{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:00:09Z","timestamp":1753891209990,"version":"3.41.2"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015696","name":"NATIONAL HEALTH INSURANCE SERVICE ILSANHOSPITAL","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015696","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> We investigated the effects of anthropometric, laboratory, and lifestyle factors on the development of non-alcoholic fatty liver disease (NAFLD) in a nationwide, population-based, 4-year retrospective cohort.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The propensity score-matched study and control groups contained 1,474 subjects who had data in the Korean National Health Insurance Service-National Sample Cohort in 2009, 2011, and 2013. NAFLD was defined using medical records of a diagnosis confirmed by primary clinicians and meeting two previously validated fatty liver prediction models. Chronological changes in anthropometric variables, laboratory results, and lifestyle factors during two periods were compared between patient and control groups in order to find out parameters with consistent dynamics in pre-NAFLD stage which was defined as period just before the NAFLD development.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Among the 5 anthropometric, 10 laboratory, and 3 lifestyle factors, prominent chronological decremental changes in serum triglycerides were consistently observed during the pre-NAFLD stage, although the degrees of changes were more predominant in men (\u22129.46 mg\/dL) than women (\u22125.98 mg\/dL). Furthermore, weight and waist circumference changes during the pre-NAFLD stage were noticeable only in women (+0.36 kg and +0.9 cm for weight and waist circumference, respectively), which suggest gender difference in NAFLD.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Early screening strategies for people with abrupt chronological changes in serum triglycerides to predict NAFLD development before the progression is recommended.<\/jats:p>","DOI":"10.3389\/fmed.2021.637241","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T04:35:46Z","timestamp":1615350946000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Dynamic Chronological Changes in Serum Triglycerides Are Associated With the Time Point for Non-alcoholic Fatty Liver Disease Development in the Nationwide Korean Population Cohort"],"prefix":"10.3389","volume":"8","author":[{"given":"John Hoon","family":"Rim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taemi","family":"Youk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heon Yung","family":"Gee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jooyoung","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jongha","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,3,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/s2213-8587(18)30154-2","article-title":"Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies","volume":"7","author":"Stefan","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1038\/ajg.2012.314","article-title":"Association of nonalcoholic fatty liver disease with components of metabolic syndrome according to body mass index in Korean adults","volume":"107","author":"Kwon","year":"2012","journal-title":"Am J Gastroenterol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1007\/s10620-016-4153-y","article-title":"Lifestyle and dietary interventions in the management of nonalcoholic fatty liver disease","volume":"61","author":"Hannah","year":"2016","journal-title":"Dig Dis Sci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"519","DOI":"10.3109\/07853890.2015.1077989","article-title":"Television viewing and fatty liver in early midlife. 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