{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:14:17Z","timestamp":1793999657083,"version":"4.8.0"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930088"],"award-info":[{"award-number":["81930088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["26181725018"],"award-info":[{"award-number":["26181725018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703118"],"award-info":[{"award-number":["81703118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803123"],"award-info":[{"award-number":["81803123"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Psoriasis is a chronic immune-mediated skin disease, whose hallmarks include keratinocyte hyperproliferation and CD4<jats:sup>+<\/jats:sup> T cell subsets imbalance. Dysregulated microRNAs (miRNAs) identified in psoriasis have been shown to affect keratinocyte and T cell functions, with studies on the molecular mechanisms and intrinsic relationships of the miRNAs on the way. Here, we focus on the dysregulated miRNAs that contribute to the two hallmarks of psoriasis with the miRNA target genes confirmed. We review a network, in which, upregulated miR-31\/miR-203\/miR-155\/miR-21 and downregulated miR-99a\/miR-125b facilitate the excessive proliferation and abnormal differentiation of psoriatic keratinocytes; upregulated miR-210 and downregulated miR-138 work in concert to distort CD4<jats:sup>+<\/jats:sup> T cell subsets balance in psoriasis. The miRNAs exert their functions through regulating key psoriasis-associated transcription factors including NF-\u03baB and STAT3. Whether flowing up or down, these miRNAs collaborate to promote the development and maintenance of psoriasis.<\/jats:p>","DOI":"10.3389\/fmed.2021.646796","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T04:42:27Z","timestamp":1614314547000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":38,"title":["miRNAs Flowing Up and Down: The Concerto of Psoriasis"],"prefix":"10.3389","volume":"8","author":[{"given":"Yang","family":"Xiuli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Honglin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,2,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1001\/jama.2020.4006","article-title":"Pathophysiology, clinical presentation, and treatment of psoriasis: a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nrdp.2016.82","article-title":"Psoriasis","volume":"2","author":"Greb","year":"2016","journal-title":"Nat Rev Dis Primers."},{"key":"B3","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/S0140-6736(14)61909-7","article-title":"Psoriasis","volume":"386","author":"Boehncke","year":"2015","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s12016-016-8535-x","article-title":"The inflammatory response in psoriasis: a comprehensive review","volume":"50","author":"Deng","year":"2016","journal-title":"Clin Rev Allergy Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1002\/JLB.5MR0120-439R","article-title":"Keratinocyte: a trigger or an executor of psoriasis?","volume":"108","author":"Ni","year":"2020","journal-title":"J Leukoc Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jdermsci.2019.11.003","article-title":"Integrated microRNA\/mRNA expression profiling of the skin of psoriasis patients","volume":"97","author":"Deli\u0107","year":"2020","journal-title":"J Dermatol Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/JID.2015.409","article-title":"microRNAs in psoriasis","volume":"136","author":"Hawkes","year":"2016","journal-title":"J Investig Dermatol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/nrg1379","article-title":"MicroRNAs: small RNAs with a big role in gene regulation","volume":"5","author":"He","year":"2004","journal-title":"Nat Rev Genet."},{"key":"B9","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","article-title":"Metazoan MicroRNAs","volume":"173","author":"Bartel","year":"2018","journal-title":"Cell"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0000610","article-title":"MicroRNAs: novel regulators involved in the pathogenesis of psoriasis?","volume":"2","author":"Sonkoly","year":"2007","journal-title":"PLoS ONE."},{"key":"B11","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.imlet.2015.05.014","article-title":"MicroRNA-138 regulates the balance of Th1\/Th2 via targeting RUNX3 in psoriasis","volume":"166","author":"Fu","year":"2015","journal-title":"Immunol Lett."},{"key":"B12","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1111\/j.1600-0625.2012.01462.x","article-title":"MiR-21 is up-regulated in psoriasis and suppresses T cell apoptosis","volume":"21","author":"Meisgen","year":"2012","journal-title":"Exp Dermatol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.1172\/JCI97426","article-title":"MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation","volume":"128","author":"Wu","year":"2018","journal-title":"J Clin Investig."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms8652","article-title":"NF-\u03baB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis","volume":"6","author":"Yan","year":"2015","journal-title":"Nat Commun."},{"key":"B15","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.biopha.2018.06.136","article-title":"Emerging landscape in psoriasis management: from topical application to targeting biomolecules","volume":"106","author":"Rapalli","year":"2018","journal-title":"Biomed Pharmacother."},{"key":"B16","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.jep.2016.08.028","article-title":"MicroRNA-146a and miR-99a are potential biomarkers for disease activity and clinical efficacy assessment in psoriasis patients treated with traditional Chinese medicine","volume":"194","author":"Yang","year":"2016","journal-title":"J Ethnopharmacol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1111\/jcmm.12359","article-title":"A single-nucleotide polymorphism of miR-146a and psoriasis: an association and functional study","volume":"18","author":"Zhang","year":"2014","journal-title":"J Cell Mol Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"14030","DOI":"10.1073\/pnas.1111292109","article-title":"microRNA-31\/factor-inhibiting hypoxia-inducible factor 1 nexus regulates keratinocyte differentiation","volume":"109","author":"Peng","year":"2012","journal-title":"Proc Natl Acad Sci USA."},{"key":"B19","doi-asserted-by":"publisher","first-page":"987","DOI":"10.33549\/physiolres.933615","article-title":"Roles of miR-31 and endothelin-1 in psoriasis vulgaris: pathophysiological functions and potential biomarkers","volume":"66","author":"Borska","year":"2017","journal-title":"Physiol Res"},{"key":"B20","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/jid.2009.294","article-title":"Protein KINASE C-dependent upregulation of miR-203 induces the differentiation of human keratinocytes","volume":"130","author":"Sonkoly","year":"2010","journal-title":"J Investig Dermatol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1038\/cdd.2008.69","article-title":"miR-203 represses \u2018stemness' by repressing \u0394Np63","volume":"15","author":"Lena","year":"2008","journal-title":"Cell Death Differ."},{"key":"B22","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/nature06642","article-title":"A skin microRNA promotes differentiation by repressing \u2018stemness'","volume":"452","author":"Yi","year":"2008","journal-title":"Nature."},{"key":"B23","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/cdd.2014.113","article-title":"MicroRNAs and p63 in epithelial stemness","volume":"22","author":"Candi","year":"2014","journal-title":"Cell Death Differ."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.1242\/dev.089649","article-title":"Rapid and widespread suppression of self-renewal by microRNA-203 during epidermal differentiation","volume":"140","author":"Jackson","year":"2013","journal-title":"Development."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1080\/15384101.2020.1783934","article-title":"miR-203 promotes HaCaT cell overproliferation through targeting LXR-\u03b1 and PPAR-\u03b3","volume":"19","author":"Xiao","year":"2020","journal-title":"Cell Cycle."},{"key":"B26","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1111\/jdv.13861","article-title":"Increased expression of microRNA-155 in peripheral blood mononuclear cells from psoriasis patients is related to disease activity","volume":"31","author":"Garc\u00eda-Rodr\u00edguez","year":"2017","journal-title":"J Eur Acad Dermatol Venereol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1111\/exd.14117","article-title":"The miR-155\/GATA3\/IL37 axis modulates the production of proinflammatory cytokines upon TNF-\u03b1 stimulation to affect psoriasis development","volume":"29","author":"Wang","year":"2020","journal-title":"Exp Dermatol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.biopha.2017.03.105","article-title":"MiR-155 promotes cell proliferation and inhibits apoptosis by PTEN signaling pathway in the psoriasis","volume":"90","author":"Xu","year":"2017","journal-title":"Biomed Pharmacother."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1007\/s11064-006-9142-7","article-title":"pERK, pAkt and pBad: a possible role in cell proliferation and sustained cellular survival during tumorigenesis and tumor progression in ENU induced transplacental glioma rat model","volume":"31","author":"Bhaskara","year":"2006","journal-title":"Neurochem Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1111\/ijd.12061","article-title":"Downregulation of PTEN expression in psoriatic lesions","volume":"53","author":"Li","year":"2014","journal-title":"Int J Dermatol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/scitranslmed.3008089","article-title":"Targeting miR-21 to treat psoriasis","volume":"6","author":"Guinea-Viniegra","year":"2014","journal-title":"Sci Transl Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12860-019-0229-9","article-title":"LncRNA MEG3 influences the proliferation and apoptosis of psoriasis epidermal cells by targeting miR-21\/caspase-8","volume":"20","author":"Jia","year":"2019","journal-title":"BMC Mol Cell Biol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.3727\/096504017X14841698396829","article-title":"MicroRNA-21 inhibits the apoptosis of osteosarcoma cell line SAOS-2 via targeting caspase 8","volume":"25","author":"Xu","year":"2017","journal-title":"Oncol Res Featur Preclin Clin Cancer Ther."},{"key":"B34","doi-asserted-by":"publisher","first-page":"5227","DOI":"10.3892\/mmr.2019.10187","article-title":"miR-125b-mediated regulation of cell proliferation through the Jagged-1\/Notch signaling pathway by inhibiting BRD4 expression in psoriasis","volume":"19","author":"Pan","year":"2019","journal-title":"Mol Med Rep"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1038\/jid.2011.55","article-title":"MiR-125b, a MicroRNA downregulated in psoriasis, modulates keratinocyte proliferation by targeting FGFR2","volume":"131","author":"Xu","year":"2011","journal-title":"J Investig Dermatol."},{"key":"B36","first-page":"1619","article-title":"Altered expression of keratinocyte growth factor and its receptor in psoriasis","volume":"151","author":"Finch","year":"1997","journal-title":"Am J Pathol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejphar.2019.172659","article-title":"MiR-125b-5p and miR-181b-5p inhibit keratinocyte proliferation in skin by targeting Akt3","volume":"862","author":"Zheng","year":"2019","journal-title":"Eur J Pharmacol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1111\/bjd.14916","article-title":"Ubiquitin-specific peptidase 2 as a potential link between microRNA-125b and psoriasis","volume":"176","author":"Wei","year":"2017","journal-title":"Br J Dermatol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"e20916","DOI":"10.1371\/journal.pone.0020916","article-title":"MiRNA expression in psoriatic skin: reciprocal regulation of hsa-miR-99a and IGF-1R","volume":"6","author":"Lerman","year":"2011","journal-title":"PLoS ONE."},{"key":"B40","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1691\/ph.2017.7018","article-title":"MiR-99a inhibits keratinocyte proliferation by targeting Frizzled-5 (FZD5) \/ FZD8 through \u03b2-catenin signaling in psoriasis","volume":"72","author":"Shen","year":"2017","journal-title":"Pharmazie"},{"key":"B41","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.cell.2016.12.012","article-title":"30 Years of NF-\u03baB: a blossoming of relevance to human pathobiology","volume":"168","author":"Zhang","year":"2017","journal-title":"Cell"},{"key":"B42","doi-asserted-by":"publisher","first-page":"546","DOI":"10.3389\/fimmu.2018.00546","article-title":"MicroRNA roles in the nuclear factor kappa B signaling pathway in cancer","volume":"9","author":"Wu","year":"2018","journal-title":"Front Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1038\/jid.2014.89","article-title":"MiR-146a negatively regulates TLR2-induced inflammatory responses in keratinocytes","volume":"134","author":"Meisgen","year":"2014","journal-title":"J Investig Dermatol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"678","DOI":"10.4049\/jimmunol.1202695","article-title":"MicroRNA-31 is overexpressed in psoriasis and modulates inflammatory cytokine and chemokine production in keratinocytes via targeting serine\/threonine kinase 40","volume":"190","author":"Xu","year":"2013","journal-title":"J Immunol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.jaci.2016.07.025","article-title":"MicroRNA-146a suppresses IL-17\u2013mediated skin inflammation and is genetically associated with psoriasis","volume":"139","author":"Srivastava","year":"2017","journal-title":"J Allergy Clin Immunol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1016\/j.jid.2017.05.012","article-title":"miR-146b Probably assists miRNA-146a in the suppression of keratinocyte proliferation and inflammatory responses in psoriasis","volume":"137","author":"Hermann","year":"2017","journal-title":"J Investig Dermatol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"3003","DOI":"10.1074\/jbc.M117.809780","article-title":"MicroRNA-146 and cell trauma down-regulate expression of the psoriasis-associated atypical chemokine receptor ACKR2","volume":"293","author":"Shams","year":"2018","journal-title":"J Biol Chem."},{"key":"B48","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1089\/dna.2016.3517","article-title":"microRNA-130a promotes human keratinocyte viability and migration and inhibits apoptosis through direct regulation of STK40-mediated NF-\u03baB pathway and indirect regulation of SOX9-meditated JNK\/MAPK pathway: a potential role in psoriasis","volume":"36","author":"Xiong","year":"2017","journal-title":"DNA Cell Biol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"5498","DOI":"10.18632\/oncotarget.12534","article-title":"Role of an imbalanced miRNAs axis in pathogenesis of psoriasis: novel perspectives based on review of the literature","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1016\/j.cell.2007.06.009","article-title":"AKT\/PKB signaling: navigating downstream","volume":"129","author":"Manning","year":"2007","journal-title":"Cell."},{"key":"B51","doi-asserted-by":"publisher","first-page":"2160","DOI":"10.1007\/s10753-018-0859-7","article-title":"miR-320b is down-regulated in psoriasis and modulates keratinocyte proliferation by targeting AKT3","volume":"41","author":"Wang","year":"2018","journal-title":"Inflammation."},{"key":"B52","doi-asserted-by":"publisher","first-page":"742","DOI":"10.2340\/00015555-2394","article-title":"MicroRNA-155 is dysregulated in the skin of patients with vitiligo and inhibits melanogenesis-associated genes in melanocytes and keratinocytes","volume":"96","author":"\u0160ahmatova","year":"2014","journal-title":"Acta Dermato Venereol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/1471-2199-14-24","article-title":"Identification of an NF-\u03baB p50\/p65-responsive site in the human MIR155HG promoter","volume":"14","author":"Thompson","year":"2013","journal-title":"BMC Mol Biol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.lfs.2019.05.045","article-title":"MiR-223 regulates proliferation and apoptosis of IL-22-stimulated HaCat human keratinocyte cell lines via the PTEN\/Akt pathway","volume":"230","author":"Wang","year":"2019","journal-title":"Life Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jdermsci.2010.03.004","article-title":"MicroRNAs and potential target interactions in psoriasis","volume":"58","author":"Zibert","year":"2010","journal-title":"J Dermatol Sci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1111\/exd.13520","article-title":"The contribution of feedback loops between miRNAs, cytokines and growth factors to the pathogenesis of psoriasis","volume":"27","author":"Masalha","year":"2018","journal-title":"Exp Dermatol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"919","DOI":"10.15252\/emmm.201505384","article-title":"Identification of a novel PPAR \u03b2\/\u03b4\/miR-21-3p axis in UV-induced skin inflammation","volume":"8","author":"Degueurce","year":"2016","journal-title":"EMBO Mol Med."},{"key":"B58","doi-asserted-by":"publisher","first-page":"e11240","DOI":"10.1371\/journal.pone.0112408","article-title":"Involvement of TNF-\u03b1 converting enzyme in the development of psoriasis-like lesions in a mouse model","volume":"9","author":"Sato","year":"2014","journal-title":"PLoS ONE."},{"key":"B59","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.cyto.2012.07.031","article-title":"Regulation of pro-inflammatory cytokines TNF\u03b1 and IL24 by microRNA-203 in primary keratinocytes","volume":"60","author":"Primo","year":"2012","journal-title":"Cytokine."},{"key":"B60","doi-asserted-by":"publisher","first-page":"8989","DOI":"10.3892\/mmr.2017.7759","article-title":"miR-203 contributes to IL-17-induced VEGF secretion by targeting SOCS3 in keratinocytes","volume":"16","author":"Xu","year":"2017","journal-title":"Mol Med Rep."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1002\/jcp.24608","article-title":"hsa-miR-4516 mediated downregulation of STAT3\/CDK6\/UBE2N plays a role in PUVA induced apoptosis in keratinocytes","volume":"229","author":"Chowdhari","year":"2014","journal-title":"J Cell Physiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"3142","DOI":"10.1016\/j.bbadis.2017.08.014","article-title":"miR-4516, a microRNA downregulated in psoriasis inhibits keratinocyte motility by targeting fibronectin\/integrin \u03b19 signaling","volume":"1863","author":"Chowdhari","year":"2017","journal-title":"Biochim Biophys Acta Mol Basis Dis."},{"key":"B63","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/exd.13139","article-title":"TNF-\u03b1 inhibitors reduce the pathological Th1-Th17\/Th2imbalance in cutaneous mesenchymal stem cells of psoriasis patients","volume":"26","author":"Campanati","year":"2017","journal-title":"Exp Dermatol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1159\/000330330","article-title":"Th1, Th2, Th17 and regulatory T cell pattern in psoriatic patients: modulation of cytokines and gene targets induced by etanercept treatment and correlation with clinical response","volume":"223","author":"Quaglino","year":"2011","journal-title":"Dermatology."},{"key":"B65","doi-asserted-by":"publisher","first-page":"6976","DOI":"10.1073\/pnas.1001653107","article-title":"Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds","volume":"107","author":"Biswas","year":"2010","journal-title":"Proc Natl Acad Sci USA."},{"key":"B66","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.clim.2013.10.009","article-title":"Up-regulation of microRNA-210 induces immune dysfunction via targeting FOXP3 in CD4+ T cells of psoriasis vulgaris","volume":"150","author":"Zhao","year":"2014","journal-title":"Clin Immunol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/1346-8138.15149","article-title":"Topical administration of nanocarrier miRNA-210 antisense ameliorates imiquimod-induced psoriasis-like dermatitis in mice","volume":"47","author":"Feng","year":"2019","journal-title":"J Dermatol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"4606","DOI":"10.3892\/mmr.2016.5108","article-title":"Downregulation of RUNX3 moderates the frequency of Th17 and Th22 cells in patients with psoriasis","volume":"13","author":"Fu","year":"2016","journal-title":"Mol Med Rep."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1016\/j.biopha.2017.06.055","article-title":"MiR-200a expression in CD4+ T cells correlates with the expression of Th17\/Treg cells and relevant cytokines in psoriasis vulgaris: a case control study","volume":"93","author":"Wang","year":"2017","journal-title":"Biomed Pharmacother."},{"key":"B70","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/j.cell.2010.08.012","article-title":"Function of miR-146a in controlling treg cell-mediated regulation of Th1 responses","volume":"142","author":"Lu","year":"2010","journal-title":"Cell."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2021.646796\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T04:42:31Z","timestamp":1614314551000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2021.646796\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,26]]},"references-count":70,"alternative-id":["10.3389\/fmed.2021.646796"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2021.646796","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,26]]},"article-number":"646796"}}