110","article-title":"Clinical practice guideline: recommendations on inpatient treatment of patients with COVID-19","author":"Kluge","year":"2021","journal-title":"Dtsch Arztebl Int."},{"key":"B31","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4269\/ajtmh.20-1064","article-title":"Pragmatic recommendations for identification and triage of patients with COVID-19 disease in low- and middle-income countries","volume":"104","author":"Barros","year":"2021","journal-title":"Am J Trop Med Hyg."},{"key":"B32","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1515\/jpm-2020-0265","article-title":"Clinical management of coronavirus disease 2019 (COVID-19) in pregnancy: recommendations of WAPM-world association of perinatal medicine","volume":"48","author":"Api","year":"2020","journal-title":"J Perinat Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.ijid.2020.11.173","article-title":"Algorithms for testing COVID-19 focused on use of RT-PCR and high-affinity serological testing: a consensus statement from a panel of Latin American experts","volume":"103","author":"Ferreira","year":"2021","journal-title":"Int J Infect Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s40779-020-00270-8","article-title":"Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: an evidence-based clinical practice guideline (updated version)","volume":"7","author":"Jin","year":"2020","journal-title":"Mil Med Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2002197","DOI":"10.1183\/13993003.02197-2020","article-title":"COVID-19: interim guidance on rehabilitation in the hospital and post-hospital phase from a European respiratory society and American thoracic society-coordinated international task force","volume":"56","author":"Spruit","year":"2020","journal-title":"Eur Respir J."},{"key":"B36","doi-asserted-by":"publisher","first-page":"E63","DOI":"10.1148\/radiol.2020203173","article-title":"Use of chest imaging in the diagnosis and management of COVID-19: a WHO rapid advice guide","volume":"298","author":"Akl","year":"2021","journal-title":"Radiology."},{"key":"B37","doi-asserted-by":"publisher","first-page":"m2924","DOI":"10.1136\/bmj.m2924","article-title":"Remdesivir for severe covid-19: a clinical practice guideline","volume":"370","author":"Rochwerg","year":"2020","journal-title":"BMJ."},{"key":"B38","doi-asserted-by":"publisher","first-page":"200287","DOI":"10.1183\/16000617.0287-2020","article-title":"Updated guidance on the management of COVID-19: from an American thoracic society\/European respiratory society coordinated international task force (29 July 2020)","volume":"29","author":"Bai","year":"2020","journal-title":"Eur Respir Rev."},{"key":"B39","doi-asserted-by":"publisher","first-page":"891","DOI":"10.19852\/j.cnki.jtcm.20200902.001","article-title":"Traditional Chinese medicine guidelines for coronavirus disease 2019","volume":"40","author":"Liang","year":"2020","journal-title":"J Tradit Chin Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"166","DOI":"10.5935\/0103-507x.20200039","article-title":"Guidelines for the pharmacological treatment of COVID-19","volume":"32","author":"Falavigna","year":"2020","journal-title":"Rev Bras Ter Intensiva."},{"key":"B41","doi-asserted-by":"publisher","first-page":"100470","DOI":"10.1016\/j.imr.2020.100470","article-title":"A consensus guideline of herbal medicine for coronavirus disease 2019","volume":"9","author":"Lee","year":"2020","journal-title":"Integr Med Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"617","DOI":"10.21037\/atm-20-3754","article-title":"Rapid advice guidelines for management of children with COVID-19","volume":"8","author":"Liu","year":"2020","journal-title":"Ann Transl Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1002\/ijgo.13146","article-title":"Expert consensus for managing pregnant women and neonates born to mothers with suspected or confirmed novel coronavirus (COVID-19) infection","volume":"149","author":"Chen","year":"2020","journal-title":"Int J Gynaecol Obstet."},{"key":"B44","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1177\/0846537120924606","article-title":"Canadian society of thoracic radiology\/Canadian association of radiologists consensus statement regarding chest imaging in suspected and confirmed COVID-19","volume":"71","author":"Dennie","year":"2020","journal-title":"Can Assoc Radiol J."},{"key":"B45","doi-asserted-by":"publisher","first-page":"E536","DOI":"10.1503\/cmaj.200648","article-title":"Treatment of patients with nonsevere and severe coronavirus disease 2019: an evidence-based guideline","volume":"192","author":"Ye","year":"2020","journal-title":"CMAJ."},{"key":"B46","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1007\/s12519-020-00362-4","article-title":"Updated diagnosis, treatment and prevention of COVID-19 in children: experts' consensus statement (condensed version of the second edition)","volume":"16","author":"Shen","year":"2020","journal-title":"World J Pediatr."},{"key":"B47","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3947\/ic.2020.52.2.281","article-title":"Interim guidelines on antiviral therapy for COVID-19","volume":"52","author":"Kim","year":"2020","journal-title":"Infect Chemother."},{"key":"B48","doi-asserted-by":"publisher","first-page":"109008","DOI":"10.1016\/j.ejrad.2020.109008","article-title":"Imaging of coronavirus disease 2019: a Chinese expert consensus statement","volume":"127","author":"Yang","year":"2020","journal-title":"Eur J Radiol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.chest.2020.04.003","article-title":"The role of chest imaging in patient management during the COVID-19 pandemic: a multinational consensus statement from the Fleischner society","volume":"158","author":"Rubin","year":"2020","journal-title":"Chest."},{"key":"B50","unstructured":"Guideline for Critical Care of Seriously Ill Adults Patients With Coronavirus (COVID-19) in the Americans."},{"key":"B51","unstructured":"Perinatal-Neonatal Management of COVID-19 Infection."},{"key":"B52","doi-asserted-by":"publisher","first-page":"47","DOI":"10.21037\/atm.2020.02.20","article-title":"Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (first edition)","volume":"8","author":"Wang","year":"2020","journal-title":"Ann Transl Med."},{"key":"B53","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s40779-020-0233-6","article-title":"A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)","volume":"7","author":"Jin","year":"2020","journal-title":"Mil Med Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"209","DOI":"10.12173\/j.issn.1004-5511.2020.03.07","article-title":"Evidence-based Chinese expert recommendations on drug prevention, diagnosis, treatment, and discharge management of covid-19 a protocol","volume":"30","author":"Jin","year":"2020","journal-title":"Yixue Xinzhi Zazhi."},{"key":"B55","unstructured":"COVID-19: MAGIC Making a Difference and MAGICapp Now Available to Develop Living Guidelines"},{"key":"B56","unstructured":"GRADEproGDT\n          GRADE Your Evidence and Improve Your Guideline Development in Health Care"},{"key":"B57","doi-asserted-by":"publisher","first-page":"3997","DOI":"10.3390\/ijerph17113997","article-title":"COVID-19: time for post-exposure prophylaxis?","volume":"17","author":"Gentile","year":"2020","journal-title":"Int J Environ Res Public Health."},{"key":"B58","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1007\/s11596-020-2203-3","article-title":"Potential of arbidol for post-exposure prophylaxis of COVID-19 transmission: a preliminary report of a retrospective cohort study","volume":"40","author":"Zhang","year":"2020","journal-title":"Curr Med Sci."},{"key":"B59","doi-asserted-by":"publisher","first-page":"495","DOI":"10.15585\/mmwr.mm7013e3","article-title":"Interim estimates of vaccine effectiveness of BNT162b2 and mRNA-1273 COVID-19 vaccines in preventing SARS-CoV-2 infection among health care personnel, first responders, and other essential and frontline workers - eight U.S. Locations, December 2020-March 2021","volume":"70","author":"Thompson","year":"2021","journal-title":"MMWR Morb Mortal Wkly Rep."},{"key":"B60","doi-asserted-by":"publisher","first-page":"4420","DOI":"10.1002\/jmv.26996","article-title":"Adverse effects of COVID-19 mRNA-1273 vaccine: a randomized, cross-sectional study on healthcare workers with detailed self-reported symptoms","volume":"93","author":"Kadali","year":"2021","journal-title":"J Med Virol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet."},{"key":"B62","article-title":"Covert coronavirus infections could be seeding new outbreaks","volume-title":"Nature.","author":"Qiu","year":"2020"},{"key":"B63","doi-asserted-by":"publisher","first-page":"101754","DOI":"10.1016\/j.tmaid.2020.101754","article-title":"Comparison of clinical and epidemiological characteristics of asymptomatic and symptomatic SARS-CoV-2 infection: a multi-center study in Sichuan Province, China","volume":"37","author":"Kong","year":"2020","journal-title":"Travel Med Infect Dis."},{"key":"B64","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1002\/jmv.25786","article-title":"Stability issues of RT-PCR testing of SARS-CoV-2 for hospitalized patients clinically diagnosed with COVID-19","volume":"92","author":"Li","year":"2020","journal-title":"J Med Virol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1002\/jmv.26211","article-title":"Diagnostic efficacy of anti-SARS-CoV-2 IgG\/IgM test for COVID-19: a meta-analysis","volume":"93","author":"Zhang","year":"2021","journal-title":"J Med Virol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"5720","DOI":"10.1007\/s00330-020-06934-2","article-title":"Chest CT for detecting COVID-19: a systematic review and meta-analysis of diagnostic accuracy","volume":"30","author":"Xu","year":"2020","journal-title":"Eur Radiol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3389\/fmed.2020.00231","article-title":"Clinical features, diagnosis, and treatment of COVID-19 in hospitalized patients: A systematic review of case reports and case series","volume":"7","author":"Tahvildari","year":"2020","journal-title":"Front Med."},{"key":"B68","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.medcli.2020.05.017","article-title":"Crucial laboratory parameters in COVID-19 diagnosis and prognosis: an updated meta-analysis","volume":"155","author":"Soraya","year":"2020","journal-title":"Med Clin."},{"key":"B69","doi-asserted-by":"publisher","first-page":"2666","DOI":"10.1002\/jmv.26127","article-title":"Lopinavir\/ritonavir and interferon combination therapy may help shorten the duration of viral shedding in patients with COVID-19: a retrospective study in two designated hospitals in Anhui, China","volume":"92","author":"Zuo","year":"2020","journal-title":"J Med Virol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1016\/S0140-6736(20)31042","article-title":"Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial","volume":"395","author":"Hung","year":"2020","journal-title":"Lancet."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.13210\/j.cnki.jhmu.20200528.001","article-title":"Meta-analysis of the efficacy and safety of Lianhua Qingwen combined with western medicine in the treatment of common patients with new coronary pneumonia","volume":"26","author":"Zhang","year":"2020","journal-title":"J Hainan Med Univ."},{"key":"B72","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1053\/j.gastro.2020.03.065","article-title":"Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from a Hong Kong cohort: systematic review and meta-analysis","volume":"159","author":"Cheung","year":"2020","journal-title":"Gastroenterology."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/S1473-3099(20)30433-3","article-title":"Assessment of patients who tested positive for COVID-19 after recovery","volume":"20","author":"Mei","year":"2020","journal-title":"Lancet Infect Dis."},{"key":"B74","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s40779-021-00298-4","article-title":"Development of rapid advice guideline and standard and continuous updating guideline: experiences and practice","volume":"8","author":"Jin","year":"2021","journal-title":"Mil Med Res."},{"key":"B75","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1097\/CM9.0000000000001169","article-title":"Some thoughts on conducting and implementing clinical practice guidelines in a pandemic","volume":"134","author":"Yao","year":"2021","journal-title":"Chin Med J."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2021.630765\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T06:26:58Z","timestamp":1623306418000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2021.630765\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,10]]},"references-count":75,"alternative-id":["10.3389\/fmed.2021.630765"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2021.630765","relation":{},"ISSN":["2296-858X"],"issn-type":[{"type":"electronic","value":"2296-858X"}],"subject":[],"published":{"date-parts":[[2021,6,10]]},"article-number":"630765"}}